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GBP4 Gene(Protein Coding)

Guanylate Binding Protein 4

GCID:
GC01M089181
GIFtS:
52
Genes Participants
UDN Logo

Aliases for GBP4 Gene

Aliases for GBP4 Gene

  • Guanylate Binding Protein 4 2 3 5
  • Guanine Nucleotide-Binding Protein 4 3 4
  • GTP-Binding Protein 4 3 4
  • GBP-4 3 4
  • Guanylate-Binding Protein 4 3
  • EC 3.6.5.- 4
  • Mpa2 3

External Ids for GBP4 Gene

Previous GeneCards Identifiers for GBP4 Gene

  • GC01M090127
  • GC01M088817
  • GC01M088984
  • GC01M089114
  • GC01M089359
  • GC01M089420
  • GC01M089646
  • GC01M087764

Summaries for GBP4 Gene

Entrez Gene Summary for GBP4 Gene

  • Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]

GeneCards Summary for GBP4 Gene

GBP4 (Guanylate Binding Protein 4) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7.

UniProtKB/Swiss-Prot for GBP4 Gene

  • Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP4 Gene

Genomics for GBP4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GBP4 Gene

Enhancers for GBP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G089284 1.6 FANTOM5 Ensembl ENCODE dbSUPER 35.2 -87.5 -87491 3.4 MAFG JUNB MAX YY1 ZNF316 MAFF HNF4G IRF1 HNF4A EMSY GBP1 GBP5 GBP4 GBP2 GBP6 GTF2B LRRC8C GBP3 GC01P089283 LOC729930
GH01G089271 1.8 FANTOM5 Ensembl ENCODE dbSUPER 25.3 -74.8 -74753 4.0 KLF17 INSM2 RAD21 YY1 ZNF335 GLIS2 ZNF366 EGR1 SCRT2 ZNF416 GBP1 GBP5 GBP4 GBP2 GTF2B GBP3 LRRC8C GC01P089283
GH01G089128 1.5 FANTOM5 ENCODE dbSUPER 28.2 +69.7 69668 1.8 ARNT SIN3A ZBTB40 RAD21 YY1 FOS RELB IKZF2 CEBPB TBX21 GBP1 GBP5 GBP4 GBP2 GBP7 GTF2B GBP3 PTGES3P1 LOC105378842
GH01G089277 1.3 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -80.2 -80218 2.8 PKNOX1 SP7 GBP1 GBP5 GBP4 GBP2 LOC100421401 GBP7 GTF2B LRRC8C KYAT3 GBP3
GH01G089309 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.9 -111.9 -111949 2.5 MAX YY1 ZNF316 GATA2 NFE2 RELB NFE2L2 STAT1 MTA2 ZBTB2 GBP1 GBP5 GBP4 GBP2 GTF2B PKN2 GBP3 LOC101927975 LRRC8C ENSG00000233235
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GBP4 on UCSC Golden Path with GeneCards custom track

Promoters for GBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009531 150 2001 CTCF WRNIP1 ASH2L EBF1 RAD21 RELA ARID3A EED RELB ETV6

Transcription factor binding sites by QIAGEN in the GBP4 gene promoter:

Genomic Location for GBP4 Gene

Chromosome:
1
Start:
89,181,148 bp from pter
End:
89,198,950 bp from pter
Size:
17,803 bases
Orientation:
Minus strand

Genomic View for GBP4 Gene

Genes around GBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GBP4 Gene

Proteins for GBP4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PP9-GBP4_HUMAN
    Recommended name:
    Guanylate-binding protein 4
    Protein Accession:
    Q96PP9
    Secondary Accessions:
    • B2R630
    • Q05D63
    • Q6NSL0
    • Q86T99

    Protein attributes for GBP4 Gene

    Size:
    640 amino acids
    Molecular mass:
    73165 Da
    Quaternary structure:
    • Heterodimer with other family members, including GBP1, GBP2 and GBP5 (PubMed:21151871). Dimerization regulates subcellular location.
    SequenceCaution:
    • Sequence=BAC85144.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GBP4 Gene

Protein Expression for GBP4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GBP4
  • Santa Cruz Biotechnology (SCBT) Antibodies for GBP4

No data available for DME Specific Peptides for GBP4 Gene

Domains & Families for GBP4 Gene

Protein Domains for GBP4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GBP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PP9

UniProtKB/Swiss-Prot:

GBP4_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP4: view

No data available for Gene Families for GBP4 Gene

Function for GBP4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GBP4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
By IFNG during macrophage activation.

Enzyme Numbers (IUBMB) for GBP4 Gene

Gene Ontology (GO) - Molecular Function for GBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GBP4: view
genes like me logo Genes that share phenotypes with GBP4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP4 Gene

Localization for GBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP4 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Golgi apparatus membrane. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi aparatus. {ECO:0000269 PubMed:21151871}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP4 gene
Compartment Confidence
nucleus 4
golgi apparatus 3
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GBP4: view

Pathways & Interactions for GBP4 Gene

genes like me logo Genes that share pathways with GBP4: view

Pathways by source for GBP4 Gene

1 KEGG pathway for GBP4 Gene

Interacting Proteins for GBP4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359490%0d%0a9606.ENSP00000343129%0d%0a9606.ENSP00000256649%0d%0a9606.ENSP00000366005%0d%0a9606.ENSP00000254436%0d%0a9606.ENSP00000364114%0d%0a
Selected Interacting proteins: ENSP00000359490 Q96PP9-GBP4_HUMAN for GBP4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GBP4 Gene

None

No data available for SIGNOR curated interactions for GBP4 Gene

Drugs & Compounds for GBP4 Gene

Products:

  1. Drug

(1) Drugs for GBP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GBP4: view

Transcripts for GBP4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GBP4 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(96) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GBP4 Gene

Guanylate binding protein 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBP4 Gene

No ASD Table

Relevant External Links for GBP4 Gene

GeneLoc Exon Structure for
GBP4
ECgene alternative splicing isoforms for
GBP4

Expression for GBP4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GBP4 Gene

mRNA expression in normal human tissues for GBP4 Gene
mRNA expression by BioGPS for GBP4 GenemRNA expression by GTEx for GBP4 Gene

Protein differential expression in normal tissues from HIPED for GBP4 Gene

This gene is overexpressed in Lymph node (20.7) and Heart (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GBP4 Gene



Protein tissue co-expression partners for GBP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GBP4 Gene:

GBP4

SOURCE GeneReport for Unigene cluster for GBP4 Gene:

Hs.409925

Evidence on tissue expression from TISSUES for GBP4 Gene

  • Spleen(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GBP4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP4 Gene

Orthologs for GBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GBP4 34 35
  • 99.27 (n)
mouse
(Mus musculus)
 Mammalia Gbp3 34 16 35
  • 78.55 (n)
Gbp7 35
  • 68 (a)
 ManyToMany
rat
(Rattus norvegicus)
 Mammalia Gbp4 34
  • 78.5 (n)
cow
(Bos Taurus)
 Mammalia -- 35
  • 70 (a)
 ManyToMany
-- 35
  • 70 (a)
 ManyToMany
-- 35
  • 69 (a)
 ManyToMany
-- 35
  • 69 (a)
 ManyToMany
BT.37579 35
  • 68 (a)
 ManyToMany
-- 35
  • 66 (a)
 ManyToMany
GBP4 35
  • 66 (a)
 ManyToMany
GBP6 35
  • 63 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 58 (a)
 ManyToMany
-- 35
  • 58 (a)
 ManyToMany
-- 35
  • 50 (a)
 ManyToMany
-- 35
  • 47 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 55 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves -- 35
  • 33 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 48 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100496810 34
  • 54.56 (n)
zebrafish
(Danio rerio)
 Actinopterygii gbp2 35
  • 43 (a)
 ManyToMany
Species where no ortholog for GBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP4 Gene

ENSEMBL:
Gene Tree for GBP4 (if available)
TreeFam:
Gene Tree for GBP4 (if available)

Paralogs for GBP4 Gene

Paralogs for GBP4 Gene

(7) SIMAP similar genes for GBP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GBP4: view

Variants for GBP4 Gene

Sequence variations from dbSNP and Humsavar for GBP4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000354273 -- 89,200,152(+) AATAG(C/T)CCTAG intron-variant, upstream-variant-2KB
rs1000483885 -- 89,193,320(+) AGGGC(C/G)TGGTG reference, missense
rs1000619580 -- 89,182,171(+) AGGAT(A/G)AGCTG utr-variant-3-prime
rs1000923684 -- 89,199,910(+) GGCAC(C/T)CCTTT intron-variant, upstream-variant-2KB
rs1001095737 -- 89,186,837(+) ACTAT(A/C)GTCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GBP4 Gene

Variant ID Type Subtype PubMed ID
esv2714562 CNV deletion 23290073
nsv546796 CNV loss 21841781
nsv830548 CNV gain 17160897

Variation tolerance for GBP4 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GBP4 Gene

Human Gene Mutation Database (HGMD)
GBP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP4 Gene

Disorders for GBP4 Gene

Relevant External Links for GBP4

Genetic Association Database (GAD)
GBP4
Human Genome Epidemiology (HuGE) Navigator
GBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GBP4

No disorders were found for GBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP4 Gene

Publications for GBP4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. (PMID: 16689661) Olszewski M.A. … Vestal D.J. (J. Interferon Cytokine Res. 2006) 2 3 64
  3. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3 64
  4. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3 64
  5. HIV gp120 induced gene expression signatures in vaginal epithelial cells. (PMID: 23867815) Fanibunda S.E. … Bandivdekar A.H. (Microbes Infect. 2013) 3 64

Products for GBP4 Gene

Sources for GBP4 Gene

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