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GATA3 Gene

protein-coding GIFtS: 68

GC10P008136

GATA binding protein 3
(Previous name: GATA-binding protein 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
HDR ^¹, ², ⁵
MGC2346 ^²
MGC5199 ^²
MGC5445 ^²
OTTHUMP00000019070 ^²
OTTHUMP00000019071 ^²

Descriptions
GATA binding protein 3 ^²
GATA-binding factor 3 ^³
GATA-binding protein 3 ^¹, ²

External Ids
HGNC: 4172¹
Entrez Gene: 2625²
UniProtKB: P23771³
Ensembl: ENSG00000107485⁷

Search outside databases for aliases for GATA3 gene

Previous GC identifers: GC10P008040 GC10P008246 GC10P008100

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: GATA3_HUMAN, P23771

Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and

delta genes. Binds to the consensus sequence 5'-AGATAG-3'

Gene Wiki entry for GATA3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GATA3 gene

Entrez Gene cytogenetic band: 10p15 Ensembl cytogenetic band: 10p14 HGNC cytogenetic band: 10p15

GATA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P008136: (about GC identifiers)

Start:	8,136,673 bp from pter
End:	8,157,170 bp from pter
Size:	20,498 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_077569.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GATA3_HUMAN, P23771 (See protein sequence)

Recommended Name: Trans-acting T-cell-specific transcription factor GATA-3

Size: 443 amino acids; 47916 Da

Subcellular location: Nucleus

Secondary accessions: Q96J16

Alternative splicing: 2 isoforms: P23771-1 P23771-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001002295.1 NP_002042.1

ENSEMBL proteins:

ENSP00000341619 ENSP00000368632

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GATA3)
	Human Recombinant Proteins from Abnova (GATA3)

OriGene Purified Recombinant Human Proteins (see all 2): GATA3

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for GATA3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GATA3
	R&D Systems Antibodies for GATA3 (GATA-3)
	Antibodies from Abcam (GATA3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GATA3)
	Novus Biologicals Antibodies for GATA3

Assays for GATA3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P23771

ProtoNet protein and cluster: P23771

1 Blocks protein family: IPB000679 Zn-finger

UniProtKB/Swiss-Prot: GATA3_HUMAN, P23771

Similarity: Contains 2 GATA-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GATA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GATA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): BC006793

Applied Biosystems Silencer® siRNAs for GATA3

Sigma-Aldrich siRNA for GATA3

Sigma-Aldrich shRNA Panels and shRNA for GATA3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GATA3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001002295
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001002295
untagged cDNA clones in CMV expression vector (see all 2): NM_001002295

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001002295

UniProtKB/Swiss-Prot: GATA3_HUMAN, P23771

Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and

delta genes. Binds to the consensus sequence 5'-AGATAG-3'

Genatlas biochemistry entry for GATA3:

T cell specific transcription factor,GATA sequence binding protein in T cell receptor,also

expressed in endothelial cell,placenta,transcriptional regulator in kidney,adrenal gland,embryonic

brain,adult nervous system endocardium,associated with a special class of nuclear bodies

15/21 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Gata3) (see all 21 ):

	adipose tissue	craniofacial	embryogenesis	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	nervous system	no phenotypic analysis	normal	pigmentation

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	2050118 8088776
GO:0008134	transcription factor binding	IPI	15016828
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for GATA3 (Your Favorite Gene powered by Ingenuity)

Thrombin Signaling

GeneDecks GATA3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GATA3

5/86 Interacting proteins for GATA3 (ENSP00000368632³) via UniProtKB, MINT, and/or STRING (see all 86 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL4	ENSP00000231449³	STRING (score=.998)
IL5	ENSP00000231454³	STRING (score=.998)
ZBTB32	ENSP00000262630³	STRING (score=.987)
IL10	ENSP00000356066³	STRING (score=.985)
STAT1	ENSP00000354394³	STRING (score=.972)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	1871134
GO:0006952	defense response	TAS	7592673
GO:0007605	sensory perception of sound	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GATA3
10 Novoseek chemical compound relationships for GATA3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	35.42	15	17210674 (2), 18338249 (1), 18445004 (1), 16912130 (1) (see all 11)
ionomycin	28.53	1	15996929 (1)
tgf beta1	17.74	1	16916450 (1)
estradiol	0.00	5	17616709 (3), 10096242 (1)
allergens	0.00	1	18154619 (1)
oligonucleotide	0.00	2	11937547 (1)
lipid	0.00	2	17116754 (1)
progesterone	0.00	2	16357129 (1), 17078870 (1)
tyrosine	0.00	3	15662016 (1), 15699483 (1), 15907913 (1)
cyclic amp	0.00	3	18772129 (2), 16753225 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GATA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GATA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): BC006793

Sigma-Aldrich siRNA for GATA3

Sigma-Aldrich shRNA Panels and shRNA for GATA3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001002295 NM_002051

REFSEQ mRNAs for GATA3 gene (2 alternative transcripts):

NM_001002295.1 NM_002051.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001002295 NM_002051

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001002295
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001002295
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001002295

Additional cDNA sequence:

AK298213.1 BC003070.2 BC006793.1 BC006839.1 M69106.1 X55037.1 X55122.1 X58072.1

7 DOTS entries:

DT.448323 DT.91733280 DT.121225701 DT.97794782 DT.91930736 DT.100776576 DT.91733248

24/166 AceView cDNA sequences (see all 166 ):

H88809 BF594726 BG285517 AA359752 BG619327 BQ068878 BM706223 NM_002051

CB145787 AI972378 BQ882897 NM_001002295 BP429648 AA384707 AA384739 BC003070

AA312327 AI307323 AI686327 BE084816 AA600879 BM785293 BG683464 BQ072011

highest scoring ESTs for GATA3:

X58072 AA025379 AA025380 AA319161 AA319742 AA355987 AA384707 AA384739 AA418167 AA600879

Unigene Cluster for GATA3:

GATA binding protein 3

Hs.524134 [show with all ESTs]

Unigene Representative Sequence: NM_001002295

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GATA3

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b
SP1:
SP2:
SP3:									-

About this scheme

ECgene alternative splicing isoforms for GATA3

2 Ensembl transcripts including schematic representations:

ENST00000346208 ENST00000379328

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GATA3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GATA3

¹ / ² / ³

7 probe-sets matching GATA3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40511_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X58072	1.00	1.00	1.00	1
209604_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003070	0.80	1.00	0.91	1
209602_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI796169	0.80	1.00	0.91	1
209603_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI796169	0.80	1.00	0.91	1
209604_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209602_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209603_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GATA3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGGATGCCA

SOURCE GeneReport for Unigene cluster: Hs.524134
Expression variation in blood from EXPOLDB for GATA3
UniProtKB/Swiss-Prot: GATA3_HUMAN, P23771
Tissue specificity: T-cells and endothelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GATA3 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GATA3¹	--	GATA binding protein 3	90.37(n) 95.49(a)	487134 XM_853059.1 XP_858152.1
chimpanzee (Pan troglodytes)	GATA3¹	--	GATA binding protein 3	99.4(n) 99.77(a)	450296 XM_001149347.1 XP_001149347.1
cow (Bos taurus)	GATA3¹	--	GATA binding protein 3	90.67(n) 96.39(a)	505169 NM_001076804.1 NP_001070272.1
rat (Rattus norvegicus)	Gata3¹	--	GATA binding protein 3	89.84(n) 96.39(a)	85471 NM_133293.1 NP_579827.1
mouse (Mus musculus)	Gata3^{1, 5}	2 (7.00 cM)⁵	GATA binding protein 3^{1, 5}	89.89(n)¹ 96.61(a)¹	14462¹ NM_008091.2¹ NP_032117.1¹ AA759391⁵ AK090089⁵ (see all 26)

About this table Species with no ortholog for GATA3

ENSEMBL Gene Tree for GATA3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GATA3 gene

GATA4² GATA2² GATA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/289 NCBI SNPs in GATA3 are shown (see all 289 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 187)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1058240^1,2	A,C,F,H,O	8156604(+)	`TTGCCA/GTTGAG`	2	--	ut3¹		19	NS MN NA CSAM EA EU WA	1658
	rs2229360^1,2	C,F,H,O	8156085(+)	`CTAAAC/TGCGAT`	2	--	ut3¹ ese³		21	MN EA NS EU WA NA CSAM	3880
	rs412359^1,2	A,C,F	8137567(+)	`CCGCCC/TTCCCT`	2	--	ut5¹ trp³		9	NS MN CSAM EA	1048
	rs11255509^1,2	C,F,H	8157058(+)	`CGGCCC/TGGCTG`	2	--	ut3¹ ese³		9	NS EU EA WA NA	620
--	rs9746^1,2	C,F	8156509(+)	`AAAAGA/GAAAAA`	2	--	ut3¹ trp³		10	EA NS MN CSAM	2610
--	rs11567942^1,2	C,F	8137576(+)	`CTCCCC/TGCGCG`	2	--	ut5¹ trp³		8	NS MN CSAM EA	528
--	rs11567887^1,2	C,F	8137565(+)	`GACCGC/TCYTCC`	2	--	ut5¹ trp³		8	NS MN CSAM EA	520
	rs12782127^1,2	H	8156298(+)	`TACTGT/GACAAT`	2	--	ut3¹ ese³		4	EU EA WA	398
	rs35977416^1,2	F	8157293(+)	`AGGAAC/TCGATG`	2	--	ng3¹		5	MN CSAM EA	408
--	rs1778076^1,2	C	8140652(+)	`GACCGC/AYCTGG`	2	D/A	mis¹ ese³		5	MN CSAM EA	404

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HapMap Linkage Disequilibrium images for GATA3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 131320 disorders: 146255

UniProtKB/Swiss-Prot: GATA3_HUMAN, P23771

Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal

dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome

10/29 Novoseek disease relationships for GATA3 gene (see all 29 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypoparathyroidism	68.63	19	16912130 (4), 15705923 (2), 17210674 (2), 19057839 (2) (see all 9)
renal dysplasia	61.00	5	15705923 (2), 19248180 (1), 19022243 (1)
renal anomaly	58.89	2	16509533 (1), 16319112 (1)
deafness sensorineural	58.58	3	16509533 (1), 19022243 (1)
asthma allergic	52.49	2	9949310 (1), 11295643 (1)
allergic rhinitis	43.77	24	19452711 (6), 18260379 (5), 15563083 (5), 10856149 (2) (see all 7)
asthma	40.07	16	11295643 (3), 16489117 (2), 12900517 (1), 15853749 (1) (see all 11)
lupus nephritis	34.87	1	16461436 (1)
inflammation	28.80	8	18691059 (2), 15907913 (1), 19124555 (1), 19436703 (1) (see all 6)
dermatitis atopic	27.76	6	18410415 (4), 15008986 (2)

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Human Gene Mutation Database: GATA3
Genetic Association Database: GATA3
Human Genome Epidemiology Navigator: GATA3 (18 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/291 PubMed articles for GATA3 gene (see all 291 ):

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. (PubMed id 2050118)^{2, 3, 4} Joulin V.... Romeo P.-H. (1991)
Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. (PubMed id 15087456)^{1, 2, 3} Yamashita M....Nakayama T. (2004)
GATA3 haplo-insufficiency causes human HDR syndrome. (PubMed id 10935639)^{1, 3, 4} Van Esch H.... Devriendt K. (2000)
Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. (PubMed id 15637551)^{3, 6} Pykalainen M....Lahesmaa R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
GATA3 abnormalities and the phenotypic spectrum of HDR syndrome. (PubMed id 11389161)^{3, 4} Muroya K....Ogata T. (2001)
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. (PubMed id 2017177)^{3, 4} Ko L.J.... Engel J.D. (1991)
Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. (PubMed id 1827068)^{3, 4} Ho I.-C....Leiden J.M. (1991)
The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. (PubMed id 1871134)^{3, 4} Marine J. and Winoto A. (1991)
GATA-3 expression in breast cancer has a strong association with estrogen receptor but lacks independent prognostic value. (PubMed id 18268121)^{1, 3} Voduc D....Nielsen T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2625	HGNC: 4172	AceView: GATA3	Ensembl:ENSG00000107485	euGenes: HUgn2625
ECgene: GATA3	H-InvDB: GATA3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GATA3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=GATA3
SeattleSNPs	http://pga.gs.washington.edu/data/gata3/

Licensable Technologies for GATA3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GATA3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GATA3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GATA3		Antibodies for GATA3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GATA3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	shRNA in GFP-retroviral vector

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
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GATA3 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for GATA3

Summaries
for GATA3

Genomic Location
for GATA3

Proteins
for GATA3

Protein Domains/
Families
for GATA3

Gene Function
for GATA3

Pathways & Interactions
for GATA3

Drugs & Compounds
for GATA3

Transcripts
for GATA3

Expression
for GATA3

Orthologs
for GATA3

Paralogs
for GATA3

SNPs/Variants
for GATA3

Disorders & Mutations
for GATA3

Medical News
for GATA3

Publications
for GATA3

Search for GATA3

Genome Databases showing GATA3

Other Databases showing GATA3

Specialized Databases showing GATA3

Licensable Technologies
for GATA3

Services
for GATA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GATA3 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor GATA3

Summariesfor GATA3

Genomic Locationfor GATA3

Proteinsfor GATA3

Protein Domains/Familiesfor GATA3

Gene Functionfor GATA3

Pathways & Interactionsfor GATA3

Drugs & Compoundsfor GATA3

Transcriptsfor GATA3

Expression for GATA3

Orthologsfor GATA3

Paralogsfor GATA3

SNPs/Variantsfor GATA3

Disorders & Mutationsfor GATA3

Medical Newsfor GATA3

Publicationsfor GATA3

Search for GATA3

Genome Databases showing GATA3

Other Databases showing GATA3

Specialized Databases showing GATA3

Licensable Technologiesfor GATA3

Servicesfor GATA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GATA3

Summaries
for GATA3

Genomic Location
for GATA3

Proteins
for GATA3

Protein Domains/
Families
for GATA3

Gene Function
for GATA3

Pathways & Interactions
for GATA3

Drugs & Compounds
for GATA3

Transcripts
for GATA3

Expression
for GATA3

Orthologs
for GATA3

Paralogs
for GATA3

SNPs/Variants
for GATA3

Disorders & Mutations
for GATA3

Medical News
for GATA3

Publications
for GATA3

Licensable Technologies
for GATA3

Services
for GATA3