Aliases for GAS7 Gene
Aliases for GAS7 Gene
External Ids for GAS7 Gene
- HGNC: 4169
- Entrez Gene: 8522
- Ensembl: ENSG00000007237
- OMIM: 603127
- UniProtKB: O60861
Previous GeneCards Identifiers for GAS7 Gene
- GC17M010179
- GC17M010928
- GC17M009756
- GC17M010014
- GC17M009754
- GC17M009813
Summaries for GAS7 Gene
-
Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for GAS7 Gene
GAS7 (Growth Arrest Specific 7) is a Protein Coding gene. Diseases associated with GAS7 include Spastic Hemiplegia and Glaucoma 1, Open Angle, E. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and actin filament binding.
UniProtKB/Swiss-Prot for GAS7 Gene
-
May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS7 Gene
Genomics for GAS7 Gene
Regulatory Elements for GAS7 Gene
Enhancers for GAS7 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around GAS7 on UCSC Golden Path with GeneCards custom track
Promoters for GAS7 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around GAS7 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for GAS7 Gene
- Chromosome:
- 17
- Start:
- 9,910,609 bp from pter
- End:
- 10,198,551 bp from pter
- Size:
- 287,943 bases
- Orientation:
- Minus strand
Genomic View for GAS7 Gene
Genes around GAS7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
GAS7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GAS7 Gene
Proteins for GAS7 Gene
-
Protein details for GAS7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60861-GAS7_HUMAN
- Recommended name:
- Growth arrest-specific protein 7
- Protein Accession:
- O60861
- A8KAC2
- B2RCK9
- O43144
- Q53Y77
- Q7Z571
Protein attributes for GAS7 Gene
- Size:
- 476 amino acids
- Molecular mass:
- 54371 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA23690.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for GAS7 Gene
Post-translational modifications for GAS7 Gene
Other Protein References for GAS7 Gene
Antibody Products
- Novus Biologicals Antibodies for GAS7
- Abcam antibodies for Growth Arrest Specific Protein 7
- Invitrogen Antibodies for GAS7
- antibodies-online Antibodies for GAS7: See all 72
- GeneTex GAS7 antibody for GAS7
-
Santa Cruz Biotechnology (SCBT) Antibodies for GAS7
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GAS7
- Origene Custom Protein Services for GAS7
- ProSpec Recombinant Proteins for GAS7
- antibodies-online Proteins for GAS7: See all 21
- Search antibodies-online for peptides
- Search GeneTex for Proteins for GAS7
- Abcam proteins for Growth Arrest Specific Protein 7
Assay Products
No data available for DME Specific Peptides for GAS7 Gene
Domains & Families for GAS7 Gene
Protein Domains for GAS7 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GAS7 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ77218, highly similar to Homo sapiens growth arrest-specific 7 (GAS7), transcript variant b, mRNA (A8KAC2_HUMAN)
- cDNA FLJ61102, highly similar to Growth-arrest-specific protein 7 (B7Z1Q2_HUMAN)
- cDNA FLJ52479, highly similar to Homo sapiens growth arrest-specific 7 (GAS7), transcript variant a, mRNA (B7Z1S0_HUMAN)
- Growth arrest-specific protein 7 (GAS7_HUMAN)
- GAS7 protein (Q29RX5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60861- Domain:
-
- Contains 1 F-BAR domain.
- Contains 1 SH3 domain.
- Contains 1 WW domain.
No data available for Gene Families for GAS7 Gene
Function for GAS7 Gene
Molecular function for GAS7 Gene
- GENATLAS Biochemistry:
- growth arrest specific gene 7,50kDa,mouse homolog
- UniProtKB/Swiss-Prot Function:
- May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 25416956 |
Phenotypes for GAS7 Gene
- MGI mutant phenotypes for GAS7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GAS7:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for GAS7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GAS7 gene
- Search ViGene Biosciences for GAS7
CRISPR Products
-
OriGene CRISPR knockouts for GAS7
-
Santa Cruz Biotechnology (SCBT) CRISPR for GAS7
- GenScript: Design CRISPR guide RNA sequences for GAS7
miRNA for GAS7 Gene
- miRTarBase miRNAs that target GAS7
-
- hsa-mir-128-3p (MIRT021949)
- hsa-mir-599 (MIRT444617)
- hsa-mir-3161 (MIRT444618)
- hsa-mir-1255b-5p (MIRT444619)
- hsa-mir-6744-5p (MIRT444620)
- hsa-mir-1255a (MIRT444621)
- hsa-mir-1287-5p (MIRT444622)
- hsa-mir-4487 (MIRT444623)
- hsa-mir-450b-5p (MIRT526747)
- hsa-mir-384 (MIRT526748)
- hsa-mir-3685 (MIRT526749)
- hsa-mir-527 (MIRT526750)
- hsa-mir-518a-5p (MIRT526751)
- hsa-mir-548aw (MIRT526752)
- hsa-mir-202-5p (MIRT526753)
- hsa-mir-337-3p (MIRT526754)
- hsa-mir-3124-3p (MIRT526755)
- hsa-mir-6837-3p (MIRT526756)
miRNA Products
- Search ViGene Biosciences for GAS7
Clone Products
- OriGene clones in human for GAS7
- OriGene ORF clones in human,mouse,rat for GAS7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GAS7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GAS7 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GAS7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GAS7 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS7 Gene
Localization for GAS7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GAS7 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 1 |
| golgi apparatus | 1 |
No data available for Gene Ontology (GO) - Cellular Components for GAS7 Gene
Pathways & Interactions for GAS7 Gene
More details on SuperPathways for GAS7
No Data Available
Interacting Proteins for GAS7 Gene
Selected Interacting proteins:
O60861-GAS7_HUMAN
ENSP00000407552
for GAS7 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 9736752 |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source for GAS7 Gene
Transcripts for GAS7 Gene
mRNA/cDNA for GAS7 Gene
- (10) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (369) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GAS7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GAS7
-
Santa Cruz Biotechnology (SCBT) CRISPR for GAS7
- GenScript: Design CRISPR guide RNA sequences for GAS7
miRNA Products
- Search ViGene Biosciences for GAS7
Clone Products
- OriGene clones in human for GAS7
- OriGene ORF clones in human,mouse,rat for GAS7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GAS7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for GAS7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Bone Marrow
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
- Retina
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for GAS7 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8).
This gene is overexpressed in Frontal cortex (24.2) and Testis (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GAS7 Gene
SOURCE GeneReport for Unigene cluster for GAS7 Gene Hs.462214
Primer Products
-
OriGene qPCR primer pairs and template standards for GAS7
-
OriGene qPCR primer pairs for GAS7
No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GAS7 Gene
Orthologs for GAS7 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | GAS7 35 |
|
||
| GAS7 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | GAS7 35 |
|
||
| GAS7 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gas7 35 |
|
||
| Gas7 16 |
|
||||
| Gas7 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | GAS7 35 |
|
||
| GAS7 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Gas7 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GAS7 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GAS7 35 |
|
||
| GAS7 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | GAS7 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gas7 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24134 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gas7a 35 |
|
||
| CABZ01102038.1 36 |
|
OneToMany | |||
| gas7a 36 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HOF1 38 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for GAS7:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GAS7 Gene
(4) SIMAP similar genes for GAS7 Gene using alignment to 9 proteins:
No data available for Paralogs for GAS7 Gene
Variants for GAS7 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs4668 | -- | 9,911,106(-) | TCCTT(A/G)GTGAC | utr-variant-3-prime | |
| rs9545 | -- | 9,910,885(-) | ACCCC(C/G)GTATG | utr-variant-3-prime | |
| rs14383 | -- | 9,911,080(-) | GCATC(C/G)CTTCC | utr-variant-3-prime | |
| rs15814 | -- | 9,913,073(-) | TTAAC(A/C)CTCCA | utr-variant-3-prime | |
| rs424873 | -- | 10,058,020(+) | aagat(A/G)tgctt | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv833361 | CNV | Gain | 17160897 |
| dgv38n68 | CNV | Loss | 17160897 |
| nsv516119 | CNV | Loss | 19592680 |
| nsv1978 | CNV | Insertion | 18451855 |
| nsv833364 | CNV | Gain | 17160897 |
| esv2715633 | CNV | Deletion | 23290073 |
| esv2715634 | CNV | Deletion | 23290073 |
| nsv907673 | CNV | Gain | 21882294 |
| nsv520771 | CNV | Gain+Loss | 19592680 |
| nsv907674 | CNV | Gain | 21882294 |
| dgv3059n71 | CNV | Gain | 21882294 |
| esv2670514 | CNV | Deletion | 23128226 |
| nsv833365 | CNV | Gain | 17160897 |
| esv269561 | CNV | Insertion | 20981092 |
| nsv907678 | CNV | Gain | 21882294 |
Residual Variation Intolerance Score:
7.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.85;
17.82% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GAS7 Gene
- Human Gene Mutation Database (HGMD)
- GAS7
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS7 Gene
Disorders for GAS7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spastic hemiplegia |
|
|
| glaucoma 1, open angle, e |
|
|
Search GAS7 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GAS7_HUMAN- Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1. {ECO:0000269 PubMed:10706619}.
Relevant External Links for GAS7
No data available for Genatlas for GAS7 Gene
Publications for GAS7 Gene
- Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48 67
- Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. (PMID: 15948147) Chao C.C. … Lu H.H. (J. Neurosci. Res. 2005) 3 23
- Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. (PMID: 11795944) She B.R. … Lin-Chao S. (Exp. Cell Res. 2002) 3 23
- gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. (PMID: 9736752) Ju Y.T. … Lin-Chao S. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
- Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/I^-TrCP/I^-catenin pathways in lung cancer. (PMID: 26506240) Tseng R.C. … Wang Y.C. (Oncotarget 2015) 3
Products for GAS7 Gene
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- OriGene qPCR primer pairs for GAS7
- OriGene qPCR primer pairs and template standards for GAS7
- OriGene CRISPR knockouts for GAS7
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- Novus Biologicals Antibodies for GAS7
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for Growth Arrest Specific Protein 7
- Abcam proteins for Growth Arrest Specific Protein 7
- Search for Assays for GAS7 at Abcam
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- Search knockout validated antibodies
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- ProSpec Recombinant Proteins for GAS7
- antibodies-online Antibodies for GAS7: See all 72
- Search antibodies-online for kits
- antibodies-online Proteins for GAS7: See all 21
- Search antibodies-online for peptides
- GeneTex GAS7 antibody for GAS7
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- ViGene Biosciences adenoviral particle packaged cDNA for GAS7 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for GAS7 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GAS7 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GAS7 gene
- Search ViGene Biosciences for GAS7
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- Santa Cruz Biotechnology (SCBT) Antibodies for GAS7
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- Santa Cruz Biotechnology (SCBT) CRISPR for GAS7
Sources for GAS7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon