Aliases for GAS6 Gene
Aliases for GAS6 Gene
External Ids for GAS6 Gene
- HGNC: 4168
- Entrez Gene: 2621
- Ensembl: ENSG00000183087
- OMIM: 600441
- UniProtKB: Q14393
Previous HGNC Symbols for GAS6 Gene
- AXLLG
Previous GeneCards Identifiers for GAS6 Gene
- GC13U990018
- GC13P113563
- GC13P112446
- GC13P113546
- GC13M114523
- GC13P094864
Summaries for GAS6 Gene
-
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
GeneCards Summary for GAS6 Gene
GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Acute Maxillary Sinusitis and Mesangial Proliferative Glomerulonephritis. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include calcium ion binding and voltage-gated calcium channel activity. An important paralog of this gene is PROS1.
UniProtKB/Swiss-Prot for GAS6 Gene
-
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
-
(Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS6 Gene
Genomics for GAS6 Gene
Regulatory Elements for GAS6 Gene
Enhancers for GAS6 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH13F113895 | 1.2 | FANTOM5 Ensembl ENCODE | 20.1 | -33.1 | -33082 | 3.4 | JUND POLR2A JUN BHLHE40 FOS | GAS6 RASA3 LINC00452 PIR38561 |
| GH13F113859 | 1.3 | FANTOM5 ENCODE | 11.7 | +2.0 | 1974 | 6.0 | HDAC1 INSM2 ZNF76 KLF17 ZEB1 GLIS2 SCRT2 KLF7 EGR2 SP3 | GAS6 GAS6-AS1 TMEM255B LOC105370380 |
| GH13F113905 | 1.2 | FANTOM5 Ensembl ENCODE | 12.4 | -43.6 | -43581 | 3.5 | PKNOX1 BHLHE40 ZBTB8A ZIC2 ZFP69B JUND SMARCA4 POLR2A PBX2 GLIS1 | CDC16 ENSG00000237699 GAS6 RASA3 DCUN1D2 DCUN1D2-AS LINC00565 PIR38561 LINC00452 |
| GH13F113903 | 0.6 | Ensembl ENCODE | 18.6 | -39.4 | -39387 | 1.0 | RFX1 | GAS6 ENSG00000237699 CDC16 DCUN1D2 DCUN1D2-AS LINC00452 PIR38561 |
| GH13F113852 | 1.3 | FANTOM5 Ensembl ENCODE | 7.2 | +8.6 | 8646 | 5.8 | HDAC1 PKNOX1 ZMYM3 ZIC2 ZFHX2 FOXK2 GATA2 MAFK ZNF280C EGR2 | GAS6 GAS6-AS1 LOC105370380 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GAS6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GAS6 gene promoter:
Regulatory Element Products
Genomic Location for GAS6 Gene
- Chromosome:
- 13
- Start:
- 113,820,549 bp from pter
- End:
- 113,864,103 bp from pter
- Size:
- 43,555 bases
- Orientation:
- Minus strand
Genomic View for GAS6 Gene
Genes around GAS6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q34 by Ensembl
- 13q34 by Entrez Gene
- 13q34 by HGNC
GAS6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GAS6 Gene
Proteins for GAS6 Gene
-
Protein details for GAS6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14393-GAS6_HUMAN
- Recommended name:
- Growth arrest-specific protein 6
- Protein Accession:
- Q14393
- B3KRQ7
- B3KVL4
- E9PBL7
- Q6IMN1
- Q7Z7N3
Protein attributes for GAS6 Gene
- Size:
- 721 amino acids
- Molecular mass:
- 79677 Da
- Quaternary structure:
-
- Heterodimer and heterotetramer with AXL.
Protein Expression for GAS6 Gene
Post-translational modifications for GAS6 Gene
- Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
- Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
- Glycosylation at Asn 463
- Modification sites at PhosphoSitePlus
Other Protein References for GAS6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GAS6 (Gas6)
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-
Cloud-Clone Corp. Antibodies for GAS6
- Invitrogen Antibodies for GAS6
- antibodies-online Antibodies for GAS6: See all 60
- GeneTex GAS6 antibody for GAS6
-
St John's Laboratory Antibodies for GAS6
-
Custom Antibody ServicesProSci Antibodies for GAS6
-
Santa Cruz Biotechnology (SCBT) Antibodies for GAS6
Protein Products
- R&D Systems Proteins and Enzymes for GAS6 (Gas6)
-
OriGene Purified Proteins for GAS6
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- Browse Sino Biological Cell Lysates
-
Cloud-Clone Corp. Proteins for GAS6
- antibodies-online Proteins for GAS6: See all 19
- Search antibodies-online for peptides
- Search GeneTex for Proteins for GAS6
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for GAS6
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for GAS6 (Gas6)
-
Cloud-Clone Corp Assay Kits for GAS6
- antibodies-online Kits for GAS6: See all 32
No data available for DME Specific Peptides for GAS6 Gene
Domains & Families for GAS6 Gene
Gene Families for GAS6 Gene
Protein Domains for GAS6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GAS6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14393- Domain:
-
- Contains 4 EGF-like domains.
- Contains 1 Gla (gamma-carboxy-glutamate) domain.
- Contains 2 laminin G-like domains.
Function for GAS6 Gene
Molecular function for GAS6 Gene
- GENATLAS Biochemistry:
- growth arrest specific gene 6,with homology to PROS1,ligand for TYRO3/AXL family of receptor tyrosine kinase
- UniProtKB/Swiss-Prot Function:
- Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001786 | phosphatidylserine binding | IDA | 21501828 |
| GO:0005102 | receptor binding | IPI | 7854420 |
| GO:0005245 | voltage-gated calcium channel activity | IDA | 18395422 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16362042 |
Phenotypes for GAS6 Gene
- MGI mutant phenotypes for GAS6:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for GAS6:
Animal Model Products
-
Taconic Biosciences Mouse Models for GAS6
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for GAS6 gene
-
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CRISPR Products
-
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miRNA for GAS6 Gene
- miRTarBase miRNAs that target GAS6
miRNA Products
- Search ViGene Biosciences for GAS6
Clone Products
- Sino Biological Human cDNA Clone for GAS6
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- VectorBuilder custom plasmid, inducible vectors for GAS6
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for GAS6
-
ViGene Biosciences adenoviral particle packaged cDNA for GAS6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GAS6 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAS6 Gene
Localization for GAS6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GAS6 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| cytosol | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 8336730 |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IDA | 18395422 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
Pathways & Interactions for GAS6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||
| 5 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
Pathways by source for GAS6 Gene
12 Reactome pathways for GAS6 Gene
1 PharmGKB pathway for GAS6 Gene
1 KEGG pathway for GAS6 Gene
Interacting Proteins for GAS6 Gene
Selected Interacting proteins:
ENSP00000331831
Q14393-GAS6_HUMAN
for GAS6 Gene via
STRING
IID
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA,ISS | -- |
| GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IMP | 18840707 |
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0003104 | positive regulation of glomerular filtration | IEA,ISS | -- |
Drugs & Compounds for GAS6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for GAS6 Gene
mRNA/cDNA for GAS6 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (504) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GAS6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GAS6
- GenScript: Design CRISPR guide RNA sequences for GAS6
miRNA Products
- Search ViGene Biosciences for GAS6
Clone Products
- Sino Biological Human cDNA Clone for GAS6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GAS6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GAS6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Expression for GAS6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Cortical Stroma Cells Interstitial Stroma
- Medullary Stroma Cells Interstitial Stroma
- Interstitial Stroma
-
Intermediate Mesoderm (Gastrulation Derivatives)
- Mesonephric cells Mesonephros
- Mesonephros
- Gut Tube (Gastrointestinal Tract)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
-
Gonad
- Mesonephric cells Mesonephros
mRNA differential expression in normal tissues according to GTEx for GAS6 Gene
This gene is overexpressed in Artery - Aorta (x6.5).
This gene is overexpressed in Amniocyte (24.4), Breast (14.6), Bone marrow mesenchymal stem cell (9.5), Urine (7.9), and Bone marrow stromal cell (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GAS6 Gene
NURSA nuclear receptor signaling pathways regulating expression of GAS6 Gene:
GAS6SOURCE GeneReport for Unigene cluster for GAS6 Gene:
Hs.646346mRNA Expression by UniProt/SwissProt for GAS6 Gene:
Q14393-GAS6_HUMAN
Tissue specificity:
Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen.
Primer Products
-
OriGene qPCR primer pairs for GAS6
-
OriGene qPCR primer pairs and template standards for GAS6
No data available for Protein tissue co-expression partners for GAS6 Gene
Orthologs for GAS6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GAS6 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | GAS6 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gas6 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gas6 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GAS6 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GAS6 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GAS6 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GAS6 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GAS6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gas6 34 |
|
||
| Str.18141 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68463 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gas6 34 35 |
|
||
| wufj34a12 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for GAS6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GAS6 Gene
Variants for GAS6 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10220092 | -- | 113,843,205(-) | GCTTG(C/G/T)GGGAT | intron-variant | |
| rs10534675 | -- | 113,858,659(-) | CAGAC(-/AT)GTACA | intron-variant | |
| rs10547109 | -- | 113,846,203(-) | TAAAC(-/AT)GTGTG | intron-variant | |
| rs10603008 | -- | 113,823,887(-) | GAAAC(-/AA)GAGGA | intron-variant | |
| rs10604589 | -- | 113,845,036(-) | CTGTC(-/AC)GCGTG | intron-variant |
Residual Variation Intolerance Score:
54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.51;
55.45% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GAS6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS6 Gene
Disorders for GAS6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute maxillary sinusitis |
|
|
| mesangial proliferative glomerulonephritis |
|
|
| la crosse encephalitis |
|
|
| systemic lupus erythematosus |
|
|
Search GAS6 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for GAS6
No data available for UniProtKB/Swiss-Prot and Genatlas for GAS6 Gene
Publications for GAS6 Gene
- Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. (PMID: 15108283) Munoz X. … Sala N. (Hum. Mutat. 2004) 3 4 22 46 64
- The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. (PMID: 8336730) Manfioletti G. … Schneider C. (Mol. Cell. Biol. 1993) 2 3 4 22 64
- Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. (PMID: 19369636) Jiang L. … Zhang W. (Am. J. Clin. Pathol. 2009) 3 22 46 64
- Association of specific haplotypes of GAS6 gene with stroke. (PMID: 17721624) MuA+oz X. … Sala N. (Thromb. Haemost. 2007) 3 22 46 64
- Structural basis for Gas6-Axl signalling. (PMID: 16362042) Sasaki T. … Hohenester E. (EMBO J. 2006) 3 4 22 64
Products for GAS6 Gene
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- antibodies-online Antibodies for GAS6: See all 60
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- GeneTex GAS6 antibody for GAS6
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- Cyagen custom Knockout/knockin (KOKI) mouse models for GAS6
- VectorBuilder custom plasmid, inducible vectors for GAS6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GAS6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GAS6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab