Aliases for GATA3 Gene
External Ids for GATA3 Gene
Previous GeneCards Identifiers for GATA3 Gene
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
GeneCards Summary for GATA3 Gene
GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include hypoparathyroidism - deafness - renal disease and hypoparathyroidism, sensorineural deafness, and renal dysplasia. Among its related pathways are Hemostasis and Glucocorticoid receptor regulatory network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is GATA5.
UniProtKB/Swiss-Prot for GATA3 Gene
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5-AGATAG-3. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.