GAS7 Gene

Aliases
for GAS7 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17M010179 GC17M010928 GC17M009756 GC17M010014 GC17M009754

Summaries
for GAS7 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for GAS7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NT_010718.17  NC_018928.2  

SwitchGear Promoter luciferase reporter plasmids (see all 8): GAS7 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAS7

GAS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M009813:  view genomic region     (about GC identifiers)

Proteins
for GAS7 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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2 PDB 3D structures from and Proteopedia for GAS7:

2LX7 (3D)        2YSH (3D)    

Explore the universe of human proteins at neXtProt for GAS7: NX_O60861

Explore proteomics data for GAS7 at MOPED

Post-translational modifications: 

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GAS7 Assay Products:

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Domains /
Families
for GAS7 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: O60861

Find genes that share domains with GAS7           About GenesLikeMe

Function
for GAS7 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for GAS7

miRNA Products:		miRTarBase miRNAs that target GAS7: hsa-mir-128-3p (MIRT021949)
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		hsa-miR-548j hsa-miR-4254 hsa-miR-146a hsa-miR-374a hsa-miR-548a-5p hsa-miR-374b* hsa-miR-559 hsa-miR-548y
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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS7

Localization
for GAS7 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	3
cytoskeleton	2
cytosol	1
golgi apparatus	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for GAS7 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for GAS7 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Transcripts
for GAS7 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for GAS7 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GAS7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTAAAGAGCC

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Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Eye (Sensory Organs)    fully expand to see all 2 entries
GABAergic Amacrine Cells Inner Nuclear Layer
Retina
Testis (Reproductive System)
Pre-Sertoli Cells Testis Cord
Neurons
GABAergic Amacrine Cells Inner Nuclear Layer
Bone (Muscoskeletal System)
Bone Marrow

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS7

Orthologs
for GAS7 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for GAS7 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for GAS7 gene

4 SIMAP similar genes for GAS7 using alignment to 9 protein entries:     GAS7_HUMAN (see all proteins):

MLL/GAS7    SH3GL2    PIN1P1    SH3GL1

Find genes that share paralogs with GAS7           About GenesLikeMe

Genomic Variants
for GAS7 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GAS7 (see all 7342)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1843770501,2		--	9802888(+)	AGAATC/TGCTTG	4	--	ds5001		0	--	--	--	--
rs47919081,2	C,F,A	--	9802909(+)	gtagaG/Cgttgc	4	--	ds5001		6		NA WA CSA	14
rs1455903751,2		--	9802937(+)	CCACTG/TCACTC	4	--	ds5001		0	--	--	--	--
rs1453946541,2		--	9802944(+)	ACTCCA/CGCCTG	4	--	ds5001		0	--	--	--	--
rs1899030781,2	C	--	9802952(+)	CTGGGC/TGACAG	4	--	ds5001		0	--	--	--	--
rs1389879371,2	C	--	9802964(+)	CGAGA-/CTACTCT	4	--	ds5001		0	--	--	--	--
rs719580261,2	C	--	9802965(+)	GAGAC-/CTTCTCT	4	--	ds5001		0	--	--	--	--
rs126020991,2	C,F,H	--	9802983(+)	TCTCTC/ATATAT	4	--	ds5001		1		EA	120
rs47913761,2	C,A,H	--	9802985(+)	TCTCTA/CTATAT	4	--	ds5001		3		NA EA	242
rs1382295341,2		--	9802987(+)	TCTATA/CTATAT	4	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for GAS7 (9813926 - 10063926 bp, first 250kb of GAS7)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for GAS7 (see all 15):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2715634	CNV	Deletion	23290073
esv2670514	CNV	Deletion	23128226
esv2715633	CNV	Deletion	23290073
nsv1978	CNV	Insertion	18451855
esv269561	CNV	Insertion	20981092
dgv38n68	CNV	Loss	17160897
nsv516119	CNV	Loss	19592680
nsv833365	CNV	Gain	17160897
nsv907678	CNV	Gain	21882294
nsv907674	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GAS7

DNA2.0 Custom Variant and Variant Library Synthesis for GAS7

Disorders / Diseases
for GAS7 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Publications
for GAS7 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GAS7 gene, integrated from 10 sources (see all 37): (articles sorted by number of sources associating them with GAS7)

Utopia: connect your pdf to the dynamic world of online information

1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)^{1, 4} Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)^{1, 4} Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
3. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PubMed id 19861958)^{1, 4} Festen E.A....Weersma R.K. (Am. J. Gastroenterol. 2010)
4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
7. Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. (PubMed id 10706619)^{1, 2} Megonigal M.D.... Felix C.A. (Proc. Natl. Acad. Sci. U.S.A. 2000)
8. gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. (PubMed id 9736752)^{1, 3} Ju Y.T....Lin-Chao S. (Proc. Natl. Acad. Sci. U.S.A. 1998)
9. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)^{1, 2} Ishikawa K.... Ohara O. (DNA Res. 1997)
10. Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. (PubMed id 15948147)^{1, 9} Chao C.C....Lu H.H. (J. Neurosci. Res. 2005)

External Searches for GAS7 gene

Genome Databases showing GAS7 gene

Other Databases showing GAS7 gene

Specialized Databases showing GAS7 gene

Products
for GAS7 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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