Aliases for GATSL2 Gene
External Ids for GATSL2 Gene
Previous HGNC Symbols for GATSL2 Gene
Previous GeneCards Identifiers for GATSL2 Gene
GeneCards Summary for GATSL2 Gene
GATSL2 (GATS Protein Like 2) is a Protein Coding gene. An important paralog of this gene is GATSL3.
UniProtKB/Swiss-Prot for GATSL2 Gene
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with GATSL3, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to GATSL3 disrupts the interaction of GATSL2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.