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GAS6 Gene(Protein Coding)

Growth Arrest Specific 6

GCID:
GC13M113820
GIFtS:
63
Genes Participants
UDN Logo

Aliases for GAS6 Gene

Aliases for GAS6 Gene

  • Growth Arrest Specific 6 2 3 5
  • AXL Receptor Tyrosine Kinase Ligand 2 3 4
  • AXL Stimulatory Factor 2 3
  • AXLLG 3 4
  • Growth Arrest-Specific 6 3
  • GAS-6 4
  • AXSF 3

External Ids for GAS6 Gene

Previous HGNC Symbols for GAS6 Gene

  • AXLLG

Previous GeneCards Identifiers for GAS6 Gene

  • GC13U990018
  • GC13P113563
  • GC13P112446
  • GC13P113546
  • GC13M114523
  • GC13P094864

Summaries for GAS6 Gene

Entrez Gene Summary for GAS6 Gene

  • This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

GeneCards Summary for GAS6 Gene

GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Acute Maxillary Sinusitis and Mesangial Proliferative Glomerulonephritis. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding and voltage-gated calcium channel activity. An important paralog of this gene is SHBG.

UniProtKB/Swiss-Prot for GAS6 Gene

  • Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

  • (Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).

Gene Wiki entry for GAS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS6 Gene

Genomics for GAS6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GAS6 Gene

Enhancers for GAS6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GAS6 on UCSC Golden Path with GeneCards custom track

Promoters for GAS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAS6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GAS6 gene promoter:

Genomic Location for GAS6 Gene

Chromosome:
13
Start:
113,820,549 bp from pter
End:
113,864,103 bp from pter
Size:
43,555 bases
Orientation:
Minus strand

Genomic View for GAS6 Gene

Genes around GAS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GAS6 Gene

Proteins for GAS6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GAS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14393-GAS6_HUMAN
    Recommended name:
    Growth arrest-specific protein 6
    Protein Accession:
    Q14393
    Secondary Accessions:
    • B3KRQ7
    • B3KVL4
    • E9PBL7
    • Q6IMN1
    • Q7Z7N3

    Protein attributes for GAS6 Gene

    Size:
    721 amino acids
    Molecular mass:
    79677 Da
    Quaternary structure:
    • Heterodimer and heterotetramer with AXL.

    Three dimensional structures from OCA and Proteopedia for GAS6 Gene

    Alternative splice isoforms for GAS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS6 Gene

Proteomics data for GAS6 Gene at MOPED

Protein Expression for GAS6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GAS6 Gene

  • Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
  • Glycosylation at Asn 463
  • Modification sites at PhosphoSitePlus

Other Protein References for GAS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GAS6 Gene

Domains & Families for GAS6 Gene

Gene Families for GAS6 Gene

HGNC:

Protein Domains for GAS6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14393

UniProtKB/Swiss-Prot:

GAS6_HUMAN :
  • Contains 4 EGF-like domains.
Domain:
  • Contains 4 EGF-like domains.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 2 laminin G-like domains.
genes like me logo Genes that share domains with GAS6: view

Function for GAS6 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GAS6 Gene

GENATLAS Biochemistry:
growth arrest specific gene 6,with homology to PROS1,ligand for TYRO3/AXL family of receptor tyrosine kinase
UniProtKB/Swiss-Prot Function:
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).

Gene Ontology (GO) - Molecular Function for GAS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 16723520
genes like me logo Genes that share ontologies with GAS6: view

Phenotypes for GAS6 Gene

MGI mutant phenotypes for GAS6:
inferred from 2 alleles
GenomeRNAi human phenotypes for GAS6:
genes like me logo Genes that share phenotypes with GAS6: view

Animal Models for GAS6 Gene

MGI Knock Outs for GAS6:

Animal Model Products

  • Taconic Biosciences Mouse Models for GAS6

miRNA for GAS6 Gene

miRTarBase miRNAs that target GAS6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAS6 Gene

Localization for GAS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAS6 Gene COMPARTMENTS Subcellular localization image for GAS6 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
cytoskeleton 2
cytosol 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for GAS6 Gene

Pathways & Interactions for GAS6 Gene

genes like me logo Genes that share pathways with GAS6: view

SIGNOR curated interactions for GAS6 Gene

Activates:

Gene Ontology (GO) - Biological Process for GAS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0001934 positive regulation of protein phosphorylation IEA,ISS --
GO:0001961 positive regulation of cytokine-mediated signaling pathway IMP 18840707
GO:0002576 platelet degranulation TAS --
GO:0003104 positive regulation of glomerular filtration IEA,ISS --
genes like me logo Genes that share ontologies with GAS6: view

Drugs & Compounds for GAS6 Gene

Products:

  1. Drug

(6) Drugs for GAS6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for GAS6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GAS6: view

Transcripts for GAS6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GAS6 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(504) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAS6 Gene

Growth arrest-specific 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6: - - - - -
SP7:
SP8:
SP9: -
SP10:

Relevant External Links for GAS6 Gene

GeneLoc Exon Structure for
GAS6
ECgene alternative splicing isoforms for
GAS6

Expression for GAS6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GAS6 Gene

mRNA expression in normal human tissues for GAS6 Gene
mRNA expression by BioGPS for GAS6 GenemRNA expression by GTEx for GAS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAS6 Gene

This gene is overexpressed in Artery - Aorta (x6.5).

Protein differential expression in normal tissues from HIPED for GAS6 Gene

This gene is overexpressed in Amniocyte (24.4), Breast (14.6), Bone marrow mesenchymal stem cell (9.5), Urine (7.9), and Bone marrow stromal cell (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GAS6 Gene



SOURCE GeneReport for Unigene cluster for GAS6 Gene Hs.646346

mRNA Expression by UniProt/SwissProt for GAS6 Gene

Q14393-GAS6_HUMAN
Tissue specificity: Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen.
genes like me logo Genes that share expression patterns with GAS6: view

Primer Products

No data available for Protein tissue co-expression partners for GAS6 Gene

Orthologs for GAS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAS6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GAS6 35
  • 82.74 (n)
  • 80.83 (a)
GAS6 36
  • 76 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GAS6 35
  • 79.53 (n)
  • 77.93 (a)
GAS6 36
  • 75 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gas6 35
  • 80.48 (n)
  • 83.05 (a)
Gas6 16
Gas6 36
  • 81 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GAS6 35
  • 92.07 (n)
  • 91.29 (a)
GAS6 36
  • 91 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Gas6 35
  • 80.93 (n)
  • 84.01 (a)
oppossum
(Monodelphis domestica)
 Mammalia GAS6 36
  • 69 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GAS6 36
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GAS6 35
  • 66.84 (n)
  • 67.47 (a)
GAS6 36
  • 65 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GAS6 36
  • 65 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gas6 35
  • 63.67 (n)
  • 64.67 (a)
Str.18141 35
African clawed frog
(Xenopus laevis)
 Amphibia MGC68463 35
zebrafish
(Danio rerio)
 Actinopterygii gas6 35
  • 60.05 (n)
  • 53.17 (a)
wufj34a12 35
gas6 36
  • 50 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 22 (a)
 ManyToMany
-- 36
  • 29 (a)
 ManyToMany
Species with no ortholog for GAS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAS6 Gene

ENSEMBL:
Gene Tree for GAS6 (if available)
TreeFam:
Gene Tree for GAS6 (if available)

Paralogs for GAS6 Gene

Paralogs for GAS6 Gene

(9) SIMAP similar genes for GAS6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GAS6 Gene

genes like me logo Genes that share paralogs with GAS6: view

Variants for GAS6 Gene

Sequence variations from dbSNP and Humsavar for GAS6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_038823 -
VAR_038824 -
VAR_038825 -
VAR_038826 -
VAR_038827 -

Structural Variations from Database of Genomic Variants (DGV) for GAS6 Gene

Variant ID Type Subtype PubMed ID
nsv832727 CNV Loss 17160897
nsv826836 CNV Loss 20364138
nsv901084 CNV Loss 21882294
nsv826837 CNV Loss 20364138
esv24756 CNV Gain+Loss 19812545
nsv901089 CNV Loss 21882294
nsv901083 CNV Loss 21882294
dgv1803n71 CNV Loss 21882294
nsv901090 CNV Loss 21882294
esv2748392 CNV Deletion 23290073
esv2748393 CNV Deletion 23290073
esv2748394 CNV Deletion 23290073
esv2748395 CNV Deletion 23290073
esv2748396 CNV Deletion 23290073
esv2748398 CNV Deletion 23290073
esv2748399 CNV Deletion 23290073
dgv284e201 CNV Deletion 23290073
esv2748401 CNV Deletion 23290073
esv2748403 CNV Deletion 23290073
esv2748404 CNV Deletion 23290073
dgv285e201 CNV Deletion 23290073
esv2748406 CNV Deletion 23290073
esv2748409 CNV Deletion 23290073
nsv511027 OTHER Inversion 20534489
esv2748410 CNV Deletion 23290073
esv1993584 CNV Deletion 18987734
esv2748411 CNV Deletion 23290073
nsv820519 CNV Duplication 20802225
esv27370 CNV Loss 19812545
esv2493664 CNV Deletion 19546169
esv1157105 CNV Insertion 17803354
esv2748412 CNV Deletion 23290073
esv2748413 CNV Deletion 23290073
esv1444149 CNV Deletion 17803354
esv2677402 CNV Deletion 23128226
esv2748414 CNV Deletion 23290073
esv1344439 CNV Insertion 17803354
esv1258186 CNV Insertion 17803354
esv1443107 CNV Insertion 17803354
esv2748415 CNV Deletion 23290073
esv2748416 CNV Deletion 23290073
esv2748417 CNV Deletion 23290073

Variation tolerance for GAS6 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAS6 Gene

Human Gene Mutation Database (HGMD)
GAS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS6 Gene

Disorders for GAS6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GAS6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute maxillary sinusitis
  • acute antritis
mesangial proliferative glomerulonephritis
  • glomerulonephritis - mesangial proliferative
la crosse encephalitis
  • california encephalitis
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards
Search GAS6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GAS6

Genetic Association Database (GAD)
GAS6
Human Genome Epidemiology (HuGE) Navigator
GAS6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAS6
genes like me logo Genes that share disorders with GAS6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS6 Gene

Publications for GAS6 Gene

  1. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. (PMID: 8336730) Manfioletti G. … Schneider C. (Mol. Cell. Biol. 1993) 2 3 4 23 67
  2. GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. (PMID: 19922767) Shiozawa Y. … Taichman R.S. (Exp. Hematol. 2010) 3 23
  3. Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification. (PMID: 20048160) Son B.K. … Ouchi Y. (J. Biol. Chem. 2010) 3 23
  4. Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood. (PMID: 20088931) Ekman C. … DahlbAock B. (J. Thromb. Haemost. 2010) 3 23
  5. TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages. (PMID: 20103767) Alciato F. … Avanzi G.C. (J. Leukoc. Biol. 2010) 3 23

Products for GAS6 Gene

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