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GATA5 Gene

protein-coding   GIFtS: 57
GCID: GC20M061038

GATA Binding Protein 5

(Previous name: GATA-binding protein 5)
  See GATA5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GATA Binding Protein 51 2     bB379O24.12
GATA-Binding Protein 51 2     GATA Binding Factor-52
GATA-Binding Factor 52 3     Transcription Factor GATA-52
GATAS2     

External Ids:    HGNC: 158021   Entrez Gene: 1406282   Ensembl: ENSG000001307007   OMIM: 6114965   UniProtKB: Q9BWX53   

Export aliases for GATA5 gene to outside databases

Previous GC identifers: GC20M060803 GC20M061676 GC20M061723 GC20M060471 GC20M057816


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GATA5 Gene:
The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded
protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for
cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar
proteins may be involved in the establishment of cardiac smooth muscle cell diversity. (provided by RefSeq, Jul
2008)

GeneCards Summary for GATA5 Gene:
GATA5 (GATA binding protein 5) is a protein-coding gene. Diseases associated with GATA5 include aortic valve disease, and single ventricular septal defect. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GATA6.

UniProtKB/Swiss-Prot: GATA5_HUMAN, Q9BWX5
Function: Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific
slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s)
that underlies smooth muscle cell diversity (By similarity)

Gene Wiki entry for GATA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GATA5 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GATA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GATA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

GATA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GATA5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M061038:  view genomic region     (about GC identifiers)

Start:
61,038,553 bp from pter      End:
61,051,026 bp from pter
Size:
12,474 bases      Orientation:
minus strand

1 alternative location:
Chr20-,NW_003571063 7,015-19,488     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GATA5_HUMAN, Q9BWX5 (See protein sequence)
Recommended Name: Transcription factor GATA-5  
Size: 397 amino acids; 41299 Da
Secondary accessions: Q17RE2

Explore the universe of human proteins at neXtProt for GATA5: NX_Q9BWX5

Explore proteomics data for GATA5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GATA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_536721.1  
    ENSEMBL proteins: 
     ENSP00000252997  
    Reactome Protein details: Q9BWX5

    GATA5 Human Recombinant Protein Products:

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    antibodies-online proteins for GATA5 (7 products) 

     
    antibodies-online peptides for GATA5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GATAD: GATA zinc finger domain containing

    5 InterPro protein domains:
     IPR000679 Znf_GATA
     IPR016375 TF_GATA_4/5/6
     IPR013088 Znf_NHR/GATA
     IPR008013 GATA_N
     IPR028372 TF_GATA-5

    Graphical View of Domain Structure for InterPro Entry Q9BWX5

    ProtoNet protein and cluster: Q9BWX5

    3 Blocks protein domains:
    IPB000679 Zn-finger
    IPB001917 Aminotransferase
    IPB008013 GATA-type transcription activator


    UniProtKB/Swiss-Prot: GATA5_HUMAN, Q9BWX5
    Similarity: Contains 2 GATA-type zinc fingers


    Find genes that share domains with GATA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GATA5_HUMAN, Q9BWX5
    Function: Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific
    slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s)
    that underlies smooth muscle cell diversity (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001158enhancer sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA14986113
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with GATA5           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gata5):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 
     immune system  mortality/aging  muscle  renal/urinary system  reproductive system 
     skeleton 

    Find genes that share phenotypes with GATA5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GATA5: Gata5tm1Eno Gata5tm1.2Nemr

       genOway: Develop your customized and physiologically relevant rodent model for GATA5

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    miRTarBase miRNAs that target GATA5:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GATA5_HUMAN, Q9BWX5: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9566909
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with GATA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GATA5 About    
    See pathways by source

    SuperPathContained pathways About
    1DREAM Repression and Dynorphin Expression
    BMP Pathway0.44
    2Hemostasis
    Hemostasis0.43
    3G-AlphaQ Signaling
    Thrombin Signaling0.40
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production


    Find genes that share SuperPaths with GATA5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GATA5
        BMP Pathway
    Thrombin Signaling

    1 Reactome Pathway for GATA5
        Factors involved in megakaryocyte development and platelet production


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GATA5
    Interactions:

        GeneGlobe Interaction Network for GATA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GATA5 (Q9BWX53 ENSP000002529974) via UniProtKB, MINT, STRING, and/or I2D (see all 178)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNF1AP208233, ENSP000002575554I2D: score=1 STRING: ENSP00000257555
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    KLF2Q9Y5W33, ENSP000002480714I2D: score=1 STRING: ENSP00000248071
    SMAD4Q134853, ENSP000003415514I2D: score=1 STRING: ENSP00000341551
    RORBQ927533I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007596blood coagulation TAS--
    GO:0045893positive regulation of transcription, DNA-templated ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA14986113
    GO:0060575intestinal epithelial cell differentiation IDA9566909

    Find genes that share ontologies with GATA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GATA5

    2 Novoseek inferred chemical compound relationships for GATA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 62.9 4 17912029 (1), 16823849 (1)
    zinc 33.1 1 9915795 (1)



    Find genes that share compounds with GATA5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GATA5 gene: 
    NM_080473.4  

    Unigene Cluster for GATA5:

    GATA binding protein 5
    Hs.352250  [show with all ESTs]
    Unigene Representative Sequence: BC047790
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252997(uc002ycx.1)
    miRNA
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    Additional mRNA sequence: 

    BC047790.1 BC117356.1 BC117358.1 

    4 DOTS entries:

    DT.95152644  DT.97802394  DT.210529  DT.80102085 

    Selected AceView cDNA sequences (see all 30):

    BX099962 NM_080473 AW070312 AA127913 BC047790 AW511251 AA972923 BM985050 
    BQ953830 CA443143 BX113152 AI685293 BI767359 BU683127 BM974967 AW770386 
    AL844340 AL844350 BM972115 AI174441 AA127875 N72525 H80289 H80275 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GATA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCATTTCTG
    GATA5 Expression
    About this image


    GATA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Endocardial Cells Endocardium
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Early Lung Mesoderm Cells Lung Mesoderm
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut Endoderm Cells Foregut
     
     Smooth Muscle (Muscoskeletal System)
             Airway Smooth Muscle Cells Trachea
     
     Testis (Reproductive System)
    GATA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GATA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352250
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GATA5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gata51 , 5 GATA binding protein 51, 5 79.68(n)1
    76.83(a)1
      2 (102.85 cM)5
    144641  NM_008093.21  NP_032119.21 
     1803251335 
    chicken
    (Gallus gallus)
    Aves GATA51 GATA binding protein 5 69.96(n)
    66.58(a)
      396391  NM_205421.1  NP_990752.1 
    lizard
    (Anolis carolinensis)
    Reptilia GATA56
    GATA binding protein 5
    63(a)
    1 ↔ 1
    4(151490218-151536959)
    African clawed frog
    (Xenopus laevis)
    Amphibia GATA-5a2 transcription factor xGATA-5a 74.06(n)    L13701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gata51 GATA-binding protein 5 63.11(n)
    60.11(a)
      30482  NM_131235.2  NP_571310.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta pnr3 blastoderm segmentation transcription
    factor
    80(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for GATA5 (if available)
    TreeFam Gene Tree for GATA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GATA5 gene
    GATA62  GATA42  GATA32  GATA22  GATA12  TRPS12  
    4 SIMAP similar genes for GATA5 using alignment to 3 protein entries:     GATA5_HUMAN (see all proteins):
    GATA4    GATA6    GATA2    GATA3

    Find genes that share paralogs with GATA5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GATA5 (see all 445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733032921,2
    C,F--57829983(+) TTCAGG/ACCTGT 1 -- int13Minor allele frequency- A:0.02CSA NS WA 673
    rs1865811281,2
    --57830113(+) CAGATA/GCTCCC 1 -- int10--------
    rs759544621,2
    C,F--61038162(+) CAGGCC/TTGTTG 1 -- ds50012Minor allele frequency- T:0.02NS WA 658
    rs1902252261,2
    --61038179(+) ACTGCC/TGAGCC 1 -- ds50010--------
    rs60612411,2
    C,H--61038214(+) CTCTCC/TCAGCC 1 -- ds500112Minor allele frequency- T:0.11NA WA CSA NS EA 928
    rs1139715611,2
    F--61038224(-) GGTCCC/TCAGCG 1 -- ds50011Minor allele frequency- T:0.00NS 558
    rs61216091,2
    C,F,A,H--61038322(+) CAGAAT/CGCAGA 1 -- ds500126Minor allele frequency- C:0.31NS EA NA WA 3034
    rs1824842301,2
    C--61038335(+) ATAGCC/TGGAAA 1 -- ds50010--------
    rs1118636261,2
    F--61038342(-) CTAGCG/AATTTC 1 -- ds50011Minor allele frequency- A:0.00NS 560
    rs1131453151,2
    F--61038423(-) CACCCG/ATGGGG 1 -- ds50011Minor allele frequency- A:0.03NS 560

    HapMap Linkage Disequilibrium report for GATA5 (61038553 - 61051026 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GATA5 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678083CNV Deletion23128226
    esv2722815CNV Deletion23290073
    esv2422398CNV Duplication17116639
    dgv4609n71CNV Loss21882294
    dgv4610n71CNV Loss21882294
    nsv470556CNV Loss18288195
    dgv4603n71CNV Loss21882294
    dgv4608n71CNV Loss21882294
    nsv913083CNV Loss21882294
    nsv913047CNV Loss21882294

    Human Gene Mutation Database (HGMD): GATA5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GATA5
    DNA2.0 Custom Variant and Variant Library Synthesis for GATA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611496    OMIM disorders: --

    UniProtKB/Swiss-Prot: GATA5_HUMAN, Q9BWX5
  • Note=Rare variants in GATA5 may be a cause of susceptibility to atrial fibrillation, a common sustained
    cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and
    ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result
    in palpitations, syncope, thromboembolic stroke, and congestive heart failure

  • 5 diseases for GATA5:    
    About MalaCards
    aortic valve disease    single ventricular septal defect    familial atrial fibrillation    tetralogy of fallot
    atrial fibrillation, familial, 9

    1 disease from the University of Copenhagen DISEASES database for GATA5:
    Familial atrial fibrillation

    Find genes that share disorders with GATA5           About GenesLikeMe

    2 Novoseek inferred disease relationships for GATA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 20.7 3 17167178 (1), 16823849 (1)
    tumors 0 6 17912029 (3), 16823849 (1)


    Export disorders for GATA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GATA5 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with GATA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. (PubMed id 9566909)1, 3, 9 Gao X....Evans T. (Mol. Cell. Biol. 1998)
    2. Mutational spectrum of the GATA5 gene associated with familial atrial fibrillation. of Shanghai Jiaotong University, Shanghai 200030, China. (PubMed id 22483626)1, 2 Yang Y.Q.... Liu X. (Int. J. Cardiol. 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. (PubMed id 20222162)1, 9 Wen X.Z....Deng D.J. (World J. Gastroenterol. 2010)
    6. Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types. (PubMed id 17912029)1, 9 Fu B....Iacobuzio-Donahue C.A. (amp 2007)
    7. p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene. (PubMed id 10567378)1, 9 Kakita T....Sasayama S. (J. Biol. Chem. 1999)
    8. Hypermethylation of the GATA gene family in esophageal cancer. (PubMed id 16823849)1, 9 Guo M....Herman J.G. (Int. J. Cancer 2006)
    9. Hypermethylation of the GATA genes in lung cancer. (PubMed id 15585625)1, 9 Guo M....Brock M.V. (Clin. Cancer Res. 2004)
    10. Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter. (PubMed id 12011060)1, 9 van Wering H.M....Krasinski S.D. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 140628 HGNC: 15802 AceView: GATA5 Ensembl:ENSG00000130700 euGenes: HUgn140628
    ECgene: GATA5 H-InvDB: GATA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GATA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GATA5 gene:
    Search GeneIP for patents involving GATA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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