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Aliases for GATB Gene

Aliases for GATB Gene

  • Glutamyl-TRNA Amidotransferase Subunit B 2 3 5
  • Cytochrome C Oxidase Assembly Factor PET112 Homolog 3 4
  • Glutamyl-TRNA(Gln) Amidotransferase, Subunit B 2 3
  • Glu-AdT Subunit B 3 4
  • PET112L 3 4
  • PET112 3 4
  • Glutamyl-TRNA(Gln) Amidotransferase Subunit B, Mitochondrial 3
  • Cytochrome Oxidase Assembly Factor PET112 Homolog 3
  • PET112 (Yeast Homolog)-Like 2
  • PET112 Homolog 3
  • EC 6.3.5.- 4
  • EC 6.3.5 56
  • HSPC199 3

External Ids for GATB Gene

Previous HGNC Symbols for GATB Gene

  • PET112L
  • PET112

Summaries for GATB Gene

GeneCards Summary for GATB Gene

GATB (Glutamyl-TRNA Amidotransferase Subunit B) is a Protein Coding gene. Among its related pathways are tRNA Aminoacylation and Metabolism. Gene Ontology (GO) annotations related to this gene include ligase activity and translation factor activity, RNA binding.

UniProtKB/Swiss-Prot for GATB Gene

  • Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Additional gene information for GATB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATB Gene

Genomics for GATB Gene

GeneHancer (GH) Regulatory Elements for GATB Gene

Promoters and enhancers for GATB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I151760 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 570.4 +0.1 126 1.7 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 GATB RPS3A MIR4453HG GC04P151731
GH04I151806 Enhancer 1 Ensembl ENCODE 16.5 -46.2 -46213 2.4 NFIB INSM2 KLF17 MZF1 FEZF1 GLIS2 ZNF366 SCRT2 ZNF391 FOS GATB ENSG00000249184 ENSG00000249708
GH04I151689 Enhancer 0.8 Ensembl ENCODE dbSUPER 20.4 +69.5 69539 4.7 JUND POLR2A RCOR1 GATB ENSG00000251455 GC04M151651
GH04I151742 Enhancer 1.1 Ensembl ENCODE 14.8 +16.5 16517 4 PKNOX1 ATF1 FEZF1 IRF4 TCF12 GATA2 FOS ATF7 RUNX3 JUNB GATB GC04P151731
GH04I151539 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.4 +219.8 219769 2.8 FEZF1 ZNF2 ZNF213 FOS SP3 TSHZ1 GLIS1 MYNN STAT3 PRDM4 GATB GC04M151467 FAM160A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GATB on UCSC Golden Path with GeneCards custom track

Genomic Locations for GATB Gene

Genomic Locations for GATB Gene
90,972 bases
Minus strand

Genomic View for GATB Gene

Genes around GATB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATB Gene

Proteins for GATB Gene

  • Protein details for GATB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q4W5M8
    • Q53GP4
    • Q9P0S6
    • Q9Y2B8

    Protein attributes for GATB Gene

    557 amino acids
    Molecular mass:
    61864 Da
    Quaternary structure:
    • Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.
    • Sequence=AAF36119.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305};

neXtProt entry for GATB Gene

Selected DME Specific Peptides for GATB Gene


Post-translational modifications for GATB Gene

No Post-translational modifications

Domains & Families for GATB Gene

Gene Families for GATB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GatB/GatE family. GatB subfamily.
  • Belongs to the GatB/GatE family. GatB subfamily.
genes like me logo Genes that share domains with GATB: view

Function for GATB Gene

Molecular function for GATB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
UniProtKB/Swiss-Prot Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Enzyme Numbers (IUBMB) for GATB Gene

Gene Ontology (GO) - Molecular Function for GATB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005524 ATP binding IEA --
GO:0008135 translation factor activity, RNA binding TAS 9878253
GO:0016740 transferase activity IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with GATB: view
genes like me logo Genes that share phenotypes with GATB: view

Animal Model Products

miRNA for GATB Gene

miRTarBase miRNAs that target GATB

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GATB Gene

Localization for GATB Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GATB gene
Compartment Confidence
mitochondrion 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GATB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 19805282
GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex IDA,IEA 19805282
genes like me logo Genes that share ontologies with GATB: view

Pathways & Interactions for GATB Gene

genes like me logo Genes that share pathways with GATB: view

Pathways by source for GATB Gene

2 KEGG pathways for GATB Gene

Gene Ontology (GO) - Biological Process for GATB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS,IEA 9878253
GO:0032543 mitochondrial translation IMP,IEA 19805282
GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation IDA,IEA 19805282
genes like me logo Genes that share ontologies with GATB: view

No data available for SIGNOR curated interactions for GATB Gene

Drugs & Compounds for GATB Gene

(4) Drugs for GATB Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Phosphoric acid Approved Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for GATB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with GATB: view

Transcripts for GATB Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATB Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - - -
SP2: - - - - -
SP4: - - -
SP5: - -

Relevant External Links for GATB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GATB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GATB Gene

Protein differential expression in normal tissues from HIPED for GATB Gene

This gene is overexpressed in Liver (13.9), Lymph node (11.3), and Lung (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GATB Gene

Protein tissue co-expression partners for GATB Gene

NURSA nuclear receptor signaling pathways regulating expression of GATB Gene:


mRNA Expression by UniProt/SwissProt for GATB Gene:

Tissue specificity: Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle and heart.

Evidence on tissue expression from TISSUES for GATB Gene

  • Kidney(4.3)
  • Blood(4.1)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with GATB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GATB Gene

Orthologs for GATB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GATB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PET112 34 33
  • 99.88 (n)
(Canis familiaris)
Mammalia PET112 33 34
  • 87.29 (n)
(Mus musculus)
Mammalia Pet112 34 33
  • 86.12 (n)
Gatb 16
(Rattus norvegicus)
Mammalia Pet112l 33
  • 84.74 (n)
(Ornithorhynchus anatinus)
Mammalia PET112 34
  • 78 (a)
(Monodelphis domestica)
Mammalia PET112 34
  • 77 (a)
(Bos Taurus)
Mammalia PET112L 34
  • 77 (a)
(Gallus gallus)
Aves PET112 33 34
  • 72.61 (n)
(Anolis carolinensis)
Reptilia PET112 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pet112 33
  • 66.8 (n)
(Danio rerio)
Actinopterygii pet112 33 34
  • 65.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5463 33 34
  • 52.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003454 33
  • 49.44 (n)
(Caenorhabditis elegans)
Secernentea C39B5.6 34
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL303W 33
  • 48.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PET112 33 34 36
  • 45.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20659g 33
  • 45.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GATB 33
  • 47.56 (n)
(Oryza sativa)
Liliopsida Os11g0544800 33
  • 46.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC343.13 33
  • 44.83 (n)
Species where no ortholog for GATB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GATB Gene

Gene Tree for GATB (if available)
Gene Tree for GATB (if available)

Paralogs for GATB Gene

No data available for Paralogs for GATB Gene

Variants for GATB Gene

Sequence variations from dbSNP and Humsavar for GATB Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000038835 -- 151,673,509(-) C/T intron_variant
rs1000047906 -- 151,679,085(-) G/A intron_variant
rs1000078704 -- 151,678,767(-) C/T intron_variant
rs1000100724 -- 151,722,852(-) C/T intron_variant
rs1000142831 -- 151,678,280(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GATB Gene

Variant ID Type Subtype PubMed ID
esv22209 CNV loss 19812545
esv996950 CNV gain 20482838
nsv1026511 CNV gain 25217958
nsv1028814 CNV gain 25217958
nsv1109647 CNV deletion 24896259
nsv4551 CNV deletion 18451855
nsv4552 CNV deletion 18451855
nsv508322 CNV deletion 20534489

Variation tolerance for GATB Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GATB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATB Gene

Disorders for GATB Gene

Additional Disease Information for GATB

No disorders were found for GATB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATB Gene

Publications for GATB Gene

  1. Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. (PMID: 19805282) Nagao A … Suzuki T (Proceedings of the National Academy of Sciences of the United States of America 2009) 2 3 4 58
  2. Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. (PMID: 9878253) Petruzzella V … Zeviani M (Genomics 1998) 2 3 4 58
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GATB Gene

Sources for GATB Gene

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