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Aliases for GBP6 Gene

Aliases for GBP6 Gene

  • Guanylate Binding Protein Family Member 6 2 3 5
  • Guanylate Binding Protein Family, Member 6 2 3
  • Guanine Nucleotide-Binding Protein 6 3 4
  • GTP-Binding Protein 6 3 4
  • GBP-6 3 4

External Ids for GBP6 Gene

Previous GeneCards Identifiers for GBP6 Gene

  • GC01P089542
  • GC01P089602
  • GC01P089829
  • GC01P087946

Summaries for GBP6 Gene

Entrez Gene Summary for GBP6 Gene

  • Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

GeneCards Summary for GBP6 Gene

GBP6 (Guanylate Binding Protein Family Member 6) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7.

UniProtKB/Swiss-Prot for GBP6 Gene

  • Binds GTP, GDP and GMP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP6 Gene

Genomics for GBP6 Gene

Regulatory Elements for GBP6 Gene

Enhancers for GBP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GBP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for GBP6 Gene

89,363,877 bp from pter
89,388,160 bp from pter
24,284 bases
Plus strand

Genomic View for GBP6 Gene

Genes around GBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP6 Gene

Proteins for GBP6 Gene

  • Protein details for GBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanylate-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • A2RRM3
    • Q6ZN86
    • Q7Z3F0

    Protein attributes for GBP6 Gene

    633 amino acids
    Molecular mass:
    72427 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GBP6 Gene


neXtProt entry for GBP6 Gene

Proteomics data for GBP6 Gene at MOPED

Post-translational modifications for GBP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP6 Gene

Domains & Families for GBP6 Gene

Protein Domains for GBP6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP6: view

No data available for Gene Families for GBP6 Gene

Function for GBP6 Gene

Molecular function for GBP6 Gene

UniProtKB/Swiss-Prot Function:
Binds GTP, GDP and GMP.

Phenotypes for GBP6 Gene

genes like me logo Genes that share phenotypes with GBP6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP6 Gene

Localization for GBP6 Gene

Subcellular locations from

Jensen Localization Image for GBP6 Gene COMPARTMENTS Subcellular localization image for GBP6 gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GBP6 Gene

Pathways & Interactions for GBP6 Gene

genes like me logo Genes that share pathways with GBP6: view

Pathways by source for GBP6 Gene

Interacting Proteins for GBP6 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359485 for GBP6 Gene via STRING

Gene Ontology (GO) - Biological Process for GBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response ISS --
genes like me logo Genes that share ontologies with GBP6: view

No data available for SIGNOR curated interactions for GBP6 Gene

Drugs & Compounds for GBP6 Gene

(2) Drugs for GBP6 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with GBP6: view

Transcripts for GBP6 Gene

mRNA/cDNA for GBP6 Gene

(4) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GBP6 Gene

Guanylate binding protein family, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GBP6 Gene

No ASD Table

Relevant External Links for GBP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GBP6 Gene

mRNA expression in normal human tissues for GBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GBP6 Gene

This gene is overexpressed in Esophagus - Mucosa (x37.7) and Minor Salivary Gland (x8.2).

Protein differential expression in normal tissues from HIPED for GBP6 Gene

This gene is overexpressed in Cervix (55.0) and Esophagus (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GBP6 Gene

SOURCE GeneReport for Unigene cluster for GBP6 Gene Hs.254338

genes like me logo Genes that share expression patterns with GBP6: view

Protein tissue co-expression partners for GBP6 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GBP6 Gene

Orthologs for GBP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GBP7 35
  • 84.18 (n)
  • 75.48 (a)
-- 36
  • 75 (a)
-- 36
  • 72 (a)
GBP6 36
  • 73 (a)
(Canis familiaris)
Mammalia GBP6 35
  • 82.3 (n)
  • 74 (a)
GBP6 36
  • 74 (a)
(Mus musculus)
Mammalia Gbp6 35
  • 78.81 (n)
  • 72.34 (a)
Gbp9 16
Gbp10 36
  • 68 (a)
Gbp11 36
  • 75 (a)
Gbp11 36
  • 68 (a)
Gbp4 36
  • 63 (a)
Gbp6 36
  • 69 (a)
Gbp8 36
  • 69 (a)
Gbp9 36
  • 68 (a)
(Pan troglodytes)
Mammalia GBP6 35
  • 99.53 (n)
  • 98.89 (a)
GBP6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mpa2l 35
  • 79.14 (n)
  • 74.32 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
-- 36
  • 47 (a)
-- 36
  • 51 (a)
-- 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
(Gallus gallus)
Aves -- 36
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489592 35
  • 58.4 (n)
  • 52.08 (a)
(Danio rerio)
Actinopterygii gbp3 35
  • 55.81 (n)
  • 46.72 (a)
CABZ01068208.1 36
  • 39 (a)
Species with no ortholog for GBP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP6 Gene

Gene Tree for GBP6 (if available)
Gene Tree for GBP6 (if available)

Paralogs for GBP6 Gene

Paralogs for GBP6 Gene

(7) SIMAP similar genes for GBP6 Gene using alignment to 2 proteins: Pseudogenes for GBP6 Gene

genes like me logo Genes that share paralogs with GBP6: view

Variants for GBP6 Gene

Sequence variations from dbSNP and Humsavar for GBP6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4582772 - 89,380,593(+) AAGAA(C/T)CAAGA reference, missense
rs4658359 - 89,381,813(+) GGGCA(G/T)CTGAC reference, missense
rs4658360 - 89,381,852(+) TGAAG(C/T)TCCCC reference, missense
rs4658146 - 89,381,885(+) TGGAC(A/G)TGCAT reference, missense
rs959460 - 89,384,183(+) TCAAG(A/T)TAAGA reference, missense

Variation tolerance for GBP6 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GBP6 Gene

Disorders for GBP6 Gene

Relevant External Links for GBP6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GBP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP6 Gene

Publications for GBP6 Gene

  1. Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. (PMID: 20423481) Suarez-Gestal M. … Gonzalez A. (Arthritis Res. Ther. 2010) 3 48 67
  2. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  4. 2D-DIGE proteomic characterization of head and neck squamous cell carcinoma. (PMID: 19861202) Merkley M.A. … Dynan W.S. (Otolaryngol Head Neck Surg 2009) 23
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GBP6 Gene

Sources for GBP6 Gene