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Aliases for GAS5 Gene

Subcategory (RNA class) for GAS5 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for GAS5 Gene

  • Growth Arrest Specific 5 (Non-Protein Coding) 2 3 5
  • Small Nucleolar RNA Host Gene (Non-Protein Coding) 2 2 3
  • Growth Arrest Specific Transcript 5 3
  • Non-Protein Coding RNA 30 2
  • NCRNA00030 3
  • SNHG2 3

External Ids for GAS5 Gene

Previous GeneCards Identifiers for GAS5 Gene

  • GC01U990348
  • GC01M172108
  • GC01M172117
  • GC01M172125
  • GC01M172133
  • GC01M172142
  • GC01M172146
  • GC01M172157
  • GC01M172170
  • GC01M173843
  • GC01M173850
  • GC01M173855
  • GC01M173864
  • GC01M173874
  • GC01M173883
  • GC01M173892
  • GC01M173907
  • GC01M173919
  • GC01M173937
  • GC01M173947
  • GC01M173961
  • GC01M173977
  • GC01M173985
  • GC01M173989
  • GC01M173997

Summaries for GAS5 Gene

Entrez Gene Summary for GAS5 Gene

  • This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]

GeneCards Summary for GAS5 Gene

GAS5 (Growth Arrest Specific 5 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

Gene Wiki entry for GAS5 Gene

Additional gene information for GAS5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS5 Gene

Genomics for GAS5 Gene

Regulatory Elements for GAS5 Gene

Enhancers for GAS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H173473 1.5 FANTOM5 ENCODE 22.1 +392.1 392061 7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 KLHL20 GAS5 GAS5-AS1 PRDX6 CENPL DARS2 LOC100506023 LOC101928673
GH01H172902 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +962.2 962190 9 TBL1XR1 RAD21 CHAMP1 ZNF766 ELK1 FOS RUNX3 CAVIN1 ZBTB11 CEBPB KLHL20 TNFSF18 DNM3OS GAS5-AS1 ENSG00000224228 GAS5 ENSG00000224000 AIMP1P2
GH01H173861 1.2 ENCODE 12.1 +2.1 2123 10 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZFP41 MEF2D SSRP1 KLHL20 RC3H1 DARS2 CENPL ZBTB37 GAS5-AS1 TEX50 ANKRD45 GAS5 RNA5SP67
GH01H173714 1.2 ENCODE 11.2 +153.5 153484 2 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC ZC3H11A SSRP1 ZNF610 GLIS1 KLHL20 RC3H1 DARS2 GAS5 GAS5-AS1 RPS27P7
GH01H173924 0.8 ENCODE 15.3 -57.2 -57212 2 MAX CEBPG ZNF644 YY1 ZNF316 POLR2A HNF4G NFE2 MAFK NFE2L2 ANKRD45 GAS5 SERPINC1 ZBTB37 SNORD81 CENPL DARS2 KLHL20 RNA5SP67 GC01M174029
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GAS5 on UCSC Golden Path with GeneCards custom track

Promoters for GAS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015994 982 3001 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZFP41 MEF2D

Genomic Location for GAS5 Gene

Chromosome:
1
Start:
173,863,900 bp from pter
End:
173,868,882 bp from pter
Size:
4,983 bases
Orientation:
Minus strand

Genomic View for GAS5 Gene

Genes around GAS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS5 Gene

Proteins for GAS5 Gene

Post-translational modifications for GAS5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GAS5 Gene

Domains & Families for GAS5 Gene

Gene Families for GAS5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GAS5: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GAS5 Gene

Function for GAS5 Gene

Animal Model Products

CRISPR Products

miRNA for GAS5 Gene

miRTarBase miRNAs that target GAS5

Clone Products

  • Addgene plasmids for GAS5
  • Applied Biological Materials Clones for GAS5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS5 Gene

Localization for GAS5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS5 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAS5 Gene

Pathways & Interactions for GAS5 Gene

No Data Available

Interacting Proteins for GAS5 Gene

Gene Ontology (GO) - Biological Process for GAS5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAS5 Gene

Drugs & Compounds for GAS5 Gene

No Compound Related Data Available

Transcripts for GAS5 Gene

mRNA/cDNA for GAS5 Gene

(29) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GAS5
  • Applied Biological Materials Clones for GAS5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GAS5 Gene

No ASD Table

Relevant External Links for GAS5 Gene

GeneLoc Exon Structure for
GAS5
ECgene alternative splicing isoforms for
GAS5

Expression for GAS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAS5 Gene

mRNA differential expression in normal tissues according to GTEx for GAS5 Gene

This gene is overexpressed in Pancreas (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of GAS5 Gene:

GAS5

SOURCE GeneReport for Unigene cluster for GAS5 Gene:

Hs.531856
genes like me logo Genes that share expression patterns with GAS5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS5 Gene

Orthologs for GAS5 Gene

Evolution for GAS5 Gene

ENSEMBL:
Gene Tree for GAS5 (if available)
TreeFam:
Gene Tree for GAS5 (if available)

No data available for Orthologs for GAS5 Gene

Paralogs for GAS5 Gene

No data available for Paralogs for GAS5 Gene

Variants for GAS5 Gene

Sequence variations from dbSNP and Humsavar for GAS5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000056001 -- 173,867,389(+) CGCGC(A/G)CCTGT intron-variant, upstream-variant-2KB
rs1000127752 -- 173,867,669(+) TCGGC(A/G)TGTGC intron-variant, upstream-variant-2KB
rs1000247329 -- 173,868,599(+) GCCCC(C/T)TCGCG intron-variant, upstream-variant-2KB
rs1000390155 -- 173,863,801(+) CAAAT(A/G)CCATG nc-transcript-variant, downstream-variant-500B
rs1000450082 -- 173,868,415(+) GTGCT(A/G)CTCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GAS5 Gene

Variant ID Type Subtype PubMed ID
esv2758978 CNV loss 17122850
nsv831926 CNV gain+loss 17160897

Relevant External Links for GAS5 Gene

Human Gene Mutation Database (HGMD)
GAS5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAS5 Gene

Disorders for GAS5 Gene

Relevant External Links for GAS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAS5

No disorders were found for GAS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAS5 Gene

Publications for GAS5 Gene

  1. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang XQ … Leung GK (Neurobiology of disease 2013) 2 3 60
  2. Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. (PMID: 9819378) Smith CM … Steitz JA (Molecular and cellular biology 1998) 2 3 60
  3. LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205. (PMID: 28671039) Yang W … Jiang L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  4. Low expression of long non-coding RNA GAS5 is associated with poor prognosis of patients with thyroid cancer. (PMID: 28506768) Guo LJ … Luo DL (Experimental and molecular pathology 2017) 3 60
  5. Identification of circulating long non-coding RNA GAS5 as a potential biomarker for non-small cell lung cancer diagnosisnon-small cell lung cancer, long non-coding RNA, plasma, GAS5, biomarker. (PMID: 28339045) Tan Q … Tu J (International journal of oncology 2017) 3 60

Products for GAS5 Gene

Sources for GAS5 Gene

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