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GAS6 Gene

protein-coding GIFtS: 65

GC13P113546

growth arrest-specific 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AXLLG)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AXLLG ^², ³, ⁵
AXSF ^¹, ², ⁵
DKFZp666G247 ^¹, ²
FLJ34709 ^¹, ²
GAS-6 ^³
OTTHUMP00000018777 ^²

Descriptions
AXL receptor tyrosine kinase ligand ^², ³
AXL stimulatory factor ^²
growth arrest-specific 6 ^²

External Ids
HGNC: 4168¹
Entrez Gene: 2621²
UniProtKB: Q14393³
Ensembl: ENSG00000183087⁷

Search outside databases for aliases for GAS6 gene

Previous GC identifers: GC13U990018 GC13P113563 GC13P112446

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GAS6:

This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved

in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced

transcript variants encoding different isoforms have been found for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393

Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is

implicated in cell growth and survival, cell adhesion and cell migration. Plays a role in

thrombosis by amplifying platelet aggregation and secretion in response to known agonists (By

similarity)

Gene Wiki entry for GAS6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GAS6 gene

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

GAS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P113546: (about GC identifiers)

Start:	113,546,913 bp from pter
End:	113,590,407 bp from pter
Size:	43,495 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_077627.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393 (See protein sequence)

Recommended Name: Growth arrest-specific protein 6 precursor

Size: 721 amino acids; 79677 Da

Subunit: Heterodimer and heterotetramer with AXL

Subcellular location: Secreted

PDB structure from and Proteopedia :

1H30 (3D)

2C5D (3D)

Secondary accessions: Q6IMN1 Q7Z7N3

Alternative splicing: 3 isoforms: Q14393-1 Q14393-2 Q14393-3

Post-translational modifications:

Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a

C-terminal 50 kDa protein including the laminin G-like domains which activates AXL¹

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are

essential for the binding of calcium (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000811.1 NP_001137417.1 NP_001137418.1

ENSEMBL proteins:

ENSP00000348003 ENSP00000331831 ENSP00000349962

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for GAS6
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GAS 6)
	Human Recombinant Proteins from Abnova (GAS6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for GAS6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for GAS6
	Antibodies from Abcam (GAS 6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GAS6)
	Novus Biologicals Antibodies for GAS6

Assays for GAS6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for GAS6 (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14393

ProtoNet protein and cluster: Q14393

4 Blocks protein families:

IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

IPB001791 Laminin G

IPB001881 EGF-like calcium-binding

IPB002383 Coagulation factor GLA domain signature

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393

Similarity: Contains 4 EGF-like domains

Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain

Similarity: Contains 2 laminin G-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GAS6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GAS6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001143945

Applied Biosystems Silencer® siRNAs for GAS6

Sigma-Aldrich siRNA for GAS6

Sigma-Aldrich shRNA for GAS6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GAS6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000820
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000820
untagged cDNA clones in CMV expression vector (see all 3): NM_000820

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000820

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393

Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is

implicated in cell growth and survival, cell adhesion and cell migration. Plays a role in

thrombosis by amplifying platelet aggregation and secretion in response to known agonists (By

growth arrest specific gene 6,with homology to PROS1,ligand for TYRO3/AXL family of receptor

tyrosine kinase

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gas6):

cellular	hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging
renal/urinary system	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	7854420
GO:0005509	calcium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for GAS6

5/17 Interacting proteins for GAS6 (ENSP00000349962³ Q14393²) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AXL	P30530²	STRING (score=.999) MINT-2735822 MINT-2735908 MINT-2738515 MINT-2735786 MINT-2735853 MINT-2735881 MINT-2735935 MINT-2735964
MERTK	ENSP00000295408³	STRING (score=.999)
TYRO3	ENSP00000263798³	STRING (score=.994)
GGCX	ENSP00000233838³	STRING (score=.95)
AKT1	ENSP00000270202³	STRING (score=.913)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	7854420
GO:0008283	cell proliferation	TAS	7854420
GO:0031100	organ regeneration	IEA	--
GO:0040008	regulation of growth	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GAS6
4 Novoseek chemical compound relationships for GAS6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gamma-carboxyglutamic acid	76.90	19	9163328 (3), 18760998 (3), 12871548 (1), 18841281 (1) (see all 5)
tyrosine	72.65	81	7559388 (3), 9160883 (3), 15673687 (3), 9259426 (3) (see all 52)
wortmannin	49.21	3	9234702 (2), 11597931 (1)
phosphatidylinositol	37.48	1	9234702 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GAS6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GAS6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001143945

Sigma-Aldrich siRNA for GAS6

Sigma-Aldrich shRNA for GAS6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000820

REFSEQ mRNAs for GAS6 gene (3 alternative transcripts):

NM_000820.2 NM_001143945.1 NM_001143946.1

NM_000820

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000820
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000820
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000820

Additional cDNA sequence:

AK092028.1 AK122969.1 AK129751.1 AK290803.1 AK303145.1 AL833761.1 BC030708.1 BC038984.1

L13720.1

24/29 DOTS entries (see all 29 ):

DT.97765850 DT.100703102 DT.95314883 DT.100659748 DT.101985521 DT.118742 DT.118744 DT.428575

DT.100659746 DT.100841587 DT.40106957 DT.95314867 DT.100671601 DT.100836601 DT.120777369 DT.92439072

DT.97854076 DT.100848520 DT.101985522 DT.92439069 DT.100732636 DT.120777381 DT.120777390 DT.95201654

24/504 AceView cDNA sequences (see all 504 ):

AL044051 N45582 BM712369 BU676492 BU676888 BU624027 F07639 AI129692

CF126373 CA414189 CK000567 BU145993 BC038984 BM856754 BU527411 BU627047

AI749585 BU684662 BM706969 AI366130 BQ958297 BU552600 AI129327 CF127774

highest scoring ESTs for GAS6:

L13720 AA042857 AA056212 AA143028 AI207800 AI366130 AI500495 AI751287 AK122969 AL561996

Unigene Cluster for GAS6:

Growth arrest-specific 6

Hs.646346 [show with all ESTs]

Unigene Representative Sequence: AL833761

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GAS6 (see all 10 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b
SP1:											-												-		-
SP2:											-
SP3:
SP4:																									-		-
SP5:																																									-		-

About this scheme

ECgene alternative splicing isoforms for GAS6

3 Ensembl transcripts including schematic representations:

ENST00000355761 ENST00000327773 ENST00000357389

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GAS6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GAS6

¹ / ² / ³

8 probe-sets matching GAS6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1597_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.84	L13720	1.00	1.00	1.00	1
1598_g_at²^{, 3}	U133-A	1	1.00	1.00	0.94	1.11	L13720	1.00	1.00	1.00	1
37658_at²^{, 3}	U95-A	1	0.88	1.00	0.91	0.94	L13720	1.00	1.00	1.00	1
77433_r_at²^{, 3}	U95-D	2	0.31	0.90	0.05	1.11	AI003858	0.20	1.00	0.72	1
202177_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000820	0.60	1.00	0.82	1
1598_g_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L13720	1.00	1.00	1.00	1
202177_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1598_g_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GAS6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGAGAGCTG

SOURCE GeneReport for Unigene cluster: Hs.646346
Expression variation in blood from EXPOLDB for GAS6
UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393
Tissue specificity: Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the
predominant form in spleen

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GAS6 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GAS6¹	--	growth arrest-specific 6	83.23(n) 83.33(a)	607745 XM_844530.1 XP_849623.1
chimpanzee (Pan troglodytes)	GAS6¹	--	growth arrest-specific 6	88.85(n) 87.02(a)	739068 XM_001146448.1 XP_001146448.1
cow (Bos taurus)	GAS6¹	--	growth arrest-specific 6	82.17(n) 79.88(a)	504526 XM_580667.3 XP_580667.3
rat (Rattus norvegicus)	Gas6¹	--	growth arrest specific 6	80.82(n) 83.41(a)	58935 NM_057100.1 NP_476441.1
mouse (Mus musculus)	Gas6^{1, 5}	8 (5.00 cM)⁵	growth arrest specific 6^{1, 5}	79.96(n)¹ 82.01(a)¹	14456¹ NM_019521.1¹ NP_062394.1¹ AI482478⁵ AK086187⁵ (see all 9)

About this table Species with no ortholog for GAS6

ENSEMBL Gene Tree for GAS6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GAS6 gene

PROS1² SHBG² ENSG00000189002²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/317 NCBI SNPs in GAS6 are shown (see all 317 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 110)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8181793^1,2	A,C,F,H	113545319(+)	`cacagC/Taggtg`	1	--	ng5¹		8		EU EA WA	838
--	rs7992146^1,2	C,F,H	113587440(+)	`ACGTCG/AGGACT`	1	R/G	mis¹		4		EU EA WA	404
	rs11843390^1,2	A,C	113590564(+)	`TGGGCA/GGCCAC`	1	--	ng3¹		0	--	--	--	--
--	rs7489780^1,2	A	113590309(+)	`GAGGCC/TGGCGC`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs11843762^1,2	A	113590721(+)	`ACAAAC/TGCAGG`	1	--	ng3¹		0	--	--	--	--
	rs7400002^1,2	A,C,F	113588999(+)	`TTTGCT/CGGCGG`	1	A/A	syn¹ ese³		1		EU	218
	rs1803628^1,2	F	113583829(+)	`GGCTGC/TATGAG`	1	C/C	syn¹ ese³		4		EU NA	752
--	rs8191975^1,2	F	113582378(+)	`AACCTG/CACCGT`	1	L/L	syn¹ ese³		2		EU	590
	rs12585356^1,2	A,C,F,H	113553899(+)	`GTGACT/GACCTC`	1	--	int¹		8		EU EA WA	838
	rs8000868^1,2	A,C,F,H	113554421(+)	`CGTCCG/ATCGCT`	1	--	int¹		4		EU EA WA	412

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HapMap Linkage Disequilibrium images for GAS6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600441

10/23 Novoseek disease relationships for GAS6 gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glomerulonephritis mesangial proliferative	46.99	1	11290560 (1)
calcification	42.67	12	17196959 (2), 18495950 (2), 17339734 (2), 18385534 (2) (see all 6)
chronic glomerulonephritis	37.04	2	15619028 (1), 15199298 (1)
albuminuria	30.71	2	18374201 (1), 15199298 (1)
diabetic nephropathies	27.15	8	18374201 (3), 15619028 (1), 15199298 (1)
thyroid carcinoma	26.99	4	9492013 (2), 12490074 (2)
renal disease	26.80	6	14750094 (2), 15619028 (2), 15199298 (1), 12768229 (1)
thrombosis	24.13	6	15733062 (2), 15108283 (1), 15790929 (1), 17721624 (1) (see all 5)
glomerulonephritis	17.00	3	11290560 (1), 12644472 (1), 15199298 (1)
inflammation	16.96	6	9516131 (1), 19369636 (1), 15790929 (1), 18374195 (1) (see all 6)

About this table

Genetic Association Database: GAS6
Human Genome Epidemiology Navigator: GAS6 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/139 PubMed articles for GAS6 gene (see all 139 ):

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. (PubMed id 8336730)^{1, 2, 3, 4} Manfioletti G.... Schneider C. (1993)
Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. (PubMed id 15108283)^{1, 3, 4, 6} Munoz X....Sala N. (2004)
The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation. (PubMed id 9326369)^{1, 3, 4} Goruppi S.... Schneider C. (1997)
Characterization of Gas6, a member of the superfamily of G domain- containing proteins, as a ligand for Rse and Axl. (PubMed id 8621659)^{1, 3, 4} Mark M.R.... Godowski P.J. (1996)
Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6. (PubMed id 9326368)^{1, 3, 4} Marcandalli P.... Schneider C. (1997)
Structural basis for Gas6-Axl signalling. (PubMed id 16362042)^{1, 3, 4} Sasaki T.... Hohenester E. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. (PubMed id 8939948)^{3, 4} Nagata K....Mizuno K. (1996)
Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. (PubMed id 7854420)^{3, 4} Varnum B.C.... Yamane H.K. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2621	HGNC: 4168	AceView: GAS6	Ensembl:ENSG00000183087	euGenes: HUgn2621
ECgene: GAS6	H-InvDB: GAS6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GAS6	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/gas6/

Licensable Technologies for GAS6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GAS6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GAS6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GAS6		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GAS6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Recombinant Proteins (GAS6)
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	Recombinant Proteins (GAS 6)
	Antibodies (GAS 6)

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Antibodies for GAS6

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GAS6 Gene at Home site.
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GAS6 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for GAS6

Summaries
for GAS6

Genomic Location
for GAS6

Proteins
for GAS6

Protein Domains/
Families
for GAS6

Gene Function
for GAS6

Pathways & Interactions
for GAS6

Drugs & Compounds
for GAS6

Transcripts
for GAS6

Expression
for GAS6

Orthologs
for GAS6

Paralogs
for GAS6

SNPs/Variants
for GAS6

Disorders & Mutations
for GAS6

Medical News
for GAS6

Publications
for GAS6

Search for GAS6

Genome Databases showing GAS6

Other Databases showing GAS6

Specialized Databases showing GAS6

Licensable Technologies
for GAS6

Services
for GAS6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GAS6 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor GAS6

Summariesfor GAS6

Genomic Locationfor GAS6

Proteinsfor GAS6

Protein Domains/Familiesfor GAS6

Gene Functionfor GAS6

Pathways & Interactionsfor GAS6

Drugs & Compoundsfor GAS6

Transcriptsfor GAS6

Expression for GAS6

Orthologsfor GAS6

Paralogsfor GAS6

SNPs/Variantsfor GAS6

Disorders & Mutationsfor GAS6

Medical Newsfor GAS6

Publicationsfor GAS6

Search for GAS6

Genome Databases showing GAS6

Other Databases showing GAS6

Specialized Databases showing GAS6

Licensable Technologiesfor GAS6

Servicesfor GAS6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GAS6

Summaries
for GAS6

Genomic Location
for GAS6

Proteins
for GAS6

Protein Domains/
Families
for GAS6

Gene Function
for GAS6

Pathways & Interactions
for GAS6

Drugs & Compounds
for GAS6

Transcripts
for GAS6

Expression
for GAS6

Orthologs
for GAS6

Paralogs
for GAS6

SNPs/Variants
for GAS6

Disorders & Mutations
for GAS6

Medical News
for GAS6

Publications
for GAS6

Licensable Technologies
for GAS6

Services
for GAS6