Aliases for GBP4 Gene
Aliases for GBP4 Gene
External Ids for GBP4 Gene
- HGNC: 20480
- Entrez Gene: 115361
- Ensembl: ENSG00000162654
- OMIM: 612466
- UniProtKB: Q96PP9
Previous GeneCards Identifiers for GBP4 Gene
- GC01M090127
- GC01M088817
- GC01M088984
- GC01M089114
- GC01M089359
- GC01M089420
- GC01M089646
- GC01M087764
Summaries for GBP4 Gene
-
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
GeneCards Summary for GBP4 Gene
GBP4 (Guanylate Binding Protein 4) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7.
UniProtKB/Swiss-Prot for GBP4 Gene
-
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP4 Gene
Genomics for GBP4 Gene
Regulatory Elements for GBP4 Gene
Enhancers for GBP4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around GBP4 on UCSC Golden Path with GeneCards custom track
Promoters for GBP4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around GBP4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GBP4 gene promoter:
Regulatory Element Products
Genomic Location for GBP4 Gene
- Chromosome:
- 1
- Start:
- 89,181,148 bp from pter
- End:
- 89,198,950 bp from pter
- Size:
- 17,803 bases
- Orientation:
- Minus strand
Genomic View for GBP4 Gene
Genes around GBP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.2 by Ensembl
- 1p22.2 by Entrez Gene
- 1p22.2 by HGNC
GBP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GBP4 Gene
Proteins for GBP4 Gene
-
Protein details for GBP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PP9-GBP4_HUMAN
- Recommended name:
- Guanylate-binding protein 4
- Protein Accession:
- Q96PP9
- B2R630
- Q05D63
- Q6NSL0
- Q86T99
Protein attributes for GBP4 Gene
- Size:
- 640 amino acids
- Molecular mass:
- 73165 Da
- Quaternary structure:
-
- Heterodimer with other family members, including GBP1, GBP2 and GBP5 (PubMed:21151871). Dimerization regulates subcellular location.
- SequenceCaution:
-
- Sequence=BAC85144.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for GBP4 Gene
Post-translational modifications for GBP4 Gene
Other Protein References for GBP4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GBP4
- Abcam antibodies for GBP4
- Invitrogen Antibodies for GBP4
- antibodies-online Antibodies for GBP4: See all 41
- GeneTex GBP4 antibody for GBP4
-
Santa Cruz Biotechnology (SCBT) Antibodies for GBP4
Protein Products
-
OriGene Purified Proteins for GBP4
- Search Origene for MassSpec and Protein Over-expression Lysates for GBP4
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- antibodies-online Proteins for GBP4: See all 4
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- Abcam proteins for GBP4
Assay Products
- antibodies-online Kits for GBP4: See all 21
No data available for DME Specific Peptides for GBP4 Gene
Domains & Families for GBP4 Gene
Protein Domains for GBP4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GBP4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96PP9UniProtKB/Swiss-Prot:
GBP4_HUMAN :- Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
- Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
- Domain:
-
- Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
- Family:
-
- Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
No data available for Gene Families for GBP4 Gene
Function for GBP4 Gene
Molecular function for GBP4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- GTP + H(2)O = GDP + phosphate.
- UniProtKB/Swiss-Prot Function:
- Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By IFNG during macrophage activation.
Enzyme Numbers (IUBMB) for GBP4 Gene
Phenotypes for GBP4 Gene
- GenomeRNAi human phenotypes for GBP4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for GBP4 gene
-
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- Search ViGene Biosciences for GBP4
CRISPR Products
-
OriGene CRISPR knockouts for GBP4
-
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- GenScript: Design CRISPR guide RNA sequences for GBP4
miRNA for GBP4 Gene
- miRTarBase miRNAs that target GBP4
-
- hsa-mir-92a-3p (MIRT049565)
- hsa-mir-3143 (MIRT498324)
- hsa-mir-335-5p (MIRT498325)
- hsa-mir-543 (MIRT498326)
- hsa-mir-4279 (MIRT635458)
- hsa-mir-6778-3p (MIRT635459)
- hsa-mir-1976 (MIRT635460)
- hsa-mir-3653-5p (MIRT635461)
- hsa-mir-6747-3p (MIRT635462)
- hsa-mir-6727-3p (MIRT635463)
- hsa-mir-4722-3p (MIRT635464)
- hsa-mir-122-3p (MIRT635465)
- hsa-mir-640 (MIRT671897)
- hsa-mir-378a-5p (MIRT671898)
- hsa-mir-6821-3p (MIRT671899)
- hsa-mir-4638-5p (MIRT671900)
- hsa-mir-6790-3p (MIRT671901)
- hsa-mir-1307-3p (MIRT671902)
- hsa-mir-7107-5p (MIRT671903)
- hsa-mir-1234-3p (MIRT671904)
- hsa-mir-6827-3p (MIRT671905)
- hsa-mir-340-3p (MIRT671906)
- hsa-mir-4752 (MIRT717882)
- hsa-mir-6833-5p (MIRT717883)
- hsa-mir-6874-5p (MIRT717884)
- hsa-mir-7847-3p (MIRT717885)
- hsa-mir-6500-5p (MIRT717886)
- hsa-mir-4633-3p (MIRT717887)
- hsa-mir-558 (MIRT717888)
- hsa-mir-942-5p (MIRT717889)
- hsa-mir-1236-3p (MIRT717890)
- hsa-mir-6515-3p (MIRT717891)
- hsa-mir-6758-3p (MIRT717892)
miRNA Products
- Search ViGene Biosciences for GBP4
Inhibitory RNA Products
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-
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Clone Products
- OriGene clones in human for GBP4
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GBP4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GBP4 gene
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Flow Cytometry Products
No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP4 Gene
Localization for GBP4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GBP4 Gene
- Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Golgi apparatus membrane. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi aparatus. {ECO:0000269 PubMed:21151871}.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| golgi apparatus | 3 |
| cytosol | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
Pathways & Interactions for GBP4 Gene
More details on SuperPathways for GBP4| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Interferon gamma signaling | ||
| 2 | Interleukin-3, 5 and GM-CSF signaling | ||
| 3 | Immune System |
.52
|
Pathways by source for GBP4 Gene
4 Reactome pathways for GBP4 Gene
Interacting Proteins for GBP4 Gene
No data available for SIGNOR curated interactions for GBP4 Gene
Drugs & Compounds for GBP4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for GBP4 Gene
mRNA/cDNA for GBP4 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (96) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GBP4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GBP4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GBP4
- GenScript: Design CRISPR guide RNA sequences for GBP4
miRNA Products
- Search ViGene Biosciences for GBP4
Inhibitory RNA Products
- Origene siRNA, RNAi, shRNA, and mouse_rna products in human, mouse, rat for GBP4
- Browse OriGene Inhibitory RNA Products For GBP4
-
ViGene Biosciences ready-to-package AAV shRNAs for GBP4 gene
Clone Products
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for GBP4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lymph node (20.7) and Heart (12.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GBP4 Gene
SOURCE GeneReport for Unigene cluster for GBP4 Gene Hs.409925
Primer Products
-
OriGene qPCR primer pairs for GBP4
-
OriGene qPCR primer pairs and template standards for GBP4
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GBP4 Gene
Orthologs for GBP4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Gbp3 35 |
|
||
| Gbp3 16 |
|
||||
| Gbp3 36 |
|
ManyToMany | |||
| Gbp7 36 |
|
ManyToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | GBP4 35 |
|
||
| GBP4 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Gbp4 35 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany | |||
| -- 36 |
|
ManyToMany | |||
| -- 36 |
|
ManyToMany | |||
| -- 36 |
|
ManyToMany | |||
| BT.37579 36 |
|
ManyToMany | |||
| GBP4 36 |
|
ManyToMany | |||
| GBP6 36 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany | |||
| -- 36 |
|
ManyToMany | |||
| -- 36 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 36 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100496810 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gbp2 36 |
|
ManyToMany |
- Species with no ortholog for GBP4:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GBP4 Gene
(7) SIMAP similar genes for GBP4 Gene using alignment to 2 proteins:
Variants for GBP4 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17130745 | - | 89,193,403(+) | ATTCT(C/T)AGGGT | reference, missense | |
| rs1831240 | - | 89,190,100(+) | TGCAA(C/T)GGCTT | reference, missense | |
| rs655260 | - | 89,186,419(+) | CATGT(A/T)TTCCT | reference, missense | |
| rs608339 | - | 89,186,395(+) | CTCCA(A/T)CTTCT | reference, missense | |
| rs561037 | - | 89,186,389(-) | TGGAG(A/G)AGGAA | reference, missense |
Residual Variation Intolerance Score:
96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.04;
60.55% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GBP4 Gene
Disorders for GBP4 Gene
Relevant External Links for GBP4
No disorders were found for GBP4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP4 Gene
Publications for GBP4 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
- In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. (PMID: 16689661) Olszewski M.A. … Vestal D.J. (J. Interferon Cytokine Res. 2006) 2 3
- Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3
- CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
- HIV gp120 induced gene expression signatures in vaginal epithelial cells. (PMID: 23867815) Fanibunda S.E. … Bandivdekar A.H. (Microbes Infect. 2013) 3
Products for GBP4 Gene
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- OriGene qPCR primer pairs for GBP4
- OriGene qPCR primer pairs and template standards for GBP4
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- antibodies-online Antibodies for GBP4: See all 41
- antibodies-online Kits for GBP4: See all 21
- antibodies-online Proteins for GBP4: See all 4
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- GeneTex GBP4 antibody for GBP4
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- ViGene Biosciences adenoviral particle packaged cDNA for GBP4 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for GBP4 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for GBP4
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- Santa Cruz Biotechnology (SCBT) CRISPR for GBP4
Sources for GBP4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
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- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon