Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GATB Gene

Aliases for GATB Gene

  • Glutamyl-TRNA Amidotransferase Subunit B 2 3 5
  • Cytochrome C Oxidase Assembly Factor PET112 Homolog 3 4
  • Glutamyl-TRNA(Gln) Amidotransferase, Subunit B 2 3
  • Glu-AdT Subunit B 3 4
  • PET112L 3 4
  • PET112 3 4
  • Glutamyl-TRNA(Gln) Amidotransferase Subunit B, Mitochondrial 3
  • Cytochrome Oxidase Assembly Factor PET112 Homolog 3
  • PET112 (Yeast Homolog)-Like 2
  • PET112 Homolog 3
  • EC 6.3.5.- 4
  • EC 6.3.5 61
  • HSPC199 3

External Ids for GATB Gene

Previous HGNC Symbols for GATB Gene

  • PET112L
  • PET112

Summaries for GATB Gene

GeneCards Summary for GATB Gene

GATB (Glutamyl-TRNA Amidotransferase Subunit B) is a Protein Coding gene. Among its related pathways are Metabolism and tRNA Aminoacylation. GO annotations related to this gene include ligase activity and translation factor activity, RNA binding.

UniProtKB/Swiss-Prot for GATB Gene

  • Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATB Gene

Genomics for GATB Gene

Regulatory Elements for GATB Gene

Enhancers for GATB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G151760 1.1 ENCODE 20.4 +0.1 126 1.7 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 GATB GC04P151731
GH04G151689 1 Ensembl ENCODE dbSUPER 20.4 +69.5 69540 4.7 ZNF316 JUND ZMYM3 MAFG FOXA1 GATB ENSG00000251455 GC04M151651
GH04G151665 1 dbSUPER 20.1 +93.5 93543 4.9 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF263 TSHZ1 PPARG ZNF585B SMARCA4 GLIS1 GATB ENSG00000251455 ENSG00000251603 ENSG00000278978
GH04G151742 1.3 Ensembl ENCODE 14.8 +16.5 16518 4.0 HDGF PKNOX1 ATF1 FEZF1 TCF12 ZNF766 ELK1 GATA2 FOS JUNB GATB GC04P151731
GH04G151539 1.5 Ensembl ENCODE dbSUPER 12.4 +219.8 219770 2.8 SIN3A FEZF1 ZNF2 YY1 ZNF766 GATA2 FOS ZNF263 SP3 TSHZ1 GATB GC04M151467 FAM160A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GATB on UCSC Golden Path with GeneCards custom track

Promoters for GATB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000174801 123 1401 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for GATB Gene

Chromosome:
4
Start:
151,670,052 bp from pter
End:
151,761,023 bp from pter
Size:
90,972 bases
Orientation:
Minus strand

Genomic View for GATB Gene

Genes around GATB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATB Gene

Proteins for GATB Gene

  • Protein details for GATB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75879-GATB_HUMAN
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
    Protein Accession:
    O75879
    Secondary Accessions:
    • Q4W5M8
    • Q53GP4
    • Q9P0S6
    • Q9Y2B8

    Protein attributes for GATB Gene

    Size:
    557 amino acids
    Molecular mass:
    61864 Da
    Quaternary structure:
    • Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.
    SequenceCaution:
    • Sequence=AAF36119.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305};

neXtProt entry for GATB Gene

Selected DME Specific Peptides for GATB Gene

O75879:
  • GLEIHAQ
  • DLPAGYQI
  • PGTLPVLN
  • SNSKLFS
  • YFYADLP
  • IDLNRAG

Post-translational modifications for GATB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GATB Gene

Graphical View of Domain Structure for InterPro Entry

O75879

UniProtKB/Swiss-Prot:

GATB_HUMAN :
  • Belongs to the GatB/GatE family. GatB subfamily.
Family:
  • Belongs to the GatB/GatE family. GatB subfamily.
genes like me logo Genes that share domains with GATB: view

No data available for Gene Families for GATB Gene

Function for GATB Gene

Molecular function for GATB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
UniProtKB/Swiss-Prot Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Enzyme Numbers (IUBMB) for GATB Gene

Gene Ontology (GO) - Molecular Function for GATB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008135 translation factor activity, RNA binding TAS 9878253
GO:0016740 transferase activity IEA --
GO:0016874 ligase activity IEA --
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA --
genes like me logo Genes that share ontologies with GATB: view
genes like me logo Genes that share phenotypes with GATB: view

Animal Model Products

CRISPR Products

miRNA for GATB Gene

miRTarBase miRNAs that target GATB

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GATB Gene

Localization for GATB Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATB Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GATB gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for GATB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 19805282
GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex IEA,IDA 19805282
genes like me logo Genes that share ontologies with GATB: view

Pathways & Interactions for GATB Gene

genes like me logo Genes that share pathways with GATB: view

Pathways by source for GATB Gene

2 KEGG pathways for GATB Gene

Gene Ontology (GO) - Biological Process for GATB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,TAS 9878253
GO:0032543 mitochondrial translation IEA,IMP 19805282
GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation IEA,IDA 19805282
genes like me logo Genes that share ontologies with GATB: view

No data available for SIGNOR curated interactions for GATB Gene

Drugs & Compounds for GATB Gene

(4) Drugs for GATB Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0

(1) Additional Compounds for GATB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with GATB: view

Transcripts for GATB Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATB Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: - -
SP6:

Relevant External Links for GATB Gene

GeneLoc Exon Structure for
GATB
ECgene alternative splicing isoforms for
GATB

Expression for GATB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GATB Gene

Protein differential expression in normal tissues from HIPED for GATB Gene

This gene is overexpressed in Liver (13.9), Lymph node (11.3), and Lung (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GATB Gene



Protein tissue co-expression partners for GATB Gene

NURSA nuclear receptor signaling pathways regulating expression of GATB Gene:

GATB

mRNA Expression by UniProt/SwissProt for GATB Gene:

O75879-GATB_HUMAN
Tissue specificity: Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle and heart.

Evidence on tissue expression from TISSUES for GATB Gene

  • Kidney(4.3)
  • Blood(4.1)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with GATB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GATB Gene

Orthologs for GATB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GATB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PET112 34 35
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia PET112 34 35
  • 87.29 (n)
mouse
(Mus musculus)
Mammalia Pet112 34 35
  • 86.12 (n)
Gatb 16
rat
(Rattus norvegicus)
Mammalia Pet112l 34
  • 84.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PET112 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PET112L 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PET112 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PET112 34 35
  • 72.61 (n)
lizard
(Anolis carolinensis)
Reptilia PET112 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pet112 34
  • 66.8 (n)
zebrafish
(Danio rerio)
Actinopterygii pet112 34 35
  • 65.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5463 34 35
  • 52.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003454 34
  • 49.44 (n)
worm
(Caenorhabditis elegans)
Secernentea C39B5.6 35
  • 32 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL303W 34
  • 48.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PET112 34 35 37
  • 45.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20659g 34
  • 45.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GATB 34
  • 47.56 (n)
rice
(Oryza sativa)
Liliopsida Os11g0544800 34
  • 46.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC343.13 34
  • 44.83 (n)
Species where no ortholog for GATB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GATB Gene

ENSEMBL:
Gene Tree for GATB (if available)
TreeFam:
Gene Tree for GATB (if available)

Paralogs for GATB Gene

No data available for Paralogs for GATB Gene

Variants for GATB Gene

Sequence variations from dbSNP and Humsavar for GATB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000038835 -- 151,673,509(+) AACAA(C/T)TGAAA intron-variant, upstream-variant-2KB
rs1000047906 -- 151,679,085(+) GAGAC(A/G)GGGTT intron-variant
rs1000078704 -- 151,678,767(+) CGTTA(C/T)ATGCA intron-variant
rs1000100724 -- 151,722,852(+) GATAT(C/T)AATGG intron-variant
rs1000142831 -- 151,678,280(+) GAACC(C/T)AGCTG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GATB Gene

Variant ID Type Subtype PubMed ID
esv22209 CNV loss 19812545
esv996950 CNV gain 20482838
nsv1026511 CNV gain 25217958
nsv1028814 CNV gain 25217958
nsv1109647 CNV deletion 24896259
nsv4551 CNV deletion 18451855
nsv4552 CNV deletion 18451855
nsv508322 CNV deletion 20534489

Variation tolerance for GATB Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GATB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GATB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATB Gene

Disorders for GATB Gene

Relevant External Links for GATB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GATB

No disorders were found for GATB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATB Gene

Publications for GATB Gene

  1. Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. (PMID: 19805282) Nagao A. … Suzuki T. (Proc. Natl. Acad. Sci. U.S.A. 2009) 2 3 4 64
  2. Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. (PMID: 9878253) Petruzzella V. … Zeviani M. (Genomics 1998) 2 3 4 64
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GATB Gene

Sources for GATB Gene

Content
Loading form....