Aliases for GATA3 Gene
External Ids for GATA3 Gene
Previous GeneCards Identifiers for GATA3 Gene
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
GeneCards Summary for GATA3 Gene
GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia and Hypoparathyroidism-Deafness-Renal Disease Syndrome. Among its related pathways are IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Th2 Differentiation Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is GATA2.
UniProtKB/Swiss-Prot for GATA3 Gene
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5-AGATAG-3. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.