Aliases for GBX1 Gene
Aliases for GBX1 Gene
External Ids for GBX1 Gene
- HGNC: 4185
- Entrez Gene: 2636
- Ensembl: ENSG00000164900
- OMIM: 603354
- UniProtKB: Q14549
Previous GeneCards Identifiers for GBX1 Gene
- GC07U990039
- GC07M149093
- GC07M150160
- GC07M150237
- GC07M150283
- GC07M150476
- GC07M150845
- GC07M144657
Summaries for GBX1 Gene
GeneCards Summary for GBX1 Gene
GBX1 (Gastrulation Brain Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is GBX2.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBX1 Gene
Genomics for GBX1 Gene
Regulatory Elements for GBX1 Gene
Enhancers for GBX1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GBX1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GBX1 gene promoter:
Regulatory Element Products
Genomic Location for GBX1 Gene
- Chromosome:
- 7
- Start:
- 151,146,738 bp from pter
- End:
- 151,174,745 bp from pter
- Size:
- 28,008 bases
- Orientation:
- Minus strand
Genomic View for GBX1 Gene
Genes around GBX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q36.1 by Ensembl
- 7q36.1 by Entrez Gene
- 7q36.1 by HGNC
GBX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GBX1 Gene
Proteins for GBX1 Gene
-
Protein details for GBX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14549-GBX1_HUMAN
- Recommended name:
- Homeobox protein GBX-1
- Protein Accession:
- Q14549
Protein attributes for GBX1 Gene
- Size:
- 363 amino acids
- Molecular mass:
- 37629 Da
- Quaternary structure:
- No Data Available
Protein Expression for GBX1 Gene
Post-translational modifications for GBX1 Gene
Other Protein References for GBX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GBX1
- Novus Biologicals Antibodies for GBX1
- Invitrogen Antibodies for GBX1
- GeneTex GBX1 antibody for GBX1
Protein Products
-
OriGene Purified Proteins for GBX1
- Search Origene for MassSpec and Protein Over-expression Lysates for GBX1
- Origene Custom Protein Services for GBX1
- Novus Biologicals proteins for GBX1
- Search GeneTex for Proteins for GBX1
Assay Products
No data available for DME Specific Peptides for GBX1 Gene
Domains & Families for GBX1 Gene
Gene Families for GBX1 Gene
Protein Domains for GBX1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GBX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for GBX1 Gene
Function for GBX1 Gene
Molecular function for GBX1 Gene
- GENATLAS Biochemistry:
- mouse telencephalon expressed Gbx homolog 1,gastrulation and brain speciifc-2,homeo domain encoding gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for GBX1 Gene
- MGI mutant phenotypes for GBX1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for GBX1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GBX1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GBX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
- Search ViGene Biosciences for GBX1
CRISPR Products
-
OriGene CRISPR knockouts for GBX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GBX1
- GenScript: Design CRISPR guide RNA sequences for GBX1
miRNA Products
- Search ViGene Biosciences for GBX1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GBX1
- Browse OriGene Inhibitory RNA Products For GBX1
-
ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GBX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GBX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for GBX1
-
ViGene Biosciences adenoviral particle packaged cDNA for GBX1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GBX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GBX1 Gene
Localization for GBX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GBX1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for GBX1 Gene
No Data Available
Interacting Proteins for GBX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007628 | adult walking behavior | IEA | -- |
| GO:0019230 | proprioception | IEA | -- |
| GO:0021522 | spinal cord motor neuron differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GBX1 Gene
Transcripts for GBX1 Gene
mRNA/cDNA for GBX1 Gene
- (3) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GBX1 Gene
- Gastrulation brain homeobox 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for GBX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GBX1
- GenScript: Design CRISPR guide RNA sequences for GBX1
miRNA Products
- Search ViGene Biosciences for GBX1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GBX1
- Browse OriGene Inhibitory RNA Products For GBX1
-
ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GBX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GBX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for GBX1 Gene
mRNA differential expression in normal tissues according to GTEx for GBX1 Gene
This gene is overexpressed in Testis (x31.1) and Muscle - Skeletal (x9.5).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GBX1 Gene
NURSA nuclear receptor signaling pathways regulating expression of GBX1 Gene:
GBX1SOURCE GeneReport for Unigene cluster for GBX1 Gene:
Hs.647114Primer Products
-
OriGene qPCR primer pairs for GBX1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBX1 Gene
Orthologs for GBX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GBX1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Gbx1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gbx1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GBX1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GBX1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GBX1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GBX1 34 |
|
||
| GBX-1 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | gbx1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | unpg 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ceh-12 35 |
|
OneToMany |
- Species where no ortholog for GBX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for GBX1 Gene
Paralogs for GBX1 Gene
(8) SIMAP similar genes for GBX1 Gene using alignment to 1 proteins:
Variants for GBX1 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000016666 | -- | 151,147,577(+) | TGTAA(G/T)AACAG | downstream-variant-500B | |
| rs1000084655 | -- | 151,149,211(+) | GCCCA(C/T)GGAAC | intron-variant | |
| rs1000138844 | -- | 151,157,122(+) | GAAAC(C/G)CTGTC | intron-variant | |
| rs1000418276 | -- | 151,160,909(+) | GTTCA(G/T)ACACA | intron-variant | |
| rs1000447064 | -- | 151,162,224(+) | CACTT(C/T)CCCCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3695n106 | OTHER | inversion | 24896259 |
| nsv1067934 | OTHER | inversion | 25765185 |
| nsv1151906 | OTHER | inversion | 26484159 |
| nsv609034 | CNV | loss | 21841781 |
| nsv831188 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.94;
49.17% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GBX1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GBX1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBX1 Gene
Disorders for GBX1 Gene
Relevant External Links for GBX1
No disorders were found for GBX1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBX1 Gene
Publications for GBX1 Gene
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
- Expression of a novel human homeobox-containing gene that maps to chromosome 7q36.1 in hematopoietic cells. (PMID: 8097731) Matsui T. … Kurosawa Y. (FEBS Lett. 1993) 3 4 64
- The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PMID: 7903253) Matsui T. … Kurosawa Y. (FEBS Lett. 1993) 2 3 64
- Comprehensive comparative homeobox gene annotation in human and mouse. (PMID: 26412852) Wilming L.G. … Harrow J.L. (Database (Oxford) 2015) 3 64
- cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. (PMID: 16597639) Huntriss J. … Picton H.M. (Mol. Hum. Reprod. 2006) 3 64
Products for GBX1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for GBX1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GBX1
- Search Origene for MassSpec and Protein Over-expression Lysates for GBX1
- Origene Custom Protein Services for GBX1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GBX1
- Browse OriGene Inhibitory RNA Products For GBX1
- OriGene qPCR primer pairs for GBX1
- OriGene CRISPR knockouts for GBX1
- OriGene ORF clones in human for GBX1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GBX1
- GenScript: Next-day shipping cDNA ORF clone for GBX1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GBX1
- GenScript Custom Assay Services for GBX1
- GenScript Custom overexpressing Cell Line Services for GBX1
- GenScript: Design CRISPR guide RNA sequences for GBX1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GBX1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for GBX1
- Novus Biologicals proteins for GBX1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for GBX1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GBX1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
- Search ViGene Biosciences for GBX1
- Horizon Cell Lines for GBX1
- Cyagen custom Knockout/knockin (KOKI) mouse models for GBX1
- VectorBuilder custom plasmid, inducible vectors for GBX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GBX1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GBX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer