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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GBP1 Gene

protein-coding   GIFtS: 63
GCID: GC01M089517

Guanylate Binding Protein 1, Interferon-Inducible

(Previous names: guanylate binding protein 1, interferon-inducible, 67kDa)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanylate Binding Protein 1, Interferon-Inducible1 2     GTP-Binding Protein 12 3
Guanylate Binding Protein 1, Interferon-Inducible, 67kDa1 2     huGBP-12
Guanine Nucleotide-Binding Protein 12 3     Interferon-Induced Guanylate-Binding Protein 12
GBP-12 3     HuGBP-13

External Ids:    HGNC: 41821   Entrez Gene: 26332   Ensembl: ENSG000001172287   OMIM: 6004115   UniProtKB: P324553   

Export aliases for GBP1 gene to outside databases

Previous GC identifers: GC01M089994 GC01M088687 GC01M088854 GC01M088985 GC01M088986 GC01M089230 GC01M089290 GC01M087635


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GBP1 Gene:
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by
their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the
GTP-binding proteins by the presence of 2 binding motifs rather than 3. (provided by RefSeq, Jul 2008)

GeneCards Summary for GBP1 Gene: 
GBP1 (guanylate binding protein 1, interferon-inducible) is a protein-coding gene. Diseases associated with GBP1 include pseudopseudohypoparathyroidism, and aneurysmal bone cysts, and among its related super-pathways are Interferon Signaling and Adaptive Immune System. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP6.

UniProtKB/Swiss-Prot: GBP1_HUMAN, P32455
Function: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against
influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing
broad host protection against different pathogen classes

Gene Wiki entry for GBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GBP1 gene promoter:
         CREB   POU2F1   AML1a   POU2F1a   deltaCREB   IRF-1   LCR-F1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.2   Ensembl cytogenetic band:  1p22.2   HGNC cytogenetic band: 1p22.2

GBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GBP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M089517:  view genomic region     (about GC identifiers)

Start:
89,517,987 bp from pter      End:
89,531,043 bp from pter
Size:
13,057 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBP1_HUMAN, P32455 (See protein sequence)
Recommended Name: Interferon-induced guanylate-binding protein 1 precursor  
Size: 592 amino acids; 67931 Da
Subunit: Homodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP.
Can also heterodimerize with other members of the family
Subcellular location: Cytoplasm. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Secreted. Note=Secreted
from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma
induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced
factor
6 PDB 3D structures from and Proteopedia for GBP1:
1DG3 (3D)        1F5N (3D)        2B8W (3D)        2B92 (3D)        2BC9 (3D)        2D4H (3D)    
Secondary accessions: D3DT26 Q5T8M1

Explore the universe of human proteins at neXtProt for GBP1: NX_P32455

Explore proteomics data for GBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32455

  • GBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GBP1 Protein Expression
    REFSEQ proteins: NP_002044.2  
    ENSEMBL proteins: 
     ENSP00000359504  
    Reactome Protein details: P32455
    Human Recombinant Protein Products for GBP1: 
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    Sino Biological Recombinant Protein for GBP1
    Sino Biological Cell Lysate for GBP1 
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    Cloud-Clone Corp. Proteins for GBP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005576extracellular region IEA--
    GO:0005829cytosol TAS--

    GBP1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for GBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015894 Guanylate-bd_N
     IPR027417 P-loop_NTPase
     IPR003191 Guanylate-bd_C

    Graphical View of Domain Structure for InterPro Entry P32455

    ProtoNet protein and cluster: P32455

    1 Blocks protein domain: IPB003191 Guanylate-binding protein

    UniProtKB/Swiss-Prot: GBP1_HUMAN, P32455
    Similarity: Belongs to the GBP family


    GBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBP1_HUMAN, P32455
    Function: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against
    influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing
    broad host protection against different pathogen classes
    Induction: By IFNG/IFN-gamma during macrophage activation, and by TNF-alpha and IL-1beta

         Genatlas biochemistry entry for GBP1:
    guanylate binding protein 1,67kDa,interferon inducibleGTPase converting GTP to GMP,mediating an antiviral effect
    against stomatites virus and encephalomyocarditis virus

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
    GO:0042802identical protein binding IPI--
         
    GBP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for GBP1:
     Decreased DCP1a protein expres  Decreased Wnt reporter activit  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gbp2):
     immune system  mortality/aging 

    GBP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GBP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GBP1 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GBP1:
    hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidGBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    2Immune System
    Immune System0.56
    3Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GBP1
        Type II interferon signaling (IFNG)


    4        Reactome Pathways for GBP1
        Interferon gamma signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System



    GBP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for GBP1 (P324552, 3 ENSP000003595044) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GBP1P324552MINT-8375120 MINT-8375135 MINT-8375104
    FNTAP493543, ENSP000003034234I2D: score=2 STRING: ENSP00000303423
    FNTBP493563, ENSP000002461664I2D: score=2 STRING: ENSP00000246166
    B2MENSP000003408584STRING: ENSP00000340858
    CD44ENSP000002783854STRING: ENSP00000278385
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0051607defense response to virus IEA--
    GO:0060333interferon-gamma-mediated signaling pathway TAS--

    GBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GBP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GBP1

    1 HMDB Compound for GBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    4 Novoseek inferred chemical compound relationships for GBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 82 34 19150356 (3), 11397834 (2), 16005050 (2), 18697840 (2) (see all 16)
    gdp 63 2 19150356 (1)
    gtp 59 9 16873363 (2), 10970849 (2), 10493878 (1), 15504415 (1) (see all 5)
    guanine 27.5 1 15024646 (1)

    Search CenterWatch for drugs/clinical trials and news about GBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GBP1 gene: 
    NM_002053.2  

    Unigene Cluster for GBP1:

    Guanylate binding protein 1, interferon-inducible
    Hs.62661  [show with all ESTs]
    Unigene Representative Sequence: AB208912
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370473(uc001dmx.2) ENST00000484970 ENST00000479889 ENST00000468959
    ENST00000495131 ENST00000459831 ENST00000493139 ENST00000469194
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GBP1:
    hsa-miR-532-5p
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: GBP1 (NM_002053)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GBP1
    Sirion Biotech Customized lentivirus for stable overexpression of GBP1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GBP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GBP1

    Additional mRNA sequence: 

    AB208912.1 AK291783.1 AK298032.1 AK303893.1 AY920436.1 BC002666.2 BT006847.1 M55542.1 

    17 DOTS entries:

    DT.95149703  DT.102821184  DT.417584  DT.65288476  DT.95313748  DT.70105328  DT.95313794  DT.91774442 
    DT.121364006  DT.95313795  DT.100814944  DT.121364031  DT.121364044  DT.121364154  DT.91650955  DT.91774439 
    DT.91774443 

    24/218 AceView cDNA sequences (see all 218):

    CD366684 BE219773 AU076806 AI700268 AV656523 CB529723 CB164272 BP362266 
    BP365927 BF446717 BX282337 CA395856 BP337045 BX505942 BQ711324 CR591787 
    CD742546 AA372968 CD366936 BC002666 AA296485 BX490249 BF058809 AI457510 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GBP1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                    -           -                                                                           
    SP2:                                                                                -                           
    SP3:                    -                                                                                       
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for GBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GBP1 expression in normal human tissues (normalized intensities)      GBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGGAGTA
    GBP1 Expression
    About this image


    GBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus

    See GBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GBP1

    SOURCE GeneReport for Unigene cluster: Hs.62661
        SABiosciences Expression via Pathway-Focused PCR Arrays including GBP1: 
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GBP1 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gbp25 guanylate binding protein 2   --   3 (66.69 cM) 142620602 
    chicken
    (Gallus gallus)
    Aves GBP71 guanylate binding protein 7 57.67(n)
    46.76(a)
      429696  XM_427251.3  XP_427251.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    52(a)
    51(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL344582.1(21-10339)
    GL344491.1(18591-42206)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.100682 Transcribed sequence with weak similarity to protein more 76.28(n)    142009081 
    zebrafish
    (Danio rerio)
    Actinopterygii gbp21 guanylate binding protein 2 56.3(n)
    48.03(a)
      570622  XM_694125.3  XP_699217.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G460701 Guanylate-binding protein 42.27(n)
    29.93(a)
      834648  NM_123975.3  NP_199419.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g03070001 hypothetical protein 41.93(n)
    29.38(a)
      4329117  NM_001053176.1  NP_001046641.1 


    ENSEMBL Gene Tree for GBP1 (if available)
    TreeFam Gene Tree for GBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GBP1 gene
    GBP62  GBP52  GBP32  GBP42  GBP22  GBP72  
    7 SIMAP similar genes for GBP1 using alignment to 1 protein entry:     GBP1_HUMAN:
    GBP3    GBP2    FLJ00401    GBP5    GBP4    GBP7
    GBP6

    GBP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GBP1
    PGOHUM00000244789


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/483 SNPs in GBP1 are shown (see all 483)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs720542201,2
    C--87637693(+) AACAG-/AAAAAC
            
    AGAAA
    1 -- int10--------
    rs1433702711,2
    --89517513(+) AAAGCA/GATTAG 1 -- ds50010--------
    rs1471420351,2
    C--89517537(+) ATTAAC/TGTGGA 1 -- ds50010--------
    rs1841102641,2
    --89517644(+) ATATGA/TTTTTT 1 -- ds50010--------
    rs1872831811,2
    --89517666(+) TAACAA/CAATGC 1 -- ds50010--------
    rs75159731,2
    C,F,A--89517727(+) TATGGC/TTTATG 1 -- ds50018Minor allele frequency- T:0.25NA CSA WA EA 368
    rs101587721,2
    C,H--89517728(+) atggcT/Gtatgg 1 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs1443261511,2
    --89517777(+) ATAGCC/GACACC 1 -- ds50010--------
    rs66758661,2
    C,F,A,H--89517810(+) GGCTGC/TGTTTG 1 -- ds500121Minor allele frequency- T:0.29NS EA NA WA CSA 2211
    rs794395921,2
    F--89517824(+) TACATG/ACAGAG 1 -- ds50011Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for GBP1 (89517987 - 89531043 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33356CNV Loss17666407
    dgv68e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600411    OMIM disorders: --

    20/23 diseases for GBP1 (see all 23):    About MalaCards
    pseudopseudohypoparathyroidism    aneurysmal bone cysts    chronic active epstein-barr virus infection    bacterial meningitis
    pseudohypoparathyroidism    meningitis    stomatitis    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    kaposi's sarcoma    oral cancer    multiple sclerosis
    endotheliitis    glioblastoma    hepatitis b    influenza
    sarcoma    squamous cell carcinoma    hepatitis    thyroiditis


    GBP1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for GBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kaposi sarcoma 30.2 1 11598000 (1)
    necrosis 3.61 3 14741045 (2), 18260761 (1)
    inflammation 0.997 2 18697200 (1), 19079332 (1)
    tumors 0.501 5 16028104 (2), 17202376 (1), 18260761 (1)

    Genetic Association Database (GAD): GBP1
    Human Genome Epidemiology (HuGE) Navigator: GBP1 (2 documents)

    Export disorders for GBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GBP1 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with GBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1. (PubMed id 7518790)1, 3, 9 Strehlow I....Decker T. (1994)
    2. Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis. (PubMed id 16936281)1, 2, 9 Naschberger E....Sturzl M. (2006)
    3. Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor. (PubMed id 15937107)1, 2, 9 Modiano N....Cresswell P. (2005)
    4. Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. (PubMed id 8830800)1, 2, 9 Nantais D.E.... Buss J.E. (1996)
    5. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. (PubMed id 10676968)1, 2, 9 Prakash B.... Herrmann C. (2000)
    6. Intracellular trafficking of guanylate-binding protei ns is regulated by heterodimerization in a hierarchical manner. (PubMed id 21151871)1, 2 Britzen-Laurent N....StA1rzl M. (2010)
    7. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (2009)
    8. How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. (PubMed id 16511497)1, 2 Ghosh A....Herrmann C. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. (PubMed id 1715024)1, 2 Cheng Y.-S.E.... Staeheli P. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2633 HGNC: 4182 AceView: GBP1 Ensembl:ENSG00000117228 euGenes: HUgn2633
    ECgene: GBP1 H-InvDB: GBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GBP1 gene:
    Search GeneIP for patents involving GBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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