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Aliases for GAS2L3 Gene

Aliases for GAS2L3 Gene

  • Growth Arrest Specific 2 Like 3 2 3 5
  • Growth Arrest-Specific Protein 2-Like 3 3 4
  • Growth Arrest-Specific 2 Like 3 3
  • G2L3 3

External Ids for GAS2L3 Gene

Previous GeneCards Identifiers for GAS2L3 Gene

  • GC12P099470
  • GC12P099471
  • GC12P100967
  • GC12P098028

Summaries for GAS2L3 Gene

GeneCards Summary for GAS2L3 Gene

GAS2L3 (Growth Arrest Specific 2 Like 3) is a Protein Coding gene. GO annotations related to this gene include actin binding and microtubule binding. An important paralog of this gene is GAS2L1.

UniProtKB/Swiss-Prot for GAS2L3 Gene

  • Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS2L3 Gene

Genomics for GAS2L3 Gene

Regulatory Elements for GAS2L3 Gene

Promoters for GAS2L3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAS2L3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAS2L3 Gene

Chromosome:
12
Start:
100,573,646 bp from pter
End:
100,628,288 bp from pter
Size:
54,643 bases
Orientation:
Plus strand

Genomic View for GAS2L3 Gene

Genes around GAS2L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS2L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS2L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS2L3 Gene

Proteins for GAS2L3 Gene

  • Protein details for GAS2L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XJ1-GA2L3_HUMAN
    Recommended name:
    GAS2-like protein 3
    Protein Accession:
    Q86XJ1
    Secondary Accessions:
    • B2RCN2

    Protein attributes for GAS2L3 Gene

    Size:
    694 amino acids
    Molecular mass:
    75214 Da
    Quaternary structure:
    • Interacts (via CH domain) with F-actin. Interacts (via C terminus) with microtubules.

neXtProt entry for GAS2L3 Gene

Proteomics data for GAS2L3 Gene at MOPED

Post-translational modifications for GAS2L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAS2L3 Gene

No data available for DME Specific Peptides for GAS2L3 Gene

Domains & Families for GAS2L3 Gene

Protein Domains for GAS2L3 Gene

Suggested Antigen Peptide Sequences for GAS2L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XJ1

UniProtKB/Swiss-Prot:

GA2L3_HUMAN :
  • The GAR domain modulates the binding strength to each cytoskeletal network.
  • Belongs to the GAS2 family.
Domain:
  • The GAR domain modulates the binding strength to each cytoskeletal network.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 GAR domain.
Family:
  • Belongs to the GAS2 family.
genes like me logo Genes that share domains with GAS2L3: view

No data available for Gene Families for GAS2L3 Gene

Function for GAS2L3 Gene

Molecular function for GAS2L3 Gene

UniProtKB/Swiss-Prot Function:
Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network.

Gene Ontology (GO) - Molecular Function for GAS2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IDA 21561867
genes like me logo Genes that share ontologies with GAS2L3: view

Phenotypes for GAS2L3 Gene

genes like me logo Genes that share phenotypes with GAS2L3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS2L3 Gene

Localization for GAS2L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS2L3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes to microtubule and actin cytoskeletons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAS2L3 Gene COMPARTMENTS Subcellular localization image for GAS2L3 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for GAS2L3 Gene

Pathways & Interactions for GAS2L3 Gene

SuperPathways for GAS2L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAS2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization IDA 21561867
genes like me logo Genes that share ontologies with GAS2L3: view

No data available for Pathways by source and SIGNOR curated interactions for GAS2L3 Gene

Drugs & Compounds for GAS2L3 Gene

No Compound Related Data Available

Transcripts for GAS2L3 Gene

Unigene Clusters for GAS2L3 Gene

Growth arrest-specific 2 like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAS2L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:

Relevant External Links for GAS2L3 Gene

GeneLoc Exon Structure for
GAS2L3
ECgene alternative splicing isoforms for
GAS2L3

Expression for GAS2L3 Gene

mRNA expression in normal human tissues for GAS2L3 Gene

mRNA differential expression in normal tissues according to GTEx for GAS2L3 Gene

This gene is overexpressed in Nerve - Tibial (x22.1).

Protein differential expression in normal tissues from HIPED for GAS2L3 Gene

This gene is overexpressed in Serum (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GAS2L3 Gene



SOURCE GeneReport for Unigene cluster for GAS2L3 Gene Hs.20575

mRNA Expression by UniProt/SwissProt for GAS2L3 Gene

Q86XJ1-GA2L3_HUMAN
Tissue specificity: Expressed in the pancreas, heart, liver, placenta, brain, skeletal muscle, kidney and lung.
genes like me logo Genes that share expression patterns with GAS2L3: view

Protein tissue co-expression partners for GAS2L3 Gene

Primer Products

In Situ Assay Products

Orthologs for GAS2L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GAS2L3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAS2L3 35
  • 87.28 (n)
  • 84.18 (a)
GAS2L3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAS2L3 35
  • 76.19 (n)
  • 71.74 (a)
GAS2L3 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gas2l3 35
  • 80.59 (n)
  • 77.94 (a)
Gas2l3 16
Gas2l3 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GAS2L3 35
  • 99.57 (n)
  • 99.71 (a)
GAS2L3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gas2l3 35
  • 79.7 (n)
  • 77.04 (a)
oppossum
(Monodelphis domestica)
Mammalia GAS2L3 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAS2L3 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAS2L3 35
  • 63.63 (n)
  • 59.91 (a)
GAS2L3 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAS2L3 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gas2l3 35
  • 61.23 (n)
  • 57.39 (a)
zebrafish
(Danio rerio)
Actinopterygii gas2l3 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea D2096.11 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4664 36
  • 48 (a)
OneToMany
Species with no ortholog for GAS2L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GAS2L3 Gene

ENSEMBL:
Gene Tree for GAS2L3 (if available)
TreeFam:
Gene Tree for GAS2L3 (if available)

Paralogs for GAS2L3 Gene

Paralogs for GAS2L3 Gene

(1) SIMAP similar genes for GAS2L3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GAS2L3: view

Variants for GAS2L3 Gene

Sequence variations from dbSNP and Humsavar for GAS2L3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11834625 - 100,624,187(+) ACTTT(C/T)GCCAA reference, missense
rs17030365 - 100,624,303(+) AATGT(A/C)CCAAG reference, missense
rs1372 -- 100,626,000(+) GCACA(C/G)TCTCT utr-variant-3-prime
rs35685 -- 100,599,775(-) CATCC(C/T)AGCTG intron-variant
rs35686 -- 100,599,495(-) AGAAT(A/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAS2L3 Gene

Variant ID Type Subtype PubMed ID
dgv1484n71 CNV Gain 21882294
nsv899470 CNV Gain 21882294
esv28430 CNV Gain 19812545

Variation tolerance for GAS2L3 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAS2L3 Gene

HapMap Linkage Disequilibrium report
GAS2L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS2L3 Gene

Disorders for GAS2L3 Gene

Relevant External Links for GAS2L3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAS2L3

No disorders were found for GAS2L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAS2L3 Gene

Publications for GAS2L3 Gene

  1. Characterization of G2L3 (GAS2-like 3), a new microtubule- and actin- binding protein related to spectraplakins. (PMID: 21561867) Stroud M.J. … Ballestrem C. (J. Biol. Chem. 2011) 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscission. (PMID: 24571573) Fackler M. … Gaubatz S. (FEBS J. 2014) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. (PMID: 23341777) Dong J. … Shen H. (PLoS Genet. 2013) 3

Products for GAS2L3 Gene

Sources for GAS2L3 Gene

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