Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GAS7 Gene

protein-coding GIFtS: 61
GCID: GC17M009813

Growth Arrest-Specific 7

Alzheimer's & Parkinson's Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Growth Arrest-Specific 7¹ ²
MLL/GAS7²
Growth Arrest-Specific Protein 7²
MLL/GAS7 Fusion Protein²
GAS-7³
KIAA0394³

External Ids:	HGNC: 4169¹	Entrez Gene: 8522²	Ensembl: ENSG00000007237⁷	OMIM: 603127⁵	UniProtKB: O60861³

Export aliases for GAS7 gene to outside databases

Previous GC identifers: GC17M010179 GC17M010928 GC17M009756 GC17M010014 GC17M009754

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GAS7 Gene:

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in

mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript

variants encoding proteins which vary in the N-terminus have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for GAS7 Gene:

GAS7 (growth arrest-specific 7) is a protein-coding gene. Diseases associated with GAS7 include spastic hemiplegia, and acute myeloid leukemia with t translocation. GO annotations related to this gene include actin filament binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861

Function: May play a role in promoting maturation and morphological differentiation of cerebellar neurons

Gene Wiki entry for GAS7 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NT_010718.16 NC_018928.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GAS7 gene promoter:
p53 Pax-6 Nkx2-5 Cdc5 NF-AT NF-AT4 NF-AT2 FOXO4 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): GAS7 promoter sequence

Search SABiosciences Chromatin IP Primers for GAS7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAS7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

GAS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAS7 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M009813: view genomic region (about GC identifiers)

Start:	9,813,926 bp from pter	End:	10,101,868 bp from pter
Size:	287,943 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861 (See protein sequence)

Recommended Name: Growth arrest-specific protein 7

Size: 476 amino acids; 54371 Da

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=BAA23690.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

2 PDB 3D structures from and Proteopedia for GAS7:

2LX7 (3D)

2YSH (3D)

Secondary accessions: A8KAC2 B2RCK9 O43144 Q53Y77 Q7Z571

Alternative splicing: 4 isoforms: O60861-3 O60861-1 O60861-2 O60861-4

Explore the universe of human proteins at neXtProt for GAS7: NX_O60861

Explore proteomics data for GAS7 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_O60861

GAS7 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (4 alternative transcripts):

NP_001124303.1 NP_003635.2 NP_958836.1 NP_958839.1

ENSEMBL proteins:

ENSP00000410108 ENSP00000322608 ENSP00000407552 ENSP00000464240 ENSP00000463873

ENSP00000464088 ENSP00000443265 ENSP00000463527 ENSP00000463033 ENSP00000463007

ENSP00000462304 ENSP00000464494 ENSP00000462897 ENSP00000463551 ENSP00000379421

ENSP00000446214

Human Recombinant Protein Products for GAS7:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins for GAS7 OriGene Protein Over-expression Lysate for GAS7 OriGene MassSpec for GAS7 OriGene Custom Protein Services for GAS7
	GenScript Custom Purified and Recombinant Proteins Services for GAS7
	Novus Biologicals GAS7 Proteins Novus Biologicals GAS7 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for GAS7
	Cloud-Clone Corp. Proteins for GAS7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005884	actin filament	IEA	--

GAS7 for ontologies About GeneDecksing

GAS7 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for GAS7 OriGene Custom Antibody Services for GAS7
	GenScript Custom Superior Antibodies Services for GAS7
	Novus Biologicals GAS7 Antibodies
	Abcam antibodies for GAS7
	Cloud-Clone Corp. Antibodies for GAS7
	ThermoFisher Antibodies for GAS7
	LSBio Antibodies in human, mouse, rat for GAS7

Assay Products for GAS7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for GAS7
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GAS7
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for GAS7 Cloud-Clone Corp. CLIAs for GAS7

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR001060 FCH_dom

IPR001452 SH3_domain

IPR001202 WW_dom

Graphical View of Domain Structure for InterPro Entry O60861

ProtoNet protein and cluster: O60861

UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861

Similarity: Contains 1 FCH domain

Similarity: Contains 1 SH3 domain

Similarity: Contains 1 WW domain

GAS7 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GAS7_HUMAN, O60861

Function: May play a role in promoting maturation and morphological differentiation of cerebellar neurons

Genatlas biochemistry entry for GAS7:

growth arrest specific gene 7,50kDa,mouse homolog

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	9736752
GO:0005515	protein binding	--	--
GO:0051015	actin filament binding	IEA	--

GAS7 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for GAS7:

Decreased viability with cispl

Increased cell death in breast

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for GAS7

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GAS7

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GAS7

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GAS7

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAS7
		8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate GAS7 (see all 80):
		hsa-miR-548j hsa-miR-4254 hsa-miR-146a hsa-miR-374a hsa-miR-548a-5p hsa-miR-374b* hsa-miR-559 hsa-miR-548y

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for GAS7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAS7

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for GAS7
			Sirion Biotech Customized adenovirus for overexpression of GAS7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for GAS7 (see all 22) OriGene ORF clones in mouse, rat for GAS7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): GAS7 (NM_001130831)
		Sino Biological Human cDNA Clone for GAS7
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAS7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS7
		Sirion Biotech Customized lentivirus for stable overexpression of GAS7 Customized lentivirus expression plasmids for stable overexpression of GAS7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GAS7
		Search LifeMap BioReagents cell lines for GAS7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GAS7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/75 Interacting proteins for GAS7 (O60861^{2, 3} ENSP00000322608⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 75)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABI1	Q8IZP0²^,³, ENSP00000365312⁴	MINT-72912 I2D: score=3 STRING: ENSP00000365312
FMNL1	O95466²^,³, ENSP00000329219⁴	MINT-72916 I2D: score=3 STRING: ENSP00000329219
GAPDH	P04406²^,³, ENSP00000229239⁴	MINT-72922 I2D: score=3 STRING: ENSP00000229239
KHDRBS1	Q07666²^,³, ENSP00000313829⁴	MINT-72907 I2D: score=3 STRING: ENSP00000313829
RPLP0	P05388²^,³, ENSP00000339027⁴	MINT-72911 I2D: score=3 STRING: ENSP00000339027

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	TAS	9736752
GO:0007050	cell cycle arrest	TAS	9736752
GO:0008360	regulation of cell shape	IEA	--
GO:0030041	actin filament polymerization	IEA	--
GO:0030182	neuron differentiation	--	--

GAS7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GAS7

Search CenterWatch for drugs/clinical trials and news about GAS7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GAS7 gene (4 alternative transcripts):

NM_001130831.1 NM_003644.2 NM_201432.1 NM_201433.1

Unigene Cluster for GAS7:

Growth arrest-specific 7

Hs.462214 [show with all ESTs]

Unigene Representative Sequence: NM_201433

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000437099(uc002gmg.1 uc010vvc.1 uc002gmh.1 uc010vvd.1 uc002gmi.2)

ENST00000323816(uc010coh.1) ENST00000432992 ENST00000585266 ENST00000580865

ENST00000583882 ENST00000542249 ENST00000579158 ENST00000581112 ENST00000578456

ENST00000581871 ENST00000580811 ENST00000584146 ENST00000579140 ENST00000578655

ENST00000578599 ENST00000584389 ENST00000580043

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAS7
		8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate GAS7 (see all 80):
		hsa-miR-548j hsa-miR-4254 hsa-miR-146a hsa-miR-374a hsa-miR-548a-5p hsa-miR-374b* hsa-miR-559 hsa-miR-548y

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for GAS7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAS7

Clone Products:		OriGene clones in human, mouse for GAS7 (see all 22) OriGene ORF clones in mouse, rat for GAS7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): GAS7 (NM_001130831)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAS7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS7
		Sirion Biotech Customized lentivirus for stable overexpression of GAS7 Customized lentivirus expression plasmids for stable overexpression of GAS7

Primer Products:		OriGene qPCR primer pairs and template standards for GAS7 OriGene qSTAR qPCR primer pairs in human, mouse for GAS7
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GAS7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAS7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAS7

Additional mRNA sequence:

AB007854.1 AB209030.1 AJ224876.1 AK057761.1 AK225165.1 AK292987.1 AK293755.1 AK293834.1

AK294829.1 AK299574.1 AK307987.1 AK309722.1 AK315162.1 AY327406.1 BC001152.1 BC006454.1

BC113835.1 BT006891.1

21 DOTS entries:

DT.87014326 DT.95106979 DT.92400005 DT.92471376 DT.120961609 DT.97800020 DT.120961650 DT.120961708

DT.120961668 DT.100779119 DT.120961716 DT.92471333 DT.95106989 DT.100853466 DT.92471334 DT.120961613

DT.120961715 DT.95106972 DT.95106980 DT.95191861 DT.97796365

24/369 AceView cDNA sequences (see all 369):

AA683418 CN479858 CR608158 BF769556 AI916953 BU194048 AI693692 T33038

AI720127 AI189451 BM673553 AI954641 BE858058 AA411406 BP361596 AI356071

AA326642 AA350259 BG482273 T33023 AA309507 BI752247 N73310 AI082576

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GAS7 expression in normal human tissues (normalized intensities) GAS7 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTAAAGAGCC

About this image

GAS7 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/9 selected tissues (see all 9) fully expand


Brain (Nervous System) fully expand to see all 7 entries
Cerebral Cortex
Fetal Neuronal Stem Cells (NSC)
cerebellum

Eye (Sensory Organs) fully expand to see all 4 entries
GABAergic Amacrine Cells Inner Nuclear Layer
Human Retinal Pigment Epithelial Cells (HRPEpiC)
retinal progenitor cell e16.5

Testis (Reproductive System) fully expand to see all 2 entries
Pre-Sertoli Cells Testis Cord
testis ; cells in seminiferus ducts

Blood (Hematopoietic System) fully expand to see all 2 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow
bone marrow-derived macrophages

Gut Tube (Gastrointestinal Tract)
Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

See GAS7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAS7

SOURCE GeneReport for Unigene cluster: Hs.462214

SABiosciences Custom PCR Arrays for GAS7

Primer Products:		OriGene qPCR primer pairs and template standards for GAS7 OriGene qSTAR qPCR primer pairs in human, mouse for GAS7
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GAS7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAS7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAS7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GAS7 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gas7^{1 , 5}	growth arrest specific 7^{1, 5}	91.13(n)¹ 97.36(a)¹		11 (41.13 cM)⁵ 14457¹ NM_008088.4¹ NP_032114.2¹ 67455437⁵
chicken (Gallus gallus)	Aves	GAS7¹	growth arrest-specific 7	79.55(n) 84.45(a)		417305 XM_415577.3 XP_415577.2
lizard (Anolis carolinensis)	Reptilia	GAS7⁶	Uncharacterized protein	79(a)	1 ↔ 1	2(109213804-109321439)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24134²	Xenopus laevis transcribed sequence with moderate similarity more	82.2(n)		BJ625620.1
zebrafish (Danio rerio)	Actinopterygii	gas7¹	growth arrest-specific 7	75.44(n) 81.5(a)		793701 XM_001333471.2 XP_001333507.2

ENSEMBL Gene Tree for GAS7 (if available)
TreeFam Gene Tree for GAS7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GAS7 gene

5 SIMAP similar genes for GAS7 using alignment to 13 protein entries: GAS7_HUMAN (see all proteins):

MLL/GAS7 PSTPIP1 SH3GL2 PIN1P1 SH3GL1

GAS7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184377050^1,2		--	9802888(+)	`AGAATC/TGCTTG`	4	--	ds500¹		0	--	--	--	--
rs4791908^1,2	C,F,A	--	9802909(+)	`gtagaG/Cgttgc`	4	--	ds500¹		6		NA WA CSA	14
rs145590375^1,2		--	9802937(+)	`CCACTG/TCACTC`	4	--	ds500¹		0	--	--	--	--
rs145394654^1,2		--	9802944(+)	`ACTCCA/CGCCTG`	4	--	ds500¹		0	--	--	--	--
rs189903078^1,2	C	--	9802952(+)	`CTGGGC/TGACAG`	4	--	ds500¹		0	--	--	--	--
rs138987937^1,2	C	--	9802964(+)	`CGAGA-/CTACTCT`	4	--	ds500¹		0	--	--	--	--
rs71958026^1,2	C	--	9802965(+)	`GAGAC-/CTTCTCT`	4	--	ds500¹		0	--	--	--	--
rs12602099^1,2	C,F,H	--	9802983(+)	`TCTCTC/ATATAT`	4	--	ds500¹		1		EA	120
rs4791376^1,2	C,A,H	--	9802985(+)	`TCTCTA/CTATAT`	4	--	ds500¹		3		NA EA	242
rs138229534^1,2		--	9802987(+)	`TCTATA/CTATAT`	4	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GAS7 (9813926 - 10063926 bp, first 250kb of GAS7)

Structural Variations
Database of Genomic Variants (DGV) 10/15 variations for GAS7 (see all 15): About this table

Variant ID	Type	Subtype	PubMed ID
esv2715634	CNV	Deletion	23290073
esv2670514	CNV	Deletion	23128226
esv2715633	CNV	Deletion	23290073
nsv1978	CNV	Insertion	18451855
esv269561	CNV	Insertion	20981092
dgv38n68	CNV	Loss	17160897
nsv516119	CNV	Loss	19592680
nsv833365	CNV	Gain	17160897
nsv907678	CNV	Gain	21882294
nsv907674	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing GAS7

DNA2.0 Custom Variant and Variant Library Synthesis for GAS7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 603127 OMIM disorders: --

UniProtKB/Swiss-Prot: GAS7_HUMAN, O60861

Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation

t(11;17)(q23;p13) with KMT2A/MLL1

17 diseases for GAS7: About MalaCards

spastic hemiplegia acute myeloid leukemia with t translocation hemiplegia pediatric osteosarcoma

primary open angle glaucoma open-angle glaucoma spasticity neuronitis

osteosarcoma glaucoma acute leukemia ulcerative colitis

acute myeloid leukemia myeloid leukemia neuroblastoma alzheimer's disease

leukemia

1 disease from the University of Copenhagen DISEASES database for GAS7:

Spastic hemiplegia

GAS7 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): GAS7
Human Genome Epidemiology (HuGE) Navigator: GAS7 (8 documents)

Export disorders for GAS7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GAS7 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with GAS7)

Utopia: connect your pdf to the dynamic
world of online information

Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)^{1, 4} Oguri M....Yamada Y. (2010)
Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)^{1, 4} Yoshida T....Yamada Y. (2010)
Genetic analysis in a Dutch study sample identifies m ore ulcerative colitis susceptibility loci and shows their additive role in dis ease risk. (PubMed id 19861958)^{1, 4} Festen E.A....Weersma R.K. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. (PubMed id 10706619)^{1, 2} Megonigal M.D.... Felix C.A. (2000)
gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. (PubMed id 9736752)^{1, 3} Ju Y.T....Lin-Chao S. (1998)
Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)^{1, 2} Ishikawa K....Ohara O. (1997)
Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. (PubMed id 15948147)^{1, 9} Chao C.C....Lu H.H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8522	HGNC: 4169	AceView: GAS7	Ensembl:ENSG00000007237	euGenes: HUgn8522
ECgene: GAS7	H-InvDB: GAS7

(According to HUGE)
About This Section

HUGE: KIAA0394

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GAS7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GAS7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GAS7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GAS7 gene:
Search GeneIP for patents involving GAS7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for GAS7		OriGene RNAi products in human, mouse, rat for GAS7
	OriGene qPCR primer pairs and template standards for GAS7		OriGene Protein Over-expression Lysate for GAS7
	OriGene MassSpec something-or-other for GAS7		OriGene clones in human, mouse for GAS7
	OriGene qSTAR qPCR primer pairs in human, mouse for GAS7		OriGene Purified Protein for GAS7
	OriGene ORF clones in mouse, rat for GAS7		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GAS7		OriGene Custom Protein Services for GAS7

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAS7
	QIAGEN SeqTarget long-range PCR primers for resequencing GAS7
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAS7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAS7
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAS7
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAS7

	GenScript Custom Purified and Recombinant Proteins Services for GAS7		GenScript cDNA clones with any tag delivered in your preferred vector for GAS7
	GenScript Custom Assay Services for GAS7		GenScript Custom Superior Antibodies Services for GAS7
	GenScript Custom overexpressing Cell Line Services for GAS7		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GAS7 promoter
	Search Chromatin IP Primers for GAS7
	RT² qPCR Primer Assay in human, mouse, rat GAS7
	Search GNC Networks for GAS7
	SABiosciences Custom PCR Arrays for GAS7

Search Tocris compounds for GAS7

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	cDNA Clones for GAS7
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GAS7 antibodies
	GAS7 proteins
	GAS7 lysates

	Antibodies for GAS7
	See all of Abcam's Antibodies, Kits and Proteins for GAS7
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for GAS7

	Proteins for GAS7
	Antibodies for GAS7
	ELISAs for GAS7
	CLIAs for GAS7

Search LifeMap BioReagents cell lines for GAS7

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS7

	Browse SwitchGear 3'UTR luciferase reporter plasmids for GAS7
	SwitchGear Promoter luciferase reporter plasmids for GAS7

ThermoFisher Antibodies for GAS7

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS7

	inGenious Targeting Laboratory - Custom generated mouse model solutions for GAS7
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GAS7

Customized:

	lentivirus for stable overexpression of GAS7
	lentivirus expression plasmids for stable overexpression of GAS7
	adenovirus for overexpression of GAS7

LSBio Antibodies in human, mouse, rat for GAS7

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GAS7 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

GAS7 Gene

Growth Arrest-Specific 7

Aliases
for GAS7 gene

Summaries
for GAS7 gene

Genomic Views
for GAS7 gene

Proteins
for GAS7 gene

Protein Domains /
Families
for GAS7 gene

Function
for GAS7 gene

Pathways & Interactions
for GAS7 gene

Drugs & Compounds
for GAS7 gene

Transcripts
for GAS7 gene

Expression
for GAS7 gene

Orthologs
for GAS7 gene

Paralogs
for GAS7 gene

Genomic Variants
for GAS7 gene

Disorders / Diseases
for GAS7 gene

Publications
for GAS7 gene

External Searches for GAS7 gene

Genome Databases showing GAS7 gene

Other Databases showing GAS7 gene

Specialized Databases showing GAS7 gene

Intellectual Property
for GAS7 gene

Products
for GAS7 gene

View Random Gene

Advanced Search

Export list of displayed genes

GAS7 Gene

Growth Arrest-Specific 7

Aliasesfor GAS7 gene

Summariesfor GAS7 gene

Genomic Viewsfor GAS7 gene

Proteinsfor GAS7 gene

Protein Domains /Familiesfor GAS7 gene

Functionfor GAS7 gene

Pathways & Interactionsfor GAS7 gene

Drugs & Compoundsfor GAS7 gene

Transcriptsfor GAS7 gene

Expression for GAS7 gene

Orthologsfor GAS7 gene

Paralogsfor GAS7 gene

Genomic Variantsfor GAS7 gene

Disorders / Diseasesfor GAS7 gene

Publicationsfor GAS7 gene

External Searches for GAS7 gene

Genome Databases showing GAS7 gene

Other Databases showing GAS7 gene

Specialized Databases showing GAS7 gene

Intellectual Propertyfor GAS7 gene

Productsfor GAS7 gene

View Random Gene

Aliases
for GAS7 gene

Summaries
for GAS7 gene

Genomic Views
for GAS7 gene

Proteins
for GAS7 gene

Protein Domains /
Families
for GAS7 gene

Function
for GAS7 gene

Pathways & Interactions
for GAS7 gene

Drugs & Compounds
for GAS7 gene

Transcripts
for GAS7 gene

Expression
for GAS7 gene

Orthologs
for GAS7 gene

Paralogs
for GAS7 gene

Genomic Variants
for GAS7 gene

Disorders / Diseases
for GAS7 gene

Publications
for GAS7 gene

Intellectual Property
for GAS7 gene

Products
for GAS7 gene