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Aliases for GATA5 Gene

Aliases for GATA5 Gene

  • GATA Binding Protein 5 2 3
  • GATA-Binding Protein 5 2 3
  • GATA-Binding Factor 5 3 4
  • Transcription Factor GATA-5 3
  • GATA Binding Factor-5 3
  • BB379O24.1 3
  • GATAS 3

External Ids for GATA5 Gene

Previous GeneCards Identifiers for GATA5 Gene

  • GC20M060803
  • GC20M061676
  • GC20M061723
  • GC20M060471
  • GC20M061038
  • GC20M057816

Summaries for GATA5 Gene

Entrez Gene Summary for GATA5 Gene

  • The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]

GeneCards Summary for GATA5 Gene

GATA5 (GATA Binding Protein 5) is a Protein Coding gene. Diseases associated with GATA5 include single ventricular septal defect and familial atrial fibrillation. Among its related pathways are Hemostasis and G-AlphaQ Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GATA3.

UniProtKB/Swiss-Prot for GATA5 Gene

  • Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity).

Gene Wiki entry for GATA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATA5 Gene

Genomics for GATA5 Gene

Regulatory Elements for GATA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GATA5 Gene

Start:
62,463,497 bp from pter
End:
62,475,970 bp from pter
Size:
12,474 bases
Orientation:
Minus strand

Genomic View for GATA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GATA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATA5 Gene

Proteins for GATA5 Gene

  • Protein details for GATA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWX5-GATA5_HUMAN
    Recommended name:
    Transcription factor GATA-5
    Protein Accession:
    Q9BWX5
    Secondary Accessions:
    • D9ZGF7
    • Q17RE2
    • Q86VU4

    Protein attributes for GATA5 Gene

    Size:
    397 amino acids
    Molecular mass:
    41299 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47790.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GATA5 Gene

Proteomics data for GATA5 Gene at MOPED

Post-translational modifications for GATA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GATA5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GATA5 Gene

Domains for GATA5 Gene

Gene Families for GATA5 Gene

HGNC:
  • GATAD :GATA zinc finger domain containing

Suggested Antigen Peptide Sequences for GATA5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWX5

UniProtKB/Swiss-Prot:

GATA5_HUMAN :
  • Q9BWX5
Similarity:
  • Contains 2 GATA-type zinc fingers.
genes like me logo Genes that share domains with GATA5: view

Function for GATA5 Gene

Molecular function for GATA5 Gene

UniProtKB/Swiss-Prot Function:
Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity).

Gene Ontology (GO) - Molecular Function for GATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001158 enhancer sequence-specific DNA binding IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 14986113
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GATA5: view
genes like me logo Genes that share phenotypes with GATA5: view

Animal Models for GATA5 Gene

MGI Knock Outs for GATA5:

Animal Model Products

miRNA for GATA5 Gene

miRTarBase miRNAs that target GATA5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GATA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GATA5 Gene

Localization for GATA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATA5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GATA5 Gene COMPARTMENTS Subcellular localization image for GATA5 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for GATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9566909
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GATA5: view

Pathways for GATA5 Gene

genes like me logo Genes that share pathways with GATA5: view

Pathways by source for GATA5 Gene

2 Qiagen pathways for GATA5 Gene

Gene Ontology (GO) - Biological Process for GATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007596 blood coagulation TAS --
GO:0045893 positive regulation of transcription, DNA-templated --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 14986113
genes like me logo Genes that share ontologies with GATA5: view

Compounds for GATA5 Gene

(2) Novoseek inferred chemical compound relationships for GATA5 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 62.9 2
zinc 33.1 1
genes like me logo Genes that share compounds with GATA5: view

Transcripts for GATA5 Gene

mRNA/cDNA for GATA5 Gene

(30) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GATA5 Gene

GATA binding protein 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GATA5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GATA5 Gene

No ASD Table

Relevant External Links for GATA5 Gene

GeneLoc Exon Structure for
GATA5
ECgene alternative splicing isoforms for
GATA5

Expression for GATA5 Gene

mRNA expression in normal human tissues for GATA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GATA5 Gene

This gene is overexpressed in Bladder (8.4), Testis (6.7), Fallopian Tube (6.5), and Stomach (5.6).

SOURCE GeneReport for Unigene cluster for GATA5 Gene Hs.352250

genes like me logo Genes that share expressions with GATA5: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for GATA5 Gene

Orthologs for GATA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GATA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GATA5 35
  • 81.6 (n)
  • 77.97 (a)
GATA5 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GATA5 35
  • 84.05 (n)
  • 79.13 (a)
GATA5 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gata5 35
  • 79.68 (n)
  • 76.83 (a)
Gata5 16
Gata5 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GATA5 35
  • 99.24 (n)
  • 99.75 (a)
GATA5 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gata5 35
  • 79.09 (n)
  • 77.58 (a)
oppossum
(Monodelphis domestica)
Mammalia GATA5 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GATA5 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves GATA5 35
  • 69.96 (n)
  • 66.58 (a)
GATA5 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GATA5 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gata5 35
  • 64.8 (n)
  • 60.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia GATA-5a 35
zebrafish
(Danio rerio)
Actinopterygii gata5 35
  • 63.11 (n)
  • 60.11 (a)
gata5 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta grn 37
  • 74 (a)
pnr 37
  • 80 (a)
pnr 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea elt-1 37
  • 66 (a)
Species with no ortholog for GATA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GATA5 Gene

ENSEMBL:
Gene Tree for GATA5 (if available)
TreeFam:
Gene Tree for GATA5 (if available)

Paralogs for GATA5 Gene

Paralogs for GATA5 Gene

Selected SIMAP similar genes for GATA5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GATA5: view

Variants for GATA5 Gene

Sequence variations from dbSNP and Humsavar for GATA5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9965 -- 62,463,574(+) AAGTG(G/T)GGCTG utr-variant-3-prime
rs1129471 -- 62,464,125(-) TGTAT(C/T)ATGAC utr-variant-3-prime
rs4073469 -- 62,466,947(-) GTGTC(C/T)TGGCC intron-variant
rs4073470 -- 62,466,760(-) TTGGG(A/G)GGAAA intron-variant
rs4422227 -- 62,471,370(+) TTTTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GATA5 Gene

Variant ID Type Subtype PubMed ID
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
nsv913077 CNV Loss 21882294
dgv4608n71 CNV Loss 21882294
dgv4609n71 CNV Loss 21882294
nsv913083 CNV Loss 21882294
dgv4610n71 CNV Loss 21882294
nsv459068 CNV Gain 19166990
dgv1341e1 CNV Complex 17122850
essv22589 CNV CNV 17122850
esv2722815 CNV Deletion 23290073
esv2678083 CNV Deletion 23128226

Relevant External Links for GATA5 Gene

HapMap Linkage Disequilibrium report
GATA5
Human Gene Mutation Database (HGMD)
GATA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATA5 Gene

Disorders for GATA5 Gene

UniProtKB/Swiss-Prot

GATA5_HUMAN
  • Note=Rare variants in GATA5 may be a cause of susceptibility to atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:22483626, ECO:0000269 PubMed:23175127}.
  • Note=Rare variants in GATA5 may be a cause of susceptibility to Tetraology of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. {ECO:0000269 PubMed:23289003}.
  • Note=Rare variants in GATA5 may be a cause of susceptibility to ventriculoseptal defect (VSD). VSD is a congenital heart disease which may lead to cardiac enlargement, ventricular dysfunction or heart failure, poor quality of life, pulmonary hypertension, Eisenmengers syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death in the absence of surgical treatment or transcatheter repair. {ECO:0000269 PubMed:22961344}.

(1) University of Copenhagen DISEASES for GATA5 Gene

(2) Novoseek inferred disease relationships for GATA5 Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma 20.7 2
tumors 0 4
genes like me logo Genes that share disorders with GATA5: view

No data available for OMIM , Genatlas and External Links for GATA5 Gene

Publications for GATA5 Gene

  1. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. (PMID: 9566909) Gao X. … Evans T. (Mol. Cell. Biol. 1998) 2 3 23
  2. p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene. (PMID: 10567378) Kakita T. … Sasayama S. (J. Biol. Chem. 1999) 3 23
  3. Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. (PMID: 11408257) Krasinski S.D. … Grand R.J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2001) 3 23
  4. Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter. (PMID: 12011060) van Wering H.M. … Krasinski S.D. (J. Biol. Chem. 2002) 3 23
  5. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. (PMID: 14612389) Akiyama Y. … Baylin S.B. (Mol. Cell. Biol. 2003) 3 23

Products for GATA5 Gene

Sources for GATA5 Gene

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