Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAS7 Gene

protein-coding   GIFtS: 60
GCID: GC17M009813

growth arrest-specific 7
 Explore 12 diseases affiliated with
GAS7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GAS7    

Aliases
for GAS7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Growth Arrest-Specific 71 2     Growth Arrest-Specific Protein 72
KIAA03941 3     MLL/GAS7 Fusion Protein2
MGC13481     GAS-73
MLL/GAS72     

External Ids:    HGNC: 41691   Entrez Gene: 85222   Ensembl: ENSG000000072377   OMIM: 6031275   UniProtKB: O608613   

Export aliases for GAS7 gene to outside databases

Previous GC identifers: GC17M010179 GC17M010928 GC17M009756 GC17M010014 GC17M009754


Summaries
for GAS7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GAS7:
Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature
cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding
proteins which vary in the N-terminus have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861
Function: May play a role in promoting maturation and morphological differentiation of cerebellar neurons

Gene Wiki entry for GAS7


Genomic Views
for GAS7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAS7 gene promoter:
         p53   Pax-6   Nkx2-5   Cdc5   NF-AT   NF-AT4   NF-AT2   FOXO4   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): GAS7 promoter sequence
   Search SABiosciences Chromatin IP Primers for GAS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

GAS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAS7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M009813:  view genomic region     (about GC identifiers)

Start:
 9,813,926 bp from pter      End:
 10,101,868 bp from pter
Size:
 287,943 bases      Orientation:
 minus strand

Proteins
for GAS7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861 (See protein sequence)
Recommended Name: Growth arrest-specific protein 7  
Size: 476 amino acids; 54371 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA23690.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for GAS7:
2LX7 (3D)        2YSH (3D)    
Secondary accessions: A8KAC2 B2RCK9 O43144 Q53Y77 Q7Z571
Alternative splicing: 4 isoforms:  O60861-3   O60861-1   O60861-2   O60861-4   

Explore the universe of human proteins at neXtProt for GAS7: NX_O60861

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60861

    • GAS7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001124303.1  NP_003635.2  NP_958836.1  NP_958839.1  

    ENSEMBL proteins: 
     ENSP00000410108   ENSP00000322608   ENSP00000407552   ENSP00000464240   ENSP00000463873  
     ENSP00000464088   ENSP00000443265   ENSP00000463527   ENSP00000463033   ENSP00000463007  
     ENSP00000462304   ENSP00000464494   ENSP00000462897   ENSP00000463551   ENSP00000379421  
     ENSP00000445184   ENSP00000446214   ENSP00000437520  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): GAS7
    OriGene Protein Over-expression Lysate (see all 2): GAS7
    OriGene Custom Protein Services for GAS7 
    GenScript Custom Purified and Recombinant Proteins Services for GAS7
    Novus Biologicals GAS7 Proteins
    Novus Biologicals GAS7 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for GAS7
    Uscn Proteins for GAS7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm IEA--
    GO:0005884actin filament IEA--


    GAS7 for ontologies           About GeneDecksing



    GAS7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 6): GAS7
    OriGene Custom Antibody Services for GAS7 
    GenScript Custom Superior Antibodies Services for GAS7
    Novus Biologicals GAS7 Antibodies
    Abcam antibodies for GAS7 
    Uscn Antibodies for GAS7
    ThermoFisher Antibodies for GAS7

    Assay Products for GAS7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GAS7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GAS7

    Protein Domains /
    Families
    for GAS7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GAS7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001060 FCH
     IPR001452 SH3_domain
     IPR001202 WW_Rsp5_WWP

    Graphical View of Domain Structure for InterPro Entry O60861

    ProtoNet protein and cluster: O60861

    UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 WW domain


    Function
    for GAS7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861
    Function: May play a role in promoting maturation and morphological differentiation of cerebellar neurons

         Genatlas biochemistry entry for GAS7:
    growth arrest specific gene 7,50kDa,mouse homolog

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): GAS7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAS7
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate GAS7 (see all 80):
    hsa-miR-548j hsa-miR-4254 hsa-miR-146a hsa-miR-374a hsa-miR-548a-5p hsa-miR-374b* hsa-miR-559 hsa-miR-548y
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAS7 (see all 7)
    OriGene shRNA RFP: GAS7
    OriGene siRNA: GAS7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAS7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GAS7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAS7 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAS7 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): GAS7 (NM_001130831)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS7 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for GAS7
    Search LifeMap BioReagents cell lines for GAS7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS7

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9736752
    GO:0051015actin filament binding IEA--


    GAS7 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for GAS7:
     Decreased viability with cispl  Increased cell death in breast 


    Pathways & Interactions
    for GAS7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAS7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for GAS7 (O608612, 3 ENSP000003226084) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI1Q8IZP02, 3, ENSP000003653124MINT-72912 I2D: score=3 STRING: ENSP00000365312
    FMNL1O954662, 3, ENSP000003292194MINT-72916 I2D: score=3 STRING: ENSP00000329219
    GAPDHP044062, 3, ENSP000002292394MINT-72922 I2D: score=3 STRING: ENSP00000229239
    KHDRBS1Q076662, 3, ENSP000003138294MINT-72907 I2D: score=3 STRING: ENSP00000313829
    RPLP0P053882, 3, ENSP000003390274MINT-72911 I2D: score=3 STRING: ENSP00000339027
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS9736752
    GO:0007050cell cycle arrest TAS9736752
    GO:0008360regulation of cell shape IEA--
    GO:0030041actin filament polymerization IEA--
    GO:0030182neuron differentiation ----


    GAS7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GAS7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAS7
    Search CenterWatch for drugs/clinical trials and news about GAS7 

    Transcripts
    for GAS7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GAS7 gene (4 alternative transcripts): 
    NM_001130831.1  NM_003644.2  NM_201432.1  NM_201433.1  

    Unigene Cluster for GAS7:

    Growth arrest-specific 7
    Hs.462214  [show with all ESTs]
    Unigene Representative Sequence: NM_201433
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000437099(uc002gmg.1 uc010vvc.1 uc002gmh.1 uc010vvd.1 uc002gmi.2)
    ENST00000323816(uc010coh.1) ENST00000432992 ENST00000585266 ENST00000580865
    ENST00000583882 ENST00000542249 ENST00000579158 ENST00000581112 ENST00000578456
    ENST00000581871 ENST00000580811 ENST00000584146 ENST00000579140 ENST00000578655
    ENST00000578599 ENST00000584389 ENST00000580043

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): GAS7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAS7
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate GAS7 (see all 80):
    hsa-miR-548j hsa-miR-4254 hsa-miR-146a hsa-miR-374a hsa-miR-548a-5p hsa-miR-374b* hsa-miR-559 hsa-miR-548y
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAS7 (see all 7)
    OriGene shRNA RFP: GAS7
    OriGene siRNA: GAS7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAS7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAS7 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAS7 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): GAS7 (NM_001130831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS7 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAS7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GAS7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAS7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAS7

    Additional cDNA sequence: 

    AB007854.1 AB209030.1 AJ224876.1 AK057761.1 AK225165.1 AK292987.1 AK293755.1 AK293834.1 
    AK294829.1 AK299574.1 AK307987.1 AK309722.1 AK315162.1 AY327406.1 BC001152.1 BC006454.1 
    BC113835.1 BT006891.1 

    21 DOTS entries:

    DT.87014326  DT.95106979  DT.92400005  DT.92471376  DT.120961609  DT.97800020  DT.120961650  DT.120961708 
    DT.120961668  DT.100779119  DT.120961716  DT.92471333  DT.95106989  DT.100853466  DT.92471334  DT.120961613 
    DT.120961715  DT.95106972  DT.95106980  DT.95191861  DT.97796365 

    24/369 AceView cDNA sequences (see all 369):

    AW593485 AA309507 AA350259 BG056686 AA600973 BQ879120 CD368825 BE711134 
    AI417814 AI082576 AI356071 AA434413 BC006454 AI371807 BE327411 AI806848 
    H85959 AI276703 BM684183 BE671619 BE326370 AI802261 T33023 BT006891 

    GeneLoc Exon Structure


    Expression
    for GAS7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAAGAGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GAS7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GAS7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAS7

    SOURCE GeneReport for Unigene cluster: Hs.462214
        SABiosciences Custom PCR Arrays for GAS7
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAS7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GAS7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAS7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAS7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS7

    Orthologs
    for GAS7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for GAS7 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GAS71 growth arrest-specific 7 79.55(n)
    84.45(a)    		   417305  XM_415577.3  XP_415577.2 
    lizard
    (Anolis carolinensis)    		 Reptilia GAS76
    		 --
    		 89(a)
    		 1 ↔ 1
    		 2(109298494-109321439)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.241342 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_003635.1 (H.sapiens) growth arrest-specific 7 isoform a [Homo sapiens] less 82.2(n)    BJ625620.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gas71 growth arrest-specific 7 75.44(n)
    81.5(a)    		   793701  XM_001333471.2  XP_001333507.2 


    ENSEMBL Gene Tree for GAS7 (if available)
    TreeFam Gene Tree for GAS7 (if available) 

    Paralogs
    for GAS7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAS7 gene
    PSTPIP12  PSTPIP22  
    5 SIMAP similar genes for GAS7 using alignment to 13 protein entries:     GAS7_HUMAN (see all proteins):
    MLL/GAS7    PSTPIP1    SH3GL2    PIN1P1    SH3GL1

    GAS7 for paralogs           About GeneDecksing



    Genomic Variants
    for GAS7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6225 NCBI SNPs in GAS7 are shown (see all 6225)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1843770501,2
    		--9813436(+) AGAATC/TGCTTG 4 -- ds50010--------
    rs47919081,2
    		C,F,A,--9813457(+) GTAGAG/CGTTGC 4 -- ds50016Minor allele frequency- C:0.50NA WA CSA 14
    rs1455903751,2
    		--9813485(+) CCACTG/TCACTC 4 -- ds50010--------
    rs1453946541,2
    		--9813492(+) ACTCCA/CGCCTG 4 -- ds50010--------
    rs1899030781,2
    		--9813500(+) CTGGGC/TGACAG 4 -- ds50010--------
    rs1389879371,2
    		C,--9813512(+) CGAGA-/CTACTCT 4 -- ds50010--------
    rs126020991,2
    		C,F,H,--9813531(+) TCTCTC/ATATAT 4 -- ds50011Minor allele frequency- A:0.08EA 120
    rs47913761,2
    		C,A,H,--9813533(+) TCTCTA/CTATAT 4 -- ds50013Minor allele frequency- C:0.22NA EA 242
    rs1382295341,2
    		--9813535(+) TCTATA/CTATAT 4 -- ds50010--------
    rs1137504481,2
    		C,--9813549(+) TATAAA/GTGAAC 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for GAS7 (9813926 - 10063926 bp, first 250kb of GAS7)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GAS7
         2 CNVs: 49951 4989

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAS7
    DNA2.0 Custom Variant and Variant Library Synthesis for GAS7

    Disorders / Diseases
    for GAS7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GAS7 for disorders           About GeneDecksing

    OMIM gene information: 603127    OMIM disorders: --

    UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861
  • Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation
    • t(11;17)(q23;p13) with MLL/HRX

    12 diseases for GAS7:    About MalaCards
    dna topoisomerase ii    spastic hemiplegia    pediatric osteosarcoma    neuronitis
    hemiplegia    ulcerative colitis    osteosarcoma    acute leukemia
    spasticity    leukemia    alzheimer's disease    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for GAS7:
    Spastic hemiplegia
    Human Genome Epidemiology (HuGE) Navigator: GAS7 (8 documents)

    Export disorders for GAS7 gene to outside databases

    Publications
    for GAS7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAS7 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with GAS7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. (PubMed id 10706619)1, 2 Megonigal M.D.... Felix C.A. (2000)
    3. gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. (PubMed id 9736752)1, 3 Ju Y.T....Lin-Chao S. (1998)
    4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    5. Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. (PubMed id 15948147)1, 9 Chao C.C....Lu H.H. (2005)
    6. Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. (PubMed id 11795944)1, 9 She B.R....Lin-Chao S. (2002)
    7. Common genetic determinants of intraocular pressure an d primary open-angle glaucoma. (PubMed id 22570627)1 van Koolwijk L.M....van Duijn C.M. (2012)
    8. Gas7-deficient mouse reveals roles in motor function a nd muscle fiber composition during aging. (PubMed id 22662195)1 Huang B.T....Lin-Chao S. (2012)
    9. Gas7 mediates the differentiation of human bone marro w-derived mesenchymal stem cells into functional osteoblasts by enhancing Runx2 -dependent gene expression. (PubMed id 21452305)1 Hung F.C....Chao C.C. (2011)
    10. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)

    External Searches for GAS7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GAS7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8522 HGNC: 4169 AceView: GAS7 Ensembl:ENSG00000007237 euGenes: HUgn8522
    ECgene: GAS7 H-InvDB: GAS7

    Other Databases showing GAS7 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0394

    Specialized Databases showing GAS7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAS7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAS7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for GAS7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GAS7 gene:
    Search GeneIP for patents involving GAS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for GAS7 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for GAS7   OriGene shRNA RFP for GAS7  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAS7   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAS7  
     OriGene Protein Over-expression Lysate for GAS7   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for GAS7   OriGene 3'-UTR Clone for GAS7  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAS7   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAS7  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for GAS7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GAS7   OriGene Custom Protein Services for GAS7  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAS7
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAS7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAS7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAS7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAS7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAS7
     GenScript Custom Purified and Recombinant Proteins Services for GAS7 GenScript cDNA clones with any tag delivered in your preferred vector for GAS7
     GenScript Custom Assay Services for GAS7 GenScript Custom Superior Antibodies Services for GAS7
     GenScript Custom overexpressing Cell Line Services for GAS7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GAS7 promoter
     Search Chromatin IP Primers for GAS7
     RT2 qPCR Primer Assay in human, mouse, rat GAS7
     Search GNC Networks for GAS7
     SABiosciences Custom PCR Arrays for GAS7
     Search Tocris compounds for GAS7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GAS7 antibodies
     GAS7 proteins
     GAS7 lysates
     Antibodies for GAS7
     See all of Abcam's Antibodies, Kits and Proteins for GAS7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GAS7




     GAS7 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for GAS7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS7
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GAS7
     SwitchGear Promoter luciferase reporter plasmids for GAS7
     ThermoFisher Antibodies for GAS7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS7
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      GAS7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4