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Aliases for GAS2 Gene

Aliases for GAS2 Gene

  • Growth Arrest-Specific 2 2 3
  • GAS-2 3 4
  • Growth Arrest-Specific Protein 2 3

External Ids for GAS2 Gene

Summaries for GAS2 Gene

Entrez Gene Summary for GAS2 Gene

  • The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

GeneCards Summary for GAS2 Gene

GAS2 (Growth Arrest-Specific 2) is a Protein Coding gene. Diseases associated with GAS2 include gnathodiaphyseal dysplasia. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. An important paralog of this gene is GAS2L3.

UniProtKB/Swiss-Prot for GAS2 Gene

  • May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).

Gene Wiki entry for GAS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS2 Gene

Genomics for GAS2 Gene

Genomic Location for GAS2 Gene

Start:
22,625,642 bp from pter
End:
22,813,055 bp from pter
Size:
187,414 bases
Orientation:
Plus strand

Genomic View for GAS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS2 Gene

Regulatory Elements for GAS2 Gene

Proteins for GAS2 Gene

  • Protein details for GAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43903-GAS2_HUMAN
    Recommended name:
    Growth arrest-specific protein 2
    Protein Accession:
    O43903
    Secondary Accessions:
    • B2R9C8
    • D3DQZ0
    • Q6ICV8
    • Q7Z3X8

    Protein attributes for GAS2 Gene

    Size:
    313 amino acids
    Molecular mass:
    34945 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS2 Gene

Proteomics data for GAS2 Gene at MOPED

Post-translational modifications for GAS2 Gene

  • Cleaved, during apoptosis, on a specific aspartic residue by caspases
  • Phosphorylated on serine residues during the G0-G1 transition phase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAS2 Gene

No data available for DME Specific Peptides for GAS2 Gene

Domains for GAS2 Gene

Protein Domains for GAS2 Gene

Suggested Antigen Peptide Sequences for GAS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43903

UniProtKB/Swiss-Prot:

GAS2_HUMAN
Domain:
  • Contains 1 CH (calponin-homology) domain.:
    • O43903
  • Contains 1 GAR domain.:
    • O43903
Family:
  • Belongs to the GAS2 family.:
    • O43903
genes like me logo Genes that share domains with GAS2: view

No data available for Gene Families for GAS2 Gene

Function for GAS2 Gene

Molecular function for GAS2 Gene

GENATLAS Biochemistry: growth arrest specific gene 2,expressed in liver,lung and kidney,involved in the regulation of microfilament dynamico during both cell cycle and apoptosis,homolog to GAR22,? same family
UniProtKB/Swiss-Prot Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).

Gene Ontology (GO) - Molecular Function for GAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GAS2: view

Phenotypes for GAS2 Gene

GenomeRNAi human phenotypes for GAS2:
genes like me logo Genes that share phenotypes with GAS2: view

miRNA for GAS2 Gene

miRTarBase miRNAs that target GAS2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GAS2 Gene

Localization for GAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS2 Gene

Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAS2 Gene COMPARTMENTS Subcellular localization image for GAS2 gene
Compartment Confidence
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for GAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005884 actin filament TAS 1607387
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GAS2: view

Pathways for GAS2 Gene

genes like me logo Genes that share pathways with GAS2: view

Interacting Proteins for GAS2 Gene

Gene Ontology (GO) - Biological Process for GAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0007050 cell cycle arrest IEA --
GO:0008360 regulation of cell shape IEA --
GO:0012501 programmed cell death TAS --
genes like me logo Genes that share ontologies with GAS2: view

Transcripts for GAS2 Gene

Unigene Clusters for GAS2 Gene

Growth arrest-specific 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAS2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for GAS2 Gene

GeneLoc Exon Structure for
GAS2
ECgene alternative splicing isoforms for
GAS2

Expression for GAS2 Gene

mRNA expression in normal human tissues for GAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAS2 Gene

This gene is overexpressed in Liver (7.1) and Brain - Spinal cord (cervical c-1) (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GAS2 Gene

SOURCE GeneReport for Unigene cluster for GAS2 Gene Hs.711297

mRNA Expression by UniProt/SwissProt for GAS2 Gene

O43903-GAS2_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen
genes like me logo Genes that share expressions with GAS2: view

Orthologs for GAS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAS2 35
  • 99.79 (n)
  • 100 (a)
GAS2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAS2 35
  • 93.82 (n)
  • 98.08 (a)
GAS2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAS2 35
  • 95.1 (n)
  • 98.08 (a)
GAS2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gas2 35
  • 89.35 (n)
  • 97.44 (a)
Gas2 16
Gas2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAS2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAS2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gas2 35
  • 88.82 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves GAS2 35
  • 81.73 (n)
  • 91.99 (a)
GAS2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAS2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gas2 35
  • 74.68 (n)
  • 86.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5535 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28064 35
GAS2 36
  • 75 (a)
OneToOne
gas2b 35
  • 63.35 (n)
  • 60.14 (a)
worm
(Caenorhabditis elegans)
Secernentea D2096.11 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4664 36
  • 50 (a)
OneToMany
Species with no ortholog for GAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GAS2 Gene

ENSEMBL:
Gene Tree for GAS2 (if available)
TreeFam:
Gene Tree for GAS2 (if available)

Paralogs for GAS2 Gene

Paralogs for GAS2 Gene

Selected SIMAP similar genes for GAS2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GAS2: view

Variants for GAS2 Gene

Sequence variations from dbSNP and Humsavar for GAS2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs91293 -- 22,689,688(-) TTAAA(C/T)TTGTA intron-variant
rs91294 -- 22,689,598(-) TGAGT(G/T)TAACA intron-variant
rs91295 -- 22,689,544(-) TAACC(C/T)TCTGG intron-variant
rs173063 -- 22,706,218(-) cttca(C/T)ttctc intron-variant
rs184609 -- 22,687,681(-) TGGTG(C/T)CCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAS2 Gene

Variant ID Type Subtype PubMed ID
nsv510246 CNV Loss 20534489
nsv523451 CNV Loss 19592680

Relevant External Links for GAS2 Gene

HapMap Linkage Disequilibrium report
GAS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS2 Gene

Disorders for GAS2 Gene

Relevant External Links for GAS2

Genetic Association Database (GAD)
GAS2
Human Genome Epidemiology (HuGE) Navigator
GAS2
genes like me logo Genes that share disorders with GAS2: view

No data available for UniProtKB/Swiss-Prot for GAS2 Gene

Publications for GAS2 Gene

  1. cDNA characterization and chromosome mapping of the human GAS2 gene. (PMID: 9521882) Collavin L. … Schneider C. (Genomics 1998) 2 3 4 23
  2. Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis. (PMID: 10564664) Sgorbissa A. … Brancolini C. (J. Cell. Sci. 1999) 3 23
  3. Gas2, a growth arrest-specific protein, is a component of the microfilament network system. (PMID: 1607387) Brancolini C. … Schneider C. (J. Cell Biol. 1992) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48

Products for GAS2 Gene

Sources for GAS2 Gene

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