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Aliases for GBP1 Gene

Aliases for GBP1 Gene

  • Guanylate Binding Protein 1 2 3
  • Guanylate Binding Protein 1, Interferon-Inducible 2 3 5
  • Guanylate Binding Protein 1, Interferon-Inducible, 67kDa 2 3
  • Interferon-Induced Guanylate-Binding Protein 1 3 4
  • Guanine Nucleotide-Binding Protein 1 3 4
  • GTP-Binding Protein 1 3 4
  • HuGBP-1 3 4
  • GBP-1 3 4
  • EC 3.6.5.- 4

External Ids for GBP1 Gene

Previous GeneCards Identifiers for GBP1 Gene

  • GC01M089994
  • GC01M088687
  • GC01M088854
  • GC01M088985
  • GC01M088986
  • GC01M089230
  • GC01M089290
  • GC01M089517
  • GC01M087635

Summaries for GBP1 Gene

Entrez Gene Summary for GBP1 Gene

  • Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for GBP1 Gene

GBP1 (Guanylate Binding Protein 1) is a Protein Coding gene. Diseases associated with GBP1 include chronic active epstein-barr virus infection and aneurysmal bone cysts. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include identical protein binding and enzyme binding. An important paralog of this gene is GBP7.

UniProtKB/Swiss-Prot for GBP1 Gene

  • Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.

Gene Wiki entry for GBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP1 Gene

Genomics for GBP1 Gene

Regulatory Elements for GBP1 Gene

Promoters for GBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GBP1 Gene

Chromosome:
1
Start:
89,052,304 bp from pter
End:
89,065,360 bp from pter
Size:
13,057 bases
Orientation:
Minus strand

Genomic View for GBP1 Gene

Genes around GBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP1 Gene

Proteins for GBP1 Gene

  • Protein details for GBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32455-GBP1_HUMAN
    Recommended name:
    Guanylate-binding protein 1
    Protein Accession:
    P32455
    Secondary Accessions:
    • D3DT26
    • Q5T8M1

    Protein attributes for GBP1 Gene

    Size:
    592 amino acids
    Molecular mass:
    67931 Da
    Quaternary structure:
    • Homodimer; homodimerization occurs upon GTP-binding and is required for the second hydrolysis step from GDP to GMP. Heterodimer with other family members, including GBP2, GBP3, GBP4 and GBP5. Dimerization regulates subcellular location to membranous structures.

    Three dimensional structures from OCA and Proteopedia for GBP1 Gene

neXtProt entry for GBP1 Gene

Proteomics data for GBP1 Gene at MOPED

Post-translational modifications for GBP1 Gene

  • Isoprenylation is required for proper subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GBP1 Gene

Domains & Families for GBP1 Gene

Protein Domains for GBP1 Gene

Suggested Antigen Peptide Sequences for GBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32455

UniProtKB/Swiss-Prot:

GBP1_HUMAN :
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP1: view

No data available for Gene Families for GBP1 Gene

Function for GBP1 Gene

Molecular function for GBP1 Gene

GENATLAS Biochemistry:
guanylate binding protein 1,67kDa,interferon inducibleGTPase converting GTP to GMP,mediating an antiviral effect against stomatites virus and encephalomyocarditis virus
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
UniProtKB/Swiss-Prot Induction:
By IFNG during macrophage activation, and by TNF and IL1B.

Enzyme Numbers (IUBMB) for GBP1 Gene

Gene Ontology (GO) - Molecular Function for GBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 24337748
GO:0030507 spectrin binding IPI 24337748
GO:0042802 identical protein binding IPI 22059445
GO:0051879 Hsp90 protein binding IPI 24337748
genes like me logo Genes that share ontologies with GBP1: view
genes like me logo Genes that share phenotypes with GBP1: view

Animal Model Products

miRNA for GBP1 Gene

miRTarBase miRNAs that target GBP1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP1 Gene

Localization for GBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP1 Gene

Cytoplasm. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cell membrane. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GBP1 Gene COMPARTMENTS Subcellular localization image for GBP1 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 4
plasma membrane 3
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for GBP1 Gene

Pathways & Interactions for GBP1 Gene

genes like me logo Genes that share pathways with GBP1: view

Pathways by source for GBP1 Gene

Gene Ontology (GO) - Biological Process for GBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050860 negative regulation of T cell receptor signaling pathway IMP 24337748
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
GO:0070373 negative regulation of ERK1 and ERK2 cascade IMP 24337748
GO:1900041 negative regulation of interleukin-2 secretion IMP 24337748
GO:1903076 regulation of protein localization to plasma membrane IGI 24337748
genes like me logo Genes that share ontologies with GBP1: view

No data available for SIGNOR curated interactions for GBP1 Gene

Drugs & Compounds for GBP1 Gene

(2) Drugs for GBP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for GBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GBP1: view

Transcripts for GBP1 Gene

Unigene Clusters for GBP1 Gene

Guanylate binding protein 1, interferon-inducible:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for GBP1 Gene

GeneLoc Exon Structure for
GBP1
ECgene alternative splicing isoforms for
GBP1

Expression for GBP1 Gene

mRNA expression in normal human tissues for GBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GBP1 Gene

This gene is overexpressed in Spleen (24.7) and Oral epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GBP1 Gene



SOURCE GeneReport for Unigene cluster for GBP1 Gene Hs.62661

genes like me logo Genes that share expression patterns with GBP1: view

Protein tissue co-expression partners for GBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GBP1 Gene

Orthologs for GBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC512486 35
  • 85.07 (n)
  • 82.79 (a)
-- 36
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia GBP1 35
  • 84.29 (n)
  • 80.51 (a)
-- 36
  • 80 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GBP1 35
  • 99.04 (n)
  • 98.82 (a)
GBP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gbp1 35
  • 78.73 (n)
  • 72.73 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GBP7 35
  • 59.46 (n)
  • 49.61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10068 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-209n20.1 35
  • 59.24 (n)
  • 54.89 (a)
si:ch211-209n20.1 36
  • 53 (a)
ManyToMany
Species with no ortholog for GBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP1 Gene

ENSEMBL:
Gene Tree for GBP1 (if available)
TreeFam:
Gene Tree for GBP1 (if available)

Paralogs for GBP1 Gene

Paralogs for GBP1 Gene

(7) SIMAP similar genes for GBP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GBP1 Gene

genes like me logo Genes that share paralogs with GBP1: view

Variants for GBP1 Gene

Sequence variations from dbSNP and Humsavar for GBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_014849 -
VAR_033950 -
VAR_033951 -
VAR_046550 -

Structural Variations from Database of Genomic Variants (DGV) for GBP1 Gene

Variant ID Type Subtype PubMed ID
dgv68e1 CNV Complex 17122850
esv33356 CNV Loss 17666407

Variation tolerance for GBP1 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GBP1 Gene

HapMap Linkage Disequilibrium report
GBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP1 Gene

Disorders for GBP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic active epstein-barr virus infection
  • caebv infection
aneurysmal bone cysts
  • bone cysts aneurysmal
ulceroglandular tularemia
- elite association - COSMIC cancer census association via MalaCards
Search GBP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GBP1

Genetic Association Database (GAD)
GBP1
Human Genome Epidemiology (HuGE) Navigator
GBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GBP1
genes like me logo Genes that share disorders with GBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GBP1 Gene

Publications for GBP1 Gene

  1. The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1. (PMID: 7518790) Strehlow I. … Decker T. (Gene 1994) 2 3 23 67
  2. Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine. (PMID: 20483731) Mirpuri J. … Louis N.A. (J. Immunol. 2010) 3 23
  3. Guanylate-binding protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-gamma and regulates barrier function through effects on apoptosis. (PMID: 19079332) Schnoor M. … Parkos C.A. (Mucosal Immunol 2009) 3 23
  4. Role of individual domains and identification of internal gap in human guanylate binding protein-1. (PMID: 19150356) Abdullah N. … Sau A.K. (J. Mol. Biol. 2009) 3 23
  5. An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass. (PMID: 19223260) Lei S.F. … Deng H.W. (Bone 2009) 3 23

Products for GBP1 Gene

Sources for GBP1 Gene

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