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Aliases for GC Gene

Aliases for GC Gene

  • Group-Specific Component (Vitamin D Binding Protein) 2 3
  • DBP 3 4 6
  • Gc-Globulin 3 4
  • GRD3 3 6
  • VDB 3 4
  • Epididymis Secretory Protein Li 51 3
  • Vitamin D-Binding Alpha-Globulin 3
  • Vitamin D-Binding Protein 3
  • Group-Specific Component 4
  • EC 6.3.1.5 63
  • HEL-S-51 3
  • DBP/GC 3
  • VDBG 3
  • VDBP 3

External Ids for GC Gene

Previous GeneCards Identifiers for GC Gene

  • GC04M072596
  • GC04M072847
  • GC04M073008
  • GC04M073073
  • GC04M072972
  • GC04M072826
  • GC04M068412

Summaries for GC Gene

Entrez Gene Summary for GC Gene

  • The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GeneCards Summary for GC Gene

GC (Group-Specific Component (Vitamin D Binding Protein)) is a Protein Coding gene. Diseases associated with GC include graves' disease and central nervous system disease. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include actin binding and vitamin transporter activity. An important paralog of this gene is AFM.

UniProtKB/Swiss-Prot for GC Gene

  • Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes

Gene Wiki entry for GC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GC Gene

Genomics for GC Gene

Regulatory Elements for GC Gene

Genomic Location for GC Gene

Start:
71,741,678 bp from pter
End:
71,805,520 bp from pter
Size:
63,843 bases
Orientation:
Minus strand

Genomic View for GC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GC Gene

Proteins for GC Gene

  • Protein details for GC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02774-VTDB_HUMAN
    Recommended name:
    Vitamin D-binding protein
    Protein Accession:
    P02774
    Secondary Accessions:
    • B4DPP2
    • D6RAK8
    • Q16309
    • Q16310
    • Q53F31
    • Q6GTG1

    Protein attributes for GC Gene

    Size:
    474 amino acids
    Molecular mass:
    52964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG60654.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GC Gene

    Alternative splice isoforms for GC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GC Gene

Proteomics data for GC Gene at MOPED

Selected DME Specific Peptides for GC Gene

Post-translational modifications for GC Gene

  • Glycosylation at Asn288
  • Modification sites at PhosphoSitePlus

Other Protein References for GC Gene

Antibody Products

Domains for GC Gene

Suggested Antigen Peptide Sequences for GC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02774

UniProtKB/Swiss-Prot:

VTDB_HUMAN :
  • P02774
Domain:
  • Contains 3 albumin domains.
Family:
  • Belongs to the ALB/AFP/VDB family.
genes like me logo Genes that share domains with GC: view

No data available for Gene Families for GC Gene

Function for GC Gene

Molecular function for GC Gene

GENATLAS Biochemistry: group-specific component (vitamin D binding protein),52.9kDa,found in plasma,CSF,urine and the cell surface of many cell types
UniProtKB/Swiss-Prot Function: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes

Enzyme Numbers (IUBMB) for GC Gene

Gene Ontology (GO) - Molecular Function for GC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IPI 12119014
GO:0005499 vitamin D binding TAS 1696927
GO:0051183 vitamin transporter activity IEA --
GO:1902118 calcidiol binding IDA 11799400
genes like me logo Genes that share ontologies with GC: view
genes like me logo Genes that share phenotypes with GC: view

Animal Models for GC Gene

MGI Knock Outs for GC:
  • Gc tm1Nec

Animal Model Products

CRISPR Products

miRNA for GC Gene

miRTarBase miRNAs that target GC

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for GC Gene

Localization for GC Gene

Subcellular locations from UniProtKB/Swiss-Prot for GC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GC Gene COMPARTMENTS Subcellular localization image for GC gene
Compartment Confidence
extracellular 5
cytosol 4
lysosome 4
vacuole 4
cytoskeleton 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005829 cytosol TAS --
GO:0043202 lysosomal lumen TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GC: view

Pathways for GC Gene

genes like me logo Genes that share pathways with GC: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008202 steroid metabolic process TAS --
GO:0042359 vitamin D metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0051180 vitamin transport IEA --
genes like me logo Genes that share ontologies with GC: view

Compounds for GC Gene

(3) Drugbank Compounds for GC Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alfacalcidol
  • 1-hydroxycholecalciferol
41294-56-8 carrier substrate
Cholecalciferol
  • (+)-vitamin D3
67-97-0 carrier
Oleic Acid
112-80-1 carrier

(50) Novoseek inferred chemical compound relationships for GC Gene

Compound -log(P) Hits PubMed IDs
vitamin d 91 198
25-hydroxyvitamin d 86.2 48
calcitriol 86.1 53
bromoacetate 74.5 3
bnps-skatole 72.5 2
genes like me logo Genes that share compounds with GC: view

Transcripts for GC Gene

Unigene Clusters for GC Gene

Group-specific component (vitamin D binding protein):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GC Gene

No ASD Table

Relevant External Links for GC Gene

GeneLoc Exon Structure for
GC
ECgene alternative splicing isoforms for
GC

Expression for GC Gene

mRNA expression in normal human tissues for GC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GC Gene

This gene is overexpressed in Liver (52.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GC Gene

SOURCE GeneReport for Unigene cluster for GC Gene Hs.418497

genes like me logo Genes that share expressions with GC: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GC Gene

Orthologs for GC Gene

This gene was present in the common ancestor of chordates.

Orthologs for GC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GC 35
  • 99.51 (n)
  • 99.58 (a)
GC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GC 35
  • 84.6 (n)
  • 80.51 (a)
GC 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GC 35
  • 84.6 (n)
  • 82.28 (a)
GC 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gc 35
  • 80.45 (n)
  • 78.06 (a)
Gc 16
Gc 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GC 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gc 35
  • 80.31 (n)
  • 77.64 (a)
chicken
(Gallus gallus)
Aves GC 35
  • 59.36 (n)
  • 50.64 (a)
GC 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GC 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gc 35
  • 55.44 (n)
  • 42.43 (a)
zebrafish
(Danio rerio)
Actinopterygii gc 35
  • 46.74 (n)
  • 32.05 (a)
gc 36
  • 30 (a)
OneToOne
Species with no ortholog for GC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GC Gene

ENSEMBL:
Gene Tree for GC (if available)
TreeFam:
Gene Tree for GC (if available)

Paralogs for GC Gene

Paralogs for GC Gene

genes like me logo Genes that share paralogs with GC: view

Variants for GC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GC Gene

P02774-VTDB_HUMAN
Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*2 allele

Sequence variations from dbSNP and Humsavar for GC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4588 Benign, - 71,752,606(-) ACCCA(A/C)GGAAC missense, reference, intron-variant
rs4752 -- 71,756,849(-) GACTG(C/T)TGTCA synonymous-codon, reference
rs7041 Benign, - 71,752,617(-) CCTGA(G/T)GCCAC missense, reference, intron-variant
rs9016 - 71,752,579(-) CAAGC(A/G)CTCAG reference, missense, intron-variant
rs170292 -- 71,779,910(+) AAAGG(A/G)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GC Gene

Variant ID Type Subtype PubMed ID
nsv829967 CNV Loss 17160897
nsv822615 CNV Gain 20364138
nsv879476 CNV Loss 21882294
nsv437395 CNV Loss 16327808
nsv879477 CNV Gain 21882294

Relevant External Links for GC Gene

HapMap Linkage Disequilibrium report
GC
Human Gene Mutation Database (HGMD)
GC

Disorders for GC Gene

(45) Novoseek inferred disease relationships for GC Gene

Disease -log(P) Hits PubMed IDs
vitamin d deficiency 61.4 1
idiopathic osteoporosis 55.9 2
rickets 49.5 3
hepatic failure fulminant 48.2 7
pulmonary disease chronic obstructive 41.5 7

Relevant External Links for GC

Genetic Association Database (GAD)
GC
Human Genome Epidemiology (HuGE) Navigator
GC
genes like me logo Genes that share disorders with GC: view

No data available for UniProtKB/Swiss-Prot for GC Gene

Publications for GC Gene

  1. A structural basis for the unique binding features of the human vitamin D-binding protein. (PMID: 11799400) Verboven C. … De Ranter C. (Nat. Struct. Biol. 2002) 3 4 23 25
  2. [The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease]. (PMID: 15059409) Lu M. … Cai Y.Y. (Zhonghua Nei Ke Za Zhi 2004) 3 23 48
  3. [Allele polymorphism of alkaline phosphatase, acid soluble phosphatase, and vitamin D-binding protein genes in postmenopausal osteoporosis]. (PMID: 15230135) Krylov M.I.u. … Benevolenskaia L.I. (Ter. Arkh. 2004) 3 23 48
  4. Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland. (PMID: 14987123) Laufs J. … Hakonarson H. (Am J Pharmacogenomics 2004) 3 23 48
  5. Vitamin D binding protein, bone status and body composition in community-dwelling elderly men. (PMID: 16309986) Taes Y.E. … Kaufman J.M. (Bone 2006) 3 23 48

Products for GC Gene

Sources for GC Gene

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