Aliases for GATAD2B Gene
External Ids for GATAD2B Gene
Previous GeneCards Identifiers for GATAD2B Gene
This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability. [provided by RefSeq, Jun 2016]
GeneCards Summary for GATAD2B Gene
GATAD2B (GATA Zinc Finger Domain Containing 2B) is a Protein Coding gene. Diseases associated with GATAD2B include Mental Retardation, Autosomal Dominant 18 and Koolen-De Vries Syndrome. Among its related pathways are Chromatin organization and RNA Polymerase I Promoter Escape. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is GATAD2A.
UniProtKB/Swiss-Prot for GATAD2B Gene
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.