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Aliases for GATAD2A Gene

Aliases for GATAD2A Gene

  • GATA Zinc Finger Domain Containing 2A 2 3 5
  • GATA Zinc Finger Domain-Containing Protein 2A 3 4
  • Transcriptional Repressor P66-Alpha 3
  • P66 Alpha 2
  • Hp66alpha 4
  • P66alpha 3

External Ids for GATAD2A Gene

Previous GeneCards Identifiers for GATAD2A Gene

  • GC19P019238
  • GC19P019431
  • GC19P019496
  • GC19P019058

Summaries for GATAD2A Gene

GeneCards Summary for GATAD2A Gene

GATAD2A (GATA Zinc Finger Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein binding, bridging. An important paralog of this gene is GATAD2B.

UniProtKB/Swiss-Prot for GATAD2A Gene

  • Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATAD2A Gene

Genomics for GATAD2A Gene

Regulatory Elements for GATAD2A Gene

Enhancers for GATAD2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GATAD2A on UCSC Golden Path with GeneCards custom track

Promoters for GATAD2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GATAD2A on UCSC Golden Path with GeneCards custom track

Genomic Location for GATAD2A Gene

Chromosome:
19
Start:
19,385,826 bp from pter
End:
19,508,932 bp from pter
Size:
123,107 bases
Orientation:
Plus strand

Genomic View for GATAD2A Gene

Genes around GATAD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATAD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATAD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATAD2A Gene

Proteins for GATAD2A Gene

  • Protein details for GATAD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YP4-P66A_HUMAN
    Recommended name:
    Transcriptional repressor p66-alpha
    Protein Accession:
    Q86YP4
    Secondary Accessions:
    • B5MC40
    • Q7L3J2
    • Q96F28
    • Q9NPU2
    • Q9NXS1

    Protein attributes for GATAD2A Gene

    Size:
    633 amino acids
    Molecular mass:
    68063 Da
    Quaternary structure:
    • Binds MBD2 and MBD3. Interaction with MBD2 is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin. Component of the MeCP1 histone deacetylase complex. Interacts with histone tails, including that of histones H2A, H2B, H3 and H4. This interaction is reduced by histone acetylation.
    SequenceCaution:
    • Sequence=AAH11684.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90939.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GATAD2A Gene

    Alternative splice isoforms for GATAD2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GATAD2A Gene

Post-translational modifications for GATAD2A Gene

  • Ubiquitination at Lys 464
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GATAD2A Gene

Domains & Families for GATAD2A Gene

Gene Families for GATAD2A Gene

Protein Domains for GATAD2A Gene

Suggested Antigen Peptide Sequences for GATAD2A Gene

Graphical View of Domain Structure for InterPro Entry

Q86YP4

UniProtKB/Swiss-Prot:

P66A_HUMAN :
  • Both CR1 and CR2 regions are required for speckled nuclear localization.
  • Contains 1 GATA-type zinc finger.
Domain:
  • Both CR1 and CR2 regions are required for speckled nuclear localization.
Similarity:
  • Contains 1 GATA-type zinc finger.
genes like me logo Genes that share domains with GATAD2A: view

Function for GATAD2A Gene

Molecular function for GATAD2A Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.

Gene Ontology (GO) - Molecular Function for GATAD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 contributes_to RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 12183469
GO:0008270 zinc ion binding IEA --
GO:0030674 protein binding, bridging IDA 12183469
genes like me logo Genes that share ontologies with GATAD2A: view
genes like me logo Genes that share phenotypes with GATAD2A: view

Animal Models for GATAD2A Gene

MGI Knock Outs for GATAD2A:

Animal Model Products

CRISPR Products

miRNA for GATAD2A Gene

miRTarBase miRNAs that target GATAD2A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GATAD2A Gene

Localization for GATAD2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATAD2A Gene

Nucleus speckle. Note=Speckled nuclear localization requires both CR1 and CR2 regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GATAD2A Gene COMPARTMENTS Subcellular localization image for GATAD2A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GATAD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12183469
GO:0005654 nucleoplasm IDA --
GO:0016581 NuRD complex IDA 12183469
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with GATAD2A: view

Pathways & Interactions for GATAD2A Gene

genes like me logo Genes that share pathways with GATAD2A: view

Gene Ontology (GO) - Biological Process for GATAD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006306 DNA methylation TAS 12183469
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 12183469
genes like me logo Genes that share ontologies with GATAD2A: view

No data available for SIGNOR curated interactions for GATAD2A Gene

Drugs & Compounds for GATAD2A Gene

No Compound Related Data Available

Transcripts for GATAD2A Gene

Unigene Clusters for GATAD2A Gene

GATA zinc finger domain containing 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATAD2A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - - - -
SP2:
SP3:
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - -
SP10: - -
SP11: -
SP12: -
SP13: -
SP14:
SP15:

ExUns: 18b ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for GATAD2A Gene

GeneLoc Exon Structure for
GATAD2A
ECgene alternative splicing isoforms for
GATAD2A

Expression for GATAD2A Gene

mRNA expression in normal human tissues for GATAD2A Gene

Protein differential expression in normal tissues from HIPED for GATAD2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.5) and CD8 Tcells (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GATAD2A Gene



Protein tissue co-expression partners for GATAD2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GATAD2A Gene:

GATAD2A

SOURCE GeneReport for Unigene cluster for GATAD2A Gene:

Hs.118964

mRNA Expression by UniProt/SwissProt for GATAD2A Gene:

Q86YP4-P66A_HUMAN
Tissue specificity: Ubiquitous, both in fetal and adult tissues.
genes like me logo Genes that share expression patterns with GATAD2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GATAD2A Gene

Orthologs for GATAD2A Gene

This gene was present in the common ancestor of animals.

Orthologs for GATAD2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GATAD2A 34
  • 89.8 (n)
  • 92.55 (a)
GATAD2A 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GATAD2A 34
  • 89.7 (n)
  • 93.03 (a)
GATAD2A 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gatad2a 34
  • 84.29 (n)
  • 89.46 (a)
Gatad2a 16
Gatad2a 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GATAD2A 34
  • 99.32 (n)
  • 99.68 (a)
GATAD2A 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gatad2a 34
  • 84.98 (n)
  • 90.42 (a)
oppossum
(Monodelphis domestica)
Mammalia GATAD2A 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GATAD2A 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GATAD2A 34
  • 72.52 (n)
  • 76.45 (a)
GATAD2A 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gatad2a 34
  • 68.13 (n)
  • 72.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398154 34
zebrafish
(Danio rerio)
Actinopterygii gatad2ab 34
  • 62.71 (n)
  • 60.37 (a)
nszf-a189 34
gatad2ab 35
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9074 34
fruit fly
(Drosophila melanogaster)
Insecta simj 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dcp-66 35
  • 16 (a)
OneToMany
Species where no ortholog for GATAD2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GATAD2A Gene

ENSEMBL:
Gene Tree for GATAD2A (if available)
TreeFam:
Gene Tree for GATAD2A (if available)

Paralogs for GATAD2A Gene

Paralogs for GATAD2A Gene

genes like me logo Genes that share paralogs with GATAD2A: view

Variants for GATAD2A Gene

Sequence variations from dbSNP and Humsavar for GATAD2A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10426883 - 19,465,395(+) TGAAC(A/G)GGACC upstream-variant-2KB, reference, missense
rs2288851 - 19,496,182(-) GAACA(C/T)TGGCG reference, missense
rs3031870 -- 19,450,762(+) AAAAA(-/A)CTCTT intron-variant
rs3067692 -- 19,495,655(+) aaaaa(-/AA/AAA)CTAGT intron-variant
rs3194807 -- 19,506,577(+) TGTCC(C/T)TAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GATAD2A Gene

Variant ID Type Subtype PubMed ID
esv3583269 CNV loss 25503493
nsv1056419 CNV gain 25217958
nsv1144871 CNV deletion 24896259

Variation tolerance for GATAD2A Gene

Residual Variation Intolerance Score: 5.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GATAD2A Gene

Human Gene Mutation Database (HGMD)
GATAD2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GATAD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATAD2A Gene

Disorders for GATAD2A Gene

Relevant External Links for GATAD2A

Genetic Association Database (GAD)
GATAD2A
Human Genome Epidemiology (HuGE) Navigator
GATAD2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GATAD2A

No disorders were found for GATAD2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATAD2A Gene

Publications for GATAD2A Gene

  1. Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. (PMID: 12183469) Brackertz M. … Renkawitz R. (J. Biol. Chem. 2002) 2 3 4 22 65
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 65
  3. p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. (PMID: 16415179) Brackertz M. … Renkawitz R. (Nucleic Acids Res. 2006) 3 4 65
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for GATAD2A Gene

Sources for GATAD2A Gene

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