Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GAS7 Gene

Aliases for GAS7 Gene

  • Growth Arrest Specific 7 2 3 5
  • Growth Arrest-Specific Protein 7 3
  • MLL/GAS7 Fusion Protein 3
  • MLL/GAS7 3
  • KIAA0394 4
  • GAS-7 4

External Ids for GAS7 Gene

Previous GeneCards Identifiers for GAS7 Gene

  • GC17M010179
  • GC17M010928
  • GC17M009756
  • GC17M010014
  • GC17M009754
  • GC17M009813

Summaries for GAS7 Gene

Entrez Gene Summary for GAS7 Gene

  • Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAS7 Gene

GAS7 (Growth Arrest Specific 7) is a Protein Coding gene. Diseases associated with GAS7 include Spastic Hemiplegia and Glaucoma 1, Open Angle, E. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and actin filament binding. An important paralog of this gene is PSTPIP2.

UniProtKB/Swiss-Prot for GAS7 Gene

  • May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Gene Wiki entry for GAS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS7 Gene

Genomics for GAS7 Gene

Regulatory Elements for GAS7 Gene

Enhancers for GAS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F010155 1.5 FANTOM5 Ensembl ENCODE 28.2 +41.9 41851 3.0 HDGF PKNOX1 MXI1 TBL1XR1 MAX BMI1 EBF1 ZFHX2 POLR2A EED GAS7 GC17P010160 GC17P010145
GH17F010147 1.6 FANTOM5 Ensembl ENCODE 24 +48.2 48151 6.4 PKNOX1 FEZF1 BMI1 ZBTB40 ZNF143 FOS ETV6 CREM ZNF202 SMARCC1 GAS7 ENSG00000261433 MAGOH2P GC17P010145 GC17P010160
GH17F010125 1.3 FANTOM5 Ensembl ENCODE 26.7 +71.1 71111 4.3 BHLHE40 TEAD4 REST ZFHX2 KDM1A ZNF600 FOXP2 FOS MYC MAFK GAS7 MYH4 GC17M010130 GC17M010115
GH17F010017 1.6 FANTOM5 Ensembl ENCODE 20.3 +178.9 178851 5.0 ZFP64 ZNF76 BMI1 FEZF1 YBX1 RAD21 ZNF121 ZNF143 ZNF391 ZNF202 MAGOH2P ENSG00000261433 GAS7 ENSG00000271851 GC17P010023 GC17P009965
GH17F010112 1.6 FANTOM5 Ensembl ENCODE 20 +80.1 80092 12.5 PKNOX1 ZFP64 SIN3A FEZF1 ZNF121 GLIS2 ZNF207 FOS ZNF202 REST MAGOH2P ENSG00000261433 GAS7 ENSG00000271851 MYH4 GC17M010115 GC17P010097
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GAS7 on UCSC Golden Path with GeneCards custom track

Promoters for GAS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340845 451 2601 SP3 RNF2 SP2 ZBTB8A ZIC2 GLIS2 PATZ1 SCRT2 PRDM10 ZNF600

Genomic Location for GAS7 Gene

9,910,609 bp from pter
10,198,551 bp from pter
287,943 bases
Minus strand

Genomic View for GAS7 Gene

Genes around GAS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS7 Gene

Proteins for GAS7 Gene

  • Protein details for GAS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Growth arrest-specific protein 7
    Protein Accession:
    Secondary Accessions:
    • A8KAC2
    • B2RCK9
    • O43144
    • Q53Y77
    • Q7Z571

    Protein attributes for GAS7 Gene

    476 amino acids
    Molecular mass:
    54371 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA23690.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GAS7 Gene

    Alternative splice isoforms for GAS7 Gene


neXtProt entry for GAS7 Gene

Post-translational modifications for GAS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GAS7 Gene

Domains & Families for GAS7 Gene

Gene Families for GAS7 Gene

Protein Domains for GAS7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-BAR domain.
  • Contains 1 F-BAR domain.
  • Contains 1 SH3 domain.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with GAS7: view

Function for GAS7 Gene

Molecular function for GAS7 Gene

GENATLAS Biochemistry:
growth arrest specific gene 7,50kDa,mouse homolog
UniProtKB/Swiss-Prot Function:
May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Gene Ontology (GO) - Molecular Function for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9736752
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAS7: view
genes like me logo Genes that share phenotypes with GAS7: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS7 Gene

Localization for GAS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS7 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GAS7: view

Pathways & Interactions for GAS7 Gene

No Data Available

SIGNOR curated interactions for GAS7 Gene


Gene Ontology (GO) - Biological Process for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007050 cell cycle arrest TAS 9736752
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GAS7: view

No data available for Pathways by source for GAS7 Gene

Transcripts for GAS7 Gene

Unigene Clusters for GAS7 Gene

Growth arrest-specific 7:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS7 Gene

No ASD Table

Relevant External Links for GAS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAS7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for GAS7 Gene

This gene is overexpressed in Frontal cortex (24.2) and Testis (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GAS7 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAS7 Gene:


SOURCE GeneReport for Unigene cluster for GAS7 Gene:

genes like me logo Genes that share expression patterns with GAS7: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GAS7 Gene

Orthologs for GAS7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GAS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GAS7 34 35
  • 99.65 (n)
(Bos Taurus)
Mammalia GAS7 34 35
  • 93.65 (n)
(Canis familiaris)
Mammalia GAS7 34 35
  • 92.29 (n)
(Rattus norvegicus)
Mammalia Gas7 34
  • 91.29 (n)
(Mus musculus)
Mammalia Gas7 34 16 35
  • 91.13 (n)
(Monodelphis domestica)
Mammalia GAS7 35
  • 91 (a)
(Gallus gallus)
Aves GAS7 34 35
  • 79.55 (n)
(Anolis carolinensis)
Reptilia GAS7 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gas7 34
  • 77.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24134 34
(Danio rerio)
Actinopterygii CABZ01102038.1 35
  • 87 (a)
gas7a 34 35
  • 76.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOF1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
Species where no ortholog for GAS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAS7 Gene

Gene Tree for GAS7 (if available)
Gene Tree for GAS7 (if available)

Paralogs for GAS7 Gene

Paralogs for GAS7 Gene

genes like me logo Genes that share paralogs with GAS7: view

Variants for GAS7 Gene

Sequence variations from dbSNP and Humsavar for GAS7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1003011 -- 10,037,357(+) GGAGC(A/G)GCTGA intron-variant, upstream-variant-2KB
rs10048160 -- 10,144,154(+) GACTG(C/T)GGGGT intron-variant
rs10048221 -- 10,004,896(+) TCCCA(A/G)CTACT intron-variant
rs1016134 -- 10,023,764(+) acaat(A/G)tcatg intron-variant
rs1016135 -- 10,024,266(+) GGGCA(A/G)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAS7 Gene

Variant ID Type Subtype PubMed ID
nsv833365 CNV gain 17160897
nsv833364 CNV gain 17160897
nsv833361 CNV gain 17160897
nsv520771 CNV gain+loss 19592680
nsv516119 CNV loss 19592680
nsv477662 CNV novel sequence insertion 20440878
nsv476132 CNV novel sequence insertion 20440878
nsv474610 CNV novel sequence insertion 20440878
nsv1978 CNV insertion 18451855
nsv1133229 CNV tandem duplication 24896259
nsv1065401 CNV loss 25217958
nsv1061466 CNV gain 25217958
nsv1060957 CNV gain 25217958
esv3892958 CNV loss 25118596
esv3639928 CNV loss 21293372
esv3639927 CNV loss 21293372
esv3639926 CNV gain 21293372
esv3582524 CNV loss 25503493
esv3582523 CNV loss 25503493
esv3582517 CNV loss 25503493
esv3376171 CNV insertion 20981092
esv2715634 CNV deletion 23290073
esv2715633 CNV deletion 23290073
esv2670514 CNV deletion 23128226
dgv887e212 CNV loss 25503493
dgv559e214 CNV loss 21293372
dgv5443n54 CNV gain 21841781
dgv38n68 CNV loss 17160897

Variation tolerance for GAS7 Gene

Residual Variation Intolerance Score: 7.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAS7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS7 Gene

Disorders for GAS7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GAS7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spastic hemiplegia
  • congenital hemiplegia
glaucoma 1, open angle, e
  • primary open angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search GAS7 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1. {ECO:0000269 PubMed:10706619}.

Relevant External Links for GAS7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GAS7: view

No data available for Genatlas for GAS7 Gene

Publications for GAS7 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen E.A. … Weersma R.K. (Am. J. Gastroenterol. 2010) 3 46 64

Products for GAS7 Gene

Sources for GAS7 Gene

Loading form....