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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GC Gene

protein-coding   GIFtS: 65
GCID: GC04M072596

group-specific component (vitamin D binding protein)
 Explore 81 diseases affiliated with
GC via
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Biological research products
for GC    

Aliases
for GC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Group-Specific Component (Vitamin D Binding Protein)1 2     VDBG2
DBP1 2 3 5     Gc-Globulin1
VDBP1 2     Vitamin D-Binding Alpha-Globulin2
VDB2 3     Vitamin D-Binding Protein2
GRD32 5     Gc-Globulin1
HDBP1     Group-Specific Component3
DBP/GC2     EC 6.3.1.58

External Ids:    HGNC: 41871   Entrez Gene: 26382   Ensembl: ENSG000001453217   OMIM: 1392005   UniProtKB: P027743   

Export aliases for GC gene to outside databases

Previous GC identifers: GC04M072847 GC04M073008 GC04M073073 GC04M072972 GC04M072826 GC04M068412


Summaries
for GC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GC:
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma,
ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma
metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: VTDB_HUMAN, P02774
Function: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of
many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its
monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor
on the membranes of T-lymphocytes

Gene Wiki entry for GC (Vitamin D-binding protein)


Genomic Views
for GC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GC gene promoter:
         GR   AP-1   ATF-2   HSF1 (long)   Nkx2-5   C/EBPalpha   HSF1short   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GC promoter sequence
   Search SABiosciences Chromatin IP Primers for GC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q13   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q13

GC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M072596:  view genomic region     (about GC identifiers)

Start:
 72,607,410 bp from pter      End:
 72,669,758 bp from pter
Size:
 62,349 bases      Orientation:
 minus strand

Proteins
for GC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VTDB_HUMAN, P02774 (See protein sequence)
Recommended Name: Vitamin D-binding protein precursor  
Size: 474 amino acids; 52964 Da
Subcellular location: Secreted
Sequence caution: Sequence=BAG60654.1; Type=Erroneous translation; Note=Wrong choice of CDS;
6 PDB 3D structures from and Proteopedia for GC:
1J78 (3D)        1J7E (3D)        1KW2 (3D)        1KXP (3D)        1LOT (3D)        1MA9 (3D)    
Secondary accessions: B4DPP2 D6RAK8 Q16309 Q16310 Q53F31 Q6GTG1
Alternative splicing: 3 isoforms:  P02774-1   P02774-2   P02774-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GC: NX_P02774

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02774

    • 2 DME Specific Peptides for GC (P02774)
     PTADLED  KVPTADL 

    GC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_000574.2  NP_001191235.1  NP_001191236.1  

    ENSEMBL proteins: 
     ENSP00000273951   ENSP00000421725   ENSP00000426683   ENSP00000422664   ENSP00000426718  
    Reactome Protein details: P02774
    Human Recombinant Protein Products: 
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    Novus Biologicals GC Protein
    Novus Biologicals GC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GC

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005829cytosol TAS--
    GO:0030424axon ----
    GO:0043202lysosomal lumen TAS--


    GC for ontologies           About GeneDecksing



    GC Antibody Products: 
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    R&D Systems Antibodies for GC (Vitamin D BP)
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    Uscn Antibodies for GC
    ThermoFisher Antibodies for GC

    Assay Products for GC: 
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    R&D Systems ELISAs for GC (Vitamin D BP)
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GC

    Protein Domains /
    Families
    for GC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GC for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000264 Serum_albumin
     IPR000213 VitD-bd
     IPR014760 Serum_albumin_N
     IPR015247 VitD-bind_III
     IPR020858 Serum_albumin-like

    Graphical View of Domain Structure for InterPro Entry P02774

    ProtoNet protein and cluster: P02774

    2 Blocks protein families:
    IPB000213 Vitamin D-binding protein signature
    IPB000264 Serum albumin family


    UniProtKB/Swiss-Prot: VTDB_HUMAN, P02774
    Similarity: Belongs to the ALB/AFP/VDB family
    Similarity: Contains 3 albumin domains


    Function
    for GC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VTDB_HUMAN, P02774
    Function: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of
    many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its
    monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor
    on the membranes of T-lymphocytes

         Genatlas biochemistry entry for GC:
    group-specific component (vitamin D binding protein),52.9kDa,found in plasma,CSF,urine and the cell surface of many
    cell types

    Enzyme Number (IUBMB): EC 6.3.1.52

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for GC

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IPI12119014
    GO:0005499vitamin D binding IEA--
    GO:0051183vitamin transporter activity IEA--


    GC for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for GC:
     Decreased POU5F1-GFP protein e  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Gctm1Nec for GC
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gc):
     endocrine/exocrine gland  homeostasis/metabolism  skeleton 

    GC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Vitamin D (calciferol) metabolism
    		Vitamin D (calciferol) metabolism1.00
    		Steroid hormones0.27
    		Legumain degrades DBP0.43
    		Metabolism of steroid hormones and vitamin D0.27
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3Vitamin D2 (ergocalciferol) metabolism
    		Vitamin D synthesis0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for GC 
        Vitamin D synthesis

    5/6        Reactome Pathways for GC (see all 6)
        Metabolism of steroid hormones and vitamin D
    Metabolism
    Steroid hormones
    Vitamin D (calciferol) metabolism
    Legumain degrades DBP



    GC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for GC (P027742, 3 ENSP000002739514) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681332, 3, ENSP000003556454MINT-24830 MINT-24961 I2D: score=4 STRING: ENSP00000355645
    LRIF1Q5T3J32, 3MINT-63353 I2D: score=4 
    HYPKQ9NX552, 3MINT-63354 I2D: score=1 
    SERF2P841013, ENSP000002497864I2D: score=3 STRING: ENSP00000249786
    LRP2P981643, ENSP000002638164I2D: score=2 STRING: ENSP00000263816
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy ----
    GO:0007595lactation ----
    GO:0008202steroid metabolic process TAS--
    GO:0031667response to nutrient levels ----
    GO:0032355response to estradiol stimulus ----


    GC for ontologies           About GeneDecksing



    Drugs & Compounds
    for GC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GC

    3 DrugBank Compounds for GC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alfacalcidol1-hydroxycholecalciferol (see all 3)41294-56-8carriersubstrate17023693 10052453 11799400 8660814 8759764
    Cholecalciferol(+)-vitamin D3 (see all 5)67-97-0carrier--17023693 10052453 11799400 8660814 8759764
    Oleic Acid-- 112-80-1carrier--17139284 17016423

    10/50 Novoseek chemical compound relationships for GC gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 91 568 1667458 (6), 16115686 (5), 18721734 (5), 19116321 (4) (see all 99)
    25-hydroxyvitamin d 86.2 71 17056796 (2), 2394211 (2), 11814777 (2), 19303961 (2) (see all 41)
    calcitriol 86.1 74 7554318 (3), 8147918 (2), 7976510 (2), 15868280 (2) (see all 47)
    bromoacetate 74.5 3 10620374 (3)
    bnps-skatole 72.5 3 10620374 (1), 9200691 (1)
    1,25(oh)2-16-ene-23-yne-d3 72.5 2 2004595 (1), 1796753 (1)
    1,25 dihydroxy vitamin d3 67.2 10 2173481 (2), 2153815 (1), 1667458 (1), 2224592 (1) (see all 7)
    22-oxacalcitriol 58.1 4 12417596 (1)
    dops 44.7 2 15125786 (1), 15868280 (1)
    calcipotriol 42.6 2 2004595 (1), 1796753 (1)

    Search CenterWatch for drugs/clinical trials and news about GC / VTDB 

    Transcripts
    for GC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GC gene (3 alternative transcripts): 
    NM_000583.3  NM_001204306.1  NM_001204307.1  

    Unigene Cluster for GC:

    Group-specific component (vitamin D binding protein)
    Hs.418497  [show with all ESTs]
    Unigene Representative Sequence: NM_000583
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273951(uc003hge.3 uc021xpb.1) ENST00000504199(uc010iif.3)
    ENST00000503364 ENST00000513476 ENST00000509740 ENST00000503472 ENST00000505234
    ENST00000506245

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GC (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AK223458.1 AK290827.1 AK309595.1 AK312971.1 AK315853.1 BC022310.1 BC057228.1 X03178.1 

    14 DOTS entries:

    DT.92413332  DT.454989  DT.121273216  DT.100878018  DT.100878009  DT.100651644  DT.100836279  DT.92441811 
    DT.121640641  DT.419284  DT.92441816  DT.95173051  DT.97780386  DT.87078966 

    24/354 AceView cDNA sequences (see all 354):

    T55850 CR618111 R85385 AL531267 T73316 T60971 CR599900 CR605798 
    CR625359 T39954 CR626806 CR615226 CR589987 AA694251 R84627 CR597042 
    NM_000583 T50882 AA702473 CR612125 CB114875 CR600650 BX426880 CR611556 

    GeneLoc Exon Structure


    Expression
    for GC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTATTAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See GC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GC

    SOURCE GeneReport for Unigene cluster: Hs.418497
        SABiosciences Expression via Pathway-Focused PCR Array including GC: 
              Nephrotoxicity in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for GC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for GC gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GC1 group-specific component (vitamin D binding protein) 59.84(n)
    51.08(a)    		   395696  NM_204882.1  NP_990213.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GC6
    		 --
    		 44(a)
    		 1 ↔ 1
    		 5(147578207-147596015)
    zebrafish
    (Danio rerio)    		 Actinopterygii gc1 group-specific component (vitamin D binding protein) 45.6(n)
    31.71(a)    		   436841  NM_001002568.1  NP_001002568.1 


    ENSEMBL Gene Tree for GC (if available)
    TreeFam Gene Tree for GC (if available) 

    Paralogs
    for GC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GC gene
    AFM2  ALB2  AFP2  

    GC for paralogs           About GeneDecksing



    Genomic Variants
    for GC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: VTDB_HUMAN, P02774
    Polymorphism: Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F,
    GC*1S, and GC*2. The sequence shown is that of the GC*2 allele


    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GC
         1 Indel: 10764
    Human Gene Mutation Database (HGMD): GC

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for GC

    Disorders / Diseases
    for GC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GC for disorders           About GeneDecksing

    OMIM gene information: 139200    OMIM disorders: --

    20/81 diseases for GC (see all 81):    About MalaCards
    alpha 1-antitrypsin deficiency    spinal cord injury    osteoporosis, postmenopausal    central nervous system disease
    temporal lobe epilepsy    dengue hemorrhagic fever    nervous system disease    type 2 diabetes mellitus
    hemorrhagic fever    graves' disease    diffuse panbronchiolitis    panbronchiolitis
    chronic obstructive pulmonary disease    herpes simplex    diabetes mellitus    ankylosing spondylitis
    osteoporosis    hepatic encephalopathy    secondary hyperparathyroidism    arterial calcification

    1 disease from the University of Copenhagen DISEASES database for GC:
    Osteoporosis

    10/45 Novoseek disease relationships for GC gene (see all 45)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d deficiency 61.4 1 10526241 (1)
    idiopathic osteoporosis 55.9 2 16339300 (1), 18038108 (1)
    rickets 49.5 3 1802786 (1), 2004595 (1), 2173481 (1)
    hepatic failure fulminant 48.2 8 17852808 (2), 9267951 (2), 19002085 (1), 16402919 (1) (see all 5)
    pulmonary disease chronic obstructive 41.5 12 15059409 (2), 16637263 (2), 14987123 (1), 11757623 (1) (see all 5)
    herpes simplex 41.4 10 18480440 (1), 8406590 (1), 9472620 (1), 12441085 (1) (see all 9)
    hepatic encephalopathy 40.6 3 11521994 (1), 19232164 (1)
    osteoporosis 40.3 14 12968673 (3), 16339300 (2), 19488670 (2), 10485974 (1) (see all 8)
    multiple organ failure 37.3 7 9267951 (2), 10446889 (1), 16402919 (1), 17360250 (1) (see all 5)
    hypercalcemia 35.6 2 19364661 (1), 2318935 (1)

    Genetic Association Database (GAD): GC
    Human Genome Epidemiology (HuGE) Navigator: GC (838 documents)

    Export disorders for GC gene to outside databases

    Publications
    for GC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GC gene, integrated from 9 sources (see all 502):
    (articles sorted by number of sources associating them with GC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A structural basis for the unique binding features of the human vitamin D-binding protein. (PubMed id 11799400)1, 2, 7, 9 Verboven C....De Ranter C. (2002)
    2. Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland. (PubMed id 14987123)1, 4, 9 Laufs J....Hakonarson H. (2004)
    3. [Allele polymorphism of alkaline phosphatase, acid soluble phosphatase, and vitamin D-binding protein genes in postmenopausal osteoporosis] (PubMed id 15230135)1, 4, 9 Krylov M.I.u....Benevolenskaia L.I. (2004)
    4. [The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease] (PubMed id 15059409)1, 4, 9 Lu M....Cai Y.Y. (2004)
    5. [Genetic predisposition to development of toxic liver cirrhosis caused by alcohol] (PubMed id 11436564)1, 4, 9 Spitsyn V.A....Afanas'eva I.S. (2001)
    6. Association of interleukin 10 haplotype with low bone mineral density in Korean postmenopausal women. (PubMed id 15607028)1, 4 Park B.L....Shin H.D. (2004)
    7. Phenotype and allele frequencies of some serum protein polymorphisms in populations of the Balkans. (PubMed id 15648851)1, 4 Scheil H.G....Huckenbeck W. (2004)
    8. Risk and severity of COPD is associated with the group-specific component of serum globulin 1F allele. (PubMed id 14718422)1, 4 Ito I....Mishima M. (2004)
    9. Genetic diversity of serum proteins in three subpopulations of the Maria Gond tribe of Madhya Pradesh, India. (PubMed id 14523999)1, 4 Das K....Mastana S.S. (2003)
    10. Lack of association of group specific component haplotypes with lung function in smokers. (PubMed id 12947140)1, 4 Kasuga I....Sandford A.J. (2003)

    External Searches for GC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2638 HGNC: 4187 AceView: GC Ensembl:ENSG00000145321 euGenes: HUgn2638
    ECgene: GC H-InvDB: GC

    Other Databases showing GC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GC gene:
    Search GeneIP for patents involving GC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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