GBX1 Gene

Aliases
for GBX1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC07U990039 GC07M149093 GC07M150160 GC07M150237 GC07M150283 GC07M150476 GC07M144657

Summaries
for GBX1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for GBX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000007.13  NC_018918.2  NT_007933.16  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GBX1

GBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150845:  view genomic region     (about GC identifiers)

Proteins
for GBX1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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3 PDB 3D structures from and Proteopedia for GBX1:

2M34 (3D)        2ME0 (3D)        2ME6 (3D)    

Explore the universe of human proteins at neXtProt for GBX1: NX_Q14549

Explore proteomics data for GBX1 at MOPED


See GBX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

GBX1 Human Recombinant Protein Products:

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	Search GeneTex for Proteins for GBX1
	antibodies-online proteins for GBX1 (3 products)
	antibodies-online peptides for GBX1

GBX1 Antibody Products:

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	antibodies-online antibodies for GBX1 (28 products)

GBX1 Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for GBX1 Cloud-Clone Corp. CLIAs for GBX1
	Search eBioscience for ELISAs for GBX1
	antibodies-online kits for GBX1 (5 products)

Domains /
Families
for GBX1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q14549

Find genes that share domains with GBX1           About GenesLikeMe

Function
for GBX1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

(inferred from 3 alleles) (MGI details for Gbx1)

genOway: Develop your customized and physiologically relevant rodent model for GBX1

miRNA Products:		Block miRNA regulation of human, mouse, rat GBX1 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate GBX1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for GBX1
		Predesigned siRNA for gene silencing in human, mouse, rat GBX1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GBX1

Clone Products:		OriGene clones in human, mouse for GBX1 (see all 5) OriGene ORF clones in mouse, rat for GBX1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GBX1 (NM_001098834)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GBX1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GBX1
		Browse ESI BIO Cell Lines and PureStem Progenitors for GBX1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX1

Localization
for GBX1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for GBX1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

Drugs & Compounds
for GBX1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for GBX1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for GBX1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GBX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCAACAGGTT

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for GBX1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GBX1
		QuantiTect SYBR Green Assays in human, mouse, rat GBX1
		QuantiFast Probe-based Assays in human, mouse, rat GBX1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBX1

Orthologs
for GBX1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for GBX1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for GBX1 gene

DLX2²  BARX1²  NKX1-1²  VENTX²  GBX2²  BARHL1²  BARHL2²  MNX1²  

BARX2²  DLX1²  DLX3²  LBX2²  NKX1-2²  BSX²  DLX5²  DLX6²  

DLX4²  LBX1²  MSX2²  MSX1²  

8 SIMAP similar genes for GBX1 using alignment to 1 protein entry:     GBX1_HUMAN:

HMX2    HOX B6    HOXA4    HOXB1    HHEX    HOXC13

GBX2    HOXD11

Find genes that share paralogs with GBX1           About GenesLikeMe

Genomic Variants
for GBX1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GBX1 (see all 338)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1472905691,2	C	--	150845650(+)	CCCTCA/GCCTTC	1	--	ds5001		0	--	--	--	--
rs2020465641,2		--	150845717(+)	GCTCCA/GCACAG	2	R W	mis1		0	--	--	--	--
rs2015667611,2	C	--	150845722(+)	GCACAG/ACAAAC	2	/A /V	mis1		1		EU	1323
rs1995154741,2	C	--	150845788(+)	CAGAAC/TGGCTG	2	H R	mis1		1		EU	1323
rs751762551,2	C,F	--	150845853(+)	ATCTTG/TACCTG	2	V	syn1		1		EA	120
rs2014173191,2	C	--	150845886(+)	TGGGCG/AATCTG	2	/I	syn1		1		EU	1323
rs2007853191,2		--	150845912(+)	GCTCAA/GGTATT	2	L	syn1		0	--	--	--	--
rs2003332321,2	C	--	150845977(+)	TGCGGC/TGCCGT	2	H R	mis1		0	--	--	--	--
rs2013951691,2	C	--	150846022(+)	TCACCA/GGTGCC	2	P L	mis1		0	--	--	--	--
rs69707681,2	C,H	--	150846058(+)	TTCCCT/CTTAGC	2	/K /R	mis1 ese3		5		NS EA NA	416

HapMap Linkage Disequilibrium report for GBX1 (150845676 - 150871832 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for GBX1:    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv7547n71	CNV	Loss	21882294
nsv831188	CNV	Loss	17160897
dgv7545n71	CNV	Loss	21882294
nsv889476	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing GBX1

DNA2.0 Custom Variant and Variant Library Synthesis for GBX1

Disorders / Diseases
for GBX1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for GBX1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2003)
2. Expression of a novel human homeobox-containing gene that maps to chromosome 7q36.1 in hematopoietic cells. (PubMed id 8097731)^{1, 2} Matsui T.... Kurosawa Y. (FEBS Lett. 1993)
3. The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PubMed id 7903253)^{1, 3} Matsui T.... Kurosawa Y. (FEBS Lett. 1993)
4. cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. (PubMed id 16597639)¹ Huntriss J.... Picton H.M. (Mol. Hum. Reprod. 2006)

External Searches for GBX1 gene

Genome Databases showing GBX1 gene

Other Databases showing GBX1 gene

Specialized Databases showing GBX1 gene

Products
for GBX1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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