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Aliases for GBX2 Gene

Aliases for GBX2 Gene

  • Gastrulation Brain Homeobox 2 2 3
  • Gastrulation And Brain-Specific Homeobox Protein 2 4
  • Gastrulation Brain Homeo Box 2 2

External Ids for GBX2 Gene

Previous GeneCards Identifiers for GBX2 Gene

  • GC02M235112
  • GC02M235755
  • GC02M237090
  • GC02M237361
  • GC02M236856
  • GC02M236739
  • GC02M228868

Summaries for GBX2 Gene

GeneCards Summary for GBX2 Gene

GBX2 (Gastrulation Brain Homeobox 2) is a Protein Coding gene. Diseases associated with GBX2 include prostate cancer. Among its related pathways are Neural Crest Differentiation and Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for GBX2 Gene

  • May act as a transcription factor for cell pluripotency and differentiation in the embryo

Gene Wiki entry for GBX2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBX2 Gene

Genomics for GBX2 Gene

Regulatory Elements for GBX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GBX2 Gene

236,165,236 bp from pter
236,168,369 bp from pter
3,134 bases
Minus strand

Genomic View for GBX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBX2 Gene

Proteins for GBX2 Gene

  • Protein details for GBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein GBX-2
    Protein Accession:
    Secondary Accessions:
    • B2RPH7
    • O43833
    • Q53RX5
    • Q9Y5Y1

    Protein attributes for GBX2 Gene

    348 amino acids
    Molecular mass:
    37348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GBX2 Gene

Proteomics data for GBX2 Gene at MOPED

Post-translational modifications for GBX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBX2 Gene

Domains for GBX2 Gene

Gene Families for GBX2 Gene

  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for GBX2 Gene

Suggested Antigen Peptide Sequences for GBX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P52951
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with GBX2: view

Function for GBX2 Gene

Molecular function for GBX2 Gene

GENATLAS Biochemistry: mouse telencephalon expressed Gbx homolog 2,gastrulation and brain specific-1,homeo domain encoding gene
UniProtKB/Swiss-Prot Function: May act as a transcription factor for cell pluripotency and differentiation in the embryo

Gene Ontology (GO) - Molecular Function for GBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9346236
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with GBX2: view
genes like me logo Genes that share phenotypes with GBX2: view

Animal Models for GBX2 Gene

MGI Knock Outs for GBX2:

Animal Model Products

CRISPR Products

miRNA for GBX2 Gene

miRTarBase miRNAs that target GBX2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GBX2 Gene

Localization for GBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBX2 Gene

Subcellular locations from

Jensen Localization Image for GBX2 Gene COMPARTMENTS Subcellular localization image for GBX2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for GBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with GBX2: view

Pathways for GBX2 Gene

genes like me logo Genes that share pathways with GBX2: view

Pathways by source for GBX2 Gene

1 BioSystems pathway for GBX2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GBX2 Gene

Gene Ontology (GO) - Biological Process for GBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 patterning of blood vessels IEA --
GO:0001755 neural crest cell migration IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development TAS 8838315
genes like me logo Genes that share ontologies with GBX2: view

Compounds for GBX2 Gene

(1) Novoseek inferred chemical compound relationships for GBX2 Gene

Compound -log(P) Hits PubMed IDs
alar 57 1
genes like me logo Genes that share compounds with GBX2: view

Transcripts for GBX2 Gene

mRNA/cDNA for GBX2 Gene

(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GBX2 Gene

Gastrulation brain homeobox 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GBX2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GBX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBX2 Gene

No ASD Table

Relevant External Links for GBX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GBX2 Gene

mRNA expression in normal human tissues for GBX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GBX2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (12.9), Brain - Caudate (basal ganglia) (8.4), Brain - Spinal cord (cervical c-1) (7.1), Brain - Nucleus accumbens (basal ganglia) (5.0), and Brain - Hypothalamus (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GBX2 Gene

SOURCE GeneReport for Unigene cluster for GBX2 Gene Hs.184945

genes like me logo Genes that share expressions with GBX2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GBX2 Gene

Orthologs for GBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GBX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GBX2 35
  • 99.81 (n)
  • 99.71 (a)
GBX2 36
  • 100 (a)
(Bos Taurus)
Mammalia GBX2 35
  • 94.92 (n)
  • 98.56 (a)
GBX2 36
  • 98 (a)
(Canis familiaris)
Mammalia GBX2 35
  • 95.11 (n)
  • 99.14 (a)
GBX2 36
  • 99 (a)
(Mus musculus)
Mammalia Gbx2 35
  • 92.05 (n)
  • 98.28 (a)
Gbx2 16
Gbx2 36
  • 98 (a)
(Monodelphis domestica)
Mammalia GBX2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia GBX2 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Gbx2 35
  • 92.05 (n)
  • 97.7 (a)
(Gallus gallus)
Aves GBX2 35
  • 77.25 (n)
  • 75.37 (a)
GBX2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia GBX2 36
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397824 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gbx2 35
  • 73.69 (n)
  • 82.49 (a)
Str.10703 35
(Danio rerio)
Actinopterygii gbx2 35
  • 68.73 (n)
  • 73.16 (a)
gbx2 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta unpg 36
  • 29 (a)
unpg 37
  • 78 (a)
(Caenorhabditis elegans)
Secernentea ceh-12 36
  • 32 (a)
Species with no ortholog for GBX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GBX2 Gene

Gene Tree for GBX2 (if available)
Gene Tree for GBX2 (if available)

Paralogs for GBX2 Gene

Selected SIMAP similar genes for GBX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GBX2: view

Variants for GBX2 Gene

Sequence variations from dbSNP and Humsavar for GBX2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4292047 -- 236,165,254(+) CCCCC(C/T)CTCTC downstream-variant-500B
rs6705037 -- 236,165,176(+) GCCCG(A/G)CCACA downstream-variant-500B
rs6709943 -- 236,166,786(+) GGGTG(A/G)GGACT intron-variant
rs7588069 -- 236,166,184(+) TCCAG(C/T)AGCTG synonymous-codon, reference, utr-variant-3-prime
rs10183276 -- 236,169,250(+) CACGT(C/T)GCGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GBX2 Gene

Variant ID Type Subtype PubMed ID
esv2751845 CNV Gain 17911159
esv33938 CNV Loss 17666407
dgv4456n71 CNV Loss 21882294
nsv821922 CNV Gain 20364138
nsv876036 CNV Loss 21882294
nsv821923 CNV Gain 20364138
nsv525913 CNV Loss 19592680
nsv821924 CNV Gain 20364138

Relevant External Links for GBX2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBX2 Gene

Disorders for GBX2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GBX2 Gene including...

Search for GBX2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for GBX2 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 1.85 10

Relevant External Links for GBX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GBX2: view

No data available for UniProtKB/Swiss-Prot for GBX2 Gene

Publications for GBX2 Gene

  1. Characterization and sequence analysis of the human homeobox- containing gene GBX2. (PMID: 8838315) Lin X. … Leckman J.F. (Genomics 1996) 2 3 4 23
  2. The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PMID: 7903253) Matsui T. … Kurosawa Y. (FEBS Lett. 1993) 3 4 23
  3. The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. (PMID: 9346236) Kowenz-Leutz E. … Leutz A. (Cell 1997) 2 3
  4. Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity. (PMID: 9537237) Gao A.C. … Isaacs J.T. (Cancer Res. 1998) 3 23
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for GBX2 Gene

Sources for GBX2 Gene

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