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GAS6 Gene

protein-coding GIFtS: 65
GCID: GC13M114523

Growth Arrest-Specific 6

(Previous symbol: AXLLG)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Growth Arrest-Specific 6¹ ²		AXSF² ⁵
AXLLG¹ ² ³ ⁵		Growth Arrest-Specific Protein 6²
AXL Stimulatory Factor¹ ²		GAS-6³
AXL Receptor Tyrosine Kinase Ligand² ³

External Ids:	HGNC: 4168¹	Entrez Gene: 2621²	Ensembl: ENSG00000183087⁷	OMIM: 600441⁵	UniProtKB: Q14393³

Export aliases for GAS6 gene to outside databases

Previous GC identifers: GC13U990018 GC13P113563 GC13P112446 GC13P113546 GC13P094864

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GAS6 Gene:

This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the

stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2009)

GeneCards Summary for GAS6 Gene:

GAS6 (growth arrest-specific 6) is a protein-coding gene. Diseases associated with GAS6 include critical limb ischemia, and vitamin k deficiency hemorrhagic disease. GO annotations related to this gene include voltage-gated calcium channel activity and calcium ion binding. An important paralog of this gene is PROS1.

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393

Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell

growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such

as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during

human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and

migration, platelet activation, or regulation of thrombotic responses

Gene Wiki entry for GAS6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000013.11 NC_018924.2 NT_024498.13

Regulatory elements:

Regulatory transcription factor binding sites in the GAS6 gene promoter:
HOXA9 p53 FOXF2 HSF2 Bach2 Olf-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for GAS6

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAS6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

GAS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAS6 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M114523: view genomic region (about GC identifiers)

Start:	114,523,522 bp from pter	End:	114,567,046 bp from pter
Size:	43,525 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393 (See protein sequence)

Recommended Name: Growth arrest-specific protein 6 precursor

Size: 721 amino acids; 79677 Da

Subunit: Heterodimer and heterotetramer with AXL

2 PDB 3D structures from and Proteopedia for GAS6:

1H30 (3D)

2C5D (3D)

Secondary accessions: B3KRQ7 B3KVL4 E9PBL7 Q6IMN1 Q7Z7N3

Alternative splicing: 5 isoforms: Q14393-1 Q14393-2 Q14393-3 Q14393-4 Q14393-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GAS6: NX_Q14393

Explore proteomics data for GAS6 at MOPED

Post-translational modifications:

Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50

kDa protein including the laminin G-like domains which activates AXL¹

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for

the binding of calcium (By similarity)¹

Glycosylation² at Asn463

Modification sites at PhosphoSitePlus

See GAS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_000811.1 NP_001137417.1 NP_001137418.1

ENSEMBL proteins:

ENSP00000331831 ENSP00000349962 ENSP00000348003 ENSP00000416498 ENSP00000400117

Reactome Protein details: Q14393

GAS6 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 11):

IPR017857 Coagulation_fac_subgr_Gla_dom

IPR000742 EG-like_dom

IPR013320 ConA-like_subgrp

IPR001791 Laminin_G

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

Graphical View of Domain Structure for InterPro Entry Q14393

ProtoNet protein and cluster: Q14393

4 Blocks protein domains:

IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

IPB001791 Laminin G

IPB001881 EGF-like calcium-binding

IPB002383 Coagulation factor GLA domain signature

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393

Similarity: Contains 4 EGF-like domains

Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain

Similarity: Contains 2 laminin G-like domains

GAS6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: GAS6_HUMAN, Q14393

Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell

growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such

as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during

human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and

migration, platelet activation, or regulation of thrombotic responses

Genatlas biochemistry entry for GAS6:

growth arrest specific gene 6,with homology to PROS1,ligand for TYRO3/AXL family of receptor tyrosine kinase

Gene Ontology (GO): Selected molecular function terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001786	phosphatidylserine binding	IDA	--
GO:0005102	receptor binding	IPI	7854420
GO:0005245	voltage-gated calcium channel activity	IDA	18395422
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	16362042

GAS6 for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gas6):

cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	renal/urinary system	vision/eye

GAS6 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for GAS6: Gas6^tm1Pec Gas6^tm1Hiar

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GAS6

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GAS6

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		hsa-miR-587 hsa-miR-3607-3p hsa-miR-944 hsa-miR-548c-3p
		SwitchGear 3'UTR luciferase reporter plasmid: GAS6 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

GAS6_HUMAN, Q14393: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
endoplasmic reticulum	4
golgi apparatus	4
plasma membrane	2
nucleus	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	18395422
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IDA	18395422
GO:0005788	endoplasmic reticulum lumen	TAS	--

GAS6 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for GAS6 About (see all 17)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

PTM- gamma carboxylation, hypusine formation and arylsulfatase activation

PTM- gamma carboxylation, hypusine formation and arylsulfatase activation	0.31	Removal of aminoterminal propeptides from gamma-carboxylated proteins
Warfarin Pathway, Pharmacodynamics	0.31	Gamma-carboxylation of protein precursors
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	0.00	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

Apoptotic Pathways in Synovial Fibroblasts

Mitochondrial Apoptosis	0.85	Rac1 Pathway	0.65
Cellular Apoptosis Pathway	0.85	Glioma Invasiveness	0.64
Apoptotic Pathways in Synovial Fibroblasts	0.84	Actin-Based Motility by Rho Family GTPases	0.62
p53 Mediated Apoptosis	0.84	ERK5 Signaling	0.61

GPCR Pathway

Ras Pathway	0.73	Breast Cancer Regulation by Stathmin1	0.58
Paxillin Interactions	0.73	NFAT in Immune Response	0.58
GPCR Pathway	0.62	Estrogen Pathway	0.55
Pancreatic Adenocarcinoma	0.59

ERK Signaling

Rho Family GTPases	0.61	Molecular Mechanisms of Cancer	0.51
ERK Signaling	0.61	ILK Signaling	0.49
MAPK Signaling	0.58

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	0.61			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GAS6 (see all 54)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

5 Reactome Pathways for GAS6

	Platelet degranulation
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Gamma-carboxylation of protein precursors
	Cell surface interactions at the vascular wall

1 PharmGKB Pathway for GAS6

Warfarin Pathway, Pharmacodynamics

GAS6 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including GAS6:

Polycomb & Trithorax Target Genes in human mouse rat

Interactions:

GeneGlobe Interaction Network for GAS6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for GAS6 (Q14393^{1, 2, 3} ENSP00000331831⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AXL	P30530¹^,²^,³, ENSP00000301178⁴	EBI-2802811,EBI-2850927 MINT-2735822 MINT-2735908 MINT-2738515 MINT-2735786 MINT-2735853 MINT-2735881 MINT-2735935 MINT-2735964 I2D: score=5 STRING: ENSP00000301178
TYRO3	Q06418³, ENSP00000263798⁴	I2D: score=4 STRING: ENSP00000263798
MERTK	Q12866³, ENSP00000295408⁴	I2D: score=4 STRING: ENSP00000295408
A2M	ENSP00000323929⁴	STRING: ENSP00000323929
ACTN4	ENSP00000252699⁴	STRING: ENSP00000252699

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Gene Ontology (GO): Selected biological process terms (see all 74): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0001934	positive regulation of protein phosphorylation	ISS	--
GO:0001961	positive regulation of cytokine-mediated signaling pathway	IMP	18840707
GO:0002576	platelet degranulation	TAS	--
GO:0003104	positive regulation of glomerular filtration	ISS	--

GAS6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for GAS6

1 HMDB Compound for GAS6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

8 Novoseek inferred chemical compound relationships for GAS6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gamma-carboxyglutamic acid	75.7	19	9163328 (3), 18760998 (3), 12871548 (1), 18841281 (1) (see all 5)
tyrosine	73.3	86	7559388 (3), 9160883 (3), 9259426 (3), 15673687 (3) (see all 55)
warfarin	59.7	18	15199298 (4), 15619028 (2), 9163328 (2), 15790929 (1) (see all 9)
wortmannin	46.9	3	9234702 (2), 11597931 (1)
phosphatidylinositol	34.9	1	9234702 (1)
ly294002	34.5	1	16723520 (1)
phosphatidylserine	32.8	25	10731712 (7), 18760998 (2), 18247125 (1), 15673687 (1) (see all 5)
vegf	0	2	15507525 (2)

GAS6 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for GAS6 gene (3 alternative transcripts):

NM_000820.2 NM_001143945.1 NM_001143946.1

Unigene Cluster for GAS6:

Growth arrest-specific 6

Hs.646346 [show with all ESTs]

Unigene Representative Sequence: AL833761

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000608763 ENST00000480426 ENST00000610073 ENST00000327773 ENST00000476291

ENST00000357389(uc001vud.3) ENST00000355761 ENST00000450766(uc001vuf.3)

ENST00000418959(uc001vug.3)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat GAS6 using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate GAS6:
		hsa-miR-587 hsa-miR-3607-3p hsa-miR-944 hsa-miR-548c-3p
		SwitchGear 3'UTR luciferase reporter plasmid: GAS6 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector (see all 3): GAS6 (NM_000820)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAS6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS6

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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat GAS6
		QuantiTect SYBR Green Assays in human, mouse, rat GAS6
		QuantiFast Probe-based Assays in human, mouse, rat GAS6

Additional mRNA sequence:

AK092028.1 AK122969.1 AK129751.1 AK290803.1 AK303145.1 AL833761.1 BC030708.1 BC038984.1

L13720.1

Selected DOTS entries (see all 26):

DT.97765850 DT.100703102 DT.95314883 DT.100659748 DT.101985521 DT.118742 DT.118744 DT.100659746

DT.100841587 DT.95314867 DT.100671601 DT.100836601 DT.120777369 DT.92439072 DT.97854076 DT.100848520

DT.101985522 DT.92439069 DT.120777381 DT.120777390 DT.40106957 DT.95287481 DT.95314887 DT.97854080

Selected AceView cDNA sequences (see all 504):

BM712369 NM_000820 CF132022 AW085677 BF345031 N45582 CA436131 AI366130

CA414189 BM558160 BU527895 AK126533 AL541174 CA424580 CA313373 AI472381

CB153178 BU676492 F07639 CF127892 AL134683 BQ574372 BX364780 CA422208

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for GAS6 (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b
SP1:											-												-		-
SP2:											-
SP3:
SP4:																									-		-
SP5:																																									-		-

ECgene alternative splicing isoforms for GAS6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GAS6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGAGAGCTG

About this image

GAS6 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Intermediate Mesoderm (Gastrulation Derivatives) fully expand to see all 2 entries
Mesonephric cells Mesonephros
Mesonephros

Gut Tube (Gastrointestinal Tract) fully expand to see all 2 entries
Hindgut

Ovary (Reproductive System)
Pre-Granulosa Cells Primordial Follicle

Kidney (Urinary System)
Interstitial Stroma

Gonad
Mesonephric cells Mesonephros

GAS6 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

GAS6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.646346

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393

Tissue specificity: Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in

spleen

Pathway & Disease-focused RT² Profiler PCR Array including GAS6:

Polycomb & Trithorax Target Genes in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for GAS6 OriGene qSTAR qPCR primer pairs in human, mouse for GAS6
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat GAS6
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		QuantiFast Probe-based Assays in human, mouse, rat GAS6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for GAS6 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gas6^{1 , 5}	growth arrest specific 6^{1, 5}	80.48(n)¹ 83.05(a)¹		8 (6.06 cM)⁵ 14456¹ NM_019521.2¹ NP_062394.2¹ 13465374⁵
chicken (Gallus gallus)	Aves	GAS6¹	growth arrest-specific 6	66.84(n) 67.47(a)		418737 XM_416936.4 XP_416936.4
lizard (Anolis carolinensis)	Reptilia	GAS6⁶	growth arrest-specific 6	65(a)	1 ↔ 1	3(106410994-106444972)
African clawed frog (Xenopus laevis)	Amphibia	MGC68463²	hypothetical protein MGC68463	76.13(n)		BC060355.1
zebrafish (Danio rerio)	Actinopterygii	wufj34a12²	wufj34a12	79.46(n)		335830 BC053117.1

ENSEMBL Gene Tree for GAS6 (if available)
TreeFam Gene Tree for GAS6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for GAS6 gene

PROS1² SHBG²

9 SIMAP similar genes for GAS6 using alignment to 2 protein entries: GAS6_HUMAN (see all proteins):

DKFZp666G247 PROC PROS1 PRRG3 PROC1 F9

F2 F7 HMCN1

GAS6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for GAS6
PGOHUM00000250249

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59614507^1,2	C	--	114525675(-)	`GACAG-/GT/TG ACAGG`	3	--	int¹		1		NA	2
rs67180102^1,2	C	--	114536695(-)	`ACAGT-/ACCTG TCACACCGACCTG`	3	--	int¹ ut5¹		1		NA	2
rs150698186^1,2	C	--	114544663(-)	`GAAAC-/TGGGCATAT GGAGGAAACTGTGGGG`	1	--	int¹		0	--	--	--	--
rs79491301^1,2	C	--	114546327(-)	`GCACCG/AGCTTC`	1	--	int¹		3		NA WA	240
rs148383732^1,2		--	114546363(+)	`GGTGAC/TGAGCG`	1	--	int¹		0	--	--	--	--
rs73581246^1,2	C,F	--	114546364(-)	`TCGCTC/TGTCAC`	1	--	int¹		1		WA	2
rs190833499^1,2		--	114546407(+)	`GAGGGA/GACACT`	1	--	int¹		0	--	--	--	--
rs78074493^1,2	F	--	114546545(-)	`CATAGC/GGGCCA`	1	--	int¹		1		EA	120
rs6602912^1,2	C,F,A	--	114546549(-)	`CTGCCA/CTAGCG`	1	--	int¹		8		NA WA EA	500
rs182292749^1,2		--	114546562(+)	`CGGGCA/GCGTTC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GAS6 (114523522 - 114567046 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for GAS6 (see all 42): About this table

Variant ID	Type	Subtype	PubMed ID
esv2748416	CNV	Deletion	23290073
esv2748401	CNV	Deletion	23290073
esv1444149	CNV	Deletion	17803354
dgv284e201	CNV	Deletion	23290073
esv2748395	CNV	Deletion	23290073
esv2748394	CNV	Deletion	23290073
esv2748415	CNV	Deletion	23290073
esv2748393	CNV	Deletion	23290073
esv2748399	CNV	Deletion	23290073
esv2748414	CNV	Deletion	23290073

Human Gene Mutation Database (HGMD): GAS6

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GAS6

DNA2.0 Custom Variant and Variant Library Synthesis for GAS6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600441 OMIM disorders: --

Selected diseases for GAS6 (see all 52):
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critical limb ischemia vitamin k deficiency hemorrhagic disease chronic inflammatory demyelinating polyneuropathy demyelinating polyneuropathy

ovarian endometriosis hemorrhagic disease ocular melanoma leukemia/lymphoma, t-cell

polyneuropathy glomerulonephritis diabetic nephropathy pancreatic ductal adenocarcinoma

endometriosis septic shock acute pancreatitis venous thromboembolism

leiomyoma atherosclerosis thromboembolism thyroid cancer

GAS6 for disorders About GeneDecksing

Selected Novoseek inferred disease relationships for GAS6 gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glomerulonephritis mesangial proliferative	44.9	1	11290560 (1)
calcification	42.3	17	20048160 (3), 17196959 (2), 18495950 (2), 16556867 (2) (see all 7)
chronic glomerulonephritis	34.9	2	15619028 (1), 15199298 (1)
albuminuria	27.4	2	18374201 (1), 15199298 (1)
thrombosis	24.8	7	15733062 (2), 15108283 (1), 15790929 (1), 17721624 (1) (see all 6)
diabetic nephropathies	24.2	8	18374201 (3), 15619028 (1), 15199298 (1)
thyroid carcinoma	24.1	4	9492013 (2), 12490074 (2)
renal disease	23.1	6	14750094 (2), 15619028 (2), 15199298 (1), 12768229 (1)
inflammation	22.2	8	19644365 (2), 9516131 (1), 19369636 (1), 15790929 (1) (see all 7)
glomerulonephritis	14.4	3	11290560 (1), 12644472 (1), 15199298 (1)

Genetic Association Database (GAD): GAS6
Human Genome Epidemiology (HuGE) Navigator: GAS6 (5 documents)

Export disorders for GAS6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GAS6 gene, integrated from 10 sources (see all 187):
(articles sorted by number of sources associating them with GAS6)

Utopia: connect your pdf to the dynamic
world of online information

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. (PubMed id 8336730)^{1, 2, 3, 9} Manfioletti G.... Schneider C. (Mol. Cell. Biol. 1993)
Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. (PubMed id 15108283)^{1, 2, 4, 9} Munoz X....Sala N. (Hum. Mutat. 2004)
Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. (PubMed id 19369636)^{1, 4, 9} Jiang L....Zhang W. (Am. J. Clin. Pathol. 2009)
Association of specific haplotypes of GAS6 gene with stroke. (PubMed id 17721624)^{1, 4, 9} MuA+oz X....Sala N. (Thromb. Haemost. 2007)
The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation. (PubMed id 9326369)^{1, 2, 9} Goruppi S.... Schneider C. (FEBS Lett. 1997)
Characterization of Gas6, a member of the superfamily of G domain- containing proteins, as a ligand for Rse and Axl. (PubMed id 8621659)^{1, 2, 9} Mark M.R.... Godowski P.J. (J. Biol. Chem. 1996)
Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6. (PubMed id 9326368)^{1, 2, 9} Marcandalli P.... Schneider C. (FEBS Lett. 1997)
Structural basis for Gas6-Axl signalling. (PubMed id 16362042)^{1, 2, 9} Sasaki T.... Hohenester E. (EMBO J. 2006)
Is Gas6 protein associated with sticky platelet syndrome? (PubMed id 19696043)^{1, 4} Kubisz P....Pullmann R. (Clin. Appl. Thromb. Hemost. 2010)
Association study between polymorphims in GAS6-TAM genes and carotid atherosclerosis. (PubMed id 20664904)^{1, 4} Hurtado B....Sala N. (Thromb. Haemost. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2621	HGNC: 4168	AceView: GAS6	Ensembl:ENSG00000183087	euGenes: HUgn2621
ECgene: GAS6	H-InvDB: GAS6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GAS6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GAS6	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/gas6/

Intellectual Property for GAS6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GAS6 gene:
Search GeneIP for patents involving GAS6

GeneCards and IP:
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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Growth Arrest-Specific 6

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GAS6 Gene

Growth Arrest-Specific 6

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