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Aliases for GAST Gene

Aliases for GAST Gene

  • Gastrin 2 3 5
  • Preprogastrin 2 3
  • GAS 3 4

External Ids for GAST Gene

Previous HGNC Symbols for GAST Gene

  • GAS

Previous GeneCards Identifiers for GAST Gene

  • GC17P037124
  • GC17P039868
  • GC17P035631

Summaries for GAST Gene

Entrez Gene Summary for GAST Gene

  • Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAST Gene

GAST (Gastrin) is a Protein Coding gene. Diseases associated with GAST include gastritis and duodenal ulcer. Among its related pathways are Salivary secretion and VEGF Pathway (Qiagen). GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for GAST Gene

  • Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

Gene Wiki entry for GAST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAST Gene

Genomics for GAST Gene

Regulatory Elements for GAST Gene

Enhancers for GAST Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GAST on UCSC Golden Path with GeneCards custom track

Genomic Location for GAST Gene

Chromosome:
17
Start:
41,712,326 bp from pter
End:
41,715,969 bp from pter
Size:
3,644 bases
Orientation:
Plus strand

Genomic View for GAST Gene

Genes around GAST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAST Gene

Proteins for GAST Gene

  • Protein details for GAST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01350-GAST_HUMAN
    Recommended name:
    Gastrin
    Protein Accession:
    P01350
    Secondary Accessions:
    • P78463
    • P78464

    Protein attributes for GAST Gene

    Size:
    101 amino acids
    Molecular mass:
    11394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAST Gene

Proteomics data for GAST Gene at MOPED

Post-translational modifications for GAST Gene

  • Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAST Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAST Gene

Domains & Families for GAST Gene

Gene Families for GAST Gene

Protein Domains for GAST Gene

Suggested Antigen Peptide Sequences for GAST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01350

UniProtKB/Swiss-Prot:

GAST_HUMAN :
  • Belongs to the gastrin/cholecystokinin family.
Family:
  • Belongs to the gastrin/cholecystokinin family.
genes like me logo Genes that share domains with GAST: view

Function for GAST Gene

Molecular function for GAST Gene

UniProtKB/Swiss-Prot Function:
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

LifeMap Function Summary for GAST Gene

It affects the following cells:
genes like me logo Genes that share phenotypes with GAST: view

Animal Models for GAST Gene

MGI Knock Outs for GAST:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GAST Gene

Localization for GAST Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAST Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAST Gene COMPARTMENTS Subcellular localization image for GAST gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
nucleus 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with GAST: view

Pathways & Interactions for GAST Gene

genes like me logo Genes that share pathways with GAST: view

SIGNOR curated interactions for GAST Gene

Activates:

Gene Ontology (GO) - Biological Process for GAST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0032094 response to food IBA --
genes like me logo Genes that share ontologies with GAST: view

Drugs & Compounds for GAST Gene

(83) Drugs for GAST Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
G17DT Investigational Pharma 0

(61) Additional Compounds for GAST Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GAST: view

Transcripts for GAST Gene

mRNA/cDNA for GAST Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAST Gene

Gastrin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAST Gene

No ASD Table

Relevant External Links for GAST Gene

GeneLoc Exon Structure for
GAST
ECgene alternative splicing isoforms for
GAST

Expression for GAST Gene

mRNA expression in normal human tissues for GAST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAST Gene

This gene is overexpressed in Stomach (x48.5).

Protein differential expression in normal tissues from HIPED for GAST Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GAST Gene



SOURCE GeneReport for Unigene cluster for GAST Gene Hs.2681

genes like me logo Genes that share expression patterns with GAST: view

Protein tissue co-expression partners for GAST Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GAST Gene

Orthologs for GAST Gene

This gene was present in the common ancestor of mammals.

Orthologs for GAST Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAST 35
  • 82.49 (n)
  • 69.7 (a)
GAST 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAST 35
  • 87.54 (n)
  • 80.81 (a)
GAST 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GAST 35
  • 100 (n)
  • 100 (a)
GAST 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gast 35
  • 76.9 (n)
  • 70.3 (a)
oppossum
(Monodelphis domestica)
Mammalia GAST 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gast 36
  • 69 (a)
OneToOne
Gast 16
Gast 35
  • 80.67 (n)
  • 70 (a)
Species with no ortholog for GAST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAST Gene

ENSEMBL:
Gene Tree for GAST (if available)
TreeFam:
Gene Tree for GAST (if available)

Paralogs for GAST Gene

No data available for Paralogs for GAST Gene

Variants for GAST Gene

Sequence variations from dbSNP and Humsavar for GAST Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34309618 - 41,715,444(+) GCAGC(A/C/G)ACTAT reference, missense
rs4290525 -- 41,715,774(+) CCTCC(A/T)CAGAC intron-variant
rs5014485 -- 41,714,848(+) CAGAA(A/C/T)CTAGG intron-variant
rs7209476 -- 41,712,360(+) AGCCG(C/T)GGCAC utr-variant-5-prime
rs4796684 -- 41,715,183(+) TAGTC(A/C)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAST Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
dgv962e1 CNV Complex 17122850

Variation tolerance for GAST Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAST Gene

HapMap Linkage Disequilibrium report
GAST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAST Gene

Disorders for GAST Gene

MalaCards: The human disease database

(60) MalaCards diseases for GAST Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastritis
  • acute gastric mucosal erosion
duodenal ulcer
  • curling ulcer
duodenitis
  • hemorrhagic duodenitis
gastric mucosal hypertrophy
  • familial giant hypertrophic gastritis
pernicious anemia
  • addison's anaemia
- elite association - COSMIC cancer census association via MalaCards
Search GAST in MalaCards View complete list of genes associated with diseases

Relevant External Links for GAST

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAST
genes like me logo Genes that share disorders with GAST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAST Gene

Publications for GAST Gene

  1. Identification of gastrin component I as gastrin-71. The largest possible bioactive progastrin product. (PMID: 8055952) Rehfeld J.F. … Johnsen A.H. (Eur. J. Biochem. 1994) 3 4 23 67
  2. Preprandial single oral dose of sitagliptin does not affect circulating ghrelin and gastrin levels in normal subjects. (PMID: 20145424) Huang C.L. … Weng S.F. (Pharmacology 2010) 3 23
  3. Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB. (PMID: 17889508) Cramer T. … HAPcker M. (Cell. Signal. 2008) 3 23
  4. Relationship between expression of gastrin, somatostatin, Fas/FasL and caspases in large intestinal carcinoma. (PMID: 18473402) Mao J.D. … Huang H. (World J. Gastroenterol. 2008) 3 23
  5. Distinct linkage between post-translational processing and differential secretion of progastrin derivatives in endocrine cells. (PMID: 18057001) Bundgaard J.R. … Rehfeld J.F. (J. Biol. Chem. 2008) 3 23

Products for GAST Gene

Sources for GAST Gene

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