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GAS7 Gene(Protein Coding)

Growth Arrest Specific 7

GCID:
GC17M009910
GIFtS:
57
Genes Participants
UDN Logo

Aliases for GAS7 Gene

Aliases for GAS7 Gene

  • Growth Arrest Specific 7 2 3 5
  • KIAA0394 4
  • GAS-7 4

External Ids for GAS7 Gene

Previous GeneCards Identifiers for GAS7 Gene

  • GC17M010179
  • GC17M010928
  • GC17M009756
  • GC17M010014
  • GC17M009754
  • GC17M009813

Summaries for GAS7 Gene

Entrez Gene Summary for GAS7 Gene

  • Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAS7 Gene

GAS7 (Growth Arrest Specific 7) is a Protein Coding gene. Diseases associated with GAS7 include Spastic Hemiplegia and Glaucoma 1, Open Angle, E. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and actin filament binding. An important paralog of this gene is PSTPIP1.

UniProtKB/Swiss-Prot for GAS7 Gene

  • May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Gene Wiki entry for GAS7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS7 Gene

Genomics for GAS7 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GAS7 Gene

Enhancers for GAS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G010155 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.3 +41.8 41818 2.7 HDGF PKNOX1 TBL1XR1 BMI1 RAD21 ETV6 RELB IKZF2 CREM EGR2 GAS7 GC17P010160 GC17P010145
GH17G010149 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24 +47.2 47244 3.5 PKNOX1 ZSCAN4 BMI1 ZBTB40 ZNF143 FOS ETV6 IKZF2 CREM SMARCC1 GAS7 GC17P010160 GC17P010145
GH17G010125 1.6 FANTOM5 Ensembl ENCODE dbSUPER 26.7 +71.2 71173 4.2 BHLHE40 ZSCAN4 TEAD4 RBBP5 REST ZFHX2 FOS KDM1A ZNF600 FOXP2 GAS7 MYH4 GC17M010130 GC17M010115
GH17G010017 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +178.9 178851 4.6 ZNF76 BMI1 FEZF1 YBX1 RAD21 ZSCAN5C ZNF143 ZNF207 ZNF391 ETV6 GAS7 GC17P010023 GC17P009965
GH17G010170 1.4 FANTOM5 Ensembl ENCODE dbSUPER 23.9 +26.7 26656 2.3 ZNF146 CBX8 POLR2A SMARCA4 GLIS1 ZNF600 PRDM1 MYC GAS7 MYH4 GC17M010159
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GAS7 on UCSC Golden Path with GeneCards custom track

Promoters for GAS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091261 351 2001 MXI1 ZNF777 SUZ12 RBBP5 ZIC2 GLIS2 PATZ1 SCRT2 ZNF600 PRDM10

Transcription factor binding sites by QIAGEN in the GAS7 gene promoter:

Genomic Location for GAS7 Gene

Chromosome:
17
Start:
9,910,609 bp from pter
End:
10,198,551 bp from pter
Size:
287,943 bases
Orientation:
Minus strand

Genomic View for GAS7 Gene

Genes around GAS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GAS7 Gene

Proteins for GAS7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GAS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60861-GAS7_HUMAN
    Recommended name:
    Growth arrest-specific protein 7
    Protein Accession:
    O60861
    Secondary Accessions:
    • A8KAC2
    • B2RCK9
    • O43144
    • Q53Y77
    • Q7Z571

    Protein attributes for GAS7 Gene

    Size:
    476 amino acids
    Molecular mass:
    54371 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA23690.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GAS7 Gene

    Alternative splice isoforms for GAS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS7 Gene

Protein Expression for GAS7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GAS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAS7 Gene

Domains & Families for GAS7 Gene

No data available for UniProtKB/Swiss-Prot for GAS7 Gene

Function for GAS7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GAS7 Gene

GENATLAS Biochemistry:
growth arrest specific gene 7,50kDa,mouse homolog
UniProtKB/Swiss-Prot Function:
May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Gene Ontology (GO) - Molecular Function for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9736752
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAS7: view
genes like me logo Genes that share phenotypes with GAS7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS7 Gene

Localization for GAS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS7 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GAS7: view

Pathways & Interactions for GAS7 Gene

SuperPathways for GAS7 Gene

PathCards logo More details on SuperPathways for GAS7
No Data Available

SIGNOR curated interactions for GAS7 Gene

Activates:

Gene Ontology (GO) - Biological Process for GAS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007050 cell cycle arrest TAS 9736752
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GAS7: view

No data available for Pathways by source for GAS7 Gene

Drugs & Compounds for GAS7 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GAS7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GAS7 Gene

(14) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(369) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAS7 Gene

Growth arrest-specific 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS7 Gene

No ASD Table

Relevant External Links for GAS7 Gene

GeneLoc Exon Structure for
GAS7
ECgene alternative splicing isoforms for
GAS7

Expression for GAS7 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAS7 Gene

mRNA expression in normal human tissues for GAS7 Gene
mRNA expression by BioGPS for GAS7 GenemRNA expression by GTEx for GAS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAS7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for GAS7 Gene

This gene is overexpressed in Frontal cortex (24.2) and Testis (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GAS7 Gene



NURSA nuclear receptor signaling pathways regulating expression of GAS7 Gene:

GAS7

SOURCE GeneReport for Unigene cluster for GAS7 Gene:

Hs.462214

Evidence on tissue expression from TISSUES for GAS7 Gene

  • Nervous system(5)
  • Skin(4.7)
  • Eye(4.4)
genes like me logo Genes that share expression patterns with GAS7: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS7 Gene

Orthologs for GAS7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GAS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GAS7 34 35
  • 99.65 (n)
cow
(Bos Taurus)
 Mammalia GAS7 34 35
  • 93.65 (n)
dog
(Canis familiaris)
 Mammalia GAS7 34 35
  • 92.29 (n)
rat
(Rattus norvegicus)
 Mammalia Gas7 34
  • 91.29 (n)
mouse
(Mus musculus)
 Mammalia Gas7 35 16 34
  • 91.13 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia GAS7 35
  • 91 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GAS7 34 35
  • 79.55 (n)
lizard
(Anolis carolinensis)
 Reptilia GAS7 35
  • 79 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gas7 34
  • 77.54 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.24134 34
zebrafish
(Danio rerio)
 Actinopterygii CABZ01102038.1 35
  • 87 (a)
 OneToMany
gas7a 34 35
  • 76.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HOF1 37
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 33 (a)
 OneToOne
Species where no ortholog for GAS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAS7 Gene

ENSEMBL:
Gene Tree for GAS7 (if available)
TreeFam:
Gene Tree for GAS7 (if available)

Paralogs for GAS7 Gene

Paralogs for GAS7 Gene

(4) SIMAP similar genes for GAS7 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GAS7: view

Variants for GAS7 Gene

Sequence variations from dbSNP and Humsavar for GAS7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000021400 -- 9,949,457(+) ATGGA(C/G)CTCCC intron-variant
rs1000023850 -- 10,154,066(+) TTTCA(A/T)CATGG intron-variant
rs1000034297 -- 9,932,473(+) CAGGC(A/G)TGAGC intron-variant
rs1000039968 -- 10,020,161(+) GCTAA(C/T)GGAGC intron-variant, upstream-variant-2KB
rs1000060032 -- 10,112,248(+) CACAC(A/G)GCGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAS7 Gene

Variant ID Type Subtype PubMed ID
dgv38n68 CNV loss 17160897
dgv5443n54 CNV gain 21841781
dgv559e214 CNV loss 21293372
dgv887e212 CNV loss 25503493
esv2670514 CNV deletion 23128226
esv2715633 CNV deletion 23290073
esv2715634 CNV deletion 23290073
esv3376171 CNV insertion 20981092
esv3582517 CNV loss 25503493
esv3582523 CNV loss 25503493
esv3582524 CNV loss 25503493
esv3639926 CNV gain 21293372
esv3639927 CNV loss 21293372
esv3639928 CNV loss 21293372
esv3892958 CNV loss 25118596
nsv1060957 CNV gain 25217958
nsv1061466 CNV gain 25217958
nsv1065401 CNV loss 25217958
nsv1133229 CNV tandem duplication 24896259
nsv1978 CNV insertion 18451855
nsv474610 CNV novel sequence insertion 20440878
nsv476132 CNV novel sequence insertion 20440878
nsv477662 CNV novel sequence insertion 20440878
nsv516119 CNV loss 19592680
nsv520771 CNV gain+loss 19592680
nsv833361 CNV gain 17160897
nsv833364 CNV gain 17160897
nsv833365 CNV gain 17160897

Variation tolerance for GAS7 Gene

Residual Variation Intolerance Score: 7.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAS7 Gene

Human Gene Mutation Database (HGMD)
GAS7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS7 Gene

Disorders for GAS7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GAS7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spastic hemiplegia
  • congenital hemiplegia
glaucoma 1, open angle, e
  • primary open angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search GAS7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GAS7_HUMAN
  • Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1. {ECO:0000269 PubMed:10706619}.

Relevant External Links for GAS7

Genetic Association Database (GAD)
GAS7
Human Genome Epidemiology (HuGE) Navigator
GAS7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAS7
genes like me logo Genes that share disorders with GAS7: view

No data available for Genatlas for GAS7 Gene

Publications for GAS7 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen E.A. … Weersma R.K. (Am. J. Gastroenterol. 2010) 3 46 64

Products for GAS7 Gene

Sources for GAS7 Gene

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