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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAS6 Gene

protein-coding   GIFtS: 65
GCID: GC13M114523

Growth Arrest-Specific 6


(Previous symbol: AXLLG)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Arrest-Specific 61 2     AXSF2 5
AXLLG1 2 3 5     Growth Arrest-Specific Protein 62
AXL Stimulatory Factor1 2     GAS-63
AXL Receptor Tyrosine Kinase Ligand2 3     

External Ids:    HGNC: 41681   Entrez Gene: 26212   Ensembl: ENSG000001830877   OMIM: 6004415   UniProtKB: Q143933   

Export aliases for GAS6 gene to outside databases

Previous GC identifers: GC13U990018 GC13P113563 GC13P112446 GC13P113546 GC13P094864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GAS6 Gene:
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the
stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2009)

GeneCards Summary for GAS6 Gene: 
GAS6 (growth arrest-specific 6) is a protein-coding gene. Diseases associated with GAS6 include critical limb ischemia, and thrombosis, and among its related super-pathways are Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus and Rac1 Pathway. GO annotations related to this gene include voltage-gated calcium channel activity and calcium ion binding. An important paralog of this gene is PROS1.

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393
Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell
growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such
as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during
human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and
migration, platelet activation, or regulation of thrombotic responses

Gene Wiki entry for GAS6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_077627.3  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAS6 gene promoter:
         HOXA9   p53   FOXF2   HSF2   Bach2   Olf-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GAS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

GAS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAS6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M114523:  view genomic region     (about GC identifiers)

Start:
114,523,522 bp from pter      End:
114,567,046 bp from pter
Size:
43,525 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393 (See protein sequence)
Recommended Name: Growth arrest-specific protein 6 precursor  
Size: 721 amino acids; 79677 Da
Subunit: Heterodimer and heterotetramer with AXL
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for GAS6:
1H30 (3D)        2C5D (3D)    
Secondary accessions: B3KRQ7 B3KVL4 E9PBL7 Q6IMN1 Q7Z7N3
Alternative splicing: 5 isoforms:  Q14393-1   Q14393-2   Q14393-3   Q14393-4   Q14393-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GAS6: NX_Q14393

Explore proteomics data for GAS6 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50
    kDa protein including the laminin G-like domains which activates AXL
  • UniProtKB: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for
    the binding of calcium (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14393

  • GAS6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GAS6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000811.1  NP_001137417.1  NP_001137418.1  

    ENSEMBL proteins: 
     ENSP00000331831   ENSP00000349962   ENSP00000348003   ENSP00000416498   ENSP00000400117  
    Reactome Protein details: Q14393
    Human Recombinant Protein Products for GAS6: 
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    Novus Biologicals GAS6 Proteins
    Novus Biologicals GAS6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GAS6 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA18395422
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA18395422
    GO:0005788endoplasmic reticulum lumen TAS--

    GAS6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/11 InterPro protein domains (see all 11):
     IPR017857 Coagulation_fac_subgr_Gla_dom
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR026823 cEGF

    Graphical View of Domain Structure for InterPro Entry Q14393

    ProtoNet protein and cluster: Q14393

    4 Blocks protein domains:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding
    IPB002383 Coagulation factor GLA domain signature


    UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain
    Similarity: Contains 2 laminin G-like domains


    GAS6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GAS6_HUMAN, Q14393
    Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell
    growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such
    as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during
    human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and
    migration, platelet activation, or regulation of thrombotic responses

         Genatlas biochemistry entry for GAS6:
    growth arrest specific gene 6,with homology to PROS1,ligand for TYRO3/AXL family of receptor tyrosine kinase

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IDA--
    GO:0005102receptor binding IPI7854420
    GO:0005245voltage-gated calcium channel activity IDA18395422
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16362042
         
    GAS6 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gas6):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  vision/eye 

    GAS6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GAS6: Gas6tm1Pec Gas6tm1Hiar

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GAS6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GAS6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GAS6 
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    SwitchGear 3'UTR luciferase reporter plasmidGAS6 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GAS6 About   (see all 18)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus0.89
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins0.82
    Removal of aminoterminal propeptides from gamma-carboxylated proteins0.89
    Warfarin Pathway, Pharmacodynamics0.67
    Gamma-carboxylation of protein precursors0.89
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GAS6 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    5/12        Reactome Pathways for GAS6 (see all 12)
        Hemostasis
    Removal of aminoterminal propeptides from gamma-carboxylated proteins
    Response to elevated platelet cytosolic Ca2+
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

    1 PharmGKB Pathway for GAS6
        Warfarin Pathway, Pharmacodynamics


    GAS6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for GAS6 (Q143932, 3 ENSP000003318314) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXLP305302, 3, ENSP000003011784MINT-2735822 MINT-2735908 MINT-2738515 MINT-2735786 MINT-2735853 MINT-2735881 MINT-2735935 MINT-2735964 I2D: score=5 STRING: ENSP00000301178
    TYRO3Q064183, ENSP000002637984I2D: score=4 STRING: ENSP00000263798
    MERTKQ128663, ENSP000002954084I2D: score=4 STRING: ENSP00000295408
    A2MENSP000003239294STRING: ENSP00000323929
    ACTN4ENSP000002526994STRING: ENSP00000252699
    About this table

    Gene Ontology (GO): 5/74 biological process terms (GO ID links to tree view) (see all 74):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0001961positive regulation of cytokine-mediated signaling pathway IMP18840707
    GO:0002576platelet degranulation TAS--
    GO:0003104positive regulation of glomerular filtration ISS--

    GAS6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GAS6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAS6

    1 HMDB Compound for GAS6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    8 Novoseek inferred chemical compound relationships for GAS6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gamma-carboxyglutamic acid 75.7 19 9163328 (3), 18760998 (3), 12871548 (1), 18841281 (1) (see all 5)
    tyrosine 73.3 86 7559388 (3), 9160883 (3), 9259426 (3), 15673687 (3) (see all 55)
    warfarin 59.7 18 15199298 (4), 15619028 (2), 9163328 (2), 15790929 (1) (see all 9)
    wortmannin 46.9 3 9234702 (2), 11597931 (1)
    phosphatidylinositol 34.9 1 9234702 (1)
    ly294002 34.5 1 16723520 (1)
    phosphatidylserine 32.8 25 10731712 (7), 18760998 (2), 18247125 (1), 15673687 (1) (see all 5)
    vegf 0 2 15507525 (2)

    Search CenterWatch for drugs/clinical trials and news about GAS6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for GAS6 gene (3 alternative transcripts): 
    NM_000820.2  NM_001143945.1  NM_001143946.1  

    Unigene Cluster for GAS6:

    Growth arrest-specific 6
    Hs.646346  [show with all ESTs]
    Unigene Representative Sequence: AL833761
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480426 ENST00000327773 ENST00000476291 ENST00000357389(uc001vud.3)
    ENST00000355761 ENST00000450766(uc001vuf.3) ENST00000418959(uc001vug.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK092028.1 AK122969.1 AK129751.1 AK290803.1 AK303145.1 AL833761.1 BC030708.1 BC038984.1 
    L13720.1 

    24/26 DOTS entries (see all 26):

    DT.97765850  DT.100703102  DT.95314883  DT.100659748  DT.101985521  DT.118742  DT.118744  DT.100659746 
    DT.100841587  DT.95314867  DT.100671601  DT.100836601  DT.120777369  DT.92439072  DT.97854076  DT.100848520 
    DT.101985522  DT.92439069  DT.120777381  DT.120777390  DT.40106957  DT.95287481  DT.95314887  DT.97854080 

    24/504 AceView cDNA sequences (see all 504):

    AI538804 CF131873 AW513194 AK122969 R67186 AA913507 AW085677 BU618953 
    BM129647 BU527895 BM997044 BU624027 N45582 CF131628 BM706969 BQ181803 
    CF126373 BF345031 BM558160 L13720 BG250520 AI754273 AI366130 AI129327 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GAS6 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                -                                   -     -                                                                     
    SP2:                                -                                                                                                               
    SP3:                                                                                                                                                
    SP4:                                                                          -     -                                                               
    SP5:                                                                                                                          -     -               


    ECgene alternative splicing isoforms for GAS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAS6 expression in normal human tissues (normalized intensities)      GAS6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGAGCTG
    GAS6 Expression
    About this image


    GAS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Fibroblast
             X-gene Foreskin Fibroblasts   
     
     Mesenchymal Stem Cells (Integumentary System)    fully expand to see all 4 entries
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Interstitial Stroma
             visceral organ/metanephros/calyx   
     
     Dermis (Uncategorized)    fully expand to see all 3 entries
             BH2 Dermal Fibroblasts   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived endothelial progenitor cells
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   

    See GAS6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAS6

    SOURCE GeneReport for Unigene cluster: Hs.646346

    UniProtKB/Swiss-Prot: GAS6_HUMAN, Q14393
    Tissue specificity: Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in
    spleen

        SABiosciences Expression via Pathway-Focused PCR Array including GAS6: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GAS6 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gas61 , 5 growth arrest specific 61, 5 80.04(n)1
    82.04(a)1
      8 (6.06 cM)5
    144561  NM_019521.21  NP_062394.21 
     134653745 
    chicken
    (Gallus gallus)
    Aves GAS61 growth arrest-specific 6 68.16(n)
    68.57(a)
      418737  XM_416936.3  XP_416936.3 
    lizard
    (Anolis carolinensis)
    Reptilia GAS66
    Uncharacterized protein
    65(a)
    1 ↔ 1
    3(106410994-106444972)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684632 hypothetical protein MGC68463 76.13(n)    BC060355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj34a122 wufj34a12 79.46(n)   335830  BC053117.1 


    ENSEMBL Gene Tree for GAS6 (if available)
    TreeFam Gene Tree for GAS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAS6 gene
    PROS12  SHBG2  
    9 SIMAP similar genes for GAS6 using alignment to 2 protein entries:     GAS6_HUMAN (see all proteins):
    DKFZp666G247    PROC    PROS1    PRRG3    PROC1    F9
    F2    F7    HMCN1

    GAS6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GAS6
    PGOHUM00000250249


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/564 SNPs in GAS6 are shown (see all 564)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0388264
    ----see VAR_0388262 G R mis40--------
    VAR_0388234
    ----see VAR_0388232 F L mis40--------
    VAR_0388294
    ----see VAR_0388292 R Q mis40--------
    VAR_0388284
    ----see VAR_0388282 E K mis40--------
    VAR_0388274
    ----see VAR_0388272 S L mis40--------
    VAR_0388254
    ----see VAR_0388252 V M mis40--------
    VAR_0388244
    ----see VAR_0388242 S Y mis40--------
    rs596145071,2
    C--114525675(-) GACAG-/GT/TG 
            
    ACAGG
    3 -- int11NA 2
    rs671801021,2
    C--114536695(-) ACAGT-/ACCTG 
    TCACACCG
    ACCTG
    3 -- int1 ut511Minor allele frequency- ACCTGTCACACCG:0.00NA 2
    rs1506981861,2
    C--114544663(-) GAAAC-/TGGGCATAT
    GGAGGAAACTG
    TGGGG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for GAS6 (114523522 - 114567046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/42 variations for GAS6 (see all 42):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748416CNV Deletion23290073
    esv2748401CNV Deletion23290073
    esv1444149CNV Deletion17803354
    dgv284e201CNV Deletion23290073
    esv2748395CNV Deletion23290073
    esv2748394CNV Deletion23290073
    esv2748415CNV Deletion23290073
    esv2748393CNV Deletion23290073
    esv2748399CNV Deletion23290073
    esv2748414CNV Deletion23290073


    Human Gene Mutation Database (HGMD): GAS6
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600441    OMIM disorders: --

    20/45 diseases for GAS6 (see all 45):    About MalaCards
    critical limb ischemia    thrombosis    vitamin k deficiency hemorrhagic disease    chronic inflammatory demyelinating polyneuropathy
    demyelinating polyneuropathy    ocular melanoma    hemorrhagic disease    ovarian endometriosis
    polyneuropathy    glomerulonephritis    endometriosis    pancreatic ductal adenocarcinoma
    acute pancreatitis    thromboembolism    leiomyoma    graft versus host disease
    atherosclerosis    thyroid cancer    ischemia    thyroiditis


    GAS6 for disorders           About GeneDecksing

    10/23 Novoseek inferred disease relationships for GAS6 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glomerulonephritis mesangial proliferative 44.9 1 11290560 (1)
    calcification 42.3 17 20048160 (3), 17196959 (2), 18495950 (2), 16556867 (2) (see all 7)
    chronic glomerulonephritis 34.9 2 15619028 (1), 15199298 (1)
    albuminuria 27.4 2 18374201 (1), 15199298 (1)
    thrombosis 24.8 7 15733062 (2), 15108283 (1), 15790929 (1), 17721624 (1) (see all 6)
    diabetic nephropathies 24.2 8 18374201 (3), 15619028 (1), 15199298 (1)
    thyroid carcinoma 24.1 4 9492013 (2), 12490074 (2)
    renal disease 23.1 6 14750094 (2), 15619028 (2), 15199298 (1), 12768229 (1)
    inflammation 22.2 8 19644365 (2), 9516131 (1), 19369636 (1), 15790929 (1) (see all 7)
    glomerulonephritis 14.4 3 11290560 (1), 12644472 (1), 15199298 (1)

    Genetic Association Database (GAD): GAS6
    Human Genome Epidemiology (HuGE) Navigator: GAS6 (5 documents)

    Export disorders for GAS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAS6 gene, integrated from 9 sources (see all 183):
    (articles sorted by number of sources associating them with GAS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. (PubMed id 8336730)1, 2, 3, 9 Manfioletti G.... Schneider C. (1993)
    2. Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. (PubMed id 15108283)1, 2, 4, 9 Munoz X....Sala N. (2004)
    3. Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. (PubMed id 19369636)1, 4, 9 Jiang L....Zhang W. (2009)
    4. Association of specific haplotypes of GAS6 gene with stroke. (PubMed id 17721624)1, 4, 9 Munoz X....Sala N. (2007)
    5. The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation. (PubMed id 9326369)1, 2, 9 Goruppi S.... Schneider C. (1997)
    6. Characterization of Gas6, a member of the superfamily of G domain- containing proteins, as a ligand for Rse and Axl. (PubMed id 8621659)1, 2, 9 Mark M.R.... Godowski P.J. (1996)
    7. Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6. (PubMed id 9326368)1, 2, 9 Marcandalli P.... Schneider C. (1997)
    8. Structural basis for Gas6-Axl signalling. (PubMed id 16362042)1, 2, 9 Sasaki T.... Hohenester E. (2006)
    9. Association study between polymorphims in GAS6-TAM ge nes and carotid atherosclerosis. (PubMed id 20664904)1, 4 Hurtado B....Sala N. (2010)
    10. Is Gas6 Protein Associated With Sticky Platelet Syndr ome? (PubMed id 19696043)1, 4 Kubisz P....Pullmann R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2621 HGNC: 4168 AceView: GAS6 Ensembl:ENSG00000183087 euGenes: HUgn2621
    ECgene: GAS6 H-InvDB: GAS6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAS6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAS6 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/gas6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GAS6 gene:
    Search GeneIP for patents involving GAS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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