Aliases for GBP4 Gene
Aliases for GBP4 Gene
External Ids for GBP4 Gene
- HGNC: 20480
- Entrez Gene: 115361
- Ensembl: ENSG00000162654
- OMIM: 612466
- UniProtKB: Q96PP9
Previous GeneCards Identifiers for GBP4 Gene
- GC01M090127
- GC01M088817
- GC01M088984
- GC01M089114
- GC01M089359
- GC01M089420
- GC01M089646
- GC01M087764
Summaries for GBP4 Gene
-
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
GeneCards Summary for GBP4 Gene
GBP4 (Guanylate Binding Protein 4) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7.
UniProtKB/Swiss-Prot for GBP4 Gene
-
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP4 Gene
Genomics for GBP4 Gene
GeneHancer (GH) Regulatory Elements for GBP4 Gene
Promoters and enhancers for GBP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GBP4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GBP4 Gene
Genomic Locations for GBP4 Gene
- chr1:89,181,148-89,198,950
- (GRCh38/hg38)
- Size:
- 17,803 bases
- Orientation:
- Minus strand
- chr1:89,646,831-89,664,633
- (GRCh37/hg19)
Genomic View for GBP4 Gene
Genes around GBP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.2 by Ensembl
- 1p22.2 by Entrez Gene
- 1p22.2 by HGNC
GBP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GBP4 Gene
Proteins for GBP4 Gene
-
Protein details for GBP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PP9-GBP4_HUMAN
- Recommended name:
- Guanylate-binding protein 4
- Protein Accession:
- Q96PP9
- B2R630
- Q05D63
- Q6NSL0
- Q86T99
Protein attributes for GBP4 Gene
- Size:
- 640 amino acids
- Molecular mass:
- 73165 Da
- Quaternary structure:
-
- Heterodimer with other family members, including GBP1, GBP2 and GBP5 (PubMed:21151871). Dimerization regulates subcellular location.
- SequenceCaution:
-
- Sequence=BAC85144.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for GBP4 Gene
Post-translational modifications for GBP4 Gene
No Post-translational modifications
Other Protein References for GBP4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for GBP4
-
Cloud-Clone Corp. Antibodies for GBP4
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-
Santa Cruz Biotechnology (SCBT) Antibodies for GBP4
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Cloud-Clone Corp. Proteins for GBP4
- antibodies-online: Search results for 6 available GBP4 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for GBP4
Assay Products
No data available for DME Specific Peptides for GBP4 Gene
Domains & Families for GBP4 Gene
Gene Families for GBP4 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GBP4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GBP4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96PP9UniProtKB/Swiss-Prot:
GBP4_HUMAN :- Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
- Family:
-
- Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Function for GBP4 Gene
Molecular function for GBP4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- GTP + H(2)O = GDP + phosphate.
- UniProtKB/Swiss-Prot Function:
- Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By IFNG during macrophage activation.
Enzyme Numbers (IUBMB) for GBP4 Gene
Phenotypes From GWAS Catalog for GBP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0005525 | GTP binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for GBP4 Gene
- GenomeRNAi human phenotypes for GBP4:
Animal Model Products
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-
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ViGene Biosciences lentiviral particle packaged cDNA for GBP4 gene
-
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- Overview of 75 available GBP4 gene related products
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-
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miRNA for GBP4 Gene
- miRTarBase miRNAs that target GBP4
-
- hsa-mir-92a-3p (MIRT049565)
- hsa-mir-3143 (MIRT498324)
- hsa-mir-335-5p (MIRT498325)
- hsa-mir-543 (MIRT498326)
- hsa-mir-4279 (MIRT635458)
- hsa-mir-6778-3p (MIRT635459)
- hsa-mir-1976 (MIRT635460)
- hsa-mir-3653-5p (MIRT635461)
- hsa-mir-6747-3p (MIRT635462)
- hsa-mir-6727-3p (MIRT635463)
- hsa-mir-4722-3p (MIRT635464)
- hsa-mir-122-3p (MIRT635465)
- hsa-mir-640 (MIRT671897)
- hsa-mir-378a-5p (MIRT671898)
- hsa-mir-6821-3p (MIRT671899)
- hsa-mir-4638-5p (MIRT671900)
- hsa-mir-6790-3p (MIRT671901)
- hsa-mir-1307-3p (MIRT671902)
- hsa-mir-7107-5p (MIRT671903)
- hsa-mir-1234-3p (MIRT671904)
- hsa-mir-6827-3p (MIRT671905)
- hsa-mir-340-3p (MIRT671906)
- hsa-mir-4752 (MIRT717882)
- hsa-mir-6833-5p (MIRT717883)
- hsa-mir-6874-5p (MIRT717884)
- hsa-mir-7847-3p (MIRT717885)
- hsa-mir-6500-5p (MIRT717886)
- hsa-mir-4633-3p (MIRT717887)
- hsa-mir-558 (MIRT717888)
- hsa-mir-942-5p (MIRT717889)
- hsa-mir-1236-3p (MIRT717890)
- hsa-mir-6515-3p (MIRT717891)
- hsa-mir-6758-3p (MIRT717892)
miRNA Products
- Search ViGene Biosciences for GBP4
Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GBP4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP4 Gene
Localization for GBP4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GBP4 Gene
- Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Golgi apparatus membrane. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi aparatus. {ECO:0000269 PubMed:21151871}.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| golgi apparatus | 3 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for GBP4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Interferon gamma signaling | ||
| 2 | Toll-like receptor signaling pathway | ||
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Innate Immune System |
.61
|
|
Pathways by source for GBP4 Gene
4 Reactome pathways for GBP4 Gene
1 KEGG pathway for GBP4 Gene
Interacting Proteins for GBP4 Gene
No data available for SIGNOR curated interactions for GBP4 Gene
Drugs & Compounds for GBP4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for GBP4 Gene
mRNA/cDNA for GBP4 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (96) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GBP4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GBP4
- genomics-online: gRNA clones - Search results for 75 available GBP4 gene related products
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- Applied Biological Materials CRISPR for GBP4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GBP4
- GenScript: Design CRISPR guide RNA sequences for GBP4
miRNA Products
- Search ViGene Biosciences for GBP4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GBP4
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- genomics-online: shRNA clones - Search results for 75 available GBP4 gene related products
- Overview of 75 available GBP4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GBP4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GBP4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GBP4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GBP4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GBP4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lymph node (20.7) and Heart (12.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GBP4 Gene
NURSA nuclear receptor signaling pathways regulating expression of GBP4 Gene:
GBP4SOURCE GeneReport for Unigene cluster for GBP4 Gene:
Hs.409925Evidence on tissue expression from TISSUES for GBP4 Gene
- Spleen(4.3)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for GBP4
-
OriGene qPCR primer pairs for GBP4
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No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP4 Gene
Orthologs for GBP4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GBP4 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gbp3 33 16 34 |
|
||
| Gbp7 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Gbp4 33 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| BT.37579 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| GBP4 34 |
|
ManyToMany | |||
| GBP6 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100496810 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gbp2 34 |
|
ManyToMany |
- Species where no ortholog for GBP4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GBP4 Gene
Variants for GBP4 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000354273 | -- | 89,200,152(-) | T/C | upstream_transcript_variant | |
| rs1000483885 | -- | 89,193,320(-) | C/G | coding_sequence_variant, missense_variant | |
| rs1000619580 | -- | 89,182,171(-) | G/A/T | 3_prime_UTR_variant | |
| rs1000923684 | -- | 89,199,910(-) | C/T | upstream_transcript_variant | |
| rs1001095737 | -- | 89,186,837(-) | A/C | intron_variant |
Residual Variation Intolerance Score:
96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.04;
60.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GBP4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP4 Gene
Disorders for GBP4 Gene
Additional Disease Information for GBP4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GBP4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP4 Gene
Publications for GBP4 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. (PMID: 16689661) Olszewski MA … Vestal DJ (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2006) 2 3 58
- Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard SM … Kanmogne GD (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014) 3 58
- CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim DY … Gross JD (Molecular cell 2013) 3 58
- HIV gp120 induced gene expression signatures in vaginal epithelial cells. (PMID: 23867815) Fanibunda SE … Bandivdekar AH (Microbes and infection 2013) 3 58
Products for GBP4 Gene
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- VectorBuilder custom plasmid, inducible vectors for GBP4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GBP4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 44 available GBP4 Antibodies ranked by validation data
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Sources for GBP4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
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