GBX2 Gene

Aliases
for GBX2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC02M235112 GC02M235755 GC02M237361 GC02M236856 GC02M236739 GC02M228868

Summaries
for GBX2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for GBX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NT_005403.18  NC_018913.2  

SwitchGear Promoter luciferase reporter plasmid: GBX2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GBX2

GBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M237090:  view genomic region     (about GC identifiers)

Proteins
for GBX2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for GBX2: NX_P52951

Explore proteomics data for GBX2 at MOPED

Post-translational modifications: 

GBX2 Human Recombinant Protein Products:

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	antibodies-online proteins for GBX2 (6 products)
	antibodies-online peptides for GBX2

GBX2 Antibody Products:

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	antibodies-online antibodies for GBX2 (42 products)

GBX2 Assay Products:

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	antibodies-online kits for GBX2 (6 products)

Domains /
Families
for GBX2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P52951

Find genes that share domains with GBX2           About GenesLikeMe

Function
for GBX2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

Selected MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Gbx2)

genOway: Develop your customized and physiologically relevant rodent model for GBX2

miRNA Products:		miRTarBase miRNAs that target GBX2: hsa-mir-335-5p (MIRT017008)
		Block miRNA regulation of human, mouse, rat GBX2 using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate GBX2:
		hsa-miR-520d-5p hsa-miR-374b hsa-miR-524-5p hsa-miR-374a
		SwitchGear 3'UTR luciferase reporter plasmid: GBX2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for GBX2
		Predesigned siRNA for gene silencing in human, mouse, rat GBX2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GBX2

Clone Products:		OriGene clones in human, mouse for GBX2 (see all 5) OriGene ORF clones in mouse, rat for GBX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GBX2 (NM_001485)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GBX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GBX2
		Browse ESI BIO Cell Lines and PureStem Progenitors for GBX2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX2

Localization
for GBX2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	4

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for GBX2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for GBX2 About     See pathways by source

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	SuperPath	Contained pathways About
1	Transcriptional Regulatory Network in Embryonic Stem Cell	Transcriptional Regulatory Network in Embryonic Stem Cell
2	Neural Crest Differentiation	Neural Crest Differentiation

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GBX2

Transcriptional Regulatory Network in Embryonic Stem Cell

1 BioSystems Pathway for GBX2

Neural Crest Differentiation

Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

Drugs & Compounds
for GBX2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for GBX2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for GBX2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GBX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGACTCCA

About this image

Brain (Nervous System)    fully expand to see all 11 entries
Thalamus
GABA neuron-like cells
Neural Ectoderm (Nervous System)    fully expand to see all 5 entries
Isthmus Cells Neural Plate
Neuroectoderm cells
Neural Tube (Nervous System)    fully expand to see all 5 entries
Isthmus Cells Neural Plate
Telencephalon
Neurons
GABAergic Amacrine Cells Inner Nuclear Layer
GABA neuron-like cells
Epiblast (Early Embryonic Tissues)
Early Epiblast Cells Epiblast

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for GBX2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GBX2
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		QuantiFast Probe-based Assays in human, mouse, rat GBX2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX2

Orthologs
for GBX2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for GBX2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for GBX2 gene

DLX2²  BARX1²  GBX1²  NKX1-1²  VENTX²  BARHL1²  BARHL2²  MNX1²  

BARX2²  DLX1²  DLX3²  LBX2²  NKX1-2²  BSX²  DLX5²  DLX6²  

DLX4²  LBX1²  MSX2²  MSX1²  

4 SIMAP similar genes for GBX2 using alignment to 2 protein entries:     GBX2_HUMAN (see all proteins):

HMX2    HHEX    HLX    GBX1

Find genes that share paralogs with GBX2           About GenesLikeMe

Genomic Variants
for GBX2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GBX2 (see all 105)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs102023971,2	C,F	--	237073817(+)	TTGCCC/TGGCCA	1	--	ds5001		1		WA	118
rs67050371,2	C,F,A	--	237073819(+)	GCCCGG/ACCACA	1	--	ds5001		8		WA NA CSA EA	367
rs1114906311,2	C,F	--	237073889(+)	CTTTTC/TCCCCC	1	--	ds5001		1		WA	2
rs42920471,2	C,F,H	--	237073897(+)	CCCCCT/CCTCTC	1	--	ds5001		9		NS NA CSA WA	1187
rs672526821,2	C	--	237073897(+)	CCCCC-/TCTCTC	1	--	ds5001		0	--	--	--	--
rs1380875931,2	C	--	237074047(+)	AGGCA-/AAAGC          AAAGC	1	--	ds5001		0	--	--	--	--
rs1162910981,2	C,F	--	237074487(+)	GTGGAG/ATCCAC	1	--	ut31		1		NA	120
rs2007729231,2		--	237074513(+)	GTGCGA/GGGGCT	1	--	ut31		0	--	--	--	--
rs1494793961,2	C	--	237074537(+)	GCCAGG/ACCCTG	1	--	ut31		1		EU	1235
rs1146938931,2	C,F	--	237074635(+)	ACGACG/AATCTT	2	/I	syn1		3		NA EU	5995

HapMap Linkage Disequilibrium report for GBX2 (237073879 - 237077012 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for GBX2:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv33938	CNV	Loss	17666407
dgv4456n71	CNV	Loss	21882294
nsv876036	CNV	Loss	21882294
nsv525913	CNV	Loss	19592680
nsv821923	CNV	Gain	20364138
nsv821924	CNV	Gain	20364138
nsv821922	CNV	Gain	20364138
esv2751845	CNV	Gain	17911159

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GBX2

DNA2.0 Custom Variant and Variant Library Synthesis for GBX2

Disorders / Diseases
for GBX2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for GBX2

1 Novoseek inferred disease relationship for GBX2 gene    About this table

Publications
for GBX2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GBX2 gene, integrated from 10 sources (see all 36): (articles sorted by number of sources associating them with GBX2)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization and sequence analysis of the human homeobox- containing gene GBX2. (PubMed id 8838315)^{1, 2, 3, 9} Lin X.... Leckman J.F. (Genomics 1996)
2. The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PubMed id 7903253)^{1, 2, 9} Matsui T.... Kurosawa Y. (FEBS Lett. 1993)
3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2005)
4. The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. (PubMed id 9346236)^{1, 3} Kowenz-Leutz E....Leutz A. (Cell 1997)
5. Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity. (PubMed id 9537237)^{1, 9} Gao A.C....Isaacs J.T. (Cancer Res. 1998)
6. Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene. (PubMed id 10690529)^{1, 9} Gao A.C....Isaacs J.T. (Clin. Cancer Res. 2000)
7. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. (PubMed id 23722424)¹ Rietveld C.A....Koellinger P.D. (Science 2013)
8. Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer. (PubMed id 23549873)¹ Yu K.D....Chang J.C. (Clin. Cancer Res. 2013)
9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (Genes Immun. 2010)
10. Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors. (PubMed id 17060451)¹ Heimbucher T....Czerny T. (Mol. Cell. Biol. 2007)

External Searches for GBX2 gene

Genome Databases showing GBX2 gene

Other Databases showing GBX2 gene

Specialized Databases showing GBX2 gene

Products
for GBX2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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