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Aliases for GBP5 Gene

Aliases for GBP5 Gene

  • Guanylate Binding Protein 5 2 3 5
  • Guanine Nucleotide-Binding Protein 5 3 4
  • GTP-Binding Protein 5 3 4
  • GBP-TA Antigen 3 4
  • GBP-5 3 4
  • Guanylate-Binding Protein 5 3
  • EC 3.6.5.- 4

External Ids for GBP5 Gene

Previous GeneCards Identifiers for GBP5 Gene

  • GC01M090208
  • GC01M088894
  • GC01M089061
  • GC01M089193
  • GC01M089438
  • GC01M089498
  • GC01M089724
  • GC01M087841

Summaries for GBP5 Gene

Entrez Gene Summary for GBP5 Gene

  • This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

GeneCards Summary for GBP5 Gene

GBP5 (Guanylate Binding Protein 5) is a Protein Coding gene. Diseases associated with GBP5 include Chronic Active Epstein-Barr Virus Infection. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and GTPase activity. An important paralog of this gene is GBP3.

UniProtKB/Swiss-Prot for GBP5 Gene

  • As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).

Additional gene information for GBP5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP5 Gene

Genomics for GBP5 Gene

GeneHancer (GH) Regulatory Elements for GBP5 Gene

Promoters and enhancers for GBP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I089271 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 580.9 -0.8 -841 4 STAT1 NFATC3 CEBPB CEBPG EP300 RAD21 YY1 RELA ATF4 JUND GBP5 GBP1 GBP4 GBP2 GTF2B GBP3 LRRC8C GC01P089283 LOC100421401
GH01I089309 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 34 -38.0 -38037 2.5 MAX BATF YY1 ZNF316 ATF7 NFE2 NFE2L2 SRF STAT1 RXRA GBP1 GBP5 GBP4 GBP2 GTF2B PKN2 GBP3 LOC101927975 LRRC8C ENSG00000233235
GH01I089284 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 35.7 -13.6 -13579 3.4 JUNB MAX MAFG BATF YY1 ZNF316 MAFF HNF4G HNF4A EMSY GBP1 GBP5 GBP4 GBP2 GBP6 GTF2B LRRC8C GBP3 GC01P089283 LOC729930
GH01I089128 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 33 +143.6 143578 1.8 HDAC1 TAF9B ARNT SIN3A ZBTB40 RAD21 YY1 E2F8 ZNF143 ATF7 LOC105378842 GBP1 GBP5 GBP4 GBP2 GBP7 GTF2B GBP3 PTGES3P1
GH01I089277 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 32.1 -6.3 -6306 2.8 PKNOX1 SP7 GBP1 GBP5 GBP4 GBP2 LOC100421401 GBP7 GTF2B LRRC8C KYAT3 GBP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GBP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GBP5 gene promoter:

Genomic Locations for GBP5 Gene

Genomic Locations for GBP5 Gene
chr1:89,258,950-89,272,861
(GRCh38/hg38)
Size:
13,912 bases
Orientation:
Minus strand
chr1:89,724,633-89,738,544
(GRCh37/hg19)

Genomic View for GBP5 Gene

Genes around GBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP5 Gene

Proteins for GBP5 Gene

  • Protein details for GBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PP8-GBP5_HUMAN
    Recommended name:
    Guanylate-binding protein 5
    Protein Accession:
    Q96PP8
    Secondary Accessions:
    • B2RCE1
    • Q86TM5

    Protein attributes for GBP5 Gene

    Size:
    586 amino acids
    Molecular mass:
    66617 Da
    Quaternary structure:
    • Homodimer (PubMed:21151871). Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4 (PubMed:21151871). Dimerization is nucleotide-dependent; isoform 1 and isoform 2 form dimers when GTP-bound. GDP-bound isoform 2 is monomeric, while isoform 1 remains dimeric (PubMed:20180847). Dimerization regulates subcellular location. May also form tetramers (dimer of dimers) in the presence of GTP (PubMed:20180847). Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization (PubMed:22461501).

    Alternative splice isoforms for GBP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GBP5 Gene

Post-translational modifications for GBP5 Gene

Other Protein References for GBP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GBP5 (GBP5)
  • Abcam antibodies for GBP5
  • Santa Cruz Biotechnology (SCBT) Antibodies for GBP5

No data available for DME Specific Peptides for GBP5 Gene

Domains & Families for GBP5 Gene

Gene Families for GBP5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GBP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PP8

UniProtKB/Swiss-Prot:

GBP5_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP5: view

Function for GBP5 Gene

Molecular function for GBP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).
UniProtKB/Swiss-Prot Induction:
By IFNG in endothelial cells and in LPS-primed macrophages.

Enzyme Numbers (IUBMB) for GBP5 Gene

Phenotypes From GWAS Catalog for GBP5 Gene

Gene Ontology (GO) - Molecular Function for GBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 22461501
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GBP5: view
genes like me logo Genes that share phenotypes with GBP5: view

Animal Models for GBP5 Gene

MGI Knock Outs for GBP5:

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GBP5 Gene

Localization for GBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP5 Gene

Cytoplasm. Golgi apparatus membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP5 gene
Compartment Confidence
golgi apparatus 4
endoplasmic reticulum 3
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with GBP5: view

Pathways & Interactions for GBP5 Gene

genes like me logo Genes that share pathways with GBP5: view

Pathways by source for GBP5 Gene

1 Sino Biological pathway for GBP5 Gene
1 KEGG pathway for GBP5 Gene

Gene Ontology (GO) - Biological Process for GBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IEA --
GO:0045089 positive regulation of innate immune response IEA,ISS --
GO:0050702 interleukin-1 beta secretion IMP,IEA 22461501
GO:0051289 protein homotetramerization IDA 22461501
genes like me logo Genes that share ontologies with GBP5: view

No data available for SIGNOR curated interactions for GBP5 Gene

Drugs & Compounds for GBP5 Gene

No Compound Related Data Available

Transcripts for GBP5 Gene

Unigene Clusters for GBP5 Gene

Guanylate binding protein 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1:
SP2:
SP3: -
SP4:

Relevant External Links for GBP5 Gene

GeneLoc Exon Structure for
GBP5
ECgene alternative splicing isoforms for
GBP5

Expression for GBP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GBP5 Gene

mRNA differential expression in normal tissues according to GTEx for GBP5 Gene

This gene is overexpressed in Whole Blood (x20.1) and Spleen (x5.9).

Protein differential expression in normal tissues from HIPED for GBP5 Gene

This gene is overexpressed in Spleen (19.4), NK cells (10.4), CD4 Tcells (8.2), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GBP5 Gene



Protein tissue co-expression partners for GBP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GBP5 Gene:

GBP5

SOURCE GeneReport for Unigene cluster for GBP5 Gene:

Hs.513726

mRNA Expression by UniProt/SwissProt for GBP5 Gene:

Q96PP8-GBP5_HUMAN
Tissue specificity: Expressed in peripheral blood monocytes (at protein level).

Evidence on tissue expression from TISSUES for GBP5 Gene

  • Nervous system(4.1)
  • Blood(3)
genes like me logo Genes that share expression patterns with GBP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP5 Gene

Orthologs for GBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GBP5 33 34
  • 99.2 (n)
cow
(Bos Taurus)
Mammalia GBP5 33 34
  • 79.17 (n)
dog
(Canis familiaris)
Mammalia GBP5 33 34
  • 79.01 (n)
mouse
(Mus musculus)
Mammalia Gbp5 33 16 34
  • 75.31 (n)
rat
(Rattus norvegicus)
Mammalia Gbp5 33
  • 74.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 41 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01068209.1 34
  • 43 (a)
ManyToMany
Species where no ortholog for GBP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP5 Gene

ENSEMBL:
Gene Tree for GBP5 (if available)
TreeFam:
Gene Tree for GBP5 (if available)

Paralogs for GBP5 Gene

Paralogs for GBP5 Gene

(7) SIMAP similar genes for GBP5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GBP5: view

Variants for GBP5 Gene

Sequence variations from dbSNP and Humsavar for GBP5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs386352305 uncertain-significance, not provided 89,260,720(-) G/A coding_sequence_variant, missense_variant
rs1000575270 -- 89,269,536(-) A/T coding_sequence_variant, missense_variant
rs1000684012 -- 89,268,287(-) T/C intron_variant
rs1000706017 -- 89,261,514(-) T/A intron_variant
rs1000748786 -- 89,261,880(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GBP5 Gene

Variant ID Type Subtype PubMed ID
esv3586757 CNV loss 21293372
nsv525030 CNV loss 19592680
nsv546798 CNV loss 21841781
nsv830548 CNV gain 17160897

Variation tolerance for GBP5 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GBP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GBP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP5 Gene

Disorders for GBP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GBP5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic active epstein-barr virus infection
  • caebv infection
- elite association - COSMIC cancer census association via MalaCards
Search GBP5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GBP5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GBP5 Gene

Publications for GBP5 Gene

  1. Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant. (PMID: 20180847) Wehner M … Herrmann C (The FEBS journal 2010) 3 4 22 58
  2. GBP-5 splicing variants: New guanylate-binding proteins with tumor-associated expression and antigenicity. (PMID: 15175044) Fellenberg F … Eichmüller S (The Journal of investigative dermatology 2004) 3 4 22 58
  3. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. (PMID: 22461501) Shenoy AR … MacMicking JD (Science (New York, N.Y.) 2012) 3 4 58
  4. Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. (PMID: 21151871) Britzen-Laurent N … Stürzl M (PloS one 2010) 3 4 58
  5. Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection. (PMID: 18260761) Ito Y … Kimura H (The Journal of infectious diseases 2008) 3 22 58

Products for GBP5 Gene

Sources for GBP5 Gene

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