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GATA1 Gene

protein-coding   GIFtS: 69

GC0XP048529
GATA binding protein 1 (globin transcription factor 1)
(Previous name: GATA-binding protein 1 (globin transcription factor 1) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GF1)
Services    

Aliases &
Descriptions
for GATA1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ERYF1 1, 2, 3, 5
Eryf1 3
GATA-1 3
GF-1 2, 3
GF1 2, 3, 5
NFE1 1, 2, 5
OTTHUMP00000023259 2
XLTT 2, 5
Descriptions
GATA binding protein 1 2
GATA binding protein 1 (globin transcription factor 1) 2
GATA-binding factor 1 3
GATA-binding protein 1 (globin transcription factor 1) 1
NF-E1 DNA-binding protein 2, 3
erythroid transcription factor 1 2
globin transcription factor 1 2
transcription factor GATA1 2
External Ids
HGNC: 41701
Entrez Gene: 26232
UniProtKB: P159763
Ensembl: ENSG000001021457
Search outside databases for aliases for GATA1 gene

Previous GC identifers: GC0XP047447 GC0XP046905 GC0XP047690 GC0XP048401

Summaries
for GATA1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for GATA1:
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein
plays an important role in erythroid development by regulating the switch of fetal hemoglobin to
adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic
anemia and thrombocytopenia. [provided by RefSeq]

UniProtKB/Swiss-Prot: GATA1_HUMAN, P15976
Function: Transcriptional activator which probably serves as a general switch factor for erythroid
development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory
regions of globin genes and of other genes expressed in erythroid cells

Gene Wiki entry for GATA1

Genomic Location
for GATA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the GATA1 gene  

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

GATA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048529:     (about GC identifiers)

Start:
 48,529,906 bp from pter
End:
 48,537,662 bp from pter
Size:
 7,757 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000023.9  NT_079573.3  

Proteins
for GATA1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: GATA1_HUMAN, P15976 (See protein sequence)
Recommended Name: Erythroid transcription factor  
Size: 413 amino acids; 42751 Da
Subunit: Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts
with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a
sumoylation-independent manner (By similarity)
Subcellular location: Nucleus
Secondary accessions: Q96GB8
Alternative splicing: 2 isoforms:  P15976-1   P15976-2   

Post-translational modifications:

  • Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid
    differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137 (By similarity)1
  • Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4.
    Sumoylation by SUMO1 has no effect on transcriptional activity (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002040.1  

    ENSEMBL proteins: 
    ENSP00000365858 ENSP00000365853 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (GATA1)
    Human Recombinant Proteins from Abnova (GATA1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS2300555
    GO:0005730 nucleolus IDA18029348
    About this table

    Antibodies for GATA1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for GATA1
    R&D Systems Antibodies for GATA1 (GATA-1)
    Cell Signaling Technology (CST) Antibodies for GATA1 (GATA1, GATA-1)
    Antibodies from Abcam (GATA1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (GATA1)
    Novus Biologicals Antibodies for GATA1

    Assays for GATA1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for GATA1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR013088 Znf_NHR/GATA
     IPR016374 TF_GATA-1/2/3
     IPR000679 Znf_GATA


       GeneDecks  GATA1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P15976

    ProtoNet protein and cluster: P15976

    1 Blocks protein family: IPB000679 Zn-finger

    UniProtKB/Swiss-Prot: GATA1_HUMAN, P15976
    Domain: The two fingers are functionally distinct and cooperate to achieve specific, stable DNA
    binding. The first finger is necessary only for full specificity and stability of binding, whereas
    the second one is required for binding (By similarity)
    Similarity: Contains 2 GATA-type zinc fingers

    Gene Function
    for GATA1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (GATA1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GATA1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002049

                  Applied Biosystems Silencer® siRNAs for GATA1

                  Sigma-Aldrich siRNA for GATA1  
                         Sigma-Aldrich shRNA for GATA1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for GATA1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002049
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002049
                                     untagged cDNA clone in CMV expression vector: NM_002049 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002049

    UniProtKB/Swiss-Prot: GATA1_HUMAN, P15976
    Function: Transcriptional activator which probably serves as a general switch factor for erythroid
    development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory
    regions of globin genes and of other genes expressed in erythroid cells

    Genatlas biochemistry entry for GATA1:
    erythroid specific transcription factor,GATA sequence binding protein (same as EryF1,NF-E1,EF-1,EF
    gamma-a,GF1),expressed in RBC,mast cell,megakaryocyte,hematopoietic progenitor
    cell,testis,associated with a special class of nuclear bodies,activated by
    erythropoietin,inactivated by coactivation of DEATH receptors (TNFRSF6) mediated caspase cleavage

    13 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Gata1):

    cellularembryogenesisgrowth/sizehematopoietic system
    homeostasis/metabolismimmune systemlethality-prenatal/perinatallife span-post-weaning/agingliver/biliary system
    normalskeletonskin/coat/nails

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity TAS2104960
    GO:0008270 zinc ion binding IEA--
    GO:0043565 sequence-specific DNA binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for GATA1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    2 Invitrogen iPath™ Online BioAtlas - Pathways for GATA1 (Maps provided by GeneGo):
     Transcription regulation of granulocyte development
     Transcription regulation of aminoacid metabolism

       GeneDecks  GATA1 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  GATA1  (Your Favorite Gene powered by Ingenuity) 
     Thrombin Signaling

       GeneDecks  GATA1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  GATA1 


    5/123 Interacting proteins for GATA1 (ENSP000003658583 P159762) via UniProtKB, MINT, and/or STRING (see all 123 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS27AP629882MINT-2840161
    RPS27AP11P629882MINT-2840161
    RPS27AP12P629882MINT-2840161
    RPS27AP16P629882MINT-2840161
    UBA52P629882MINT-2840161
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006357 regulation of transcription from RNA polymerase II promoter TAS2300555
    GO:0007275 multicellular organismal development TAS2467208
    About this table

    Drugs & Compounds
    for GATA1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for GATA1
    10/14 Novoseek chemical compound relationships for GATA1 gene (see all 14 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    aclacinomycin 78.87 11 8639908 (2), 8853898 (2), 9389364 (2), 8445949 (1) (see all 6)
    porphobilinogen 67.29 7 10207080 (1), 2266112 (1), 8445949 (1), 14757314 (1) (see all 7)
    zinc 58.68 50 7739529 (4), 11809723 (2), 12724402 (2), 15659837 (2) (see all 32)
    uroporphyrinogen-iii 36.67 1 11254675 (1)
    5-aminolevulinic acid 26.96 3 10207080 (1), 10828046 (1), 11675336 (1)
    oligonucleotide 17.03 7 1515647 (2), 9028940 (1), 10402242 (1), 1370462 (1)
    12-o-tetradecanoylphorbol 13-acetate 15.48 4 8562972 (2), 14623254 (1)
    cytidine 12.59 7 15687366 (2), 14744791 (1), 19260099 (1)
    progesterone 4.90 4 12490288 (4)
    thromboxane 0.00 1 12694255 (1)
    About this table


    Transcripts
    for GATA1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (GATA1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (GATA1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002049

                  Sigma-Aldrich siRNA for GATA1  
                         Sigma-Aldrich shRNA for GATA1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002049  

    REFSEQ mRNAs for GATA1 gene: 

    NM_002049.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002049  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002049
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002049
                                     untagged cDNA clone in CMV expression vector: NM_002049 

    Additional cDNA sequence: 

    BC009797.1 M30601.1 X17254.1 

    3 DOTS entries:

    DT.109910  DT.121306319  DT.95263420 

    18 AceView cDNA sequences:

    BG492904 BX644853 BI836762 BX090462 BX644559 BF212679 BF183877 NM_002049 
    X17254 BC009797 BI769078 M30601 BF210926 BF211536 R06500 T80715 
    N73047 BQ182134 

    highest scoring ESTs for GATA1:

    X17254 AI057349 AI076656 AI355322 BQ182134 M30601 N53684 R06446 BC009797 BF211536 

    Unigene Cluster for GATA1:

    GATA binding protein 1 (globin transcription factor 1)
    Hs.765  [show with all ESTs]
    Unigene Representative Sequence: NM_002049


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000376670  ENST00000376665  

    Expression
    for GATA1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    GATA1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for GATA1

    1 / 2 / 3

    4 probe-sets matching GATA1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36787_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X17254 1.00 1.00 1.00 1

    		210446_at2, 3 U133-A 1 1.00 1.00 -- -- M30601 0.80 1.00 0.91 1

    		210446_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1555590_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  GATA1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCTCCAGAG

    SOURCE GeneReport for Unigene cluster: Hs.765

    Expression variation in blood from EXPOLDB for GATA1

    UniProtKB/Swiss-Prot: GATA1_HUMAN, P15976
    Tissue specificity: Erythrocytes

    Orthologs
    for GATA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for GATA1 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 GATA11   -- GATA binding protein 1 (globin transcription factor more 89.89(n)
    95.15(a)    		 480906  XM_538026.2  XP_538026.2 
    chimpanzee
    (Pan troglodytes)    		 GATA11   -- GATA binding protein 1 (globin transcription factor more 92.18(n)
    91.33(a)    		 738894  XM_001139973.1  XP_001139973.1 
    cow
    (Bos taurus)    		 GATA11   -- GATA binding protein 1 (globin transcription factor more 88.3(n)
    92.74(a)    		 516066  XM_868355.2  XP_873448.1 
    rat
    (Rattus norvegicus)    		 Gata11   -- GATA binding protein 1 84.83(n)
    86.2(a)    		 25172  NM_012764.1  NP_036896.1 
    mouse
    (Mus musculus)    		 Gata11, 5 X (1.90 cM)5
    		 GATA binding protein 11, 5 83.29(n)1
    85.96(a)1    		 144601  NM_008089.11  NP_032115.11 
     AA0029745  AK1469155  (see all 10)
    About this table        Species with no ortholog for GATA1

    ENSEMBL Gene Tree for GATA1

    Paralogs
    for GATA1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for GATA1 gene
    GATA42  GATA32  GATA22  

    SNPs/Variants
    for GATA1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/17 NCBI SNPs in GATA1 are shown (see all 17 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 27)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs128410231,2
    		H48534511(+) CCCCAG/CTTTGT 1 H/Q mis14Minor allele frequency- C:0.00EU EA WA 416
    rs59067091,2
    		A,C,F,H48531850(+) AGCAAA/GACACT 1 -- int111Minor allele frequency- G:0.32EU EA WA NA 873
    rs22939501,2
    		H48536321(+) CCCCAT/CAGAAT 1 -- int14Minor allele frequency- C:0.00EU EA WA 418
    rs11265811,2
    		--48537576(+) GAATTC/TTGGAC 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs11265821,2
    		--48537593(+) AGTCTC/TTGGGC 1 -- ut31 ese30--------
    --
    rs596097881,2
    		--48535453(+) CCCCAA/GTAGTG 1 N/S mis10--------
    --
    rs353813311,2
    		--48528051(-) ACCCC-/AAATAA 1 -- ng510--------
    rs617534291,2
    		--48534661(+) GCTGAA/GGCCTA 1 E/E syn10--------
    rs617359691,2
    		--48537446(+) CCCACA/GGGCTC 1 T/T syn10--------
    --
    rs664801601,2
    		--48534373(+) GAGGA-/GAGAGG 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for GATA1 (up to first 250kb)

    Disorders & Mutations
    for GATA1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 305371

    UniProtKB/Swiss-Prot: GATA1_HUMAN, P15976

  • Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia
    (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and
    shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and
    abnormally small megakaryocytes
  • Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT)
    [MIM:314050]; also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin
    synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia.
    Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due
    to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling
    that of beta-thalassemia minor

    • 10/41 Novoseek disease relationships for GATA1 gene (see all 41 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    megakaryoblastic leukemia acute 92.64 33 16628190 (2), 19119459 (2), 14636651 (2), 12586620 (1) (see all 24)
    dyserythropoietic anemia 83.36 7 11809723 (1), 16103636 (1), 16158817 (1), 17538848 (1) (see all 5)
    erythroleukemia 81.32 19 7722440 (2), 9808054 (2), 1569944 (1), 8443382 (1) (see all 16)
    down syndrome 75.63 93 15390279 (3), 12747884 (3), 12816863 (3), 15686466 (3) (see all 54)
    myeloproliferative disorders 74.75 18 15686466 (2), 14636651 (2), 15390312 (1), 16628190 (1) (see all 15)
    thrombocytopenia 1 72.05 9 14656885 (2), 11675338 (2), 16158817 (1), 12200364 (1) (see all 5)
    leukemia 64.16 67 12747884 (4), 7579412 (4), 15390279 (3), 8199039 (3) (see all 37)
    leukemogenesis 64.14 11 12560215 (2), 14512321 (1), 12832487 (1), 12816863 (1) (see all 7)
    gray platelet syndrome 62.72 1 17209061 (1)
    acute leukemia 58.05 19 14636651 (3), 8035609 (2), 7780155 (2), 10360378 (1) (see all 14)
    About this table

    GeneTests: GATA1
    GATA1-Related Cytopenia

    Human Gene Mutation Database: GATA1
    Genetic Association Database: GATA1
    Human Genome Epidemiology Navigator: GATA1 (6 documents)

    Medical News
    for GATA1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for GATA1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/526 PubMed articles for GATA1 gene (see all 526 ):

    Search for GATA1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GATA1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 2623 HGNC: 4170 AceView: GATA1.1 Ensembl:ENSG00000102145 euGenes: HUgn2623
    ECgene: GATA1 H-InvDB: GATA1

    Other Databases showing GATA1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing GATA1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for GATA1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.genetests.org/query?gene=GATA1

    Licensable Technologies
    for GATA1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for GATA1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GATA1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GATA1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for GATA1 Antibodies for GATA1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GATA1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (GATA1)
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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for GATA1 (GATA1, GATA-1)

     Recombinant Proteins
    (GATA1)
     Antibodies (GATA1)
     Search OriGene for GATA1
     Search Tocris compounds for GATA1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for GATA1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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