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Aliases for GBP7 Gene

Aliases for GBP7 Gene

  • Guanylate Binding Protein 7 2 3 5
  • Guanine Nucleotide-Binding Protein 7 3 4
  • GTP-Binding Protein 7 3 4
  • GBP-7 3 4
  • GBP4L 3 4
  • Guanylate-Binding Protein 4-Like 4

External Ids for GBP7 Gene

Previous GeneCards Identifiers for GBP7 Gene

  • GC01M089310
  • GC01M089370
  • GC01M089597
  • GC01M087714

Summaries for GBP7 Gene

Entrez Gene Summary for GBP7 Gene

  • Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

GeneCards Summary for GBP7 Gene

GBP7 (Guanylate Binding Protein 7) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP2.

UniProtKB/Swiss-Prot for GBP7 Gene

  • Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP7 Gene

Genomics for GBP7 Gene

Regulatory Elements for GBP7 Gene

Genomic Location for GBP7 Gene

Chromosome:
1
Start:
89,131,751 bp from pter
End:
89,176,040 bp from pter
Size:
44,290 bases
Orientation:
Minus strand

Genomic View for GBP7 Gene

Genes around GBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP7 Gene

Proteins for GBP7 Gene

  • Protein details for GBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8V2-GBP7_HUMAN
    Recommended name:
    Guanylate-binding protein 7
    Protein Accession:
    Q8N8V2

    Protein attributes for GBP7 Gene

    Size:
    638 amino acids
    Molecular mass:
    72513 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GBP7 Gene

Proteomics data for GBP7 Gene at MOPED

Post-translational modifications for GBP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP7 Gene

Domains & Families for GBP7 Gene

Protein Domains for GBP7 Gene

Suggested Antigen Peptide Sequences for GBP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8V2

UniProtKB/Swiss-Prot:

GBP7_HUMAN :
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP7: view

No data available for Gene Families for GBP7 Gene

Function for GBP7 Gene

Molecular function for GBP7 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
genes like me logo Genes that share phenotypes with GBP7: view

Animal Model Products

CRISPR Products

miRNA for GBP7 Gene

miRTarBase miRNAs that target GBP7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP7 Gene

Localization for GBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP7 Gene

Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GBP7 Gene COMPARTMENTS Subcellular localization image for GBP7 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for GBP7 Gene

Pathways & Interactions for GBP7 Gene

genes like me logo Genes that share pathways with GBP7: view

Pathways by source for GBP7 Gene

Interacting Proteins for GBP7 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000294671%0d%0a9606.ENSP00000341044%0d%0a9606.ENSP00000344789%0d%0a9606.ENSP00000374455%0d%0a
Selected Interacting proteins: Q8N8V2-GBP7_HUMAN ENSP00000294671 for GBP7 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for GBP7 Gene

None

No data available for SIGNOR curated interactions for GBP7 Gene

Drugs & Compounds for GBP7 Gene

(1) Drugs for GBP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GBP7: view

Transcripts for GBP7 Gene

mRNA/cDNA for GBP7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(207) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GBP7 Gene

Guanylate binding protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GBP7 Gene

No ASD Table

Relevant External Links for GBP7 Gene

GeneLoc Exon Structure for
GBP7
ECgene alternative splicing isoforms for
GBP7

Expression for GBP7 Gene

mRNA expression in normal human tissues for GBP7 Gene

mRNA differential expression in normal tissues according to GTEx for GBP7 Gene

This gene is overexpressed in Liver (x49.0).

Protein differential expression in normal tissues from HIPED for GBP7 Gene

This gene is overexpressed in Cervix (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GBP7 Gene



SOURCE GeneReport for Unigene cluster for GBP7 Gene Hs.591450

genes like me logo Genes that share expression patterns with GBP7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GBP7 Gene

Orthologs for GBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP7 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gbp7 35
  • 75.29 (n)
  • 68.45 (a)
Gbp7 16
Gbp3 36
  • 70 (a)
ManyToMany
Gbp7 36
  • 68 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia GBP7 35
  • 99.27 (n)
  • 98.59 (a)
GBP7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685067 35
  • 75.63 (n)
  • 68.56 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
BT.37579 36
  • 66 (a)
ManyToMany
GBP4 36
  • 65 (a)
ManyToMany
GBP6 36
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gbp4 36
  • 34 (a)
ManyToMany
Species with no ortholog for GBP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP7 Gene

ENSEMBL:
Gene Tree for GBP7 (if available)
TreeFam:
Gene Tree for GBP7 (if available)

Paralogs for GBP7 Gene

Paralogs for GBP7 Gene

(7) SIMAP similar genes for GBP7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GBP7: view

Variants for GBP7 Gene

Sequence variations from dbSNP and Humsavar for GBP7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_037687 -
VAR_037688 -
rs527770033 -- 89,149,004(+) TTCTC(-/TAAG)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GBP7 Gene

Variant ID Type Subtype PubMed ID
nsv871277 CNV Loss 21882294
esv2714562 CNV Deletion 23290073
nsv830548 CNV Gain 17160897

Variation tolerance for GBP7 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GBP7 Gene

HapMap Linkage Disequilibrium report
GBP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP7 Gene

Disorders for GBP7 Gene

Relevant External Links for GBP7

Genetic Association Database (GAD)
GBP7
Human Genome Epidemiology (HuGE) Navigator
GBP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GBP7

No disorders were found for GBP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP7 Gene

Publications for GBP7 Gene

  1. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. (PMID: 20459687) Eid N.A. … Ibrahim M.E. (Malar. J. 2010) 3 48 67
  2. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. (PMID: 16689661) Olszewski M.A. … Vestal D.J. (J. Interferon Cytokine Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for GBP7 Gene

Sources for GBP7 Gene

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