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Aliases for GAST Gene

Aliases for GAST Gene

  • Gastrin 2 3
  • Preprogastrin 2 3
  • GAS 3 4
  • GAS, 6

External Ids for GAST Gene

Previous Symbols for GAST Gene

  • GAS

Summaries for GAST Gene

Entrez Gene Summary for GAST Gene

  • Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAST Gene

GAST (Gastrin) is a Protein Coding gene. Diseases associated with GAST include gastric mucosal hypertrophy and collagenous gastritis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for GAST Gene

  • Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine

Gene Wiki entry for GAST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAST Gene

Genomics for GAST Gene

Genomic Location for GAST Gene

Start:
41,712,326 bp from pter
End:
41,715,969 bp from pter
Size:
3,644 bases
Orientation:
Plus strand

Genomic View for GAST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAST Gene

Regulatory Elements for GAST Gene

Proteins for GAST Gene

  • Protein details for GAST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01350-GAST_HUMAN
    Recommended name:
    Gastrin
    Protein Accession:
    P01350
    Secondary Accessions:
    • P78463
    • P78464

    Protein attributes for GAST Gene

    Size:
    101 amino acids
    Molecular mass:
    11394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAST Gene

Proteomics data for GAST Gene at MOPED

Post-translational modifications for GAST Gene

  • Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAST Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GAST Gene

Domains for GAST Gene

Gene Families for GAST Gene

HGNC:

Protein Domains for GAST Gene

Suggested Antigen Peptide Sequences for GAST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01350

UniProtKB/Swiss-Prot:

GAST_HUMAN
Family:
  • Belongs to the gastrin/cholecystokinin family.:
    • P01350
genes like me logo Genes that share domains with GAST: view

Function for GAST Gene

Molecular function for GAST Gene

UniProtKB/Swiss-Prot Function: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine

LifeMap Function Summary for GAST Gene

It affects the following cells:

Gene Ontology (GO) - Molecular Function for GAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 19664057
genes like me logo Genes that share ontologies with GAST: view
genes like me logo Genes that share phenotypes with GAST: view

Animal Models for GAST Gene

MGI Knock Outs for GAST:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GAST Gene

Localization for GAST Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAST Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAST Gene COMPARTMENTS Subcellular localization image for GAST gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with GAST: view

Pathways for GAST Gene

genes like me logo Genes that share pathways with GAST: view

Gene Ontology (GO) - Biological Process for GAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 7488110
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GAST: view

Compounds for GAST Gene

(143) Novoseek inferred chemical compound relationships for GAST Gene

Compound -log(P) Hits PubMed IDs
pro-gastrin 94.8 136
gastrin 17 88.4 9
preprogastrin 83.4 5
pepsinogen 83.3 83
omeprazole 81.8 92
genes like me logo Genes that share compounds with GAST: view

Transcripts for GAST Gene

mRNA/cDNA for GAST Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAST Gene

Gastrin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAST Gene

No ASD Table

Relevant External Links for GAST Gene

GeneLoc Exon Structure for
GAST
ECgene alternative splicing isoforms for
GAST

Expression for GAST Gene

mRNA expression in normal human tissues for GAST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAST Gene

This gene is overexpressed in Stomach (48.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GAST Gene

SOURCE GeneReport for Unigene cluster for GAST Gene Hs.2681

genes like me logo Genes that share expressions with GAST: view

No data available for mRNA Expression by UniProt/SwissProt for GAST Gene

Orthologs for GAST Gene

This gene was present in the common ancestor of mammals.

Orthologs for GAST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAST 35
  • 100 (n)
  • 100 (a)
GAST 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAST 35
  • 82.49 (n)
  • 69.7 (a)
GAST 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAST 35
  • 87.54 (n)
  • 80.81 (a)
GAST 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gast 35
  • 80.67 (n)
  • 70 (a)
Gast 16
Gast 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAST 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gast 35
  • 76.9 (n)
  • 70.3 (a)
Species with no ortholog for GAST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAST Gene

ENSEMBL:
Gene Tree for GAST (if available)
TreeFam:
Gene Tree for GAST (if available)

Paralogs for GAST Gene

No data available for Paralogs for GAST Gene

Variants for GAST Gene

Sequence variations from dbSNP and Humsavar for GAST Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4290525 -- 41,715,774(+) CCTCC(A/T)CAGAC intron-variant
rs4796683 -- 41,711,947(+) CCATC(A/G)GGTTC upstream-variant-2KB
rs4796684 -- 41,715,183(+) TAGTC(A/C)CAGAT intron-variant
rs5014485 -- 41,714,848(+) CAGAA(A/C)CTAGG intron-variant
rs7209476 -- 41,712,360(+) AGCCG(C/T)GGCAC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GAST Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
dgv962e1 CNV Complex 17122850

Relevant External Links for GAST Gene

HapMap Linkage Disequilibrium report
GAST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAST Gene

Disorders for GAST Gene

(96) Novoseek inferred disease relationships for GAST Gene

Disease -log(P) Hits PubMed IDs
zollinger-ellison syndrome 93.9 47
gastrinoma 93.7 98
gastritis atrophic 88 56
duodenal ulcer 86.2 146
gastritis 85.6 96
genes like me logo Genes that share disorders with GAST: view

No data available for UniProtKB/Swiss-Prot for GAST Gene

Publications for GAST Gene

  1. Post-poly(Glu) cleavage and degradation modified by O-sulfated tyrosine: a novel post-translational processing mechanism. (PMID: 7530658) Rehfeld J.F. … Johnsen A.H. (EMBO J. 1995) 3 4 23
  2. Identification of gastrin component I as gastrin-71. The largest possible bioactive progastrin product. (PMID: 8055952) Rehfeld J.F. … Johnsen A.H. (Eur. J. Biochem. 1994) 3 4 23
  3. Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. (PMID: 8504433) Finley G.G. … Meisler A.I. (Cancer Res. 1993) 3 23
  4. Quantitative analysis of gastrin mRNA and peptide in normal and cancerous human pancreas. (PMID: 9855703) Smith J.P. … Zagon I.S. (Int. J. Mol. Med. 1998) 3 23
  5. A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. (PMID: 9645429) Kimoto Y. (Mol. Gen. Genet. 1998) 3 23

Products for GAST Gene

Sources for GAST Gene

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