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Aliases for GAS7 Gene

Aliases for GAS7 Gene

  • Growth Arrest Specific 7 2 3 5
  • Growth Arrest-Specific 7 3
  • MLL/GAS7 Fusion Protein 3
  • MLL/GAS7 3
  • KIAA0394 4
  • GAS-7 4

External Ids for GAS7 Gene

Previous GeneCards Identifiers for GAS7 Gene

  • GC17M010179
  • GC17M010928
  • GC17M009756
  • GC17M010014
  • GC17M009754
  • GC17M009813

Summaries for GAS7 Gene

Entrez Gene Summary for GAS7 Gene

  • Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAS7 Gene

GAS7 (Growth Arrest Specific 7) is a Protein Coding gene. Diseases associated with GAS7 include spastic hemiplegia and open-angle glaucoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and actin filament binding.

UniProtKB/Swiss-Prot for GAS7 Gene

  • May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Gene Wiki entry for GAS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS7 Gene

Genomics for GAS7 Gene

Regulatory Elements for GAS7 Gene

Promoters for GAS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAS7 Gene

Chromosome:
17
Start:
9,910,609 bp from pter
End:
10,198,551 bp from pter
Size:
287,943 bases
Orientation:
Minus strand

Genomic View for GAS7 Gene

Genes around GAS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS7 Gene

Proteins for GAS7 Gene

  • Protein details for GAS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60861-GAS7_HUMAN
    Recommended name:
    Growth arrest-specific protein 7
    Protein Accession:
    O60861
    Secondary Accessions:
    • A8KAC2
    • B2RCK9
    • O43144
    • Q53Y77
    • Q7Z571

    Protein attributes for GAS7 Gene

    Size:
    476 amino acids
    Molecular mass:
    54371 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA23690.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GAS7 Gene

    Alternative splice isoforms for GAS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS7 Gene

Proteomics data for GAS7 Gene at MOPED

Post-translational modifications for GAS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GAS7 Gene

Domains & Families for GAS7 Gene

Protein Domains for GAS7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60861

UniProtKB/Swiss-Prot:

GAS7_HUMAN :
  • Contains 1 F-BAR domain.
Domain:
  • Contains 1 F-BAR domain.
  • Contains 1 SH3 domain.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with GAS7: view

No data available for Gene Families for GAS7 Gene

Function for GAS7 Gene

Molecular function for GAS7 Gene

GENATLAS Biochemistry:
growth arrest specific gene 7,50kDa,mouse homolog
UniProtKB/Swiss-Prot Function:
May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Gene Ontology (GO) - Molecular Function for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with GAS7: view
genes like me logo Genes that share phenotypes with GAS7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS7 Gene

Localization for GAS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAS7 Gene COMPARTMENTS Subcellular localization image for GAS7 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for GAS7 Gene

Pathways & Interactions for GAS7 Gene

SuperPathways for GAS7 Gene

No Data Available

SIGNOR curated interactions for GAS7 Gene

Activates:

Gene Ontology (GO) - Biological Process for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 9736752
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GAS7: view

No data available for Pathways by source for GAS7 Gene

Drugs & Compounds for GAS7 Gene

No Compound Related Data Available

Transcripts for GAS7 Gene

Unigene Clusters for GAS7 Gene

Growth arrest-specific 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAS7 Gene

No ASD Table

Relevant External Links for GAS7 Gene

GeneLoc Exon Structure for
GAS7
ECgene alternative splicing isoforms for
GAS7

Expression for GAS7 Gene

mRNA expression in normal human tissues for GAS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAS7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for GAS7 Gene

This gene is overexpressed in Frontal cortex (24.2) and Testis (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GAS7 Gene



SOURCE GeneReport for Unigene cluster for GAS7 Gene Hs.462214

genes like me logo Genes that share expression patterns with GAS7: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GAS7 Gene

Orthologs for GAS7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GAS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAS7 35
  • 99.65 (n)
  • 99.79 (a)
GAS7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAS7 36
  • 76 (a)
OneToOne
GAS7 35
  • 93.65 (n)
  • 98.75 (a)
dog
(Canis familiaris)
Mammalia GAS7 35
  • 92.29 (n)
  • 98.07 (a)
GAS7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gas7 36
  • 97 (a)
OneToOne
Gas7 16
Gas7 35
  • 91.13 (n)
  • 97.36 (a)
oppossum
(Monodelphis domestica)
Mammalia GAS7 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gas7 35
  • 91.29 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves GAS7 36
  • 85 (a)
OneToOne
GAS7 35
  • 79.55 (n)
  • 84.45 (a)
lizard
(Anolis carolinensis)
Reptilia GAS7 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24134 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gas7 35
  • 77.54 (n)
  • 80.93 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01102038.1 36
  • 87 (a)
OneToMany
gas7a 36
  • 80 (a)
OneToMany
gas7a 35
  • 76.17 (n)
  • 82.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOF1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for GAS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAS7 Gene

ENSEMBL:
Gene Tree for GAS7 (if available)
TreeFam:
Gene Tree for GAS7 (if available)

Paralogs for GAS7 Gene

genes like me logo Genes that share paralogs with GAS7: view

No data available for Paralogs for GAS7 Gene

Variants for GAS7 Gene

Sequence variations from dbSNP and Humsavar for GAS7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4668 -- 9,911,106(-) TCCTT(A/G)GTGAC utr-variant-3-prime
rs14383 -- 9,911,080(-) GCATC(C/G)CTTCC utr-variant-3-prime
rs876046 -- 9,976,519(-) GGGCT(C/T)CTGAA intron-variant
rs424873 -- 10,058,020(+) aagat(A/G)tgctt intron-variant
rs887260 -- 9,968,671(+) AACCA(C/T)GGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAS7 Gene

Variant ID Type Subtype PubMed ID
nsv833361 CNV Gain 17160897
dgv38n68 CNV Loss 17160897
nsv516119 CNV Loss 19592680
nsv1978 CNV Insertion 18451855
nsv833364 CNV Gain 17160897
esv2715633 CNV Deletion 23290073
esv2715634 CNV Deletion 23290073
nsv907673 CNV Gain 21882294
nsv520771 CNV Gain+Loss 19592680
nsv907674 CNV Gain 21882294
dgv3059n71 CNV Gain 21882294
esv2670514 CNV Deletion 23128226
nsv833365 CNV Gain 17160897
esv269561 CNV Insertion 20981092
nsv907678 CNV Gain 21882294

Variation tolerance for GAS7 Gene

Residual Variation Intolerance Score: 7.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAS7 Gene

HapMap Linkage Disequilibrium report
GAS7
Human Gene Mutation Database (HGMD)
GAS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS7 Gene

Disorders for GAS7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GAS7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spastic hemiplegia
  • congenital hemiplegia
open-angle glaucoma
  • glaucoma simplex
glaucoma 1, open angle, e
  • primary open angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search GAS7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GAS7_HUMAN
  • Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1. {ECO:0000269 PubMed:10706619}.

Relevant External Links for GAS7

Genetic Association Database (GAD)
GAS7
Human Genome Epidemiology (HuGE) Navigator
GAS7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAS7
genes like me logo Genes that share disorders with GAS7: view

No data available for Genatlas for GAS7 Gene

Publications for GAS7 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48 67
  2. Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. (PMID: 15948147) Chao C.C. … Lu H.H. (J. Neurosci. Res. 2005) 3 23
  3. Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. (PMID: 11795944) She B.R. … Lin-Chao S. (Exp. Cell Res. 2002) 3 23
  4. gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. (PMID: 9736752) Ju Y.T. … Lin-Chao S. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for GAS7 Gene

Sources for GAS7 Gene

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