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Aliases for GBP2 Gene

Aliases for GBP2 Gene

  • Guanylate Binding Protein 2 2 3
  • Guanylate Binding Protein 2, Interferon-Inducible 2 5
  • Interferon-Induced Guanylate-Binding Protein 2 4
  • Guanine Nucleotide-Binding Protein 2 4
  • GTP-Binding Protein 2 4
  • EC 3.6.5.- 4
  • HuGBP-2 4
  • GBP-2 4

External Ids for GBP2 Gene

Previous GeneCards Identifiers for GBP2 Gene

  • GC01M090050
  • GC01M088741
  • GC01M088908
  • GC01M089038
  • GC01M089283
  • GC01M089344
  • GC01M089345
  • GC01M089571
  • GC01M087690

Summaries for GBP2 Gene

Entrez Gene Summary for GBP2 Gene

  • This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

GeneCards Summary for GBP2 Gene

GBP2 (Guanylate Binding Protein 2) is a Protein Coding gene. Among its related pathways are Immune System and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7.

UniProtKB/Swiss-Prot for GBP2 Gene

  • Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).

Gene Wiki entry for GBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP2 Gene

Genomics for GBP2 Gene

Regulatory Elements for GBP2 Gene

Enhancers for GBP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GBP2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GBP2 gene promoter:

Genomic Location for GBP2 Gene

Chromosome:
1
Start:
89,106,132 bp from pter
End:
89,150,456 bp from pter
Size:
44,325 bases
Orientation:
Minus strand

Genomic View for GBP2 Gene

Genes around GBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP2 Gene

Proteins for GBP2 Gene

  • Protein details for GBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32456-GBP2_HUMAN
    Recommended name:
    Guanylate-binding protein 2
    Protein Accession:
    P32456
    Secondary Accessions:
    • Q6GPH0
    • Q6IAU2
    • Q86TB0

    Protein attributes for GBP2 Gene

    Size:
    591 amino acids
    Molecular mass:
    67209 Da
    Quaternary structure:
    • Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.

neXtProt entry for GBP2 Gene

Proteomics data for GBP2 Gene at MOPED

Post-translational modifications for GBP2 Gene

  • Isoprenylation is required for proper subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP2 Gene

Domains & Families for GBP2 Gene

Protein Domains for GBP2 Gene

Suggested Antigen Peptide Sequences for GBP2 Gene

Graphical View of Domain Structure for InterPro Entry

P32456

UniProtKB/Swiss-Prot:

GBP2_HUMAN :
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP2: view

No data available for Gene Families for GBP2 Gene

Function for GBP2 Gene

Molecular function for GBP2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=313 uM for GTP {ECO:0000269 PubMed:8706832};
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma during macrophage activation, and by TNF and IL1B.

Enzyme Numbers (IUBMB) for GBP2 Gene

genes like me logo Genes that share phenotypes with GBP2: view

Animal Models for GBP2 Gene

MGI Knock Outs for GBP2:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GBP2 Gene

Localization for GBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane; Lipid-anchor. Note=GBP2-GBP5 dimers localize to the Golgi apparatus. {ECO:0000269 PubMed:21151871}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GBP2 Gene COMPARTMENTS Subcellular localization image for GBP2 gene
Compartment Confidence
cytosol 5
golgi apparatus 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with GBP2: view

Pathways & Interactions for GBP2 Gene

genes like me logo Genes that share pathways with GBP2: view

Gene Ontology (GO) - Biological Process for GBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 1715024
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with GBP2: view

No data available for SIGNOR curated interactions for GBP2 Gene

Drugs & Compounds for GBP2 Gene

(1) Drugs for GBP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GBP2: view

Transcripts for GBP2 Gene

mRNA/cDNA for GBP2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GBP2 Gene

Guanylate binding protein 2, interferon-inducible:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GBP2 Gene

No ASD Table

Relevant External Links for GBP2 Gene

GeneLoc Exon Structure for
GBP2
ECgene alternative splicing isoforms for
GBP2

Expression for GBP2 Gene

mRNA expression in normal human tissues for GBP2 Gene

mRNA differential expression in normal tissues according to GTEx for GBP2 Gene

This gene is overexpressed in Whole Blood (x9.1).

Protein differential expression in normal tissues from HIPED for GBP2 Gene

This gene is overexpressed in Spleen (19.0), Lymph node (7.0), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GBP2 Gene



SOURCE GeneReport for Unigene cluster for GBP2 Gene Hs.386567

genes like me logo Genes that share expression patterns with GBP2: view

Protein tissue co-expression partners for GBP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GBP2 Gene

Orthologs for GBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GBP2 35
  • 84.82 (n)
  • 78.69 (a)
-- 36
  • 72 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gbp2 35
  • 77.31 (n)
  • 71.48 (a)
Gbp2 16
Gbp2 36
  • 71 (a)
OneToMany
Gbp2b 36
  • 71 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GBP2 35
  • 99.49 (n)
  • 100 (a)
GBP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gbp2 35
  • 77.87 (n)
  • 71.55 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GBP 35
  • 54.33 (n)
  • 44.92 (a)
-- 36
  • 51 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398692 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-209n20.1 36
  • 42 (a)
ManyToMany
Species with no ortholog for GBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP2 Gene

ENSEMBL:
Gene Tree for GBP2 (if available)
TreeFam:
Gene Tree for GBP2 (if available)

Paralogs for GBP2 Gene

Paralogs for GBP2 Gene

(7) SIMAP similar genes for GBP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GBP2: view

Variants for GBP2 Gene

Sequence variations from dbSNP and Humsavar for GBP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2230336 - 89,117,019(-) CTCTT(A/C/T)CAGGT reference, missense
rs1803632 - 89,117,007(-) GCATT(C/G)CAGTC reference, missense
rs2230338 - 89,114,258(-) CCATC(A/G)GCAGT reference, missense
rs997160 -- 89,107,104(-) AATAA(C/G)AATCT utr-variant-3-prime
rs1056550 -- 89,107,579(-) TTTGG(A/G)TGGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GBP2 Gene

Variant ID Type Subtype PubMed ID
nsv462494 CNV Loss 19166990
nsv871277 CNV Loss 21882294

Variation tolerance for GBP2 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GBP2 Gene

Disorders for GBP2 Gene

Relevant External Links for GBP2

Genetic Association Database (GAD)
GBP2
Human Genome Epidemiology (HuGE) Navigator
GBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GBP2

No disorders were found for GBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP2 Gene

Publications for GBP2 Gene

  1. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. (PMID: 1715024) Cheng Y.-S.E. … Staeheli P. (Mol. Cell. Biol. 1991) 2 3 4 67
  2. Guanylate-binding protein 2 mRNA in peripheral blood leukocytes of liver transplant recipients as a marker for acute cellular rejection. (PMID: 19912588) Kobayashi S. … Mori M. (Transpl. Int. 2010) 3 23
  3. Interferon-inducible guanylate binding protein (GBP)-2: a novel p53-regulated tumor marker in esophageal squamous cell carcinomas. (PMID: 19003964) GuimarALes D.P. … Hainaut P. (Int. J. Cancer 2009) 3 23
  4. Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response. (PMID: 23001506) Godoy P. … Hengstler J.G. (Breast Cancer 2014) 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for GBP2 Gene

Sources for GBP2 Gene

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