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Aliases for GBP5 Gene

Aliases for GBP5 Gene

  • Guanylate Binding Protein 5 2 3
  • Guanine Nucleotide-Binding Protein 5 3 4
  • GTP-Binding Protein 5 3 4
  • GBP-TA Antigen 3 4
  • GBP-5 3 4
  • EC 3.6.5.- 4

External Ids for GBP5 Gene

Previous GeneCards Identifiers for GBP5 Gene

  • GC01M090208
  • GC01M088894
  • GC01M089061
  • GC01M089193
  • GC01M089438
  • GC01M089498
  • GC01M089724
  • GC01M087841

Summaries for GBP5 Gene

GeneCards Summary for GBP5 Gene

GBP5 (Guanylate Binding Protein 5) is a Protein Coding gene. Diseases associated with GBP5 include chronic active epstein-barr virus infection. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include identical protein binding and GTPase activity. An important paralog of this gene is GBP7.

UniProtKB/Swiss-Prot for GBP5 Gene

  • As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP5 Gene

Genomics for GBP5 Gene

Regulatory Elements for GBP5 Gene

Genomic Location for GBP5 Gene

Chromosome:
1
Start:
89,258,950 bp from pter
End:
89,272,861 bp from pter
Size:
13,912 bases
Orientation:
Minus strand

Genomic View for GBP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GBP5 Gene

Proteins for GBP5 Gene

  • Protein details for GBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PP8-GBP5_HUMAN
    Recommended name:
    Guanylate-binding protein 5
    Protein Accession:
    Q96PP8
    Secondary Accessions:
    • B2RCE1
    • Q86TM5

    Protein attributes for GBP5 Gene

    Size:
    586 amino acids
    Molecular mass:
    66617 Da
    Quaternary structure:
    • Homodimer (PubMed:21151871). Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4 (PubMed:21151871). Dimerization is nucleotide-dependent; isoform 1 and isoform 2 form dimers when GTP-bound. GDP-bound isoform 2 is monomeric, while isoform 1 remains dimeric (PubMed:20180847). Dimerization regulates subcellular location. May also form tetramers (dimer of dimers) in the presence of GTP (PubMed:20180847). Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization (PubMed:22461501).

    Alternative splice isoforms for GBP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GBP5 Gene

Proteomics data for GBP5 Gene at MOPED

Post-translational modifications for GBP5 Gene

  • Isoprenylation is required for proper subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GBP5 Gene

Domains & Families for GBP5 Gene

Protein Domains for GBP5 Gene

Suggested Antigen Peptide Sequences for GBP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PP8

UniProtKB/Swiss-Prot:

GBP5_HUMAN :
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP5: view

No data available for Gene Families for GBP5 Gene

Function for GBP5 Gene

Molecular function for GBP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).
UniProtKB/Swiss-Prot Induction:
By IFNG in endothelial cells and in LPS-primed macrophages.

Enzyme Numbers (IUBMB) for GBP5 Gene

Gene Ontology (GO) - Molecular Function for GBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 22461501
GO:0005525 GTP binding IEA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with GBP5: view
genes like me logo Genes that share phenotypes with GBP5: view

Animal Models for GBP5 Gene

MGI Knock Outs for GBP5:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GBP5

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for GBP5 Gene

Localization for GBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP5 Gene

Cytoplasm. Golgi apparatus membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GBP5 Gene COMPARTMENTS Subcellular localization image for GBP5 gene
Compartment Confidence
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for GBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with GBP5: view

Pathways & Interactions for GBP5 Gene

genes like me logo Genes that share pathways with GBP5: view

Pathways by source for GBP5 Gene

Interacting Proteins for GBP5 Gene

Selected Interacting proteins: Q96PP8-GBP5_HUMAN for GBP5 Gene via UniProtKB

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for GBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0008152 metabolic process IEA --
GO:0045089 positive regulation of innate immune response ISS --
GO:0050702 interleukin-1 beta secretion IMP 22461501
GO:0051289 protein homotetramerization IDA 22461501
genes like me logo Genes that share ontologies with GBP5: view

No data available for SIGNOR curated interactions for GBP5 Gene

Drugs & Compounds for GBP5 Gene

No Compound Related Data Available

Transcripts for GBP5 Gene

Unigene Clusters for GBP5 Gene

Guanylate binding protein 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GBP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1:
SP2:
SP3: -
SP4:

Relevant External Links for GBP5 Gene

GeneLoc Exon Structure for
GBP5
ECgene alternative splicing isoforms for
GBP5

Expression for GBP5 Gene

mRNA expression in normal human tissues for GBP5 Gene

mRNA differential expression in normal tissues according to GTEx for GBP5 Gene

This gene is overexpressed in Whole Blood (x20.1) and Spleen (x5.9).

Protein differential expression in normal tissues from HIPED for GBP5 Gene

This gene is overexpressed in Spleen (19.4), NK cells (10.4), CD4 Tcells (8.2), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GBP5 Gene



SOURCE GeneReport for Unigene cluster for GBP5 Gene Hs.513726

mRNA Expression by UniProt/SwissProt for GBP5 Gene

Q96PP8-GBP5_HUMAN
Tissue specificity: Expressed in peripheral blood monocytes (at protein level).
genes like me logo Genes that share expression patterns with GBP5: view

Protein tissue co-expression partners for GBP5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GBP5 Gene

Orthologs for GBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GBP5 35
  • 79.17 (n)
  • 70.89 (a)
GBP5 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GBP5 35
  • 79.01 (n)
  • 69.62 (a)
GBP5 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gbp5 35
  • 75.31 (n)
  • 68.13 (a)
Gbp5 16
Gbp5 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GBP5 35
  • 99.2 (n)
  • 98.29 (a)
GBP5 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gbp5 35
  • 74.07 (n)
  • 67.18 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 41 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01068209.1 36
  • 43 (a)
ManyToMany
Species with no ortholog for GBP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP5 Gene

ENSEMBL:
Gene Tree for GBP5 (if available)
TreeFam:
Gene Tree for GBP5 (if available)

Paralogs for GBP5 Gene

Paralogs for GBP5 Gene

(7) SIMAP similar genes for GBP5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GBP5: view

Variants for GBP5 Gene

Sequence variations from dbSNP and Humsavar for GBP5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs519086 -- 89,258,962(-) TTTTT(A/G)GAAAA utr-variant-3-prime
rs519909 -- 89,265,457(-) GGTAG(C/T)GCTCA intron-variant
rs535351 -- 89,260,909(-) GTTTA(C/T)TGCTA intron-variant
rs547544 -- 89,274,172(-) agctc(C/T)gcctc upstream-variant-2KB
rs553113 -- 89,264,108(-) TATCA(C/T)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GBP5 Gene

Variant ID Type Subtype PubMed ID
nsv830548 CNV Gain 17160897
nsv871785 CNV Gain 21882294
nsv525030 CNV Loss 19592680

Variation tolerance for GBP5 Gene

Residual Variation Intolerance Score: 58.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GBP5 Gene

HapMap Linkage Disequilibrium report
GBP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP5 Gene

Disorders for GBP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GBP5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic active epstein-barr virus infection
  • caebv infection
- elite association
Search GBP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GBP5

Genetic Association Database (GAD)
GBP5
Human Genome Epidemiology (HuGE) Navigator
GBP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GBP5
genes like me logo Genes that share disorders with GBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GBP5 Gene

Publications for GBP5 Gene

  1. Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant. (PMID: 20180847) Wehner M. … Herrmann C. (FEBS J. 2010) 23 67
  2. Induction of guanylate binding protein 5 by gamma interferon increases susceptibility to Salmonella enterica serovar Typhimurium-induced pyroptosis in RAW 264.7 cells. (PMID: 18362138) Rupper A.C. … Cardelli J.A. (Infect. Immun. 2008) 23 67
  3. Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection. (PMID: 18260761) Ito Y. … Kimura H. (J. Infect. Dis. 2008) 23 67
  4. GBP-5 splicing variants: New guanylate-binding proteins with tumor- associated expression and antigenicity. (PMID: 15175044) Fellenberg F. … Eichmuller S. (J. Invest. Dermatol. 2004) 23 67
  5. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67

Products for GBP5 Gene

Sources for GBP5 Gene

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