Aliases for GAS6 Gene
Aliases for GAS6 Gene
External Ids for GAS6 Gene
- HGNC: 4168
- Entrez Gene: 2621
- Ensembl: ENSG00000183087
- OMIM: 600441
- UniProtKB: Q14393
Previous HGNC Symbols for GAS6 Gene
- AXLLG
Previous GeneCards Identifiers for GAS6 Gene
- GC13U990018
- GC13P113563
- GC13P112446
- GC13P113546
- GC13M114523
- GC13P094864
Summaries for GAS6 Gene
-
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
GeneCards Summary for GAS6 Gene
GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Sticky Platelet Syndrome and Acute Maxillary Sinusitis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and voltage-gated calcium channel activity. An important paralog of this gene is PROS1.
UniProtKB/Swiss-Prot for GAS6 Gene
-
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
-
(Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).
Additional gene information for GAS6 Gene
- Monarch Initiative
- Search for GAS6 at DataMed
- Search for GAS6 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS6 Gene
Genomics for GAS6 Gene
GeneHancer (GH) Regulatory Elements for GAS6 Gene
Regulatory Element Products
Genomic Locations for GAS6 Gene
- chr13:113,820,549-113,864,103
- (GRCh38/hg38)
- Size:
- 43,555 bases
- Orientation:
- Minus strand
- chr13:114,523,522-114,567,046
- (GRCh37/hg19)
Genomic View for GAS6 Gene
- Cytogenetic band:
-
- 13q34 by Ensembl
- 13q34 by Entrez Gene
- 13q34 by HGNC


RefSeq DNA sequence for GAS6 Gene
Proteins for GAS6 Gene
-
Protein details for GAS6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14393-GAS6_HUMAN
- Recommended name:
- Growth arrest-specific protein 6
- Protein Accession:
- Q14393
- B3KRQ7
- B3KVL4
- E9PBL7
- Q6IMN1
- Q7Z7N3
Protein attributes for GAS6 Gene
- Size:
- 721 amino acids
- Molecular mass:
- 79677 Da
- Quaternary structure:
-
- Heterodimer and heterotetramer with AXL.
Three dimensional structures from OCA and Proteopedia for GAS6 Gene
Protein Expression for GAS6 Gene
Post-translational modifications for GAS6 Gene
- Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
- Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
- Glycosylation at isoforms=2, 3, 4, 5463
Other Protein References for GAS6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for GAS6
-
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-
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-
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Protein Products
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-
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-
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Assay Products
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-
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No data available for DME Specific Peptides for GAS6 Gene
Domains & Families for GAS6 Gene
Gene Families for GAS6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for GAS6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GAS6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for GAS6 Gene
Function for GAS6 Gene
Molecular function for GAS6 Gene
- GENATLAS Biochemistry:
- growth arrest specific gene 6,with homology to PROS1,ligand for TYRO3/AXL family of receptor tyrosine kinase
- UniProtKB/Swiss-Prot Function:
- Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).
Phenotypes From GWAS Catalog for GAS6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001786 | phosphatidylserine binding | IDA | 21501828 |
GO:0005102 | receptor binding | IPI | 7854420 |
GO:0005245 | voltage-gated calcium channel activity | IDA | 18395422 |
GO:0005509 | calcium ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16362042 |
Phenotypes for GAS6 Gene
- MGI mutant phenotypes for GAS6:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for GAS6:
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-
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miRNA for GAS6 Gene
- miRTarBase miRNAs that target GAS6
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Inhibitory RNA Products
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Clone Products
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-
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAS6 Gene
Localization for GAS6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GAS6 Gene
- Secreted.
- Cytosol (2)
- Microtubule organizing center (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA,IDA | 8336730 |
GO:0005622 | intracellular | IEA | -- |
GO:0005737 | cytoplasm | IDA | 18395422 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
Pathways & Interactions for GAS6 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
2 | GPCR Pathway |
.73
.62
|
.55
|
3 | ERK Signaling |
.61
.58
|
.49
|
4 | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||
5 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
Pathways by source for GAS6 Gene
1 Cell Signaling Technology pathway for GAS6 Gene
12 Reactome pathways for GAS6 Gene
1 PharmGKB pathway for GAS6 Gene
1 KEGG pathway for GAS6 Gene
Interacting Proteins for GAS6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001764 | neuron migration | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | IEA,ISS | -- |
GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IMP | 18840707 |
GO:0002576 | platelet degranulation | TAS | -- |
GO:0003104 | positive regulation of glomerular filtration | IEA,ISS | -- |
Drugs & Compounds for GAS6 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
calcium | Approved | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for GAS6 Gene
mRNA/cDNA for GAS6 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (504) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GAS6 Gene
CRISPR Products
-
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-
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-
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-
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP10: |
Expression for GAS6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Cortical Stroma Cells Interstitial Stroma
- Medullary Stroma Cells Interstitial Stroma
- Interstitial Stroma
-
Intermediate Mesoderm (Gastrulation Derivatives)
- Mesonephric cells Mesonephros
- Mesonephros
- Gut Tube (Gastrointestinal Tract)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
-
Gonad
- Mesonephric cells Mesonephros
mRNA differential expression in normal tissues according to GTEx for GAS6 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GAS6 Gene
NURSA nuclear receptor signaling pathways regulating expression of GAS6 Gene:
GAS6SOURCE GeneReport for Unigene cluster for GAS6 Gene:
Hs.646346mRNA Expression by UniProt/SwissProt for GAS6 Gene:
Q14393-GAS6_HUMANEvidence on tissue expression from TISSUES for GAS6 Gene
- Lung(4.8)
- Kidney(4.5)
- Spleen(4.4)
- Nervous system(4.3)
- Bone(2.9)
- Heart(2.7)
- Muscle(2.7)
- Blood(2.6)
- Eye(2.1)
- Skin(2.1)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for GAS6
-
OriGene qPCR primer pairs and template standards for GAS6
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS6 Gene
Orthologs for GAS6 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GAS6 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | GAS6 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Gas6 33 |
|
||
mouse (Mus musculus) |
Mammalia | Gas6 33 16 34 |
|
||
dog (Canis familiaris) |
Mammalia | GAS6 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | GAS6 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | GAS6 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GAS6 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | GAS6 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | gas6 33 |
|
||
Str.18141 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68463 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | gas6 33 34 |
|
||
wufj34a12 33 |
|
||||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany |
- Species where no ortholog for GAS6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GAS6 Gene
Variants for GAS6 Gene
SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000057786 | -- | 113,823,310(-) | G/A | intron_variant | |
rs1000073529 | -- | 113,826,882(-) | G/A/C | intron_variant | |
rs1000090831 | -- | 113,855,568(-) | C/T | intron_variant | |
rs1000290084 | -- | 113,848,605(-) | G/A | intron_variant | |
rs1000297159 | -- | 113,853,103(-) | T/C | intron_variant |
Additional Variant Information for GAS6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS6 Gene
Disorders for GAS6 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
sticky platelet syndrome |
|
|
acute maxillary sinusitis |
|
|
mesangial proliferative glomerulonephritis |
|
|
la crosse encephalitis |
|
|
systemic lupus erythematosus |
|
|
Additional Disease Information for GAS6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GAS6 Gene
Publications for GAS6 Gene
- Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. (PMID: 15108283) Muñoz X … Sala N (Human mutation 2004) 3 4 22 44 58
- The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. (PMID: 8336730) Manfioletti G … Schneider C (Molecular and cellular biology 1993) 2 3 4 22 58
- Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. (PMID: 19369636) Jiang L … Zhang W (American journal of clinical pathology 2009) 3 22 44 58
- Association of specific haplotypes of GAS6 gene with stroke. (PMID: 17721624) Muñoz X … Sala N (Thrombosis and haemostasis 2007) 3 22 44 58
- Structural basis for Gas6-Axl signalling. (PMID: 16362042) Sasaki T … Hohenester E (The EMBO journal 2006) 3 4 22 58
Products for GAS6 Gene
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- Overview of 113 available GAS6 gene related products
Sources for GAS6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
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