GBX1 Gene
protein-coding GIFtS: 41
GCID: GC07M150845
|
|
gastrulation brain homeobox 1(Previous name: gastrulation brain homeo box 1 )
| |
Aliases
for GBX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Gastrulation Brain Homeobox 11 2 | | Gastrulation Brain Homeo Box 11 2 | | Gastrulation And Brain-Specific Homeobox Protein 12 3 | | Homeobox Protein GBX-12 |
Export aliases for GBX1 gene to outside databasesPrevious GC identifers: GC07U990039 GC07M149093 GC07M150160 GC07M150237 GC07M150283 GC07M150476 GC07M144657 |
Summaries
for GBX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GBX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GBX1 gene promoter:
HNF-4alpha2 HNF-4alpha1 NF-AT NF-AT4 NF-AT2 POU2F1 POU2F1a NF-AT3 NF-AT1 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for GBX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GBX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1GBX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M150845: view genomic region
(about GC identifiers)
Start:
|
150,845,676 bp from pter |
End:
|
150,871,832 bp from pter |
Size:
|
26,157 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 150,175,196-150,194,388 |
|
Proteins
for GBX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GBX1_HUMAN, Q14549 (See
protein sequence)Recommended Name: Homeobox protein GBX-1 Size: 363 amino acids; 37629 Da
Subcellular location: Nucleus (By similarity)
1 PDB 3D structure from  and Proteopedia  for GBX1:2M34 (3D)
Explore the universe of human proteins at neXtProt for GBX1: NX_Q14549
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14549
GBX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092304.1
ENSEMBL proteins: ENSP00000297537 ENSP00000447905
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000228 | nuclear chromosome |
NAS | -- |
GBX1 for ontologies About GeneDecksing
GBX1 Antibody Products:
Assay Products for GBX1: |
Protein
Domains /
Families
for GBX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GBX1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14549ProtoNet protein and cluster: Q14549 1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature
UniProtKB/Swiss-Prot: GBX1_HUMAN, Q14549Similarity: Contains 1 homeobox DNA-binding domain |
Function
for GBX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for GBX1:mouse telencephalon expressed Gbx homolog 1,gastrulation and brain speciifc-2,homeo domain encoding gene
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GBX1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GBX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GBX1 (NM_001098834) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GBX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
GBX1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for GBX1:
|
Pathways & Interactions
for GBX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GBX1
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- |
GBX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GBX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GBX1
Search CenterWatch for drugs/clinical trials and news about GBX1
|
Transcripts
for GBX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GBX1 gene: NM_001098834.1 Unigene Cluster for GBX1: Gastrulation brain homeobox 1 Hs.647114 [show with all ESTs]Unigene Representative Sequence: NM_0010988342 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000297537(uc011kvg.2) ENST00000475831
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GBX1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GBX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GBX1 (NM_001098834) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GBX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX1 |
1 DOTS entry: DT.121044377
GeneLoc Exon Structure
|
Expression
for GBX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GBX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAACAGGTT
About this image
See GBX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GBX1
SOURCE GeneReport for Unigene cluster: Hs.647114
SABiosciences Custom PCR Arrays for GBX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GBX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GBX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GBX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GBX1 |
Orthologs
for GBX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GBX1 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for GBX1 (if available)
TreeFam Gene Tree for GBX1 (if available) |
Paralogs
for GBX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GBX1 gene
- NKX1-22 MEOX12 EVX12 MNX12 MEOX22 EVX22 NKX1-12 GBX22
9 SIMAP similar genes for GBX1 using alignment to 2 protein entries: GBX1_HUMAN (see all proteins):HMX2 HOX B6 HOXA4 HOXB1 HHEX HOXC13
GBX2 HOXD11 MEOX1
GBX1 for paralogs About GeneDecksing
|
Genomic Variants
for GBX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GBX1 (150845676 - 150871832 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GBX1
1 CNV: 4574 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for GBX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 GBX1 for disorders About MalaCards
GBX1 for disorders About GeneDecksing
OMIM gene information: 603354
OMIM disorders: --
Export disorders for GBX1 gene to outside databases
|
Publications
for GBX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GBX1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GBX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Expression of a novel human homeobox-containing gene that maps to chromosome 7q36.1 in hematopoietic cells. (PubMed id 8097731)1, 2 Matsui T.... Kurosawa Y. (1993)
- The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. (PubMed id 7903253)1, 3 Matsui T.... Kurosawa Y. (1993)
- cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. (PubMed id 16597639)1 Huntriss J.... Picton H.M. (2006)
|
External Searches for GBX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GBX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GBX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GBX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GBX1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GBX1 gene:
Search GeneIP for patents involving GBX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GBX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GBX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GBX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GBX1 | | | OriGene Protein Over-expression Lysate for GBX1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GBX1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GBX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GBX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GBX1 | | OriGene Custom Protein Services for GBX1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GBX1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GBX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GBX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GBX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GBX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GBX1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for GBX1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | GBX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for GBX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBX1 |
|
|
|
|
