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Aliases for GATSL2 Gene

Aliases for GATSL2 Gene

  • GATS Protein Like 2 2 3
  • Cellular Arginine Sensor For MTORC1 Protein 2 3 4
  • GATS Protein-Like 1 2 3
  • CASTOR2 3 4
  • GATSL1 3 4
  • GATS-Like Protein 1 3
  • GATS-Like Protein 2 3
  • GATS Protein-Like 2 5

External Ids for GATSL2 Gene

Previous HGNC Symbols for GATSL2 Gene

  • GATSL1

Previous GeneCards Identifiers for GATSL2 Gene

  • GC07M074647
  • GC07M074807

Summaries for GATSL2 Gene

GeneCards Summary for GATSL2 Gene

GATSL2 (GATS Protein Like 2) is a Protein Coding gene. An important paralog of this gene is GATSL3.

UniProtKB/Swiss-Prot for GATSL2 Gene

  • Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homooligomers or heterooligomers with GATSL3, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Does not directly bind arginine, but binding of arginine to GATSL3 disrupts the interaction of GATSL2-containing heterooligomers with GATOR2 and activates the TORC1 signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATSL2 Gene

Genomics for GATSL2 Gene

Regulatory Elements for GATSL2 Gene

Enhancers for GATSL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GATSL2 on UCSC Golden Path with GeneCards custom track

Promoters for GATSL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GATSL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GATSL2 Gene

Chromosome:
7
Start:
74,964,818 bp from pter
End:
75,031,532 bp from pter
Size:
66,715 bases
Orientation:
Plus strand

Genomic View for GATSL2 Gene

Genes around GATSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATSL2 Gene

Proteins for GATSL2 Gene

  • Protein details for GATSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHX0-GATL2_HUMAN
    Recommended name:
    GATS-like protein 2
    Protein Accession:
    A6NHX0
    Secondary Accessions:
    • A6NNH0
    • B9EJH9

    Protein attributes for GATSL2 Gene

    Size:
    329 amino acids
    Molecular mass:
    36056 Da
    Quaternary structure:
    • Forms homooligomers and heterooligomers with GATSL3 (PubMed:26972053). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by arginine (PubMed:26972053).

neXtProt entry for GATSL2 Gene

Post-translational modifications for GATSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GATSL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GATSL2 Gene

Domains & Families for GATSL2 Gene

Protein Domains for GATSL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GATSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHX0

UniProtKB/Swiss-Prot:

GATL2_HUMAN :
  • Contains 2 ACT domains.
  • Belongs to the GATS family.
Domain:
  • Contains 2 ACT domains.
Family:
  • Belongs to the GATS family.
genes like me logo Genes that share domains with GATSL2: view

No data available for Gene Families for GATSL2 Gene

Function for GATSL2 Gene

Molecular function for GATSL2 Gene

UniProtKB/Swiss-Prot Function:
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homooligomers or heterooligomers with GATSL3, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Does not directly bind arginine, but binding of arginine to GATSL3 disrupts the interaction of GATSL2-containing heterooligomers with GATOR2 and activates the TORC1 signaling pathway.

Gene Ontology (GO) - Molecular Function for GATSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26972053
GO:0034618 NOT arginine binding IDA 26972053
GO:0042802 identical protein binding IDA 26972053
genes like me logo Genes that share ontologies with GATSL2: view

Phenotypes for GATSL2 Gene

GenomeRNAi human phenotypes for GATSL2:
genes like me logo Genes that share phenotypes with GATSL2: view

Animal Model Products

CRISPR Products

miRNA for GATSL2 Gene

miRTarBase miRNAs that target GATSL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GATSL2 Gene

Localization for GATSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATSL2 Gene

Cytoplasm, cytosol.

Gene Ontology (GO) - Cellular Components for GATSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 26972053
GO:0061700 colocalizes_with GATOR2 complex IDA 26972053
genes like me logo Genes that share ontologies with GATSL2: view

No data available for Subcellular locations from COMPARTMENTS for GATSL2 Gene

Pathways & Interactions for GATSL2 Gene

SuperPathways for GATSL2 Gene

No Data Available

Interacting Proteins for GATSL2 Gene

Selected Interacting proteins: A6NHX0-GATL2_HUMAN for GATSL2 Gene via IID

Symbol External ID(s) Details
GATSL3

Gene Ontology (GO) - Biological Process for GATSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1904262 negative regulation of TORC1 signaling IMP 26972053
genes like me logo Genes that share ontologies with GATSL2: view

No data available for Pathways by source and SIGNOR curated interactions for GATSL2 Gene

Drugs & Compounds for GATSL2 Gene

No Compound Related Data Available

Transcripts for GATSL2 Gene

mRNA/cDNA for GATSL2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GATSL2 Gene

GATS protein-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATSL2 Gene

No ASD Table

Relevant External Links for GATSL2 Gene

GeneLoc Exon Structure for
GATSL2
ECgene alternative splicing isoforms for
GATSL2

Expression for GATSL2 Gene

mRNA expression in normal human tissues for GATSL2 Gene

mRNA expression in normal human tissues for GATSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GATSL2 Gene

This gene is overexpressed in Muscle - Skeletal (x10.7).

Protein differential expression in normal tissues from HIPED for GATSL2 Gene

This gene is overexpressed in Ovary (16.4), Tonsil (15.0), Retina (14.4), Uterus (8.8), and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GATSL2 Gene



Protein tissue co-expression partners for GATSL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GATSL2 Gene:

GATSL2

SOURCE GeneReport for Unigene cluster for GATSL2 Gene:

Hs.647048

mRNA Expression by UniProt/SwissProt for GATSL2 Gene:

A6NHX0-GATL2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with GATSL2: view

Primer Products

Orthologs for GATSL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GATSL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GATSL2 34
  • 91.69 (n)
  • 98.48 (a)
dog
(Canis familiaris)
Mammalia GATSL2 34
  • 88.78 (n)
  • 96.97 (a)
mouse
(Mus musculus)
Mammalia Gatsl2 34
  • 88.86 (n)
  • 97.26 (a)
Gatsl2 16
chimpanzee
(Pan troglodytes)
Mammalia GATSL2 34
  • 99.9 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Gatsl2 34
  • 87.84 (n)
  • 97.57 (a)
chicken
(Gallus gallus)
Aves GATSL2 34
  • 81.07 (n)
  • 91.54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gatsl1 34
  • 79.23 (n)
  • 92.4 (a)
zebrafish
(Danio rerio)
Actinopterygii gatsl2 34
  • 75.36 (n)
  • 84.05 (a)
Species where no ortholog for GATSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GATSL2 Gene

ENSEMBL:
Gene Tree for GATSL2 (if available)
TreeFam:
Gene Tree for GATSL2 (if available)

Paralogs for GATSL2 Gene

Paralogs for GATSL2 Gene

(4) SIMAP similar genes for GATSL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GATSL2: view

Variants for GATSL2 Gene

Sequence variations from dbSNP and Humsavar for GATSL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2354092 -- 74,976,479(+) cggct(C/G)actgc intron-variant
rs2354093 -- 74,975,584(-) cgccc(A/G)ccacc intron-variant
rs2428472 -- 74,965,889(+) tctct(C/G)tctct intron-variant
rs2523306 -- 74,964,970(+) TGGAC(C/G)GGGCG utr-variant-5-prime
rs2523307 -- 74,965,036(+) GCCAA(C/G)GAGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GATSL2 Gene

Variant ID Type Subtype PubMed ID
dgv11452n54 CNV loss 21841781
dgv3593n106 CNV deletion 24896259
esv1398337 CNV insertion 17803354
esv2658348 CNV deletion 23128226
nsv1032137 CNV gain 25217958
nsv1075033 CNV deletion 25765185
nsv1075972 CNV deletion 25765185
nsv1112935 CNV deletion 24896259
nsv1119128 CNV deletion 24896259
nsv1145144 CNV deletion 24896259
nsv7402 OTHER inversion 18451855
nsv8145 CNV gain 18304495
nsv950552 CNV deletion 24416366
nsv951355 CNV deletion 24416366
nsv970534 CNV duplication 23825009
nsv970537 CNV duplication 23825009
nsv970882 CNV duplication 23825009
nsv981529 CNV duplication 23825009
nsv981530 CNV duplication 23825009
nsv981533 CNV duplication 23825009
nsv981668 CNV duplication 23825009

Variation tolerance for GATSL2 Gene

Gene Damage Index Score: 0.20; 4.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GATSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GATSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATSL2 Gene

Disorders for GATSL2 Gene

Relevant External Links for GATSL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GATSL2

No disorders were found for GATSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATSL2 Gene

Publications for GATSL2 Gene

  1. The CASTOR proteins are arginine sensors for the mTORC1 pathway. (PMID: 26972053) Chantranupong L. … Sabatini D.M. (Cell 2016) 3 4 65
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for GATSL2 Gene

Sources for GATSL2 Gene

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