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Aliases for GATSL3 Gene

Aliases for GATSL3 Gene

  • GATS Protein-Like 3 2 3

External Ids for GATSL3 Gene

Previous GeneCards Identifiers for GATSL3 Gene

  • GC22M029018
  • GC22M029019
  • GC22M030682
  • GC22M013642

Summaries for GATSL3 Gene

GeneCards Summary for GATSL3 Gene

GATSL3 (GATS Protein-Like 3) is a Protein Coding gene. An important paralog of this gene is GATS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATSL3 Gene

Genomics for GATSL3 Gene

Regulatory Elements for GATSL3 Gene

Genomic Location for GATSL3 Gene

Chromosome:
22
Start:
30,285,117 bp from pter
End:
30,289,627 bp from pter
Size:
4,511 bases
Orientation:
Minus strand

Genomic View for GATSL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GATSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATSL3 Gene

Proteins for GATSL3 Gene

  • Protein details for GATSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTX7-GATL3_HUMAN
    Recommended name:
    GATS-like protein 3
    Protein Accession:
    Q8WTX7
    Secondary Accessions:
    • O76052
    • Q96ND9
    • Q9UIE8

    Protein attributes for GATSL3 Gene

    Size:
    329 amino acids
    Molecular mass:
    36275 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC23432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC23433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB70963.1; Type=Erroneous termination; Positions=310; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=EAW59868.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GATSL3 Gene

Proteomics data for GATSL3 Gene at MOPED

Post-translational modifications for GATSL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GATSL3 Gene

No data available for DME Specific Peptides for GATSL3 Gene

Domains & Families for GATSL3 Gene

Protein Domains for GATSL3 Gene

Suggested Antigen Peptide Sequences for GATSL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WTX7

UniProtKB/Swiss-Prot:

GATL3_HUMAN :
  • Belongs to the GATS family.
Family:
  • Belongs to the GATS family.
genes like me logo Genes that share domains with GATSL3: view

No data available for Gene Families for GATSL3 Gene

Function for GATSL3 Gene

Gene Ontology (GO) - Molecular Function for GATSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GATSL3: view

Phenotypes for GATSL3 Gene

GenomeRNAi human phenotypes for GATSL3:
genes like me logo Genes that share phenotypes with GATSL3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GATSL3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GATSL3 Gene

Localization for GATSL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GATSL3 Gene COMPARTMENTS Subcellular localization image for GATSL3 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GATSL3 Gene

Pathways & Interactions for GATSL3 Gene

SuperPathways for GATSL3 Gene

No Data Available

Interacting Proteins for GATSL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000384183%0d%0a9606.ENSP00000263849%0d%0a
Selected Interacting proteins: Q8WTX7-GATL3_HUMAN ENSP00000384183 for GATSL3 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for GATSL3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GATSL3 Gene

Drugs & Compounds for GATSL3 Gene

No Compound Related Data Available

Transcripts for GATSL3 Gene

mRNA/cDNA for GATSL3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GATSL3 Gene

GATS protein-like 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GATSL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATSL3 Gene

No ASD Table

Relevant External Links for GATSL3 Gene

GeneLoc Exon Structure for
GATSL3
ECgene alternative splicing isoforms for
GATSL3

Expression for GATSL3 Gene

mRNA expression in normal human tissues for GATSL3 Gene

mRNA differential expression in normal tissues according to GTEx for GATSL3 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for GATSL3 Gene

This gene is overexpressed in Retina (20.9), Testis (13.3), Esophagus (7.4), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GATSL3 Gene



SOURCE GeneReport for Unigene cluster for GATSL3 Gene Hs.444950

genes like me logo Genes that share expression patterns with GATSL3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GATSL3 Gene

Orthologs for GATSL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GATSL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GATSL3 35
  • 91.49 (n)
  • 95.74 (a)
GATSL3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GATSL3 35
  • 90.27 (n)
  • 95.44 (a)
GATSL3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gatsl3 35
  • 86.48 (n)
  • 92.38 (a)
Gatsl3 16
Gatsl3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GATSL3 35
  • 99.7 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Gatsl3 35
  • 86.18 (n)
  • 92.68 (a)
oppossum
(Monodelphis domestica)
Mammalia GATSL3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GATSL3 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves GATSL3 35
  • 77.47 (n)
  • 79.69 (a)
GATSL3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gatsl3 35
  • 67.59 (n)
  • 70.99 (a)
zebrafish
(Danio rerio)
Actinopterygii gatsl3 35
  • 66.97 (n)
  • 68.6 (a)
Species with no ortholog for GATSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GATSL3 Gene

ENSEMBL:
Gene Tree for GATSL3 (if available)
TreeFam:
Gene Tree for GATSL3 (if available)

Paralogs for GATSL3 Gene

Paralogs for GATSL3 Gene

(4) SIMAP similar genes for GATSL3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GATSL3: view

Variants for GATSL3 Gene

Sequence variations from dbSNP and Humsavar for GATSL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1043099 -- 30,285,268(-) GCCCC(A/C/G)CTGAC utr-variant-3-prime
rs1860216 -- 30,289,506(+) GGCTC(A/C/G)CGCGG utr-variant-5-prime
rs1860217 -- 30,289,571(+) GTGGT(C/G)CCCGA utr-variant-5-prime
rs2240421 -- 30,287,455(+) GGGCG(A/C)TCTTG missense, reference
rs4823085 -- 30,290,237(+) GCTCC(C/T)CACCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GATSL3 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
dgv4954n71 CNV Loss 21882294
nsv914970 CNV Loss 21882294
nsv834174 CNV Gain+Loss 17160897
dgv4955n71 CNV Loss 21882294
esv2676362 CNV Deletion 23128226
nsv522605 CNV Loss 19592680

Variation tolerance for GATSL3 Gene

Residual Variation Intolerance Score: 48.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GATSL3 Gene

HapMap Linkage Disequilibrium report
GATSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATSL3 Gene

Disorders for GATSL3 Gene

Relevant External Links for GATSL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GATSL3
genes like me logo Genes that share disorders with GATSL3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATSL3 Gene

Publications for GATSL3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. (PMID: 24449572) Orozco G. … Eyre S. ( 2014) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  5. Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays. (PMID: 15998911) Kapranov P. … Gingeras T.R. (Genome Res. 2005) 67

Products for GATSL3 Gene

Sources for GATSL3 Gene

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