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GAS6 Gene

protein-coding   GIFtS: 65
GCID: GC13M114523

Growth Arrest-Specific 6


(Previous symbol: AXLLG)
  See GAS6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Growth Arrest-Specific 61 2     AXSF2 5
AXLLG1 2 3 5     Growth Arrest-Specific Protein 62
AXL Stimulatory Factor1 2     GAS-63
AXL Receptor Tyrosine Kinase Ligand2 3     

External Ids:    HGNC: 41681   Entrez Gene: 26212   Ensembl: ENSG000001830877   OMIM: 6004415   UniProtKB: Q143933   

Export aliases for GAS6 gene to outside databases

Previous GC identifers: GC13U990018 GC13P113563 GC13P112446 GC13P113546 GC13P094864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GAS6 Gene:
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the
stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2009)

GeneCards Summary for GAS6 Gene:
GAS6 (growth arrest-specific 6) is a protein-coding gene. Diseases associated with GAS6 include limb ischemia, and critical limb ischemia. GO annotations related to this gene include voltage-gated calcium channel activity and calcium ion binding. An important paralog of this gene is PROS1.

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393
Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell
growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such
as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during
human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and
migration, platelet activation, or regulation of thrombotic responses

Gene Wiki entry for GAS6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024498.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GAS6 gene promoter:
         HOXA9   p53   FOXF2   HSF2   Bach2   Olf-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GAS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

GAS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAS6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M114523:  view genomic region     (about GC identifiers)

Start:
114,523,522 bp from pter      End:
114,567,046 bp from pter
Size:
43,525 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393 (See protein sequence)
Recommended Name: Growth arrest-specific protein 6 precursor  
Size: 721 amino acids; 79677 Da
Subunit: Heterodimer and heterotetramer with AXL
2 PDB 3D structures from and Proteopedia for GAS6:
1H30 (3D)        2C5D (3D)    
Secondary accessions: B3KRQ7 B3KVL4 E9PBL7 Q6IMN1 Q7Z7N3
Alternative splicing: 5 isoforms:  Q14393-1   Q14393-2   Q14393-3   Q14393-4   Q14393-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GAS6: NX_Q14393

Explore proteomics data for GAS6 at MOPED

Post-translational modifications: 

  • Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50
    kDa protein including the laminin G-like domains which activates AXL1
  • Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for
    the binding of calcium (By similarity)1
  • Glycosylation2 at Asn463
  • Modification sites at PhosphoSitePlus

  • See GAS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000811.1  NP_001137417.1  NP_001137418.1  

    ENSEMBL proteins: 
     ENSP00000331831   ENSP00000349962   ENSP00000348003   ENSP00000416498   ENSP00000400117  
    Reactome Protein details: Q14393

    GAS6 Human Recombinant Protein Products:

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    Novus Biologicals GAS6 Proteins
    Novus Biologicals GAS6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GAS6

     
    Search eBioscience for Proteins for GAS6 

     
    antibodies-online proteins for GAS6 (13 products) 

     
    Search antibodies-online for peptides for GAS6

    GAS6 Antibody Products:

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    antibodies-online antibodies for GAS6 (41 products) 

    GAS6 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 11):
     IPR017857 Coagulation_fac_subgr_Gla_dom
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site

    Graphical View of Domain Structure for InterPro Entry Q14393

    ProtoNet protein and cluster: Q14393

    4 Blocks protein domains:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding
    IPB002383 Coagulation factor GLA domain signature


    UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain
    Similarity: Contains 2 laminin G-like domains


    Find genes that share domains with GAS6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GAS6_HUMAN, Q14393
    Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell
    growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such
    as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during
    human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and
    migration, platelet activation, or regulation of thrombotic responses

         Genatlas biochemistry entry for GAS6:
    growth arrest specific gene 6,with homology to PROS1,ligand for TYRO3/AXL family of receptor tyrosine kinase

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IDA--
    GO:0005102receptor binding IPI7854420
    GO:0005245voltage-gated calcium channel activity IDA18395422
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16362042
         
    Find genes that share ontologies with GAS6           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gas6):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  vision/eye 

    Find genes that share phenotypes with GAS6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GAS6: Gas6tm1Pec Gas6tm1Hiar

       genOway: Develop your customized and physiologically relevant rodent model for GAS6

    miRNA
    Products:
        
    miRTarBase miRNAs that target GAS6:
    hsa-mir-124-3p (MIRT022472)

    Block miRNA regulation of human, mouse, rat GAS6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate GAS6:
    hsa-miR-587 hsa-miR-3607-3p hsa-miR-944 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidGAS6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GAS6

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    GenScript: all cDNA clones in your preferred vector (see all 3): GAS6 (NM_000820)
    Sino Biological Human cDNA Clone for GAS6
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GAS6_HUMAN, Q14393: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    golgi apparatus4
    plasma membrane2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA18395422
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA18395422
    GO:0005788endoplasmic reticulum lumen TAS--

    Find genes that share ontologies with GAS6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GAS6 About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    Removal of aminoterminal propeptides from gamma-carboxylated proteins0.00
    Warfarin Pathway, Pharmacodynamics0.31
    Gamma-carboxylation of protein precursors0.00
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins0.00
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus0.00
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with GAS6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GAS6 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    5 Reactome Pathways for GAS6
        Platelet degranulation
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
    Removal of aminoterminal propeptides from gamma-carboxylated proteins
    Gamma-carboxylation of protein precursors
    Cell surface interactions at the vascular wall

    1 PharmGKB Pathway for GAS6
        Warfarin Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including GAS6: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GAS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GAS6 (Q143931, 2, 3 ENSP000003318314) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXLP305301, 2, 3, ENSP000003011784EBI-2802811,EBI-2850927 MINT-2735822 MINT-2735908 MINT-2738515 MINT-2735786 MINT-2735853 MINT-2735881 MINT-2735935 MINT-2735964 I2D: score=5 STRING: ENSP00000301178
    TYRO3Q064183, ENSP000002637984I2D: score=4 STRING: ENSP00000263798
    MERTKQ128663, ENSP000002954084I2D: score=4 STRING: ENSP00000295408
    A2MENSP000003239294STRING: ENSP00000323929
    ACTN4ENSP000002526994STRING: ENSP00000252699
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    Gene Ontology (GO): Selected biological process terms (see all 74):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0001961positive regulation of cytokine-mediated signaling pathway IMP18840707
    GO:0002576platelet degranulation TAS--
    GO:0003104positive regulation of glomerular filtration ISS--

    Find genes that share ontologies with GAS6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GAS6

    1 HMDB Compound for GAS6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    8 Novoseek inferred chemical compound relationships for GAS6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gamma-carboxyglutamic acid 75.7 19 9163328 (3), 18760998 (3), 12871548 (1), 18841281 (1) (see all 5)
    tyrosine 73.3 86 7559388 (3), 9160883 (3), 9259426 (3), 15673687 (3) (see all 55)
    warfarin 59.7 18 15199298 (4), 15619028 (2), 9163328 (2), 15790929 (1) (see all 9)
    wortmannin 46.9 3 9234702 (2), 11597931 (1)
    phosphatidylinositol 34.9 1 9234702 (1)
    ly294002 34.5 1 16723520 (1)
    phosphatidylserine 32.8 25 10731712 (7), 18760998 (2), 18247125 (1), 15673687 (1) (see all 5)
    vegf 0 2 15507525 (2)



    Find genes that share compounds with GAS6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GAS6 gene (3 alternative transcripts): 
    NM_000820.2  NM_001143945.1  NM_001143946.1  

    Unigene Cluster for GAS6:

    Growth arrest-specific 6
    Hs.646346  [show with all ESTs]
    Unigene Representative Sequence: AL833761
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608763 ENST00000480426 ENST00000610073 ENST00000327773 ENST00000476291
    ENST00000357389(uc001vud.3) ENST00000355761 ENST00000450766(uc001vuf.3)
    ENST00000418959(uc001vug.3)
    miRNA
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    hsa-miR-587 hsa-miR-3607-3p hsa-miR-944 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidGAS6 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GAS6
      QuantiFast Probe-based Assays in human, mouse, rat GAS6

    Additional mRNA sequence: 

    AK092028.1 AK122969.1 AK129751.1 AK290803.1 AK303145.1 AL833761.1 BC030708.1 BC038984.1 
    L13720.1 

    Selected DOTS entries (see all 26):

    DT.97765850  DT.100703102  DT.95314883  DT.100659748  DT.101985521  DT.118742  DT.118744  DT.100659746 
    DT.100841587  DT.95314867  DT.100671601  DT.100836601  DT.120777369  DT.92439072  DT.97854076  DT.100848520 
    DT.101985522  DT.92439069  DT.120777381  DT.120777390  DT.40106957  DT.95287481  DT.95314887  DT.97854080 

    Selected AceView cDNA sequences (see all 504):

    BM712369 NM_000820 CF132022 AW085677 BF345031 N45582 CA436131 AI366130 
    CA414189 BM558160 BU527895 AK126533 AL541174 CA424580 CA313373 AI472381 
    CB153178 BU676492 F07639 CF127892 AL134683 BQ574372 BX364780 CA422208 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GAS6 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                -                                   -     -                                                                     
    SP2:                                -                                                                                                               
    SP3:                                                                                                                                                
    SP4:                                                                          -     -                                                               
    SP5:                                                                                                                          -     -               


    ECgene alternative splicing isoforms for GAS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GAS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGAGCTG
    GAS6 Expression
    About this image


    GAS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Kidney (Urinary System)
             Interstitial Stroma
     
     Gonad
             Mesonephric cells Mesonephros
    GAS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GAS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646346

    UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393
    Tissue specificity: Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in
    spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including GAS6: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GAS6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gas61 , 5 growth arrest specific 61, 5 80.48(n)1
    83.05(a)1
      8 (6.06 cM)5
    144561  NM_019521.21  NP_062394.21 
     134653745 
    chicken
    (Gallus gallus)
    Aves GAS61 growth arrest-specific 6 66.84(n)
    67.47(a)
      418737  XM_416936.4  XP_416936.4 
    lizard
    (Anolis carolinensis)
    Reptilia GAS66
    growth arrest-specific 6
    65(a)
    1 ↔ 1
    3(106410994-106444972)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684632 hypothetical protein MGC68463 76.13(n)    BC060355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj34a122 wufj34a12 79.46(n)   335830  BC053117.1 


    ENSEMBL Gene Tree for GAS6 (if available)
    TreeFam Gene Tree for GAS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GAS6 gene
    PROS12  SHBG2  
    9 SIMAP similar genes for GAS6 using alignment to 2 protein entries:     GAS6_HUMAN (see all proteins):
    DKFZp666G247    PROC    PROS1    PRRG3    PROC1    F9
    F2    F7    HMCN1

    Find genes that share paralogs with GAS6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GAS6
    PGOHUM00000250249


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GAS6 (see all 564)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs596145071,2
    C--114525675(-) GACAG-/GT/TG 
            
    ACAGG
    3 -- int11NA 2
    rs671801021,2
    C--114536695(-) ACAGT-/ACCTG 
    TCACACCG
    ACCTG
    3 -- int1 ut511Minor allele frequency- ACCTGTCACACCG:0.00NA 2
    rs1506981861,2
    C--114544663(-) GAAAC-/TGGGCATAT
    GGAGGAAACTG
    TGGGG
    1 -- int10--------
    rs794913011,2
    C--114546327(-) GCACCG/AGCTTC 1 -- int13Minor allele frequency- A:0.11NA WA 240
    rs1483837321,2
    --114546363(+) GGTGAC/TGAGCG 1 -- int10--------
    rs735812461,2
    C,F--114546364(-) TCGCTC/TGTCAC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1908334991,2
    --114546407(+) GAGGGA/GACACT 1 -- int10--------
    rs780744931,2
    F--114546545(-) CATAGC/GGGCCA 1 -- int11Minor allele frequency- G:0.01EA 120
    rs66029121,2
    C,F,A--114546549(-) CTGCCA/CTAGCG 1 -- int18Minor allele frequency- C:0.28NA WA EA 500
    rs1822927491,2
    --114546562(+) CGGGCA/GCGTTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for GAS6 (114523522 - 114567046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GAS6 (see all 42):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748416CNV Deletion23290073
    esv2748401CNV Deletion23290073
    esv1444149CNV Deletion17803354
    dgv284e201CNV Deletion23290073
    esv2748395CNV Deletion23290073
    esv2748394CNV Deletion23290073
    esv2748415CNV Deletion23290073
    esv2748393CNV Deletion23290073
    esv2748399CNV Deletion23290073
    esv2748414CNV Deletion23290073

    Human Gene Mutation Database (HGMD): GAS6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GAS6
    DNA2.0 Custom Variant and Variant Library Synthesis for GAS6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600441    OMIM disorders: --

    5 diseases for GAS6:    
    About MalaCards
    limb ischemia    critical limb ischemia    ocular melanoma    demyelinating polyneuropathy
    ovarian endometriosis


    Find genes that share disorders with GAS6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GAS6 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glomerulonephritis mesangial proliferative 44.9 1 11290560 (1)
    calcification 42.3 17 20048160 (3), 17196959 (2), 18495950 (2), 16556867 (2) (see all 7)
    chronic glomerulonephritis 34.9 2 15619028 (1), 15199298 (1)
    albuminuria 27.4 2 18374201 (1), 15199298 (1)
    thrombosis 24.8 7 15733062 (2), 15108283 (1), 15790929 (1), 17721624 (1) (see all 6)
    diabetic nephropathies 24.2 8 18374201 (3), 15619028 (1), 15199298 (1)
    thyroid carcinoma 24.1 4 9492013 (2), 12490074 (2)
    renal disease 23.1 6 14750094 (2), 15619028 (2), 15199298 (1), 12768229 (1)
    inflammation 22.2 8 19644365 (2), 9516131 (1), 19369636 (1), 15790929 (1) (see all 7)
    glomerulonephritis 14.4 3 11290560 (1), 12644472 (1), 15199298 (1)

    Genetic Association Database (GAD): GAS6
    Human Genome Epidemiology (HuGE) Navigator: GAS6 (5 documents)

    Export disorders for GAS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GAS6 gene, integrated from 10 sources (see all 187):
    (articles sorted by number of sources associating them with GAS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. (PubMed id 8336730)1, 2, 3, 9 Manfioletti G.... Schneider C. (Mol. Cell. Biol. 1993)
    2. Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. (PubMed id 15108283)1, 2, 4, 9 Munoz X....Sala N. (Hum. Mutat. 2004)
    3. Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. (PubMed id 19369636)1, 4, 9 Jiang L....Zhang W. (Am. J. Clin. Pathol. 2009)
    4. Association of specific haplotypes of GAS6 gene with stroke. (PubMed id 17721624)1, 4, 9 MuA+oz X....Sala N. (Thromb. Haemost. 2007)
    5. The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation. (PubMed id 9326369)1, 2, 9 Goruppi S.... Schneider C. (FEBS Lett. 1997)
    6. Characterization of Gas6, a member of the superfamily of G domain- containing proteins, as a ligand for Rse and Axl. (PubMed id 8621659)1, 2, 9 Mark M.R.... Godowski P.J. (J. Biol. Chem. 1996)
    7. Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6. (PubMed id 9326368)1, 2, 9 Marcandalli P.... Schneider C. (FEBS Lett. 1997)
    8. Structural basis for Gas6-Axl signalling. (PubMed id 16362042)1, 2, 9 Sasaki T.... Hohenester E. (EMBO J. 2006)
    9. Is Gas6 protein associated with sticky platelet syndrome? (PubMed id 19696043)1, 4 Kubisz P....Pullmann R. (Clin. Appl. Thromb. Hemost. 2010)
    10. Association study between polymorphims in GAS6-TAM genes and carotid atherosclerosis. (PubMed id 20664904)1, 4 Hurtado B....Sala N. (Thromb. Haemost. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2621 HGNC: 4168 AceView: GAS6 Ensembl:ENSG00000183087 euGenes: HUgn2621
    ECgene: GAS6 H-InvDB: GAS6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GAS6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAS6 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/gas6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GAS6 gene:
    Search GeneIP for patents involving GAS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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