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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GBX2 Gene

protein-coding GIFtS: 56
GCID: GC02M237090

Gastrulation Brain Homeobox 2

(Previous name: gastrulation brain homeo box 2)

8 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Gastrulation Brain Homeobox 2¹ ²
Gastrulation Brain Homeo Box 2¹ ²
Gastrulation And Brain-Specific Homeobox Protein 2² ³
Homeobox Protein GBX-2²

External Ids:	HGNC: 4186¹	Entrez Gene: 2637²	Ensembl: ENSG00000168505⁷	OMIM: 601135⁵	UniProtKB: P52951³

Export aliases for GBX2 gene to outside databases

Previous GC identifers: GC02M235112 GC02M235755 GC02M237361 GC02M236856 GC02M236739 GC02M228868

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GBX2 Gene:

GBX2 (gastrulation brain homeobox 2) is a protein-coding gene. Diseases associated with GBX2 include blindness, and prostate cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MNX1.

UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951

Function: May act as a transcription factor for cell pluripotency and differentiation in the embryo

Gene Wiki entry for GBX2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NT_005120.16 NC_018913.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GBX2 gene promoter:
ER-alpha E2F-4 E2F-3a E2F-5 E2F-2 MEF-2A Max E2F E2F-1 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GBX2 promoter sequence

Search SABiosciences Chromatin IP Primers for GBX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GBX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.2 Ensembl cytogenetic band: 2q37.2 HGNC cytogenetic band: 2q37.2

GBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GBX2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M237090: view genomic region (about GC identifiers)

Start:	237,073,879 bp from pter	End:	237,077,012 bp from pter
Size:	3,134 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951 (See protein sequence)

Recommended Name: Homeobox protein GBX-2

Size: 348 amino acids; 37348 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B2RPH7 O43833 Q53RX5 Q9Y5Y1

Explore the universe of human proteins at neXtProt for GBX2: NX_P52951

Explore proteomics data for GBX2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P52951

GBX2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001476.2

ENSEMBL proteins:

ENSP00000302251 ENSP00000448747

Human Recombinant Protein Products for GBX2:

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	Novus Biologicals GBX2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for GBX2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

GBX2 for ontologies About GeneDecksing

GBX2 Antibody Products:

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Assay Products for GBX2:

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	Cloud-Clone Corp. ELISAs for GBX2 Cloud-Clone Corp. CLIAs for GBX2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:

IPR020479 Homeobox_metazoa

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P52951

ProtoNet protein and cluster: P52951

UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951

Similarity: Contains 1 homeobox DNA-binding domain

GBX2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GBX2_HUMAN, P52951

Function: May act as a transcription factor for cell pluripotency and differentiation in the embryo

Genatlas biochemistry entry for GBX2:

mouse telencephalon expressed Gbx homolog 2,gastrulation and brain specific-1,homeo domain encoding gene

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

GBX2 for ontologies About GeneDecksing

Phenotypes:
15/18 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Gbx2) (see all 18):

cardiovascular system	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	nervous system	no phenotypic analysis	normal	respiratory system

GBX2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for GBX2: Gbx2^tm1.2Alj Gbx2^tm1.1Mrt

inGenious Targeting Laboratory - Custom generated mouse model solutions for GBX2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GBX2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GBX2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GBX2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GBX2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate GBX2:
		hsa-miR-520d-5p hsa-miR-374b hsa-miR-524-5p hsa-miR-374a
		SwitchGear 3'UTR luciferase reporter plasmid: GBX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for GBX2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for GBX2 (see all 6) OriGene ORF clones in mouse, rat for GBX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GBX2 (NM_001485)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GBX2
		Search LifeMap BioReagents cell lines for GBX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GBX2 About

See pathways by source

SuperPath

Contained pathways About

Transcription factors in neurogenesis

Transcription factors in neurogenesis

Neural Crest Differentiation

Neural Crest Differentiation

Transcriptional Regulatory Network in Embryonic Stem Cell

Transcriptional Regulatory Network in Embryonic Stem Cell

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for GBX2

Transcription factors in neurogenesis

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GBX2

Transcriptional Regulatory Network in Embryonic Stem Cell

1 BioSystems Pathway for GBX2

Neural Crest Differentiation

GBX2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GBX2

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001569	patterning of blood vessels	IEA	--
GO:0001755	neural crest cell migration	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007399	nervous system development	TAS	8838315

GBX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GBX2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GBX2

1 Novoseek inferred chemical compound relationship for GBX2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alar	57	1	11689282 (1)

Search CenterWatch for drugs/clinical trials and news about GBX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GBX2 gene:

NM_001485.2

Unigene Cluster for GBX2:

Gastrulation brain homeobox 2

Hs.184945 [show with all ESTs]

Unigene Representative Sequence: NM_001485

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000306318(uc002vvw.1 uc010zng.1) ENST00000551105 ENST00000465889

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GBX2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate GBX2:
		hsa-miR-520d-5p hsa-miR-374b hsa-miR-524-5p hsa-miR-374a
		SwitchGear 3'UTR luciferase reporter plasmid: GBX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene clones in human, mouse for GBX2 (see all 6) OriGene ORF clones in mouse, rat for GBX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX2
		Sirion Biotech Customized lentivirus for stable overexpression of GBX2 Customized lentivirus expression plasmids for stable overexpression of GBX2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for GBX2
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GBX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GBX2

Additional mRNA sequence:

AF118452.1 AK311262.1 BC137448.1 BC137449.1 BC144646.1

3 DOTS entries:

DT.434131 DT.100011563 DT.40120503

14 AceView cDNA sequences:

BM747801 AF118452 BF115559 NM_001485 BG827869 CD611885 BM747771 BE463746

AA933790 BX094347 CD611886 CD611889 AA176205 AA305563

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GBX2 expression in normal human tissues (normalized intensities) GBX2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGACTCCA

About this image

GBX2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/11 selected tissues (see all 11) fully expand


Brain (Nervous System) fully expand to see all 20 entries
Thalamus
GABA neuron-like cells ( Generation of motor and gamma-aminobutyric acid (GABA)...
Septum

Neural Tube (Nervous System) fully expand to see all 5 entries
Isthmus Cells Neural Plate
Telencephalon

Neural Ectoderm (Nervous System) fully expand to see all 3 entries
Isthmus Cells Neural Plate

Spinal Cord (Nervous System) fully expand to see all 2 entries
Dorsal Horn

Bone (Muscoskeletal System)
Mandibular Process

See GBX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GBX2

SOURCE GeneReport for Unigene cluster: Hs.184945

SABiosciences Expression via Pathway-Focused PCR Arrays including GBX2:

Cell Lineage Identification in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Embryonic Stem Cells in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GBX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GBX2 gene from 7/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gbx2^{1 , 5}	gastrulation brain homeobox 2^{1, 5}	92.05(n)¹ 98.28(a)¹		1 (45.06 cM)⁵ 14472¹ NM_010262.3¹ NP_034392.1¹ 89927962⁵
chicken (Gallus gallus)	Aves	GBX2¹	gastrulation brain homeobox 2	78.64(n) 78.64(a)		395950 NM_205068.1 NP_990399.1
lizard (Anolis carolinensis)	Reptilia	GBX2⁶	Uncharacterized protein	71(a)	1 ↔ 1	1(119835491-119838572)
African clawed frog (Xenopus laevis)	Amphibia	LOC397824²	homeobox protein Xgbx-2	76.98(n)		U04867.1
zebrafish (Danio rerio)	Actinopterygii	gbx2²	gastrulation brain homeo box 2	78.22(n)		245948 AB075028.1
fruit fly (Drosophila melanogaster)	Insecta	unpg³	RNA polymerase II transcription factor	78(a)		2 45B3 --
worm (Caenorhabditis elegans)	Secernentea	ceh-12⁶ ceh-62⁶	Uncharacterized homeobox protein R06F6.6	30(a) 11(a)	possible ortholog possible ortholog	I(5840289-5841888) II(10805394-10809992)

ENSEMBL Gene Tree for GBX2 (if available)
TreeFam Gene Tree for GBX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GBX2 gene

MNX1² EVX1² MEOX1² GBX1² EVX2² MEOX2²

4 SIMAP similar genes for GBX2 using alignment to 2 protein entries: GBX2_HUMAN (see all proteins):

HMX2 HHEX HLX GBX1

GBX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10202397^1,2	C,F	--	237073817(+)	`TTGCCC/TGGCCA`	1	--	ds500¹		1		WA	118
rs6705037^1,2	C,F,A	--	237073819(+)	`GCCCGG/ACCACA`	1	--	ds500¹		8		WA NA CSA EA	367
rs111490631^1,2	C,F	--	237073889(+)	`CTTTTC/TCCCCC`	1	--	ds500¹		1		WA	2
rs4292047^1,2	C,F,H	--	237073897(+)	`CCCCCT/CCTCTC`	1	--	ds500¹		9		NS NA CSA WA	1187
rs67252682^1,2	C	--	237073897(+)	`CCCCC-/TCTCTC`	1	--	ds500¹		0	--	--	--	--
rs138087593^1,2	C	--	237074047(+)	`AGGCA-/AAAGC AAAGC`	1	--	ds500¹		0	--	--	--	--
rs116291098^1,2	C,F	--	237074487(+)	`GTGGAG/ATCCAC`	1	--	ut3¹		1		NA	120
rs200772923^1,2		--	237074513(+)	`GTGCGA/GGGGCT`	1	--	ut3¹		0	--	--	--	--
rs149479396^1,2	C	--	237074537(+)	`GCCAGG/ACCCTG`	1	--	ut3¹		1		EU	1235
rs114693893^1,2	C,F	--	237074635(+)	`ACGACG/AATCTT`	2	/I	syn¹		3		NA EU	5995

HapMap Linkage Disequilibrium report for GBX2 (237073879 - 237077012 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for GBX2: About this table

Variant ID	Type	Subtype	PubMed ID
esv33938	CNV	Loss	17666407
dgv4456n71	CNV	Loss	21882294
nsv876036	CNV	Loss	21882294
nsv525913	CNV	Loss	19592680
nsv821923	CNV	Gain	20364138
nsv821924	CNV	Gain	20364138
nsv821922	CNV	Gain	20364138
esv2751845	CNV	Gain	17911159

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GBX2

DNA2.0 Custom Variant and Variant Library Synthesis for GBX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 601135 OMIM disorders: --

8 diseases for GBX2: About MalaCards

blindness prostate cancer hepatitis b prostatitis

hepatitis melanoma neuronitis leukemia

GBX2 for disorders About GeneDecksing

1 Novoseek inferred disease relationship for GBX2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	1.85	13	9537237 (6), 10690529 (4)

Genetic Association Database (GAD): GBX2
Human Genome Epidemiology (HuGE) Navigator: GBX2 (1 document)

Export disorders for GBX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GBX2 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with GBX2)

Utopia: connect your pdf to the dynamic
world of online information

Characterization and sequence analysis of the human homeobox-containing gene GBX2. (PubMed id 8838315)^{1, 2, 3, 9} Lin X....Leckman J.F. (1996)
The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PubMed id 7903253)^{1, 2, 9} Matsui T.... Kurosawa Y. (1993)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. (PubMed id 9346236)^{1, 3} Kowenz-Leutz E....Leutz A. (1997)
Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity. (PubMed id 9537237)^{1, 9} Gao A.C....Isaacs J.T. (1998)
Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene. (PubMed id 10690529)^{1, 9} Gao A.C....Isaacs J.T. (2000)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors. (PubMed id 17060451)¹ Heimbucher T....Czerny T. (2007)
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. (PubMed id 15931389)¹ Glinsky G.V....Glinskii A.B. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2637	HGNC: 4186	AceView: GBX2	Ensembl:ENSG00000168505	euGenes: HUgn2637
ECgene: GBX2	H-InvDB: GBX2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GBX2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GBX2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GBX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GBX2 gene:
Search GeneIP for patents involving GBX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GBX2 Gene

Gastrulation Brain Homeobox 2

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GBX2 Gene

Gastrulation Brain Homeobox 2

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