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Aliases for GATAD1 Gene

Aliases for GATAD1 Gene

  • GATA Zinc Finger Domain Containing 1 2 3
  • ODAG 3 4 6
  • Ocular Development-Associated Gene Protein 3 4
  • CMD2B 3 6
  • GATA Zinc Finger Domain-Containing Protein 1 3
  • Ocular Development Associated Gene 2
  • RG083M05.2 3

External Ids for GATAD1 Gene

Previous GeneCards Identifiers for GATAD1 Gene

  • GC07P091722
  • GC07P091914
  • GC07P092076
  • GC07P086685

Summaries for GATAD1 Gene

Entrez Gene Summary for GATAD1 Gene

  • The protein encoded by this gene contains a zinc finger at the N-terminus, and is thought to bind to a histone modification site that regulates gene expression. Mutations in this gene have been associated with autosomal recessive dilated cardiomyopathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for GATAD1 Gene

GATAD1 (GATA Zinc Finger Domain Containing 1) is a Protein Coding gene. Diseases associated with GATAD1 include cardiomyopathy, dilated, 2b and familial dilated cardiomyopathy. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for GATAD1 Gene

  • Component of some chromatin complex recruited to chromatin sites methylated Lys-4 of histone H3 (H3K4me).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATAD1 Gene

Genomics for GATAD1 Gene

Regulatory Elements for GATAD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GATAD1 Gene

Start:
92,447,448 bp from pter
End:
92,460,067 bp from pter
Size:
12,620 bases
Orientation:
Plus strand

Genomic View for GATAD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GATAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATAD1 Gene

Proteins for GATAD1 Gene

  • Protein details for GATAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUU5-GATD1_HUMAN
    Recommended name:
    GATA zinc finger domain-containing protein 1
    Protein Accession:
    Q8WUU5
    Secondary Accessions:
    • B2RE37
    • D6W5Q5
    • Q8N5Y5
    • Q99995
    • Q9H689

    Protein attributes for GATAD1 Gene

    Size:
    269 amino acids
    Molecular mass:
    28690 Da
    Quaternary structure:
    • Component of a chromatin complex, at least composed of KDM5A, GATAD1 and EMSY.
    SequenceCaution:
    • Sequence=AAB46345.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GATAD1 Gene

Proteomics data for GATAD1 Gene at MOPED

Post-translational modifications for GATAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GATAD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GATAD1 Gene

Domains for GATAD1 Gene

Gene Families for GATAD1 Gene

HGNC:
  • GATAD :GATA zinc finger domain containing

Protein Domains for GATAD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GATAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUU5

UniProtKB/Swiss-Prot:

GATD1_HUMAN :
  • Q8WUU5
Similarity:
  • Contains 1 GATA-type zinc finger.
genes like me logo Genes that share domains with GATAD1: view

Function for GATAD1 Gene

Molecular function for GATAD1 Gene

UniProtKB/Swiss-Prot Function: Component of some chromatin complex recruited to chromatin sites methylated Lys-4 of histone H3 (H3K4me).

Gene Ontology (GO) - Molecular Function for GATAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with GATAD1: view

Animal Model Products

CRISPR Products

miRNA for GATAD1 Gene

miRTarBase miRNAs that target GATAD1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GATAD1 Gene

Localization for GATAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATAD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GATAD1 Gene COMPARTMENTS Subcellular localization image for GATAD1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GATAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21965549
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with GATAD1: view

Pathways for GATAD1 Gene

SuperPathways for GATAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GATAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GATAD1: view

No data available for Pathways by source for GATAD1 Gene

Transcripts for GATAD1 Gene

mRNA/cDNA for GATAD1 Gene

Unigene Clusters for GATAD1 Gene

GATA zinc finger domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GATAD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATAD1 Gene

No ASD Table

Relevant External Links for GATAD1 Gene

GeneLoc Exon Structure for
GATAD1
ECgene alternative splicing isoforms for
GATAD1

Expression for GATAD1 Gene

mRNA expression in normal human tissues for GATAD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GATAD1 Gene

SOURCE GeneReport for Unigene cluster for GATAD1 Gene Hs.21145

mRNA Expression by UniProt/SwissProt for GATAD1 Gene

Q8WUU5-GATD1_HUMAN
Tissue specificity: Ubiquitously expressed among various tissue types. Expressed in left ventricular myocytes.
genes like me logo Genes that share expressions with GATAD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GATAD1 Gene

Orthologs for GATAD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GATAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GATAD1 35
  • 98.51 (n)
  • 97.77 (a)
GATAD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GATAD1 35
  • 89.71 (n)
  • 92.57 (a)
GATAD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GATAD1 35
  • 89.1 (n)
  • 91.45 (a)
GATAD1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gatad1 35
  • 85.84 (n)
  • 91.35 (a)
Gatad1 16
Gatad1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GATAD1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GATAD1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gatad1 35
  • 87.75 (n)
  • 90.91 (a)
chicken
(Gallus gallus)
Aves GATAD1 35
  • 78.18 (n)
  • 87.95 (a)
GATAD1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GATAD1 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia odag-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gatad1 35
  • 70.77 (n)
  • 76.12 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3949 35
zebrafish
(Danio rerio)
Actinopterygii gatad1 35
  • 68.32 (n)
  • 81.4 (a)
gatad1 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13367 36
  • 25 (a)
OneToOne
Species with no ortholog for GATAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GATAD1 Gene

ENSEMBL:
Gene Tree for GATAD1 (if available)
TreeFam:
Gene Tree for GATAD1 (if available)

Paralogs for GATAD1 Gene

No data available for Paralogs for GATAD1 Gene

Variants for GATAD1 Gene

Sequence variations from dbSNP and Humsavar for GATAD1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1045701 -- 92,458,782(+) ATAAC(C/T)TTCTA utr-variant-3-prime, nc-transcript-variant
rs1055960 -- 92,459,290(+) AAATC(A/C)AAAAA utr-variant-3-prime, nc-transcript-variant
rs1061738 -- 92,456,516(+) TGGGC(C/T)TACTC reference, missense, nc-transcript-variant
rs2287179 -- 92,451,081(+) GTGCG(A/G)TGGCA intron-variant
rs3814099 -- 92,453,453(+) TGTAC(A/G)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GATAD1 Gene

Variant ID Type Subtype PubMed ID
nsv5840 CNV Insertion 18451855

Relevant External Links for GATAD1 Gene

HapMap Linkage Disequilibrium report
GATAD1
Human Gene Mutation Database (HGMD)
GATAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATAD1 Gene

Disorders for GATAD1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for GATAD1 Gene including...

Search for GATAD1 Gene in MalaCards »

(1) OMIM Diseases for GATAD1 Gene (614518)

UniProtKB/Swiss-Prot

GATD1_HUMAN
  • Cardiomyopathy, dilated 2B (CMD2B) [MIM:614672]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:21965549}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GATAD1

Genetic Association Database (GAD)
GATAD1
Human Genome Epidemiology (HuGE) Navigator
GATAD1
genes like me logo Genes that share disorders with GATAD1: view

Publications for GATAD1 Gene

  1. Ocular development-associated gene (ODAG), a novel gene highly expressed in ocular development. (PMID: 12062807) Tsuruga T. … Mishima H.K. (Gene 2002) 2 3
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 48
  5. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M. … Mann M. (Cell 2010) 3 4

Products for GATAD1 Gene

Sources for GATAD1 Gene

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