Aliases for GATSL3 Gene
External Ids for GATSL3 Gene
Previous GeneCards Identifiers for GATSL3 Gene
GeneCards Summary for GATSL3 Gene
GATSL3 (GATS Protein Like 3) is a Protein Coding gene. An important paralog of this gene is GATSL2.
UniProtKB/Swiss-Prot for GATSL3 Gene
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with GATSL2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to GATSL3 allosterically disrupts the interaction of GATSL3-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.