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Aliases for GAS8-AS1 Gene

Subcategory (RNA class) for GAS8-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for GAS8-AS1 Gene

  • GAS8 Antisense RNA 1 2 3 4 5
  • C16orf3 3 4
  • Chromosome 16 Open Reading Frame 3 2
  • Uncharacterized Protein C16orf3 3
  • GAS8 Antisense Gene Protein 1 4

External Ids for GAS8-AS1 Gene

Previous HGNC Symbols for GAS8-AS1 Gene

  • C16orf3

Summaries for GAS8-AS1 Gene

Entrez Gene Summary for GAS8-AS1 Gene

  • This gene encodes a long non-coding RNA (lncRNA) that may function as a tumor suppressor. Mutations in this gene have been identified in human papillary thyroid carcinoma (PTC) patients that abrogate the ability of encoded lncRNA to inhibit cancer cell growth. [provided by RefSeq, May 2017]

GeneCards Summary for GAS8-AS1 Gene

GAS8-AS1 (GAS8 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with GAS8-AS1 include Differentiated Thyroid Carcinoma.

Additional gene information for GAS8-AS1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS8-AS1 Gene

Genomics for GAS8-AS1 Gene

GeneHancer (GH) Regulatory Elements for GAS8-AS1 Gene

Promoters and enhancers for GAS8-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I089993 Enhancer 1.5 Ensembl ENCODE dbSUPER 35 +34.7 34654 3.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B PIR44838 ENSG00000259877 AFG3L1P ANKRD11 MC1R ACSF3 TCF25 GAS8 LOC101927863 SNORD68
GH16I089656 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.4 +372.1 372136 2.6 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 POLR2B E2F8 ZNF143 CHMP1A SPATA33 CDK10 AFG3L1P TCF25 MC1R ENSG00000259877 GAS8-AS1 ACSF3 DBNDD1
GH16I089558 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10 +467.3 467275 7.9 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RPL13 SNORD68 GC16P089560 GC16P089561 PIR32702 AFG3L1P ANKRD11 TCF25 ENSG00000268218 ENSG00000259877
GH16I089216 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +812.6 812586 2.6 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 ENSG00000259877 PIR52460 ZNF778 AFG3L1P TCF25 CDK10 TRAPPC2L PIEZO1 CTU2 ZNF276
GH16I089639 Enhancer 1.1 Ensembl ENCODE 13.4 +388.8 388792 2.4 PKNOX1 ATF1 ARNT DMAP1 ZNF2 ZNF48 ZNF207 ZNF143 ATF7 RUNX3 CDK10 SPIRE2 GAS8-AS1 CHMP1A DPEP1 RPL13 PIR44959
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GAS8-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GAS8-AS1 Gene

Genomic Locations for GAS8-AS1 Gene
chr16:90,028,908-90,029,901
(GRCh38/hg38)
Size:
994 bases
Orientation:
Minus strand
chr16:90,095,316-90,096,309
(GRCh37/hg19)

Genomic View for GAS8-AS1 Gene

Genes around GAS8-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS8-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS8-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS8-AS1 Gene

Proteins for GAS8-AS1 Gene

  • Protein details for GAS8-AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95177-GAAS1_HUMAN
    Recommended name:
    Uncharacterized protein GAS8-AS1
    Protein Accession:
    O95177
    Secondary Accessions:
    • O95176
    • Q52LX9

    Protein attributes for GAS8-AS1 Gene

    Size:
    125 amino acids
    Molecular mass:
    12619 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAS8-AS1 Gene

Post-translational modifications for GAS8-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GAS8-AS1 Gene

Domains & Families for GAS8-AS1 Gene

Gene Families for GAS8-AS1 Gene

Protein Domains for GAS8-AS1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GAS8-AS1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GAS8-AS1 Gene

Function for GAS8-AS1 Gene

Phenotypes From GWAS Catalog for GAS8-AS1 Gene

Phenotypes for GAS8-AS1 Gene

genes like me logo Genes that share phenotypes with GAS8-AS1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAS8-AS1 Gene

Localization for GAS8-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS8-AS1 gene
Compartment Confidence
extracellular 2
plasma membrane 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAS8-AS1 Gene

Pathways & Interactions for GAS8-AS1 Gene

SuperPathways for GAS8-AS1 Gene

No Data Available

Interacting Proteins for GAS8-AS1 Gene

Gene Ontology (GO) - Biological Process for GAS8-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAS8-AS1 Gene

Drugs & Compounds for GAS8-AS1 Gene

No Compound Related Data Available

Transcripts for GAS8-AS1 Gene

mRNA/cDNA for GAS8-AS1 Gene

(1) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS8-AS1 Gene

No ASD Table

Relevant External Links for GAS8-AS1 Gene

GeneLoc Exon Structure for
GAS8-AS1
ECgene alternative splicing isoforms for
GAS8-AS1

Expression for GAS8-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAS8-AS1 Gene

genes like me logo Genes that share expression patterns with GAS8-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS8-AS1 Gene

Orthologs for GAS8-AS1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAS8-AS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16orf3 34
  • 98 (a)
OneToOne
Species where no ortholog for GAS8-AS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAS8-AS1 Gene

ENSEMBL:
Gene Tree for GAS8-AS1 (if available)
TreeFam:
Gene Tree for GAS8-AS1 (if available)

Paralogs for GAS8-AS1 Gene

No data available for Paralogs for GAS8-AS1 Gene

Variants for GAS8-AS1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GAS8-AS1 Gene

GAAS1_HUMAN-O95177
There seems to be two alleles of this protein.

Sequence variations from dbSNP and Humsavar for GAS8-AS1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs884928 benign, Ciliary dyskinesia, primary, 33 90,031,453(-) G/A/C/T upstream_transcript_variant
rs1000216103 -- 90,030,855(-) G/C upstream_transcript_variant
rs1000587765 -- 90,031,663(-) G/A upstream_transcript_variant
rs1001217069 -- 90,029,820(-) G/A non_coding_transcript_variant
rs1001490169 -- 90,029,923(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GAS8-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv3067n100 CNV gain 25217958
esv2762221 CNV gain+loss 21179565
esv3639603 CNV gain 21293372
esv3639606 CNV gain 21293372
nsv1062080 CNV loss 25217958
nsv1064351 CNV gain+loss 25217958
nsv1067164 CNV gain+loss 25217958
nsv428331 CNV gain+loss 18775914
nsv457626 CNV loss 19166990
nsv471119 CNV loss 18288195
nsv471120 CNV gain 18288195
nsv482951 CNV loss 15286789
nsv573810 CNV loss 21841781
nsv573841 CNV loss 21841781
nsv573842 CNV loss 21841781
nsv952080 CNV deletion 24416366

Variation tolerance for GAS8-AS1 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAS8-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS8-AS1

Disorders for GAS8-AS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GAS8-AS1 Gene - From: Orphanet

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GAS8-AS1

genes like me logo Genes that share disorders with GAS8-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS8-AS1 Gene

Publications for GAS8-AS1 Gene

  1. Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer. (PMID: 9790751) Whitmore SA … Callen DF (Genomics 1998) 2 3 4 58
  2. Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. (PMID: 28781594) Zhang D … Chen Z (International journal of endocrinology 2017) 2 3 58
  3. Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations. (PMID: 26941397) Pan W … Lin D (Human molecular genetics 2016) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58

Products for GAS8-AS1 Gene

Sources for GAS8-AS1 Gene

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