Aliases for GBX1 Gene
Aliases for GBX1 Gene
External Ids for GBX1 Gene
- HGNC: 4185
- Entrez Gene: 2636
- Ensembl: ENSG00000164900
- OMIM: 603354
- UniProtKB: Q14549
Previous GeneCards Identifiers for GBX1 Gene
- GC07U990039
- GC07M149093
- GC07M150160
- GC07M150237
- GC07M150283
- GC07M150476
- GC07M150845
- GC07M144657
Summaries for GBX1 Gene
GeneCards Summary for GBX1 Gene
GBX1 (Gastrulation Brain Homeobox 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is GBX2.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBX1 Gene
Genomics for GBX1 Gene
GeneHancer (GH) Regulatory Elements for GBX1 Gene
Promoters and enhancers for GBX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GBX1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GBX1 gene promoter:
Regulatory Element Products
Genomic Locations for GBX1 Gene
Genomic Locations for GBX1 Gene
- chr7:151,146,738-151,174,745
- (GRCh38/hg38)
- Size:
- 28,008 bases
- Orientation:
- Minus strand
- chr7:150,845,676-150,871,832
- (GRCh37/hg19)
Genomic View for GBX1 Gene
Genes around GBX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q36.1 by Ensembl
- 7q36.1 by Entrez Gene
- 7q36.1 by HGNC
GBX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for GBX1 Gene
Proteins for GBX1 Gene
-
Protein details for GBX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14549-GBX1_HUMAN
- Recommended name:
- Homeobox protein GBX-1
- Protein Accession:
- Q14549
Protein attributes for GBX1 Gene
- Size:
- 363 amino acids
- Molecular mass:
- 37629 Da
- Quaternary structure:
- No Data Available
Protein Expression for GBX1 Gene
Post-translational modifications for GBX1 Gene
No Post-translational modifications
Other Protein References for GBX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GBX1
- Novus Biologicals Antibodies for GBX1
-
Abcam antibodies for GBX1
- Invitrogen Antibodies for GBX1
- antibodies-online: Search results for available gbx1 related products ranked by validation data
- GeneTex GBX1 antibody for GBX1
Protein Products
-
OriGene Purified Proteins for GBX1
- Search Origene for MassSpec and Protein Over-expression Lysates for GBX1
- Origene Custom Protein Services for GBX1
- Novus Biologicals proteins for GBX1
- antibodies-online: Search results for available gbx1 related products ranked by validation data
- Search GeneTex for Proteins for GBX1
Assay Products
- antibodies-online: Search results for available gbx1 related products ranked by validation data
No data available for DME Specific Peptides for GBX1 Gene
Domains & Families for GBX1 Gene
Gene Families for GBX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for GBX1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GBX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for GBX1 Gene
Function for GBX1 Gene
Molecular function for GBX1 Gene
- GENATLAS Biochemistry:
- mouse telencephalon expressed Gbx homolog 1,gastrulation and brain speciifc-2,homeo domain encoding gene
Phenotypes From GWAS Catalog for GBX1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for GBX1 Gene
- MGI mutant phenotypes for GBX1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for GBX1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GBX1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GBX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
- Search ViGene Biosciences for GBX1
CRISPR Products
-
OriGene CRISPR knockouts for GBX1
- genomics-online: gRNA clones - Search results for available gbx1 gene related products
- Applied Biological Materials CRISPR for GBX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GBX1
- GenScript: Design CRISPR guide RNA sequences for GBX1
miRNA Products
- Search ViGene Biosciences for GBX1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GBX1
- Browse OriGene Inhibitory RNA Products For GBX1
- genomics-online: shRNA clones - Search results for available gbx1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GBX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GBX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available gbx1 gene related products
- orf clones - Search results for available gbx1 gene related products
- Applied Biological Materials Clones for GBX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GBX1
-
ViGene Biosciences adenoviral particle packaged cDNA for GBX1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GBX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GBX1 Gene
Localization for GBX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GBX1 Gene
- Nucleus.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GBX1 Gene
Pathways & Interactions for GBX1 Gene
No Data Available
Interacting Proteins for GBX1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007628 | adult walking behavior | IEA | -- |
GO:0019230 | proprioception | IEA | -- |
GO:0021522 | spinal cord motor neuron differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GBX1 Gene
Transcripts for GBX1 Gene
mRNA/cDNA for GBX1 Gene
- (3) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GBX1 Gene
- Gastrulation brain homeobox 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for GBX1
- genomics-online: gRNA clones - Search results for available gbx1 gene related products
- Applied Biological Materials CRISPR for GBX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GBX1
- GenScript: Design CRISPR guide RNA sequences for GBX1
miRNA Products
- Search ViGene Biosciences for GBX1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GBX1
- Browse OriGene Inhibitory RNA Products For GBX1
- genomics-online: shRNA clones - Search results for available gbx1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GBX1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GBX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GBX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available gbx1 gene related products
- orf clones - Search results for available gbx1 gene related products
- Applied Biological Materials Clones for GBX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GBX1 Gene
mRNA differential expression in normal tissues according to GTEx for GBX1 Gene
This gene is overexpressed in Testis (x31.1) and Muscle - Skeletal (x9.5).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GBX1 Gene
NURSA nuclear receptor signaling pathways regulating expression of GBX1 Gene:
GBX1SOURCE GeneReport for Unigene cluster for GBX1 Gene:
Hs.647114Primer Products
-
OriGene qPCR primer pairs for GBX1
- genomics-online: primer clones - Search results for available gbx1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBX1 Gene
Orthologs for GBX1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GBX1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Gbx1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Gbx1 33 |
|
||
cow (Bos Taurus) |
Mammalia | GBX1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | GBX1 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | GBX1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GBX1 33 |
|
||
GBX-1 34 |
|
OneToOne | |||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
zebrafish (Danio rerio) |
Actinopterygii | gbx1 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | unpg 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | ceh-12 34 |
|
OneToMany |
- Species where no ortholog for GBX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for GBX1 Gene
Variants for GBX1 Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000016666 | -- | 151,147,577(-) | G/T | downstream_transcript_variant | |
rs1000084655 | -- | 151,149,211(-) | T/C | intron_variant | |
rs1000138844 | -- | 151,157,122(-) | C/G | intron_variant | |
rs1000418276 | -- | 151,160,909(-) | G/T | intron_variant | |
rs1000447064 | -- | 151,162,224(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3695n106 | OTHER | inversion | 24896259 |
nsv1067934 | OTHER | inversion | 25765185 |
nsv1151906 | OTHER | inversion | 26484159 |
nsv609034 | CNV | loss | 21841781 |
nsv831188 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.94;
49.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GBX1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GBX1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBX1 Gene
Disorders for GBX1 Gene
Additional Disease Information for GBX1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GBX1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBX1 Gene
Publications for GBX1 Gene
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
- The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PMID: 7903253) Matsui T … Kurosawa Y (FEBS letters 1993) 2 3 58
- Expression of a novel human homeobox-containing gene that maps to chromosome 7q36.1 in hematopoietic cells. (PMID: 8097731) Matsui T … Kurosawa Y (FEBS letters 1993) 3 4 58
- Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding. (PMID: 27396829) Proudfoot A … Serrano P (Structure (London, England : 1993) 2016) 3 58
- Comprehensive comparative homeobox gene annotation in human and mouse. (PMID: 26412852) Wilming LG … Harrow JL (Database : the journal of biological databases and curation 2015) 3 58
Products for GBX1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody ServicesOriGene Antibodies for GBX1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GBX1
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- OriGene qPCR primer pairs for GBX1
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- GenScript: Next-day shipping of latest version cDNA ORF clones for GBX1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GBX1
- GenScript Custom Assay Services for GBX1
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- GenScript: Design CRISPR guide RNA sequences for GBX1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Cloud-Clone Corp. disease models service
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- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for GBX1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for GBX1
- VectorBuilder custom plasmid, inducible vectors for GBX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GBX1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available gbx1 related products ranked by validation data
- antibodies-online: Search results for available gbx1 related products ranked by validation data
- antibodies-online: Search results for available gbx1 related products ranked by validation data
- GeneTex GBX1 antibody for GBX1
- Search GeneTex for Proteins for GBX1
- ViGene Biosciences adenoviral particle packaged cDNA for GBX1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GBX1 gene
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- Search ViGene Biosciences for GBX1
- Horizon Cell Lines for GBX1
- genomics-online: cdna clones - Search results for available gbx1 gene related products
- orf clones - Search results for available gbx1 gene related products
- genomics-online: gRNA clones - Search results for available gbx1 gene related products
- genomics-online: primer clones - Search results for available gbx1 gene related products
- genomics-online: shRNA clones - Search results for available gbx1 gene related products
Sources for GBX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew