Aliases for GBP1 Gene
External Ids for GBP1 Gene
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
GeneCards Summary for GBP1 Gene
GBP1 (Guanylate Binding Protein 1, Interferon-Inducible) is a Protein Coding gene. Diseases associated with GBP1 include pseudopseudohypoparathyroidism and aneurysmal bone cysts. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include identical protein binding and GTPase activity. An important paralog of this gene is GBP7.
UniProtKB/Swiss-Prot for GBP1 Gene
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.