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Aliases for GBAS Gene

Aliases for GBAS Gene

  • Glioblastoma Amplified Sequence 2 3 5
  • NIPSNAP2 3 4
  • 4-Nitrophenylphosphatase Domain And Non-Neuronal SNAP25-Like 2 3
  • Glioblastoma-Amplified Sequence 4

External Ids for GBAS Gene

Previous GeneCards Identifiers for GBAS Gene

  • GC07P055496
  • GC07P055740
  • GC07P055774
  • GC07P055806
  • GC07P055999
  • GC07P055859
  • GC07P056020

Summaries for GBAS Gene

Entrez Gene Summary for GBAS Gene

  • This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. The encoded protein is localized to mitochondria and plays a role in oxidative phosphorylation. A pseudogene of this gene is located on the long arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for GBAS Gene

GBAS (Glioblastoma Amplified Sequence) is a Protein Coding gene. Diseases associated with GBAS include glioblastoma. An important paralog of this gene is NIPSNAP1.

Gene Wiki entry for GBAS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBAS Gene

Genomics for GBAS Gene

Regulatory Elements for GBAS Gene

Promoters for GBAS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GBAS on UCSC Golden Path with GeneCards custom track

Genomic Location for GBAS Gene

Chromosome:
7
Start:
55,951,793 bp from pter
End:
56,000,182 bp from pter
Size:
48,390 bases
Orientation:
Plus strand

Genomic View for GBAS Gene

Genes around GBAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBAS Gene

Proteins for GBAS Gene

  • Protein details for GBAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75323-NIPS2_HUMAN
    Recommended name:
    Protein NipSnap homolog 2
    Protein Accession:
    O75323
    Secondary Accessions:
    • C9IYJ3
    • O43801
    • Q53X96

    Protein attributes for GBAS Gene

    Size:
    286 amino acids
    Molecular mass:
    33743 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA04633.1; Type=Frameshift; Positions=8, 11, 17; Evidence={ECO:0000305};

    Alternative splice isoforms for GBAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GBAS Gene

Proteomics data for GBAS Gene at MOPED

Post-translational modifications for GBAS Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

Other Protein References for GBAS Gene

Antibody Products

No data available for DME Specific Peptides for GBAS Gene

Domains & Families for GBAS Gene

Protein Domains for GBAS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GBAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75323

UniProtKB/Swiss-Prot:

NIPS2_HUMAN :
  • Belongs to the NipSnap family.
Family:
  • Belongs to the NipSnap family.
genes like me logo Genes that share domains with GBAS: view

No data available for Gene Families for GBAS Gene

Function for GBAS Gene

Molecular function for GBAS Gene

GENATLAS Biochemistry:
glioblastoma amplified sequence,31.5kDa,coamplified with EGFR

Phenotypes for GBAS Gene

GenomeRNAi human phenotypes for GBAS:
genes like me logo Genes that share phenotypes with GBAS: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBAS Gene

Localization for GBAS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GBAS Gene COMPARTMENTS Subcellular localization image for GBAS gene
Compartment Confidence
mitochondrion 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for GBAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0016020 membrane TAS 9615231
genes like me logo Genes that share ontologies with GBAS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GBAS Gene

Pathways & Interactions for GBAS Gene

SuperPathways for GBAS Gene

No Data Available

Gene Ontology (GO) - Biological Process for GBAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000984 negative regulation of ATP citrate synthase activity IMP 20888800
genes like me logo Genes that share ontologies with GBAS: view

No data available for Pathways by source and SIGNOR curated interactions for GBAS Gene

Drugs & Compounds for GBAS Gene

No Compound Related Data Available

Transcripts for GBAS Gene

Unigene Clusters for GBAS Gene

Glioblastoma amplified sequence:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GBAS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - -
SP2:
SP3: - - - - - -
SP4: -
SP5: -
SP6: - - -

Relevant External Links for GBAS Gene

GeneLoc Exon Structure for
GBAS
ECgene alternative splicing isoforms for
GBAS

Expression for GBAS Gene

mRNA expression in normal human tissues for GBAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GBAS Gene

This gene is overexpressed in Muscle - Skeletal (x8.0) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for GBAS Gene

This gene is overexpressed in Heart (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GBAS Gene



SOURCE GeneReport for Unigene cluster for GBAS Gene Hs.591069

mRNA Expression by UniProt/SwissProt for GBAS Gene

O75323-NIPS2_HUMAN
Tissue specificity: Widely expressed. Most abundant in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with GBAS: view

Protein tissue co-expression partners for GBAS Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GBAS Gene

This gene was present in the common ancestor of animals.

Orthologs for GBAS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GBAS 35
  • 90.33 (n)
  • 92.31 (a)
GBAS 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GBAS 35
  • 91.84 (n)
  • 93.71 (a)
GBAS 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gbas 35
  • 85.88 (n)
  • 92.17 (a)
Gbas 16
Gbas 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GBAS 35
  • 99.3 (n)
  • 99.3 (a)
GBAS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gbas 35
  • 86.71 (n)
  • 93.24 (a)
oppossum
(Monodelphis domestica)
Mammalia GBAS 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GBAS 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves GBAS 35
  • 78.76 (n)
  • 85.21 (a)
GBAS 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gbas 35
  • 74.91 (n)
  • 84.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2666 35
zebrafish
(Danio rerio)
Actinopterygii gbas 35
  • 70.92 (n)
  • 77.3 (a)
gbas 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nipsnap 37
  • 45 (a)
Nipsnap 35
  • 52.42 (n)
  • 46.27 (a)
Nipsnap 36
  • 44 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003200 35
  • 53.46 (n)
  • 46.54 (a)
worm
(Caenorhabditis elegans)
Secernentea K02D10.1a 37
  • 38 (a)
K02D10.1b 37
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2429 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6771 36
  • 55 (a)
OneToMany
Species with no ortholog for GBAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GBAS Gene

ENSEMBL:
Gene Tree for GBAS (if available)
TreeFam:
Gene Tree for GBAS (if available)

Paralogs for GBAS Gene

Paralogs for GBAS Gene

(1) SIMAP similar genes for GBAS Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for GBAS Gene

genes like me logo Genes that share paralogs with GBAS: view

Variants for GBAS Gene

Sequence variations from dbSNP and Humsavar for GBAS Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs4689 -- 55,999,323(+) ACACT(G/T)AGCCA utr-variant-3-prime
rs1078650 -- 55,967,989(+) ttgct(A/G)tgttc intron-variant
rs1344176 -- 55,987,084(+) cttga(C/G)cctgg intron-variant
rs1059309 -- 55,994,142(+) GGGGT(G/T)GTCCC intron-variant
rs1059722 -- 55,991,118(+) TATGA(A/G)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GBAS Gene

Variant ID Type Subtype PubMed ID
esv28230 CNV Gain+Loss 19812545
esv2734447 CNV Deletion 23290073
dgv1201e199 CNV Deletion 23128226
nsv888064 CNV Gain 21882294
esv2734448 CNV Deletion 23290073
esv1007870 OTHER Inversion 20482838

Variation tolerance for GBAS Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GBAS Gene

HapMap Linkage Disequilibrium report
GBAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBAS Gene

Disorders for GBAS Gene

MalaCards: The human disease database

(1) MalaCards diseases for GBAS Gene - From: GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards
Search GBAS in MalaCards View complete list of genes associated with diseases

Relevant External Links for GBAS

Genetic Association Database (GAD)
GBAS
Human Genome Epidemiology (HuGE) Navigator
GBAS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GBAS
genes like me logo Genes that share disorders with GBAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GBAS Gene

Publications for GBAS Gene

  1. GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR. (PMID: 9615231) Wang X.-Y. … James C.D. (Genomics 1998) 2 3 4 23 67
  2. Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family. (PMID: 9661659) Seroussi E. … Dumanski J.P. (Gene 1998) 2 3 23
  3. Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association. (PMID: 20888800) Martherus R.S. … Ayoubi T.A. (Biochem. Biophys. Res. Commun. 2010) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for GBAS Gene

Sources for GBAS Gene

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