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Aliases for GAS7 Gene

Aliases for GAS7 Gene

  • Growth Arrest-Specific 7 2 3
  • Growth Arrest-Specific Protein 7 3
  • MLL/GAS7 Fusion Protein 3
  • MLL/GAS7 3
  • KIAA0394 4
  • GAS-7 4

External Ids for GAS7 Gene

Previous GeneCards Identifiers for GAS7 Gene

  • GC17M010179
  • GC17M010928
  • GC17M009756
  • GC17M010014
  • GC17M009754
  • GC17M009813

Summaries for GAS7 Gene

Entrez Gene Summary for GAS7 Gene

  • Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAS7 Gene

GAS7 (Growth Arrest-Specific 7) is a Protein Coding gene. Diseases associated with GAS7 include spastic hemiplegia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and actin filament binding.

UniProtKB/Swiss-Prot for GAS7 Gene

  • May play a role in promoting maturation and morphological differentiation of cerebellar neurons

Gene Wiki entry for GAS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS7 Gene

Genomics for GAS7 Gene

Regulatory Elements for GAS7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GAS7 Gene

Start:
9,910,609 bp from pter
End:
10,198,551 bp from pter
Size:
287,943 bases
Orientation:
Minus strand

Genomic View for GAS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS7 Gene

Proteins for GAS7 Gene

  • Protein details for GAS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60861-GAS7_HUMAN
    Recommended name:
    Growth arrest-specific protein 7
    Protein Accession:
    O60861
    Secondary Accessions:
    • A8KAC2
    • B2RCK9
    • O43144
    • Q53Y77
    • Q7Z571

    Protein attributes for GAS7 Gene

    Size:
    476 amino acids
    Molecular mass:
    54371 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA23690.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GAS7 Gene

    Alternative splice isoforms for GAS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS7 Gene

Proteomics data for GAS7 Gene at MOPED

Post-translational modifications for GAS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for GAS7 Gene

Domains for GAS7 Gene

Protein Domains for GAS7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60861

UniProtKB/Swiss-Prot:

GAS7_HUMAN :
  • O60861
Domain:
  • Contains 1 F-BAR domain.
  • Contains 1 SH3 domain.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with GAS7: view

No data available for Gene Families for GAS7 Gene

Function for GAS7 Gene

Molecular function for GAS7 Gene

GENATLAS Biochemistry: growth arrest specific gene 7,50kDa,mouse homolog
UniProtKB/Swiss-Prot Function: May play a role in promoting maturation and morphological differentiation of cerebellar neurons

Gene Ontology (GO) - Molecular Function for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9736752
GO:0005515 protein binding IPI 25416956
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with GAS7: view
genes like me logo Genes that share phenotypes with GAS7: view

Animal Model Products

CRISPR Products

miRNA for GAS7 Gene

miRTarBase miRNAs that target GAS7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAS7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GAS7 Gene

Localization for GAS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAS7 Gene COMPARTMENTS Subcellular localization image for GAS7 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm IEA --
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with GAS7: view

Pathways for GAS7 Gene

SuperPathways for GAS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 9736752
GO:0007050 cell cycle arrest TAS 9736752
GO:0008360 regulation of cell shape IEA --
GO:0030041 actin filament polymerization IEA --
GO:0030182 neuron differentiation --
genes like me logo Genes that share ontologies with GAS7: view

No data available for Pathways by source for GAS7 Gene

Transcripts for GAS7 Gene

Unigene Clusters for GAS7 Gene

Growth arrest-specific 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAS7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS7 Gene

No ASD Table

Relevant External Links for GAS7 Gene

GeneLoc Exon Structure for
GAS7
ECgene alternative splicing isoforms for
GAS7

Expression for GAS7 Gene

mRNA expression in normal human tissues for GAS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAS7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GAS7 Gene

SOURCE GeneReport for Unigene cluster for GAS7 Gene Hs.462214

genes like me logo Genes that share expressions with GAS7: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GAS7 Gene

Orthologs for GAS7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GAS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAS7 35
  • 99.65 (n)
  • 99.79 (a)
GAS7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAS7 35
  • 93.65 (n)
  • 98.75 (a)
GAS7 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAS7 35
  • 92.29 (n)
  • 98.07 (a)
GAS7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gas7 35
  • 91.13 (n)
  • 97.36 (a)
Gas7 16
Gas7 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAS7 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gas7 35
  • 91.29 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves GAS7 35
  • 79.55 (n)
  • 84.45 (a)
GAS7 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAS7 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24134 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gas7 35
  • 77.54 (n)
  • 80.93 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01102038.1 36
  • 87 (a)
OneToMany
gas7a 35
  • 76.17 (n)
  • 82.95 (a)
gas7a 36
  • 80 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOF1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for GAS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAS7 Gene

ENSEMBL:
Gene Tree for GAS7 (if available)
TreeFam:
Gene Tree for GAS7 (if available)

Paralogs for GAS7 Gene

Selected SIMAP similar genes for GAS7 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GAS7: view

No data available for Paralogs for GAS7 Gene

Variants for GAS7 Gene

Sequence variations from dbSNP and Humsavar for GAS7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4668 -- 9,911,106(-) TCCTT(A/G)GTGAC utr-variant-3-prime
rs9545 -- 9,910,885(-) ACCCC(C/G)GTATG utr-variant-3-prime
rs14383 -- 9,911,080(-) GCATC(C/G)CTTCC utr-variant-3-prime
rs15814 -- 9,913,073(-) TTAAC(A/C)CTCCA utr-variant-3-prime
rs424873 -- 10,058,020(+) aagat(A/G)tgctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAS7 Gene

Variant ID Type Subtype PubMed ID
nsv833361 CNV Gain 17160897
dgv38n68 CNV Loss 17160897
nsv516119 CNV Loss 19592680
nsv1978 CNV Insertion 18451855
nsv833364 CNV Gain 17160897
esv2715633 CNV Deletion 23290073
esv2715634 CNV Deletion 23290073
nsv907673 CNV Gain 21882294
nsv520771 CNV Gain+Loss 19592680
nsv907674 CNV Gain 21882294
dgv3059n71 CNV Gain 21882294
esv2670514 CNV Deletion 23128226
nsv833365 CNV Gain 17160897
esv269561 CNV Insertion 20981092
nsv907678 CNV Gain 21882294

Relevant External Links for GAS7 Gene

HapMap Linkage Disequilibrium report
GAS7
Human Gene Mutation Database (HGMD)
GAS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS7 Gene

Disorders for GAS7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GAS7 Gene including...

Search for GAS7 Gene in MalaCards »

UniProtKB/Swiss-Prot

GAS7_HUMAN
  • Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1.

(1) University of Copenhagen DISEASES for GAS7 Gene

Relevant External Links for GAS7

Genetic Association Database (GAD)
GAS7
Human Genome Epidemiology (HuGE) Navigator
GAS7
genes like me logo Genes that share disorders with GAS7: view

Publications for GAS7 Gene

  1. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. (PMID: 11795944) She B.R. … Lin-Chao S. (Exp. Cell Res. 2002) 3 23
  5. Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. (PMID: 15948147) Chao C.C. … Lu H.H. (J. Neurosci. Res. 2005) 3 23

Products for GAS7 Gene

Sources for GAS7 Gene

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