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Aliases for GATSL3 Gene

Aliases for GATSL3 Gene

  • GATS Protein Like 3 2 3 5
  • Cellular Arginine Sensor For MTORC1 Protein 1 3 4
  • CASTOR1 3 4
  • GATS Protein-Like 3 2
  • GATS-Like Protein 3 3

External Ids for GATSL3 Gene

Previous GeneCards Identifiers for GATSL3 Gene

  • GC22M029018
  • GC22M029019
  • GC22M030682
  • GC22M013642

Summaries for GATSL3 Gene

GeneCards Summary for GATSL3 Gene

GATSL3 (GATS Protein Like 3) is a Protein Coding gene. An important paralog of this gene is GATSL2.

UniProtKB/Swiss-Prot for GATSL3 Gene

  • Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with GATSL2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to GATSL3 allosterically disrupts the interaction of GATSL3-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATSL3 Gene

Genomics for GATSL3 Gene

Regulatory Elements for GATSL3 Gene

Enhancers for GATSL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F030300 1.3 FANTOM5 ENCODE 20.4 -21.4 -21359 20.9 HDGF PKNOX1 SIN3A YY1 GATA2 FOS ZNF263 YY2 JUNB REST RNF215 GATSL3 CCDC157 SEC14L3 SEC14L2 MTMR3 LIF TBC1D10A SF3A1 ENSG00000248751
GH22F030322 1.3 FANTOM5 ENCODE 20.2 -37.3 -37293 8.0 HDGF PKNOX1 WRNIP1 ARID4B SIN3A GLIS2 SP3 SP5 JUNB TSHZ1 RNF215 CCDC157 GATSL3 SEC14L3 TUG1 SF3A1 ENSG00000248751 SEC14L2 ENSG00000249590 MORC2
GH22F030390 1.2 Ensembl ENCODE 21.1 -101.8 -101817 1.4 ELF3 CBX3 ARID4B YBX1 RAD21 ZNF143 FOS MIXL1 THAP11 ZNF654 GATSL3 TBC1D10A ENSG00000248751 OSM CCDC157 SF3A1 SEC14L3 ENSG00000181123 LIF SEC14L2
GH22F030385 0.9 ENCODE 25.8 -97.4 -97370 2.1 HDGF INSM2 KLF17 ARID4B ZNF2 RAD21 GLIS2 ZNF143 FOS ZNF654 GATSL3 ENSG00000249590 TBC1D10A ENSG00000248751 OSM CCDC157 SF3A1 LIF ENSG00000181123 SEC14L3
GH22F030287 1 ENCODE 19.1 -0.5 -531 5.0 HDGF ATF1 WRNIP1 ARID4B SIN3A ZNF48 ZNF2 YY1 ZNF121 GLIS2 RNF215 GATSL3 CCDC157 DUSP18 ENSG00000248751
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GATSL3 on UCSC Golden Path with GeneCards custom track

Promoters for GATSL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000616849 327 1801 WRNIP1 ARID4B SIN3A NFXL1 RAD21 YY1 GLIS2 EGR1 KLF13 SMARCA5

Genomic Location for GATSL3 Gene

Chromosome:
22
Start:
30,285,117 bp from pter
End:
30,289,627 bp from pter
Size:
4,511 bases
Orientation:
Minus strand

Genomic View for GATSL3 Gene

Genes around GATSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATSL3 Gene

Proteins for GATSL3 Gene

  • Protein details for GATSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTX7-GATL3_HUMAN
    Recommended name:
    GATS-like protein 3
    Protein Accession:
    Q8WTX7
    Secondary Accessions:
    • O76052
    • Q96ND9
    • Q9UIE8

    Protein attributes for GATSL3 Gene

    Size:
    329 amino acids
    Molecular mass:
    36275 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with GATSL2 (PubMed:26972053, PubMed:27487210). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (PubMed:26972053, PubMed:27487210).
    SequenceCaution:
    • Sequence=AAC23432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC23433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB70963.1; Type=Erroneous termination; Positions=310; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=EAW59868.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GATSL3 Gene

neXtProt entry for GATSL3 Gene

Post-translational modifications for GATSL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GATSL3 Gene

No data available for DME Specific Peptides for GATSL3 Gene

Domains & Families for GATSL3 Gene

Protein Domains for GATSL3 Gene

Suggested Antigen Peptide Sequences for GATSL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WTX7

UniProtKB/Swiss-Prot:

GATL3_HUMAN :
  • Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
  • Belongs to the GATS family.
Domain:
  • Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
  • Contains 2 ACT domains.
Family:
  • Belongs to the GATS family.
genes like me logo Genes that share domains with GATSL3: view

No data available for Gene Families for GATSL3 Gene

Function for GATSL3 Gene

Molecular function for GATSL3 Gene

UniProtKB/Swiss-Prot Function:
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with GATSL2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to GATSL3 allosterically disrupts the interaction of GATSL3-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

Gene Ontology (GO) - Molecular Function for GATSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0034618 arginine binding IDA 26972053
GO:0042802 identical protein binding IDA,IPI 25416956
genes like me logo Genes that share ontologies with GATSL3: view

Phenotypes for GATSL3 Gene

MGI mutant phenotypes for GATSL3:
inferred from 1 alleles
GenomeRNAi human phenotypes for GATSL3:
genes like me logo Genes that share phenotypes with GATSL3: view

Animal Models for GATSL3 Gene

MGI Knock Outs for GATSL3:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GATSL3 Gene

Localization for GATSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATSL3 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GATSL3 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for GATSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 26972053
GO:0061700 colocalizes_with GATOR2 complex IDA 26972053
genes like me logo Genes that share ontologies with GATSL3: view

Pathways & Interactions for GATSL3 Gene

SuperPathways for GATSL3 Gene

No Data Available

Interacting Proteins for GATSL3 Gene

Gene Ontology (GO) - Biological Process for GATSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903577 cellular response to L-arginine IMP 26972053
GO:1904262 negative regulation of TORC1 signaling IMP 26972053
genes like me logo Genes that share ontologies with GATSL3: view

No data available for Pathways by source and SIGNOR curated interactions for GATSL3 Gene

Transcripts for GATSL3 Gene

mRNA/cDNA for GATSL3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GATSL3 Gene

GATS protein-like 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATSL3 Gene

No ASD Table

Relevant External Links for GATSL3 Gene

GeneLoc Exon Structure for
GATSL3
ECgene alternative splicing isoforms for
GATSL3

Expression for GATSL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GATSL3 Gene

mRNA differential expression in normal tissues according to GTEx for GATSL3 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for GATSL3 Gene

This gene is overexpressed in Retina (20.9), Testis (13.3), Esophagus (7.4), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GATSL3 Gene



NURSA nuclear receptor signaling pathways regulating expression of GATSL3 Gene:

GATSL3

SOURCE GeneReport for Unigene cluster for GATSL3 Gene:

Hs.444950

mRNA Expression by UniProt/SwissProt for GATSL3 Gene:

Q8WTX7-GATL3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with GATSL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for GATSL3 Gene

Orthologs for GATSL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GATSL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GATSL3 34
  • 99.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GATSL3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GATSL3 34 35
  • 91.49 (n)
dog
(Canis familiaris)
Mammalia GATSL3 34 35
  • 90.27 (n)
mouse
(Mus musculus)
Mammalia Gatsl3 34 16 35
  • 86.48 (n)
rat
(Rattus norvegicus)
Mammalia Gatsl3 34
  • 86.18 (n)
oppossum
(Monodelphis domestica)
Mammalia GATSL3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GATSL3 34 35
  • 77.47 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gatsl3 34
  • 67.59 (n)
zebrafish
(Danio rerio)
Actinopterygii gatsl3 34
  • 66.97 (n)
Species where no ortholog for GATSL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GATSL3 Gene

ENSEMBL:
Gene Tree for GATSL3 (if available)
TreeFam:
Gene Tree for GATSL3 (if available)

Paralogs for GATSL3 Gene

Paralogs for GATSL3 Gene

(4) SIMAP similar genes for GATSL3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GATSL3: view

Variants for GATSL3 Gene

Sequence variations from dbSNP and Humsavar for GATSL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1043099 -- 30,285,268(-) GCCCC(C/G)CTGAC utr-variant-3-prime
rs114641895 -- 30,290,152(+) CTTCC(C/T)CGCTT upstream-variant-2KB
rs115548734 -- 30,285,830(+) TGCTC(A/C)CCAGG splice-donor-variant
rs116527400 -- 30,287,116(+) GAGGA(A/G)GCCCT intron-variant
rs117489753 -- 30,291,048(+) CAGCT(A/G)TACCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GATSL3 Gene

Variant ID Type Subtype PubMed ID
nsv834174 CNV gain+loss 17160897
nsv829171 CNV loss 20364138
nsv588885 CNV loss 21841781
nsv522605 CNV loss 19592680
nsv1110864 OTHER inversion 24896259
nsv1062388 CNV gain 25217958
esv2676362 CNV deletion 23128226

Variation tolerance for GATSL3 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GATSL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GATSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATSL3 Gene

Disorders for GATSL3 Gene

Relevant External Links for GATSL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GATSL3

No disorders were found for GATSL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATSL3 Gene

Publications for GATSL3 Gene

  1. The CASTOR proteins are arginine sensors for the mTORC1 pathway. (PMID: 26972053) Chantranupong L. … Sabatini D.M. (Cell 2016) 3 4 64
  2. Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. (PMID: 27487210) Saxton R.A. … Sabatini D.M. (Nature 2016) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GATSL3 Gene

Sources for GATSL3 Gene

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