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GBX2 Gene

protein-coding GIFtS: 56
GCID: GC02M237090

Gastrulation Brain Homeobox 2

(Previous name: gastrulation brain homeo box 2)

See GBX2-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Gastrulation Brain Homeobox 2¹ ²
Gastrulation Brain Homeo Box 2¹ ²
Gastrulation And Brain-Specific Homeobox Protein 2² ³
Homeobox Protein GBX-2²

External Ids:	HGNC: 4186¹	Entrez Gene: 2637²	Ensembl: ENSG00000168505⁷	OMIM: 601135⁵	UniProtKB: P52951³

Export aliases for GBX2 gene to outside databases

Previous GC identifers: GC02M235112 GC02M235755 GC02M237361 GC02M236856 GC02M236739 GC02M228868

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GBX2 Gene:

GBX2 (gastrulation brain homeobox 2) is a protein-coding gene. Diseases associated with GBX2 include prostate cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951

Function: May act as a transcription factor for cell pluripotency and differentiation in the embryo

Gene Wiki entry for GBX2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NT_005403.18 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the GBX2 gene promoter:
ER-alpha E2F-4 E2F-3a E2F-5 E2F-2 MEF-2A Max E2F E2F-1 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GBX2 promoter sequence

Search Chromatin IP Primers for GBX2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GBX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.2 Ensembl cytogenetic band: 2q37.2 HGNC cytogenetic band: 2q37.2

GBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GBX2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M237090: view genomic region (about GC identifiers)

Start:	237,073,879 bp from pter	End:	237,077,012 bp from pter
Size:	3,134 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951 (See protein sequence)

Recommended Name: Homeobox protein GBX-2

Size: 348 amino acids; 37348 Da

Secondary accessions: B2RPH7 O43833 Q53RX5 Q9Y5Y1

Explore the universe of human proteins at neXtProt for GBX2: NX_P52951

Explore proteomics data for GBX2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See GBX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001476.2

ENSEMBL proteins:

ENSP00000302251 ENSP00000448747

GBX2 Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for GBX2 OriGene Protein Over-expression Lysate for GBX2 OriGene Custom MassSpec OriGene Custom Protein Services for GBX2
	GenScript Custom Purified and Recombinant Proteins Services for GBX2
	Novus Biologicals GBX2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for GBX2
	Search eBioscience for Proteins for GBX2
	antibodies-online proteins for GBX2 (6 products)
	antibodies-online peptides for GBX2

GBX2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for GBX2
	OriGene Antibodies for GBX2 OriGene Custom Antibody Services for GBX2
	Novus Biologicals GBX2 Antibodies
	Abcam antibodies for GBX2
	Cloud-Clone Corp. Antibodies for GBX2
	ThermoFisher Antibodies for GBX2
	antibodies-online antibodies for GBX2 (42 products)

GBX2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GBX2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for GBX2 Cloud-Clone Corp. CLIAs for GBX2
	Search eBioscience for ELISAs for GBX2
	antibodies-online kits for GBX2 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:

IPR020479 Homeobox_metazoa

IPR017970 Homeobox_CS

IPR001356 Homeobox_dom

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P52951

ProtoNet protein and cluster: P52951

UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951

Similarity: Contains 1 homeobox DNA-binding domain

Find genes that share domains with GBX2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: GBX2_HUMAN, P52951

Function: May act as a transcription factor for cell pluripotency and differentiation in the embryo

Genatlas biochemistry entry for GBX2:

mouse telencephalon expressed Gbx homolog 2,gastrulation and brain specific-1,homeo domain encoding gene

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

Find genes that share ontologies with GBX2 About GenesLikeMe

Phenotypes:
Selected MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Gbx2) (see all 18):

cardiovascular system	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	nervous system	no phenotypic analysis	normal	respiratory system

Find genes that share phenotypes with GBX2 About GenesLikeMe

Animal Models:
MGI mouse knock-outs for GBX2: Gbx2^tm1.2Alj Gbx2^tm1.1Mrt

genOway: Develop your customized and physiologically relevant rodent model for GBX2

miRNA Products:		miRTarBase miRNAs that target GBX2: hsa-mir-335-5p (MIRT017008)

		Block miRNA regulation of human, mouse, rat GBX2 using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate GBX2:
		hsa-miR-520d-5p hsa-miR-374b hsa-miR-524-5p hsa-miR-374a
		SwitchGear 3'UTR luciferase reporter plasmid: GBX2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for GBX2
		Predesigned siRNA for gene silencing in human, mouse, rat GBX2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GBX2

Clone Products:		OriGene clones in human, mouse for GBX2 (see all 5) OriGene ORF clones in mouse, rat for GBX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GBX2 (NM_001485)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GBX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GBX2
		Browse ESI BIO Cell Lines and PureStem Progenitors for GBX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

GBX2_HUMAN, P52951: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4

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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

Find genes that share ontologies with GBX2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for GBX2 About

See pathways by source

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SuperPath

Contained pathways About

Transcriptional Regulatory Network in Embryonic Stem Cell

Transcriptional Regulatory Network in Embryonic Stem Cell

Neural Crest Differentiation

Neural Crest Differentiation

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GBX2

Transcriptional Regulatory Network in Embryonic Stem Cell

1 BioSystems Pathway for GBX2

Neural Crest Differentiation

Pathway & Disease-focused RT² Profiler PCR Arrays including GBX2:

Cell Lineage Identification in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Embryonic Stem Cells in human mouse rat

Interactions:

GeneGlobe Interaction Network for GBX2

Gene Ontology (GO): Selected biological process terms (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001569	patterning of blood vessels	IEA	--
GO:0001755	neural crest cell migration	IEA	--
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0007399	nervous system development	TAS	8838315

Find genes that share ontologies with GBX2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for GBX2

1 Novoseek inferred chemical compound relationship for GBX2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alar	57	1	11689282 (1)

Find genes that share compounds with GBX2 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for GBX2 gene:

NM_001485.2

Unigene Cluster for GBX2:

Gastrulation brain homeobox 2

Hs.184945 [show with all ESTs]

Unigene Representative Sequence: NM_001485

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000306318(uc002vvw.1 uc010zng.1) ENST00000551105 ENST00000465889

miRNA Products:		Block miRNA regulation of human, mouse, rat GBX2 using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate GBX2:
		hsa-miR-520d-5p hsa-miR-374b hsa-miR-524-5p hsa-miR-374a
		SwitchGear 3'UTR luciferase reporter plasmid: GBX2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for GBX2
		Predesigned siRNA for gene silencing in human, mouse, rat GBX2

Clone Products:		OriGene clones in human, mouse for GBX2 (see all 5) OriGene ORF clones in mouse, rat for GBX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GBX2 (NM_001485)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GBX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for GBX2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat GBX2
		QuantiTect SYBR Green Assays in human, mouse, rat GBX2
		QuantiFast Probe-based Assays in human, mouse, rat GBX2

Additional mRNA sequence:

AF118452.1 AK311262.1 BC137448.1 BC137449.1 BC144646.1

3 DOTS entries:

DT.434131 DT.100011563 DT.40120503

14 AceView cDNA sequences:

NM_001485 AF118452 BM747801 BF115559 BM747771 BG827869 AA933790 CD611885

BE463746 BX094347 CD611886 AA176205 CD611889 AA305563

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GBX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGACTCCA

About this image

GBX2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 12) fully expand


Brain (Nervous System) fully expand to see all 11 entries
Thalamus
GABA neuron-like cells

Neural Ectoderm (Nervous System) fully expand to see all 5 entries
Isthmus Cells Neural Plate
Neuroectoderm cells

Neural Tube (Nervous System) fully expand to see all 5 entries
Isthmus Cells Neural Plate
Telencephalon

Neurons
GABAergic Amacrine Cells Inner Nuclear Layer
GABA neuron-like cells

Epiblast (Early Embryonic Tissues)
Early Epiblast Cells Epiblast

GBX2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

GBX2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.184945

Pathway & Disease-focused RT² Profiler PCR Arrays including GBX2:

Cell Lineage Identification in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Embryonic Stem Cells in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for GBX2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat GBX2
		QuantiTect SYBR Green Assays in human, mouse, rat GBX2
		QuantiFast Probe-based Assays in human, mouse, rat GBX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for GBX2 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gbx2^{1 , 5}	gastrulation brain homeobox 2^{1, 5}	92.05(n)¹ 98.28(a)¹		1 (45.06 cM)⁵ 14472¹ NM_010262.3¹ NP_034392.1¹ 89927962⁵
chicken (Gallus gallus)	Aves	GBX2¹	gastrulation brain homeobox 2	77.25(n) 75.37(a)		395950 NM_205068.1 NP_990399.1
lizard (Anolis carolinensis)	Reptilia	GBX2⁶	gastrulation brain homeobox 2	71(a)	1 ↔ 1	1(119835491-119838572)
African clawed frog (Xenopus laevis)	Amphibia	LOC397824²	homeobox protein Xgbx-2	76.98(n)		U04867.1
zebrafish (Danio rerio)	Actinopterygii	gbx2²	gastrulation brain homeo box 2	78.22(n)		245948 AB075028.1
fruit fly (Drosophila melanogaster)	Insecta	unpg³	RNA polymerase II transcription factor	78(a)		2 45B3 --
worm (Caenorhabditis elegans)	Secernentea	ceh-12⁶	Protein CEH-12 (ceh-12) mRNA, complete cds	32(a)	1 → many	I(5840289-5841888) WBGene00000436

ENSEMBL Gene Tree for GBX2 (if available)
TreeFam Gene Tree for GBX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for GBX2 gene

DLX2² BARX1² GBX1² NKX1-1² VENTX² BARHL1² BARHL2² MNX1²

BARX2² DLX1² DLX3² LBX2² NKX1-2² BSX² DLX5² DLX6²

DLX4² LBX1² MSX2² MSX1²

4 SIMAP similar genes for GBX2 using alignment to 2 protein entries: GBX2_HUMAN (see all proteins):

HMX2 HHEX HLX GBX1

Find genes that share paralogs with GBX2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10202397^1,2	C,F	--	237073817(+)	`TTGCCC/TGGCCA`	1	--	ds500¹		1		WA	118
rs6705037^1,2	C,F,A	--	237073819(+)	`GCCCGG/ACCACA`	1	--	ds500¹		8		WA NA CSA EA	367
rs111490631^1,2	C,F	--	237073889(+)	`CTTTTC/TCCCCC`	1	--	ds500¹		1		WA	2
rs4292047^1,2	C,F,H	--	237073897(+)	`CCCCCT/CCTCTC`	1	--	ds500¹		9		NS NA CSA WA	1187
rs67252682^1,2	C	--	237073897(+)	`CCCCC-/TCTCTC`	1	--	ds500¹		0	--	--	--	--
rs138087593^1,2	C	--	237074047(+)	`AGGCA-/AAAGC AAAGC`	1	--	ds500¹		0	--	--	--	--
rs116291098^1,2	C,F	--	237074487(+)	`GTGGAG/ATCCAC`	1	--	ut3¹		1		NA	120
rs200772923^1,2		--	237074513(+)	`GTGCGA/GGGGCT`	1	--	ut3¹		0	--	--	--	--
rs149479396^1,2	C	--	237074537(+)	`GCCAGG/ACCCTG`	1	--	ut3¹		1		EU	1235
rs114693893^1,2	C,F	--	237074635(+)	`ACGACG/AATCTT`	2	/I	syn¹		3		NA EU	5995

HapMap Linkage Disequilibrium report for GBX2 (237073879 - 237077012 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for GBX2: About this table

Variant ID	Type	Subtype	PubMed ID
esv33938	CNV	Loss	17666407
dgv4456n71	CNV	Loss	21882294
nsv876036	CNV	Loss	21882294
nsv525913	CNV	Loss	19592680
nsv821923	CNV	Gain	20364138
nsv821924	CNV	Gain	20364138
nsv821922	CNV	Gain	20364138
esv2751845	CNV	Gain	17911159

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GBX2

DNA2.0 Custom Variant and Variant Library Synthesis for GBX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601135 OMIM disorders: --

1 disease for GBX2:
About MalaCards

prostate cancer

Find genes that share disorders with GBX2 About GenesLikeMe

1 Novoseek inferred disease relationship for GBX2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	1.85	13	9537237 (6), 10690529 (4)

Genetic Association Database (GAD): GBX2
Human Genome Epidemiology (HuGE) Navigator: GBX2 (1 document)

Export disorders for GBX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GBX2 gene, integrated from 10 sources (see all 36):
(articles sorted by number of sources associating them with GBX2)

Utopia: connect your pdf to the dynamic
world of online information

Characterization and sequence analysis of the human homeobox- containing gene GBX2. (PubMed id 8838315)^{1, 2, 3, 9} Lin X.... Leckman J.F. (Genomics 1996)
The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PubMed id 7903253)^{1, 2, 9} Matsui T.... Kurosawa Y. (FEBS Lett. 1993)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2005)
The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. (PubMed id 9346236)^{1, 3} Kowenz-Leutz E....Leutz A. (Cell 1997)
Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity. (PubMed id 9537237)^{1, 9} Gao A.C....Isaacs J.T. (Cancer Res. 1998)
Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene. (PubMed id 10690529)^{1, 9} Gao A.C....Isaacs J.T. (Clin. Cancer Res. 2000)
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. (PubMed id 23722424)¹ Rietveld C.A....Koellinger P.D. (Science 2013)
Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer. (PubMed id 23549873)¹ Yu K.D....Chang J.C. (Clin. Cancer Res. 2013)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (Genes Immun. 2010)
Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors. (PubMed id 17060451)¹ Heimbucher T....Czerny T. (Mol. Cell. Biol. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2637	HGNC: 4186	AceView: GBX2	Ensembl:ENSG00000168505	euGenes: HUgn2637
ECgene: GBX2	H-InvDB: GBX2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GBX2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GBX2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GBX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GBX2 gene:
Search GeneIP for patents involving GBX2

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Gastrulation Brain Homeobox 2

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Gastrulation Brain Homeobox 2

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