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Aliases for GBP6 Gene

Aliases for GBP6 Gene

  • Guanylate Binding Protein Family Member 6 2 3 5
  • Guanine Nucleotide-Binding Protein 6 3 4
  • GTP-Binding Protein 6 3 4
  • GBP-6 3 4
  • Guanylate Binding Protein Family, Member 6 2
  • Guanylate-Binding Protein 6 3

External Ids for GBP6 Gene

Previous GeneCards Identifiers for GBP6 Gene

  • GC01P089542
  • GC01P089602
  • GC01P089829
  • GC01P087946

Summaries for GBP6 Gene

Entrez Gene Summary for GBP6 Gene

  • Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

GeneCards Summary for GBP6 Gene

GBP6 (Guanylate Binding Protein Family Member 6) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP4.

UniProtKB/Swiss-Prot for GBP6 Gene

  • Binds GTP, GDP and GMP.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP6 Gene

Genomics for GBP6 Gene

Regulatory Elements for GBP6 Gene

Enhancers for GBP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G089284 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -77.4 -77437 3.4 MAFG JUNB MAX YY1 ZNF316 MAFF HNF4G IRF1 HNF4A EMSY GBP1 GBP5 GBP4 GBP2 GBP6 GTF2B LRRC8C GBP3 GC01P089283 LOC729930
GH01G088990 1.6 FANTOM5 ENCODE dbSUPER 10.8 -371.3 -371321 4.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GBP3 GBP5 GBP6 GBP7 PTGES3P1 KYAT3 RBMXL1 GC01M088952
GH01G089069 1.2 FANTOM5 Ensembl ENCODE 10.3 -293.6 -293645 1.1 IRF2 STAT1 PKNOX1 CEBPB CEBPG RAD21 YY1 ZNF512 STAT3 HMBOX1 GBP1 GBP5 GBP7 GBP4 GBP2 GBP6 GBP3 GTF2B GC01M089104
GH01G088983 1.1 Ensembl ENCODE 10.7 -378.9 -378902 3.0 HDAC1 PKNOX1 RAD21 CHAMP1 RFX5 YY1 RCOR1 ZNF654 HMG20B JUNB GBP6 RBMXL1 GBP5 LOC100421401 KYAT3 GC01M088952
GH01G089020 1.1 ENCODE dbSUPER 10.6 -341.5 -341525 2.7 TBP SOX13 IRF2 FOXA2 SAP130 TAF1 CEBPG YY1 ZFHX2 RCOR1 GBP3 GBP6 GBP5 GBP1 ENSG00000202385 GC01M089021
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GBP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for GBP6 Gene

Chromosome:
1
Start:
89,363,877 bp from pter
End:
89,388,160 bp from pter
Size:
24,284 bases
Orientation:
Plus strand

Genomic View for GBP6 Gene

Genes around GBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP6 Gene

Proteins for GBP6 Gene

  • Protein details for GBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN66-GBP6_HUMAN
    Recommended name:
    Guanylate-binding protein 6
    Protein Accession:
    Q6ZN66
    Secondary Accessions:
    • A2RRM3
    • Q6ZN86
    • Q7Z3F0

    Protein attributes for GBP6 Gene

    Size:
    633 amino acids
    Molecular mass:
    72427 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GBP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GBP6 Gene

Post-translational modifications for GBP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP6 Gene

Domains & Families for GBP6 Gene

Protein Domains for GBP6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZN66

UniProtKB/Swiss-Prot:

GBP6_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP6: view

No data available for Gene Families for GBP6 Gene

Function for GBP6 Gene

Molecular function for GBP6 Gene

UniProtKB/Swiss-Prot Function:
Binds GTP, GDP and GMP.

Gene Ontology (GO) - Molecular Function for GBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GBP6: view

Phenotypes for GBP6 Gene

genes like me logo Genes that share phenotypes with GBP6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP6 Gene

Localization for GBP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP6 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with GBP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GBP6 Gene

Pathways & Interactions for GBP6 Gene

genes like me logo Genes that share pathways with GBP6: view

Pathways by source for GBP6 Gene

1 Sino Biological pathway for GBP6 Gene

Interacting Proteins for GBP6 Gene

Gene Ontology (GO) - Biological Process for GBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response ISS --
GO:0042742 defense response to bacterium ISS --
GO:0071346 cellular response to interferon-gamma ISS --
genes like me logo Genes that share ontologies with GBP6: view

No data available for SIGNOR curated interactions for GBP6 Gene

Drugs & Compounds for GBP6 Gene

(2) Drugs for GBP6 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with GBP6: view

Transcripts for GBP6 Gene

mRNA/cDNA for GBP6 Gene

(3) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GBP6 Gene

Guanylate binding protein family, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBP6 Gene

No ASD Table

Relevant External Links for GBP6 Gene

GeneLoc Exon Structure for
GBP6
ECgene alternative splicing isoforms for
GBP6

Expression for GBP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GBP6 Gene

This gene is overexpressed in Esophagus - Mucosa (x37.7) and Minor Salivary Gland (x8.2).

Protein differential expression in normal tissues from HIPED for GBP6 Gene

This gene is overexpressed in Cervix (55.0) and Esophagus (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GBP6 Gene



Protein tissue co-expression partners for GBP6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GBP6 Gene:

GBP6

SOURCE GeneReport for Unigene cluster for GBP6 Gene:

Hs.254338

Evidence on tissue expression from TISSUES for GBP6 Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with GBP6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP6 Gene

Orthologs for GBP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GBP6 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia GBP7 34
  • 84.18 (n)
-- 35
  • 75 (a)
OneToMany
GBP6 35
  • 73 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GBP6 34 35
  • 82.3 (n)
rat
(Rattus norvegicus)
Mammalia Mpa2l 34
  • 79.14 (n)
mouse
(Mus musculus)
Mammalia Gbp6 34 35
  • 78.81 (n)
Gbp11 35 35
  • 75 (a)
OneToMany
Gbp8 35
  • 69 (a)
OneToMany
Gbp9 16 35
  • 68 (a)
Gbp10 35
  • 68 (a)
OneToMany
Gbp4 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489592 34
  • 58.4 (n)
zebrafish
(Danio rerio)
Actinopterygii gbp3 34
  • 55.81 (n)
CABZ01068208.1 35
  • 39 (a)
ManyToMany
Species where no ortholog for GBP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP6 Gene

ENSEMBL:
Gene Tree for GBP6 (if available)
TreeFam:
Gene Tree for GBP6 (if available)

Paralogs for GBP6 Gene

Paralogs for GBP6 Gene

(7) SIMAP similar genes for GBP6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GBP6 Gene

genes like me logo Genes that share paralogs with GBP6: view

Variants for GBP6 Gene

Sequence variations from dbSNP and Humsavar for GBP6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000003489 -- 89,370,234(+) TCACA(A/G)CTTTC intron-variant
rs1000006190 -- 89,383,131(+) ACAAC(C/T)AACTC intron-variant
rs1000071573 -- 89,371,437(+) GAATC(C/T)AGCAG intron-variant
rs1000097538 -- 89,379,354(+) GGGGG(G/T)GGGGT intron-variant
rs1000150369 -- 89,362,770(+) GATGG(A/T)CTTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GBP6 Gene

Variant ID Type Subtype PubMed ID
esv3586760 CNV gain 21293372
esv3586763 CNV gain 21293372
nsv1078569 CNV deletion 25765185
nsv1142762 CNV deletion 24896259

Variation tolerance for GBP6 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GBP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GBP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP6 Gene

Disorders for GBP6 Gene

Relevant External Links for GBP6

Genetic Association Database (GAD)
GBP6
Human Genome Epidemiology (HuGE) Navigator
GBP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GBP6

No disorders were found for GBP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP6 Gene

Publications for GBP6 Gene

  1. Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. (PMID: 20423481) Suarez-Gestal M. … Gonzalez A. (Arthritis Res. Ther. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3 64
  5. 2D-DIGE proteomic characterization of head and neck squamous cell carcinoma. (PMID: 19861202) Merkley M.A. … Dynan W.S. (Otolaryngol Head Neck Surg 2009) 22 64

Products for GBP6 Gene

Sources for GBP6 Gene

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