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Aliases for GATD1 Gene

Aliases for GATD1 Gene

  • Glutamine Amidotransferase Like Class 1 Domain Containing 1 2 3 5
  • Parkinson Disease 7 Domain-Containing Protein 1 3 4
  • Parkinson Disease 7 Domain Containing 1 2 3
  • PDDC1 3 4
  • Glutamine Amidotransferase-Like Class 1 Domain-Containing Protein 1 3

External Ids for GATD1 Gene

Previous HGNC Symbols for GATD1 Gene

  • PDDC1

Summaries for GATD1 Gene

GeneCards Summary for GATD1 Gene

GATD1 (Glutamine Amidotransferase Like Class 1 Domain Containing 1) is a Protein Coding gene.

Additional gene information for GATD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATD1 Gene

Genomics for GATD1 Gene

GeneHancer (GH) Regulatory Elements for GATD1 Gene

Promoters and enhancers for GATD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I000775 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 167 3.9 ARNT ARID4B SIN3A DMAP1 YY1 ZNF121 POLR2B GLIS2 ZNF143 FOS GATD1 LOC171391 ENSG00000255108 TALDO1 TMEM80 MIR210
GH11I000234 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.5 +541.0 540951 3.5 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 PSMD13 SIRT3 RIC8A BET1L SNORA52 RNH1 GATD1 TMEM80 ENSG00000255237 RPLP2
GH11I000839 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 -66.3 -66280 7.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 TSPAN4 POLR2L GC11M000841 CD151 SNORA52 RPLP2 TMEM80 PIDD1 RIC8A BET1L
GH11I000501 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.8 +272.3 272270 6.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 RNH1 GC11M000505 GC11M000506 GC11P000507 LRRC56 PTDSS2 GATD1 DRD4 TMEM80 GC11P000497
GH11I000534 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.8 +241.2 241212 4.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A ZBTB7B POLR2B LRRC56 HRAS TMEM80 RNH1 PIDD1 DRD4 PHRF1 GATD1 ENSG00000255142 ENSG00000255158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GATD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GATD1 Gene

Genomic Locations for GATD1 Gene
chr11:767,217-777,501
(GRCh38/hg38)
Size:
10,285 bases
Orientation:
Minus strand
chr11:767,220-777,488
(GRCh37/hg19)

Genomic View for GATD1 Gene

Genes around GATD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATD1 Gene

Proteins for GATD1 Gene

  • Protein details for GATD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB37-GALD1_HUMAN
    Recommended name:
    Glutamine amidotransferase-like class 1 domain-containing protein 1
    Protein Accession:
    Q8NB37
    Secondary Accessions:
    • B7ZKW5
    • Q2NL76
    • Q6ZQY0
    • Q8NAE0

    Protein attributes for GATD1 Gene

    Size:
    220 amino acids
    Molecular mass:
    23298 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GATD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GATD1 Gene

Post-translational modifications for GATD1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GATD1 Gene

Domains & Families for GATD1 Gene

Gene Families for GATD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for GATD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NB37

UniProtKB/Swiss-Prot:

GALD1_HUMAN :
  • Belongs to the peptidase C56 family.
Family:
  • Belongs to the peptidase C56 family.
genes like me logo Genes that share domains with GATD1: view

Function for GATD1 Gene

Phenotypes From GWAS Catalog for GATD1 Gene

Gene Ontology (GO) - Molecular Function for GATD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GATD1: view
genes like me logo Genes that share phenotypes with GATD1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GATD1 Gene

Localization for GATD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GATD1 gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GATD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with GATD1: view

Pathways & Interactions for GATD1 Gene

SuperPathways for GATD1 Gene

No Data Available

Interacting Proteins for GATD1 Gene

Gene Ontology (GO) - Biological Process for GATD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GATD1: view

No data available for Pathways by source and SIGNOR curated interactions for GATD1 Gene

Drugs & Compounds for GATD1 Gene

No Compound Related Data Available

Transcripts for GATD1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATD1 Gene

No ASD Table

Relevant External Links for GATD1 Gene

GeneLoc Exon Structure for
GATD1
ECgene alternative splicing isoforms for
GATD1

Expression for GATD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GATD1 Gene:

GATD1

Evidence on tissue expression from TISSUES for GATD1 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GATD1 Gene

Orthologs for GATD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GATD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDDC1 33
  • 90.72 (n)
dog
(Canis familiaris)
Mammalia PDDC1 34 34 33
  • 88.48 (n)
OneToMany
cow
(Bos Taurus)
Mammalia PDDC1 34 33
  • 87.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pddc1 34 33
  • 85.76 (n)
OneToOne
Gatd1 16
rat
(Rattus norvegicus)
Mammalia LOC100911365 33
  • 85.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PDDC1 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDDC1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDDC1 34 33
  • 74.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDDC1 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pddc1 33
  • 67.43 (n)
Str.11868 33
zebrafish
(Danio rerio)
Actinopterygii pddc1 34 33
  • 65.73 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2124 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4136 34
  • 51 (a)
OneToOne
Species where no ortholog for GATD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GATD1 Gene

ENSEMBL:
Gene Tree for GATD1 (if available)
TreeFam:
Gene Tree for GATD1 (if available)

Paralogs for GATD1 Gene

No data available for Paralogs for GATD1 Gene

Variants for GATD1 Gene

Sequence variations from dbSNP and Humsavar for GATD1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000167206 -- 776,293(-) T/C intron_variant
rs1000352175 -- 776,331(-) T/C intron_variant
rs1000424456 -- 776,108(-) G/C intron_variant
rs1000456980 -- 775,836(-) A/C intron_variant
rs1000603710 -- 777,109(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GATD1 Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv182e199 CNV deletion 23128226
dgv566n106 CNV deletion 24896259
esv1306344 CNV deletion 17803354
esv2743871 CNV deletion 23290073
esv2743872 CNV deletion 23290073
esv2759794 CNV loss 17122850
esv3547183 CNV deletion 23714750
esv3625077 CNV gain 21293372
esv3625081 CNV gain 21293372
esv990408 CNV deletion 20482838
nsv1040044 CNV gain+loss 25217958
nsv1146743 CNV deletion 26484159
nsv1147384 CNV deletion 26484159
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv552870 CNV loss 21841781
nsv552871 CNV loss 21841781
nsv8758 CNV gain 18304495
nsv8759 CNV gain 18304495
nsv951272 CNV deletion 24416366

Variation tolerance for GATD1 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GATD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GATD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATD1 Gene

Disorders for GATD1 Gene

No disorders were found for GATD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATD1 Gene

Publications for GATD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for GATD1 Gene

Sources for GATD1 Gene

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