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Aliases for GBP3 Gene

Aliases for GBP3 Gene

  • Guanylate Binding Protein 3 2 3 5
  • Guanine Nucleotide-Binding Protein 3 4
  • GTP-Binding Protein 3 4
  • EC 3.6.5.- 4
  • GBP-3 4

External Ids for GBP3 Gene

Previous GeneCards Identifiers for GBP3 Gene

  • GC00U990115
  • GC01M088642
  • GC01M088808
  • GC01M088939
  • GC01M089184
  • GC01M089244
  • GC01M089472
  • GC01M087589

Summaries for GBP3 Gene

Entrez Gene Summary for GBP3 Gene

  • This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for GBP3 Gene

GBP3 (Guanylate Binding Protein 3) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Immune System. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP1.

UniProtKB/Swiss-Prot for GBP3 Gene

  • Exhibits antiviral activity against influenza virus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP3 Gene

Genomics for GBP3 Gene

Regulatory Elements for GBP3 Gene

Enhancers for GBP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F088990 1.4 FANTOM5 ENCODE 86.1 +30.3 30338 4.0 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS GBP3 GBP5 GBP6 GBP7 PTGES3P1 KYAT3 RBMXL1 GC01M088952
GH01F089043 0.9 ENCODE 55.3 -22.4 -22404 3.1 ELF3 MLX ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 RARA YY1 GATA4 GBP3 GBP5 GBP7 RBMXL1 GC01M089045 LOC105378841
GH01F089051 0.6 ENCODE 49.5 -29.2 -29177 1.5 ZNF316 MAFG EMSY MAFK NR2F2 GBP3 GBP5 GBP7 RBMXL1 GC01M089045 GBP1
GH01F089124 1 ENCODE 20.8 -103.3 -103332 3.9 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 FOS NFYC PPARG KAT8 GBP7 GBP3 GBP4 GBP5 PTGES3P1 LOC105378842
GH01F089081 0.9 Ensembl ENCODE 23 -58.4 -58407 0.6 PKNOX1 ZNF740 ZBTB11 GTF2E2 RELA TFDP1 ATF3 IKZF1 NFE2 ZNF584 GBP7 GBP3 GBP5 RBMXL1 GBP1 GC01M089104
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GBP3 on UCSC Golden Path with GeneCards custom track

Promoters for GBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000540347 794 1801 SOX13 TBP SAP130 JUN RELA YY1 ZFHX2 RCOR1 EGR2 SOX5

Genomic Location for GBP3 Gene

Chromosome:
1
Start:
89,006,666 bp from pter
End:
89,022,894 bp from pter
Size:
16,229 bases
Orientation:
Minus strand

Genomic View for GBP3 Gene

Genes around GBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP3 Gene

Proteins for GBP3 Gene

  • Protein details for GBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R5-GBP3_HUMAN
    Recommended name:
    Guanylate-binding protein 3
    Protein Accession:
    Q9H0R5
    Secondary Accessions:
    • A2A317
    • A6NF86
    • B2RTW0
    • F8UW81
    • Q05D54
    • Q5T8L8
    • Q5T8L9
    • Q6P3V3
    • Q9NV33

    Protein attributes for GBP3 Gene

    Size:
    595 amino acids
    Molecular mass:
    68114 Da
    Quaternary structure:
    • Heterodimer with other family members, including GBP1, GBP2 and GBP5 (PubMed:21151871). Dimerization regulates subcellular location.
    SequenceCaution:
    • Sequence=AAH17992.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAB66615.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=CAI21697.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW73151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GBP3 Gene

Post-translational modifications for GBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for GBP3
  • Santa Cruz Biotechnology (SCBT) Antibodies for GBP3

No data available for DME Specific Peptides for GBP3 Gene

Domains & Families for GBP3 Gene

Protein Domains for GBP3 Gene

Suggested Antigen Peptide Sequences for GBP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0R5

UniProtKB/Swiss-Prot:

GBP3_HUMAN :
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP3: view

No data available for Gene Families for GBP3 Gene

Function for GBP3 Gene

Molecular function for GBP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
Exhibits antiviral activity against influenza virus.

Enzyme Numbers (IUBMB) for GBP3 Gene

Gene Ontology (GO) - Molecular Function for GBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 12387898
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GBP3: view
genes like me logo Genes that share phenotypes with GBP3: view

Animal Models for GBP3 Gene

MGI Knock Outs for GBP3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GBP3 Gene

Localization for GBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP3 Gene

Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi aparatus. {ECO:0000269 PubMed:21151871}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP3 gene
Compartment Confidence
golgi apparatus 4
cytosol 2
nucleus 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with GBP3: view

Pathways & Interactions for GBP3 Gene

genes like me logo Genes that share pathways with GBP3: view

Pathways by source for GBP3 Gene

Gene Ontology (GO) - Biological Process for GBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with GBP3: view

No data available for SIGNOR curated interactions for GBP3 Gene

Drugs & Compounds for GBP3 Gene

(1) Drugs for GBP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GBP3: view

Transcripts for GBP3 Gene

Unigene Clusters for GBP3 Gene

Guanylate binding protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: -
SP2:
SP3: - - -
SP4:
SP5:
SP6: - - -
SP7:
SP8: - - - - -
SP9:

Relevant External Links for GBP3 Gene

GeneLoc Exon Structure for
GBP3
ECgene alternative splicing isoforms for
GBP3

Expression for GBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GBP3 Gene

Protein differential expression in normal tissues from HIPED for GBP3 Gene

This gene is overexpressed in Heart (53.9) and Urine (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GBP3 Gene



Protein tissue co-expression partners for GBP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GBP3 Gene:

GBP3

SOURCE GeneReport for Unigene cluster for GBP3 Gene:

Hs.720167
genes like me logo Genes that share expression patterns with GBP3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GBP3 Gene

Orthologs for GBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GBP3 34 35
  • 98.94 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 81 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gbp2b 34 16
  • 75.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gbp1 35
  • 41 (a)
ManyToMany
Species where no ortholog for GBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP3 Gene

ENSEMBL:
Gene Tree for GBP3 (if available)
TreeFam:
Gene Tree for GBP3 (if available)

Paralogs for GBP3 Gene

Paralogs for GBP3 Gene

genes like me logo Genes that share paralogs with GBP3: view

Variants for GBP3 Gene

Sequence variations from dbSNP and Humsavar for GBP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10493821 -- 89,009,452(+) GGTCA(C/T)AGACT nc-transcript-variant, reference, missense
rs10801702 -- 89,017,704(+) ctcaa(C/T)attac intron-variant
rs10922537 -- 89,006,909(+) GACTA(A/G)CTTAT nc-transcript-variant, utr-variant-3-prime
rs10922538 -- 89,017,490(+) gaaaa(A/G)ctttt intron-variant
rs10922539 -- 89,017,987(+) ggtag(A/G)agaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GBP3 Gene

Variant ID Type Subtype PubMed ID
dgv361n54 CNV gain 21841781
dgv362n54 CNV loss 21841781
dgv363n54 CNV loss 21841781
dgv55n67 CNV loss 20364138
dgv62e212 CNV loss 25503493
esv22437 CNV gain 19812545
esv2667765 CNV deletion 23128226
esv2714551 CNV deletion 23290073
esv2758948 CNV gain 17122850
esv3565560 CNV deletion 23714750
esv3586751 CNV loss 21293372
nsv10361 CNV gain 18304495
nsv1071104 CNV deletion 25765185
nsv546785 CNV loss 21841781
nsv546786 CNV loss 21841781
nsv546793 CNV loss 21841781
nsv546794 CNV loss 21841781
nsv819062 CNV gain 19587683
nsv820541 CNV deletion 20802225
nsv946055 CNV duplication 23825009

Variation tolerance for GBP3 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.77; 99.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP3 Gene

Disorders for GBP3 Gene

Relevant External Links for GBP3

Human Genome Epidemiology (HuGE) Navigator
GBP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GBP3

No disorders were found for GBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP3 Gene

Publications for GBP3 Gene

  1. A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication. (PMID: 22106366) Nordmann A. … Ludwig S. (FASEB J. 2012) 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1. (PMID: 7518790) Strehlow I. … Decker T. (Gene 1994) 2 3 64
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64

Products for GBP3 Gene

Sources for GBP3 Gene

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