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Aliases for GATD1 Gene

Aliases for GATD1 Gene

  • Glutamine Amidotransferase Like Class 1 Domain Containing 1 2 3
  • Parkinson Disease 7 Domain Containing 1 2 3 5
  • PDDC1 3 4 5
  • Parkinson Disease 7 Domain-Containing Protein 1 3

External Ids for GATD1 Gene

Previous HGNC Symbols for GATD1 Gene

  • PDDC1

Summaries for GATD1 Gene

GeneCards Summary for GATD1 Gene

GATD1 (Glutamine Amidotransferase Like Class 1 Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATD1 Gene

Genomics for GATD1 Gene

Regulatory Elements for GATD1 Gene

Enhancers for GATD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G000654 1.2 FANTOM5 ENCODE 11.6 +122.2 122182 0.9 HNRNPUL1 FOXA2 MLX ARID4B SIN3A THRB ZNF48 RAD21 RARA MIXL1 TMEM80 CDHR5 EPS8L2 DEAF1 IRF7 TALDO1 ENSG00000255142 GATD1 LOC171391 CEND1
GH11G000662 0.8 ENCODE 11.5 +114.6 114616 0.2 CTCF SAP130 MAX ARID4B IRF3 RAD21 ZNF143 SMC3 NR2F6 CREM EPS8L2 TMEM80 CDHR5 DEAF1 IRF7 LOC171391 GATD1 ENSG00000255142 CEND1 SLC25A22
GH11G000657 0.8 ENCODE 11.2 +119.6 119582 1.3 SAP130 ARID4B MAX CEBPG THRB RAD21 YY1 RARA NCOR1 HNF4G TMEM80 EPS8L2 DEAF1 CDHR5 IRF7 TALDO1 CEND1 SLC25A22 RPLP2 PIDD1
GH11G001530 0.9 ENCODE dbSUPER 4.5 -754.8 -754756 3.1 ZNF263 CTCF KLF1 MAZ SP3 ZNF687 MNT ZIC2 RAD21 GLIS2 MOB2 KRTAP5-AS1 TOLLIP-AS1 TOLLIP KRTAP5-5 GATD1 GC11M001525 GC11P001533
GH11G000775 1.3 ENCODE dbSUPER 0.7 +0.2 167 3.9 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 ZNF143 FOS TALDO1 TMEM80 MIR210 GATD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GATD1 on UCSC Golden Path with GeneCards custom track

Promoters for GATD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035688 101 1601 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 ZNF143 REST

Genomic Location for GATD1 Gene

Chromosome:
11
Start:
767,217 bp from pter
End:
777,501 bp from pter
Size:
10,285 bases
Orientation:
Minus strand

Genomic View for GATD1 Gene

Genes around GATD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATD1 Gene

Proteins for GATD1 Gene

  • Protein details for GATD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB37-PDDC1_HUMAN
    Recommended name:
    Parkinson disease 7 domain-containing protein 1
    Protein Accession:
    Q8NB37
    Secondary Accessions:
    • B7ZKW5
    • Q2NL76
    • Q6ZQY0
    • Q8NAE0

    Protein attributes for GATD1 Gene

    Size:
    220 amino acids
    Molecular mass:
    23298 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GATD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GATD1 Gene

Post-translational modifications for GATD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GATD1 Gene

Domains & Families for GATD1 Gene

Protein Domains for GATD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NB37

UniProtKB/Swiss-Prot:

PDDC1_HUMAN :
  • Belongs to the peptidase C56 family.
Family:
  • Belongs to the peptidase C56 family.
genes like me logo Genes that share domains with GATD1: view

Function for GATD1 Gene

Gene Ontology (GO) - Molecular Function for GATD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GATD1: view
genes like me logo Genes that share phenotypes with GATD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GATD1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GATD1 Gene

Localization for GATD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GATD1 gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GATD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GATD1: view

Pathways & Interactions for GATD1 Gene

SuperPathways for GATD1 Gene

No Data Available

Interacting Proteins for GATD1 Gene

Gene Ontology (GO) - Biological Process for GATD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GATD1: view

No data available for Pathways by source and SIGNOR curated interactions for GATD1 Gene

Drugs & Compounds for GATD1 Gene

No Compound Related Data Available

Transcripts for GATD1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATD1 Gene

No ASD Table

Relevant External Links for GATD1 Gene

GeneLoc Exon Structure for
GATD1
ECgene alternative splicing isoforms for
GATD1

Expression for GATD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GATD1 Gene:

GATD1

Evidence on tissue expression from TISSUES for GATD1 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GATD1 Gene

Orthologs for GATD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GATD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDDC1 34
  • 90.72 (n)
dog
(Canis familiaris)
Mammalia PDDC1 34 35 35
  • 88.48 (n)
cow
(Bos Taurus)
Mammalia PDDC1 34 35
  • 87.42 (n)
mouse
(Mus musculus)
Mammalia Pddc1 34 35
  • 85.76 (n)
Gatd1 16
rat
(Rattus norvegicus)
Mammalia LOC100911365 34
  • 85.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PDDC1 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDDC1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDDC1 34 35
  • 74.04 (n)
lizard
(Anolis carolinensis)
Reptilia PDDC1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pddc1 34
  • 67.43 (n)
Str.11868 34
zebrafish
(Danio rerio)
Actinopterygii pddc1 34 35
  • 65.73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2124 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4136 35
  • 51 (a)
OneToOne
Species where no ortholog for GATD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GATD1 Gene

ENSEMBL:
Gene Tree for GATD1 (if available)
TreeFam:
Gene Tree for GATD1 (if available)

Paralogs for GATD1 Gene

No data available for Paralogs for GATD1 Gene

Variants for GATD1 Gene

Sequence variations from dbSNP and Humsavar for GATD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000167206 -- 776,293(+) TCTTA(C/T)ATAAG intron-variant, upstream-variant-2KB
rs1000352175 -- 776,331(+) ACTTA(C/T)CGAGG intron-variant, upstream-variant-2KB
rs1000424456 -- 776,108(+) CTCCC(C/G)AGTAG intron-variant, upstream-variant-2KB
rs1000456980 -- 775,836(+) GTCCT(A/C)CCAGG intron-variant, upstream-variant-2KB
rs1000603710 -- 777,109(+) CGCCG(A/C/G)GCAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GATD1 Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv182e199 CNV deletion 23128226
dgv566n106 CNV deletion 24896259
esv1306344 CNV deletion 17803354
esv2743871 CNV deletion 23290073
esv2743872 CNV deletion 23290073
esv2759794 CNV loss 17122850
esv3547183 CNV deletion 23714750
esv3625077 CNV gain 21293372
esv3625081 CNV gain 21293372
esv990408 CNV deletion 20482838
nsv1040044 CNV gain+loss 25217958
nsv1146743 CNV deletion 26484159
nsv1147384 CNV deletion 26484159
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv552870 CNV loss 21841781
nsv552871 CNV loss 21841781
nsv8758 CNV gain 18304495
nsv8759 CNV gain 18304495
nsv951272 CNV deletion 24416366

Variation tolerance for GATD1 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GATD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GATD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATD1 Gene

Disorders for GATD1 Gene

Relevant External Links for GATD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GATD1

No disorders were found for GATD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATD1 Gene

Publications for GATD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for GATD1 Gene

Sources for GATD1 Gene

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