Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GATA3 Gene

Aliases for GATA3 Gene

  • GATA Binding Protein 3 2 3
  • GATA-Binding Factor 3 3 4
  • HDRS 3 6
  • HDR 3 6
  • Trans-Acting T-Cell-Specific Transcription Factor GATA-3 3
  • GATA-Binding Protein 3 2

External Ids for GATA3 Gene

Summaries for GATA3 Gene

Entrez Gene Summary for GATA3 Gene

  • This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]

GeneCards Summary for GATA3 Gene

GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include hypoparathyroidism, sensorineural deafness, and renal dysplasia and renal dysplasia. Among its related pathways are Hemostasis and Glucocorticoid receptor regulatory network. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is GATA5.

UniProtKB/Swiss-Prot for GATA3 Gene

  • Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5-AGATAG-3. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.

Gene Wiki entry for GATA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATA3 Gene

Genomics for GATA3 Gene

Genomic Location for GATA3 Gene

8,045,473 bp from pter
8,075,201 bp from pter
29,729 bases
Plus strand

Genomic View for GATA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GATA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATA3 Gene

Regulatory Elements for GATA3 Gene

Transcription factor binding sites by QIAGEN in the GATA3 gene promoter:

Proteins for GATA3 Gene

  • Protein details for GATA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trans-acting T-cell-specific transcription factor GATA-3
    Protein Accession:
    Secondary Accessions:
    • Q5VWG7
    • Q5VWG8
    • Q96J16

    Protein attributes for GATA3 Gene

    443 amino acids
    Molecular mass:
    47916 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GATA3 Gene

    Alternative splice isoforms for GATA3 Gene


neXtProt entry for GATA3 Gene

Proteomics data for GATA3 Gene at MOPED

Post-translational modifications for GATA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GATA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GATA3 Gene

Domains for GATA3 Gene

Gene Families for GATA3 Gene

  • GATAD :GATA zinc finger domain containing

Protein Domains for GATA3 Gene


  • Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation:
    • P23771
  • The YxKxHxxxRP motif is critical for DNA-binding and function.:
    • P23771
  • Contains 2 GATA-type zinc fingers.:
    • P23771
genes like me logo Genes that share domains with GATA3: view

Function for GATA3 Gene

Molecular function for GATA3 Gene

GENATLAS Biochemistry: T cell specific transcription factor,GATA sequence binding protein in T cell receptor,also expressed in endothelial cell,placenta,transcriptional regulator in kidney,adrenal gland,embryonic brain,adult nervous system endocardium,associated with a special class of nuclear bodies
UniProtKB/Swiss-Prot Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5-AGATAG-3. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.

Gene Ontology (GO) - Molecular Function for GATA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 19723756
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000987 core promoter proximal region sequence-specific DNA binding IDA 19232384
GO:0001046 core promoter sequence-specific DNA binding IDA 19674970
genes like me logo Genes that share ontologies with GATA3: view
genes like me logo Genes that share phenotypes with GATA3: view

Animal Models for GATA3 Gene

MGI Knock Outs for GATA3:

miRNA for GATA3 Gene

miRTarBase miRNAs that target GATA3
Targeting motifs for GATA3 Gene
HOMER Transcription Factor Regulatory Elements motif GATA3
  • Consensus sequence: AGATAASR Submotif: canonical Cell Type: iTreg GeoId: GSE20898

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for GATA3 Gene

Localization for GATA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATA3 Gene

Subcellular locations from

Jensen Localization Image for GATA3 Gene COMPARTMENTS Subcellular localization image for GATA3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GATA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 20855495
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with GATA3: view

Pathways for GATA3 Gene

genes like me logo Genes that share pathways with GATA3: view

Pathways by source for GATA3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for GATA3 Gene
2 Qiagen pathways for GATA3 Gene
1 Cell Signaling Technology pathway for GATA3 Gene

Gene Ontology (GO) - Biological Process for GATA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000902 cell morphogenesis --
GO:0001701 in utero embryonic development IEA --
GO:0001709 cell fate determination ISS --
GO:0001764 neuron migration IEA --
genes like me logo Genes that share ontologies with GATA3: view

Compounds for GATA3 Gene

(15) Novoseek inferred chemical compound relationships for GATA3 Gene

Compound -log(P) Hits PubMed IDs
zinc 31.7 12
ionomycin 25.6 1
estrogen 24 17
tgf beta1 13.8 1
lipid 5.27 1

(13) PharmGKB related drug/compound annotations for GATA3 Gene

genes like me logo Genes that share compounds with GATA3: view

Transcripts for GATA3 Gene

Unigene Clusters for GATA3 Gene

GATA binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GATA3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP3: -

Relevant External Links for GATA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GATA3 Gene

mRNA expression in normal human tissues for GATA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GATA3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (15.6), Skin - Not Sun Exposed (Suprapubic) (15.0), Bladder (7.0), and Breast - Mammary Tissue (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GATA3 Gene

SOURCE GeneReport for Unigene cluster for GATA3 Gene Hs.524134

mRNA Expression by UniProt/SwissProt for GATA3 Gene

Tissue specificity: T-cells and endothelial cells
genes like me logo Genes that share expressions with GATA3: view

Orthologs for GATA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GATA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GATA3 36
  • 99.4 (n)
  • 99.77 (a)
GATA3 37
  • 100 (a)
(Bos Taurus)
Mammalia GATA3 36
  • 90.67 (n)
  • 96.39 (a)
GATA3 37
  • 96 (a)
(Canis familiaris)
Mammalia GATA3 36
  • 91.5 (n)
  • 96.84 (a)
GATA3 37
  • 97 (a)
(Mus musculus)
Mammalia Gata3 36
  • 89.89 (n)
  • 96.61 (a)
Gata3 16
Gata3 37
  • 97 (a)
(Monodelphis domestica)
Mammalia GATA3 37
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia GATA3 37
  • 81 (a)
(Rattus norvegicus)
Mammalia Gata3 36
  • 89.84 (n)
  • 96.39 (a)
(Gallus gallus)
Aves GATA3 36
  • 83.45 (n)
  • 92.33 (a)
GATA3 37
  • 92 (a)
(Anolis carolinensis)
Reptilia GATA3 37
  • 92 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.793 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gata3 36
  • 76.54 (n)
  • 82.18 (a)
Str.10665 36
(Danio rerio)
Actinopterygii gata3 36
  • 75 (n)
  • 81.48 (a)
gata3 37
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta grn 37
  • 26 (a)
grn 38
  • 86 (a)
pnr 38
  • 78 (a)
(Caenorhabditis elegans)
Secernentea elt-1 37
  • 25 (a)
elt-1 38
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL80 37
  • 15 (a)
GAT1 37
  • 15 (a)
GLN3 37
  • 11 (a)
GZF3 37
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
Species with no ortholog for GATA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GATA3 Gene

Gene Tree for GATA3 (if available)
Gene Tree for GATA3 (if available)

Paralogs for GATA3 Gene

Paralogs for GATA3 Gene

Selected SIMAP similar genes for GATA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GATA3: view

Variants for GATA3 Gene

Sequence variations from dbSNP and Humsavar for GATA3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9746 -- 8,074,540(+) AAAAG(A/G)AAAAA utr-variant-3-prime
rs11128 -- 8,074,383(+) AGAAG(A/T)TTAAG utr-variant-3-prime
rs196526 -- 8,073,518(+) ACAAT(C/T)GTACT intron-variant
rs263423 -- 8,047,070(+) CATTT(A/G)CACCC intron-variant
rs263424 -- 8,046,691(+) TGTGT(C/G)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GATA3 Gene

Variant ID Type Subtype PubMed ID
nsv894851 CNV Loss 21882294
nsv831780 CNV Loss 17160897
nsv5754 CNV Insertion 18451855
nsv517198 CNV Loss 19592680
dgv610n71 CNV Loss 21882294
esv1000455 CNV Deletion 20482838
dgv118e199 CNV Deletion 23128226
nsv894854 CNV Loss 21882294
nsv894855 CNV Loss 21882294

Relevant External Links for GATA3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for GATA3 Gene

(1) OMIM Diseases for GATA3 Gene (131320)


  • Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255]: A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia. {ECO:0000269 PubMed:10935639, ECO:0000269 PubMed:11389161}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(31) Novoseek inferred disease relationships for GATA3 Gene

Disease -log(P) Hits PubMed IDs
hypoparathyroidism 70 16
renal dysplasia 67.6 5
deafness sensorineural 61.6 2
renal anomaly 56 2
asthma allergic 51.5 2

Relevant External Links for GATA3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GATA3: view

Publications for GATA3 Gene

  1. GATA3 haplo-insufficiency causes human HDR syndrome. (PMID: 10935639) Van Esch H. … Devriendt K. (Nature 2000) 3 4 23
  2. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. (PMID: 15087456) Yamashita M. … Nakayama T. (J. Biol. Chem. 2004) 2 3 23
  3. Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status. (PMID: 18006915) Garcia-Closas M. … Perou C.M. (Cancer Epidemiol. Biomarkers Prev. 2007) 3 23 49
  4. Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort. (PMID: 18037162) Huebner M. … Arshad S.H. (J. Allergy Clin. Immunol. 2008) 3 23 49
  5. Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood. (PMID: 18410415) Arshad S.H. … Ewart S. (Br. J. Dermatol. 2008) 3 23 49

Products for GATA3 Gene

Sources for GATA3 Gene

Back to Top