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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GBX2 Gene

protein-coding   GIFtS: 55
GCID: GC02M237090

gastrulation brain homeobox 2

(Previous name: gastrulation brain homeo box 2 )
 Explore 10 diseases affiliated with
GBX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GBX2    

Aliases
for GBX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Gastrulation Brain Homeobox 21 2
Gastrulation Brain Homeo Box 21 2
Gastrulation And Brain-Specific Homeobox Protein 22 3
Homeobox Protein GBX-22

External Ids:    HGNC: 41861   Entrez Gene: 26372   Ensembl: ENSG000001685057   OMIM: 6011355   UniProtKB: P529513   

Export aliases for GBX2 gene to outside databases

Previous GC identifers: GC02M235112 GC02M235755 GC02M237361 GC02M236856 GC02M236739 GC02M228868


Summaries
for GBX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951
Function: May act as a transcription factor for cell pluripotency and differentiation in the embryo

Gene Wiki entry for GBX2


Genomic Views
for GBX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GBX2 gene promoter:
         ER-alpha   E2F-4   E2F-3a   E2F-5   E2F-2   MEF-2A   Max   E2F   E2F-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GBX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GBX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GBX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.2   Ensembl cytogenetic band:  2q37.2   HGNC cytogenetic band: 2q37.2

GBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GBX2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M237090:  view genomic region     (about GC identifiers)

Start:
 237,073,879 bp from pter      End:
 237,077,012 bp from pter
Size:
 3,134 bases      Orientation:
 minus strand

Proteins
for GBX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951 (See protein sequence)
Recommended Name: Homeobox protein GBX-2  
Size: 348 amino acids; 37348 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RPH7 O43833 Q53RX5 Q9Y5Y1

Explore the universe of human proteins at neXtProt for GBX2: NX_P52951

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52951

    • GBX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001476.2  
    ENSEMBL proteins: 
     ENSP00000302251   ENSP00000448747  

    Human Recombinant Protein Products: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GBX2
    OriGene Custom Protein Services for GBX2 
    GenScript Custom Purified and Recombinant Proteins Services for GBX2
    Novus Biologicals GBX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GBX2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    GBX2 for ontologies           About GeneDecksing



    GBX2 Antibody Products: 
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    R&D Systems Antibodies for GBX2
    OriGene Antibodies: GBX2
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    Novus Biologicals GBX2 Antibodies
    Search for Antibodies for GBX2 at Abcam  
    Uscn Antibodies for GBX2
    ThermoFisher Antibodies for GBX2

    Assay Products for GBX2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for GBX2
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    Uscn ELISAs and CLIAs for GBX2

    Protein Domains /
    Families
    for GBX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GBX2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P52951

    ProtoNet protein and cluster: P52951

    UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for GBX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GBX2_HUMAN, P52951
    Function: May act as a transcription factor for cell pluripotency and differentiation in the embryo

         Genatlas biochemistry entry for GBX2:
    mouse telencephalon expressed Gbx homolog 2,gastrulation and brain specific-1,homeo domain encoding gene

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GBX2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate GBX2:
    hsa-miR-520d-5p hsa-miR-374b hsa-miR-524-5p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: GBX2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GBX2 (see all 4)
    OriGene shRNA RFP: GBX2
    OriGene siRNA: GBX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GBX2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GBX2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GBX2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GBX2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GBX2 (NM_001485)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GBX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for GBX2
    Search LifeMap BioReagents cell lines for GBX2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    GBX2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Gbx2tm1.1Mrt for GBX2
         15/18 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Gbx2) (see all 18):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  no phenotypic analysis  normal  respiratory system 

    GBX2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GBX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00
    2Neural Crest Differentiation
    		Neural Crest Differentiation1.00
    3Transcriptional Regulatory Network in Embryonic Stem Cell
    		Transcriptional Regulatory Network in Embryonic Stem Cell1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GBX2
        Transcription factors in neurogenesis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GBX2
        Transcriptional Regulatory Network in Embryonic Stem Cell

    1 BioSystems Pathway for GBX2 
        Neural Crest Differentiation



    GBX2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GBX2

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels IEA--
    GO:0001755neural crest cell migration IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007399nervous system development TAS8838315


    GBX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GBX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GBX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GBX2
    1 Novoseek chemical compound relationship for GBX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alar 57 1 11689282 (1)

    Search CenterWatch for drugs/clinical trials and news about GBX2 

    Transcripts
    for GBX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GBX2 gene: 
    NM_001485.2  

    Unigene Cluster for GBX2:

    Gastrulation brain homeobox 2
    Hs.184945  [show with all ESTs]
    Unigene Representative Sequence: NM_001485
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306318(uc002vvw.1 uc010zng.1) ENST00000551105 ENST00000465889


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GBX2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate GBX2:
    hsa-miR-520d-5p hsa-miR-374b hsa-miR-524-5p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: GBX2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GBX2 (see all 4)
    OriGene shRNA RFP: GBX2
    OriGene siRNA: GBX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GBX2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GBX2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GBX2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GBX2 (NM_001485)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GBX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GBX2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GBX2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GBX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GBX2

    Additional cDNA sequence: 

    AF118452.1 AK311262.1 BC137448.1 BC137449.1 BC144646.1 

    3 DOTS entries:

    DT.434131  DT.100011563  DT.40120503 

    14 AceView cDNA sequences:

    BF115559 BM747801 NM_001485 AF118452 BE463746 AA933790 CD611885 BG827869 
    BM747771 CD611886 BX094347 CD611889 AA176205 AA305563 

    GeneLoc Exon Structure


    Expression
    for GBX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GBX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGACTCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GBX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EpiblastEpiblastEarly Epiblast CellsEarly Embryo
    Neural EctodermNeural PlateCranial Neural Plate CellsNeural Ectoderm
    Neural EctodermNeural PlateIsthmus CellsNeural Ectoderm
    Neural TubeRhombencephalonNeural Fold CellsNeural Ectoderm
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    BoneMandibular ProcessBone
    BoneMaxillary ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    GABA neuron-like cells (Generation of motor ...)Brain
    Neuroectoderm cells (Generation of human ...)

    See GBX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GBX2

    SOURCE GeneReport for Unigene cluster: Hs.184945
        SABiosciences Expression via Pathway-Focused PCR Arrays including GBX2: 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GBX2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX2

    Orthologs
    for GBX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GBX2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GBX21 gastrulation brain homeobox 2 78.64(n)
    78.64(a)    		   395950  NM_205068.1  NP_990399.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GBX26
    		 --
    		 69(a)
    		 1 ↔ 1
    		 1(119835491-119838572)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3978242 homeobox protein Xgbx-2 76.98(n)    U04867.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gbx22 gastrulation brain homeo box 2 78.22(n)   245948  AB075028.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta unpg3 RNA polymerase II transcription factor 78(a)   2 45B3   --


    ENSEMBL Gene Tree for GBX2 (if available)
    TreeFam Gene Tree for GBX2 (if available) 

    Paralogs
    for GBX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GBX2 gene
    NKX1-22  MEOX12  EVX22  GBX12  NKX1-12  MNX12  EVX12  MEOX22  
    4 SIMAP similar genes for GBX2 using alignment to 2 protein entries:     GBX2_HUMAN (see all proteins):
    HMX2    HHEX    HLX    GBX1

    GBX2 for paralogs           About GeneDecksing



    Genomic Variants
    for GBX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/68 NCBI SNPs in GBX2 are shown (see all 68)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs102023971,2
    		C,F,--237073817(+) TTGCCC/TGGCCA 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs67050371,2
    		C,F,A,--237073819(+) GCCCGG/ACCACA 1 -- ds50018Minor allele frequency- A:0.43WA NA CSA EA 367
    rs1114906311,2
    		C,--237073889(+) CTTTTC/TCCCCC 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs42920471,2
    		C,F,H,--237073897(+) CCCCCT/CCTCTC 1 -- ds50019Minor allele frequency- C:0.12NS NA CSA WA 1187
    rs672526821,2
    		C,--237073897(+) CCCCC-/TCTCTC 1 -- ds50010--------
    rs1380875931,2
    		C,--237074047(+) AGGCA-/AAAGC 
                AAAGC     		1 -- ds50010--------
    rs1162910981,2
    		--237074487(+) GTGGAG/ATCCAC 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs2007729231,2
    		--237074513(+) GTGCGA/GGGGCT 1 -- ut310--------
    rs1494793961,2
    		C,--237074537(+) GCCAGG/ACCCTG 1 -- ut311Minor allele frequency- A:0.00EU 1235
    rs1146938931,2
    		C,F,--237074635(+) ACGACG/AATCTT 2 /I syn13Minor allele frequency- A:0.01NA EU 5995

    HapMap Linkage Disequilibrium report for GBX2 (237073879 - 237077012 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GBX2
         2 CNVs: 7254 8399

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GBX2
    DNA2.0 Custom Variant and Variant Library Synthesis for GBX2

    Disorders / Diseases
    for GBX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GBX2 for disorders           About GeneDecksing

    OMIM gene information: 601135    OMIM disorders: --

    10 diseases for GBX2:    About MalaCards
    embryonal carcinoma    hepatitis b    prostate cancer    blindness
    prostatitis    hepatitis    melanoma    carcinoma
    leukemia    neuronitis

    1 Novoseek disease relationship for GBX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 1.85 13 9537237 (6), 10690529 (4)

    Human Genome Epidemiology (HuGE) Navigator: GBX2 (1 document)

    Export disorders for GBX2 gene to outside databases

    Publications
    for GBX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GBX2 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with GBX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and sequence analysis of the human homeobox-containing gene GBX2. (PubMed id 8838315)1, 2, 3, 9 Lin X....Leckman J.F. (1996)
    2. The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PubMed id 7903253)1, 2, 9 Matsui T.... Kurosawa Y. (1993)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. (PubMed id 9346236)1, 3 Kowenz-Leutz E....Leutz A. (1997)
    5. Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity. (PubMed id 9537237)1, 9 Gao A.C....Isaacs J.T. (1998)
    6. Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene. (PubMed id 10690529)1, 9 Gao A.C....Isaacs J.T. (2000)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    8. Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors. (PubMed id 17060451)1 Heimbucher T....Czerny T. (2007)
    9. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. (PubMed id 15931389)1 Glinsky G.V....Glinskii A.B. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for GBX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing GBX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2637 HGNC: 4186 AceView: GBX2 Ensembl:ENSG00000168505 euGenes: HUgn2637
    ECgene: GBX2 H-InvDB: GBX2

    Other Databases showing GBX2 gene

    (According to HUGE)
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    Specialized Databases showing GBX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GBX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GBX2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
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    Licensable technologies from WIS Yeda, Salk, Tufts,
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    		Patent Information for GBX2 gene:
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