Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GAS2 Gene

protein-coding   GIFtS: 55
GCID: GC11P022688

Growth Arrest-Specific 2

  See GAS2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Growth Arrest-Specific 21 2
GAS-22 3
Growth Arrest-Specific Protein 22

External Ids:    HGNC: 41671   Entrez Gene: 26202   Ensembl: ENSG000001489357   OMIM: 6028355   UniProtKB: O439033   

Export aliases for GAS2 gene to outside databases

Previous GC identifers: GC11P024106 GC11P023491 GC11P022728 GC11P022653 GC11P022646 GC11P022371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GAS2 Gene:
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell
shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting
calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.
(provided by RefSeq, Jan 2009)

GeneCards Summary for GAS2 Gene:
GAS2 (growth arrest-specific 2) is a protein-coding gene. Diseases associated with GAS2 include gnathodiaphyseal dysplasia. An important paralog of this gene is GAS2L2.

UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903
Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during
apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in
the shape of the affected cells. May be involved in the membrane ruffling process (By similarity)

Gene Wiki entry for GAS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the GAS2 gene promoter:
         Max1   HNF-3beta   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GAS2 promoter sequence
   Search Chromatin IP Primers for GAS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3   Ensembl cytogenetic band:  11p14.3   HGNC cytogenetic band: 11p14.3

GAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAS2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P022688:  view genomic region     (about GC identifiers)

Start:
22,647,188 bp from pter      End:
22,834,601 bp from pter
Size:
187,414 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903 (See protein sequence)
Recommended Name: Growth arrest-specific protein 2  
Size: 313 amino acids; 34945 Da
Developmental stage: Specifically expressed at growth arrest
Secondary accessions: B2R9C8 D3DQZ0 Q6ICV8

Explore the universe of human proteins at neXtProt for GAS2: NX_O43903

Explore proteomics data for GAS2 at MOPED

Post-translational modifications: 

  • Cleaved, during apoptosis, on a specific aspartic residue by caspases1
  • Phosphorylated on serine residues during the G0-G1 transition phase (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GAS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137302.1  NP_005247.1  NP_808221.1  

    ENSEMBL proteins: 
     ENSP00000432584   ENSP00000401145   ENSP00000434478   ENSP00000278187   ENSP00000432026  
     ENSP00000433182   ENSP00000435946   ENSP00000396708  
    Reactome Protein details: O43903

    GAS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for GAS2
    OriGene Protein Over-expression Lysate for GAS2
    OriGene MassSpec for GAS2
    OriGene Custom Protein Services for GAS2
    GenScript Custom Purified and Recombinant Proteins Services for GAS2
    Novus Biologicals GAS2 Proteins
    Novus Biologicals GAS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GAS2

     
    Search eBioscience for Proteins for GAS2 

     
    antibodies-online proteins for GAS2 (7 products) 

     
    antibodies-online peptides for GAS2

    GAS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GAS2
    OriGene Custom Antibody Services for GAS2
    Novus Biologicals GAS2 Antibodies
    Abcam antibodies for GAS2
    Cloud-Clone Corp. Antibodies for GAS2
    Search ThermoFisher Antibodies for GAS2
    antibodies-online antibodies for GAS2 (39 products) 

    GAS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GAS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GAS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GAS2
    Cloud-Clone Corp. CLIAs for GAS2
    Search eBioscience for ELISAs for GAS2 
    antibodies-online kits for GAS2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR003108 GAS2_dom
     IPR001715 CH-domain

    Graphical View of Domain Structure for InterPro Entry O43903

    ProtoNet protein and cluster: O43903

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB003108 Growth-arrest-specific protein 2


    UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903
    Similarity: Belongs to the GAS2 family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 GAR domain


    Find genes that share domains with GAS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GAS2_HUMAN, O43903
    Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during
    apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in
    the shape of the affected cells. May be involved in the membrane ruffling process (By similarity)

         Genatlas biochemistry entry for GAS2:
    growth arrest specific gene 2,expressed in liver,lung and kidney,involved in the regulation of microfilament
    dynamico during both cell cycle and apoptosis,homolog to GAR22,? same family

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with GAS2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GAS2:
     Decreased Hepatitis C virus re 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GAS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target GAS2:
    hsa-mir-26b-5p (MIRT029431)

    Block miRNA regulation of human, mouse, rat GAS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GAS2 (see all 11):
    hsa-miR-520f hsa-miR-300 hsa-miR-539 hsa-miR-381 hsa-miR-1267 hsa-miR-133b hsa-miR-512-3p hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidGAS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GAS2
    Predesigned siRNA for gene silencing in human, mouse, rat GAS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GAS2

    Clone
    Products:
         
    OriGene clones in human, mouse for GAS2 (see all 16)
    OriGene ORF clones in mouse, rat for GAS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GAS2 (NM_005256)
    Sino Biological Human cDNA Clone for GAS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GAS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for GAS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GAS2_HUMAN, O43903: Cytoplasm, cytoskeleton (By similarity). Membrane; Peripheral membrane protein (By
    similarity). Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and
    along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated,
    accumulates at membrane ruffles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005884actin filament TAS1607387
    GO:0016020membrane IEA--

    Find genes that share ontologies with GAS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GAS2 About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51


    Find genes that share SuperPaths with GAS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GAS2 (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for GAS2
        Caspase cascade in apoptosis


    1 Reactome Pathway for GAS2
        Caspase-mediated cleavage of cytoskeletal proteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GAS2
    Interactions:

        GeneGlobe Interaction Network for GAS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GAS2 (O439033 ENSP000002781874) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN1P073843, ENSP000002792474I2D: score=1 STRING: ENSP00000279247
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    CAPN2P176553, ENSP000002950064I2D: score=1 STRING: ENSP00000295006
    CASP3ENSP000003110324STRING: ENSP00000311032
    ACTC1ENSP000002903784STRING: ENSP00000290378
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007050cell cycle arrest IEA--
    GO:0008360regulation of cell shape IEA--

    Find genes that share ontologies with GAS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GAS2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GAS2 gene (3 alternative transcripts): 
    NM_001143830.1  NM_005256.3  NM_177553.2  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528582 ENST00000533092 ENST00000454584(uc009yie.3) ENST00000533363
    ENST00000278187 ENST00000524701(uc001mqm.3 uc001mqn.3) ENST00000534801
    ENST00000532398 ENST00000526665 ENST00000433790(uc001mqo.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GAS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GAS2 (see all 11):
    hsa-miR-520f hsa-miR-300 hsa-miR-539 hsa-miR-381 hsa-miR-1267 hsa-miR-133b hsa-miR-512-3p hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidGAS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GAS2
    Predesigned siRNA for gene silencing in human, mouse, rat GAS2
    Clone
    Products:
         
    OriGene clones in human, mouse for GAS2 (see all 16)
    OriGene ORF clones in mouse, rat for GAS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GAS2 (NM_005256)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GAS2
    OriGene qSTAR qPCR primer pairs in human, mouse for GAS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GAS2
      QuantiTect SYBR Green Assays in human, mouse, rat GAS2
      QuantiFast Probe-based Assays in human, mouse, rat GAS2

    Selected AceView cDNA sequences (see all 47):

    NM_005256 NM_177553 AU119167 BM718174 BV174364 AU099094 AA347777 BE047747 
    BM126952 BF109696 AI866528 BC040470 BX118863 CK821078 AI038844 BX500361 
    BI793201 BE550832 AI758363 CR450285 AI565342 BV179615 BG493040 U95032 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GAS2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -                 -                                   -                     
    SP2:              -                 -                 -                 -                     
    SP3:                                -                 -                 -                     
    SP4:        -     -                 -                                                         
    SP5:                                                                                          


    ECgene alternative splicing isoforms for GAS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GAS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GAS2 Expression
    About this image


    GAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Epiphyseal End
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Periportal Hepatocytes Liver Lobule
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    GAS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GAS2 Protein Expression

    UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903
    Tissue specificity: Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen

        Custom PCR Arrays for GAS2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GAS2
    OriGene qSTAR qPCR primer pairs in human, mouse for GAS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GAS2
    QuantiTect SYBR Green Assays in human, mouse, rat GAS2
    QuantiFast Probe-based Assays in human, mouse, rat GAS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GAS2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gas21 , 5 growth arrest specific 21, 5 89.35(n)1
    97.44(a)1
      7 (32.87 cM)5
    144531  NM_008087.21  NP_032113.11 
     518620155 
    chicken
    (Gallus gallus)
    Aves GAS21 growth arrest-specific 2 81.73(n)
    91.99(a)
      422970  NM_001199470.1  NP_001186399.1 
    lizard
    (Anolis carolinensis)
    Reptilia GAS26
    growth arrest-specific 2
    92(a)
    1 ↔ 1
    1(58867801-58989611)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gas21 growth arrest-specific 2 74.68(n)
    86.86(a)
      100485604  XM_002943108.2  XP_002943154.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.280642 Transcribed sequence with weak similarity to protein more 72.24(n)    AL916292.1 
    worm
    (Caenorhabditis elegans)
    Secernentea D2096.116
    Protein D2096.11 (D2096.11) mRNA, complete cds
    9(a)
    1 → many
    IV(8389147-8392863) WBGene00017078


    ENSEMBL Gene Tree for GAS2 (if available)
    TreeFam Gene Tree for GAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GAS2 gene
    GAS2L22  GAS2L32  GAS2L12  
    3 SIMAP similar genes for GAS2 using alignment to 6 protein entries:     GAS2_HUMAN (see all proteins):
    GAS2L3    GAS2L2    GAS2L1

    Find genes that share paralogs with GAS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GAS2 (see all 3284)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399463001,2
    Cuntested122721997(+) AAGACA/G/TGAAGA 3 -- int10--------
    rs629954631,2
    C--22621663(+) TCATA-/A/CTATAG 3 -- int11NA 2
    rs1853691341,2
    --22686237(+) AAAATA/TCTTAG 1 -- us2k10--------
    rs1428729151,2
    --22686305(+) TATTGA/GTTTTG 1 -- us2k10--------
    rs1462283831,2
    --22686381(+) TATCCA/GTGTCT 1 -- us2k10--------
    rs2014266701,2
    --22686424(+) TCACC-/AAAAAA 1 -- us2k10--------
    rs1393115731,2
    --22686484(+) TATTTA/CTTCTC 1 -- us2k10--------
    rs671061311,2
    C--22686551(+) AAGAC-/AAAAAA 1 -- us2k12Minor allele frequency- A:0.00NA CSA 4
    rs1878912601,2
    C--22686751(+) CTGGGC/GAGAAA 1 -- us2k10--------
    rs1499574431,2
    --22686930(+) TTGTTA/GGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GAS2 (22647188 - 22834601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GAS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510246CNV Loss20534489
    nsv523451CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GAS2
    DNA2.0 Custom Variant and Variant Library Synthesis for GAS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602835    OMIM disorders: --

    1 disease for GAS2:    
    About MalaCards
    gnathodiaphyseal dysplasia


    Find genes that share disorders with GAS2           About GenesLikeMe

    Genetic Association Database (GAD): GAS2
    Human Genome Epidemiology (HuGE) Navigator: GAS2 (1 document)

    Export disorders for GAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GAS2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with GAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA characterization and chromosome mapping of the human GAS2 gene. (PubMed id 9521882)1, 2, 3, 9 Collavin L.... Schneider C. (Genomics 1998)
    2. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1, 4 Murea M....Freedman B.I. (Am. J. Nephrol. 2011)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis. (PubMed id 10564664)1, 9 Sgorbissa A....Brancolini C. (J. Cell. Sci. 1999)
    6. Gas2, a growth arrest-specific protein, is a component of the microfilament network system. (PubMed id 1607387)1, 9 Brancolini C....Schneider C. (J. Cell Biol. 1992)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. (PubMed id 20679491)1 Huang W....Eklund E.A. (Mol. Cell. Biol. 2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2620 HGNC: 4167 AceView: GAS2 Ensembl:ENSG00000148935 euGenes: HUgn2620
    ECgene: GAS2 H-InvDB: GAS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GAS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GAS2 gene:
    Search GeneIP for patents involving GAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GAS2   OriGene RNAi products in human, mouse, rat for GAS2  
     OriGene qPCR primer pairs and template standards for GAS2   OriGene Protein Over-expression Lysate for GAS2  
     OriGene MassSpec for GAS2   OriGene clones in human, mouse for GAS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for GAS2   OriGene Purified Protein for GAS2  
     OriGene ORF clones in mouse, rat for GAS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GAS2   OriGene Custom Protein Services for GAS2  

     
     
     Block miRNA regulation of human, mouse, rat GAS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GAS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAS2 Predesigned siRNA for gene silencing in human, mouse, rat GAS2
     QuantiFast Probe-based Assays in human, mouse, rat GAS2 QuantiTect SYBR Green Assays in human, mouse, rat GAS2
     Custom PCR Arrays for GAS2 Search Chromatin IP Primers for GAS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GAS2  GeneGlobe Interaction Network for GAS2
     Regulatory tfbs in GAS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GAS2 GenScript cDNA clones with any tag delivered in your preferred vector for GAS2
     GenScript Custom Assay Services for GAS2 GenScript Custom overexpressing Cell Line Services for GAS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GAS2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GAS2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GAS2 antibodies
     GAS2 proteins
     GAS2 lysates
     Antibodies for GAS2
     See all of Abcam's Antibodies, Kits and Proteins for GAS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GAS2
     Antibodies for GAS2
     ELISAs for GAS2
     CLIAs for GAS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for GAS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS2
     SwitchGear 3'UTR luciferase reporter plasmids for GAS2
     SwitchGear Promoter luciferase reporter plasmids for GAS2
     Search ThermoFisher Antibodies for GAS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAS2
     Browse compounds at ApexBio
     Search Addgene for plasmids for GAS2
      Search eBioscience for proteins for GAS2
      Search eBioscience for elisas for GAS2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for GAS2
     antibodies-online antibodies for GAS2 (39 products)
     antibodies-online kits for GAS2 (4 products)
     antibodies-online peptides for GAS2
     antibodies-online proteins for GAS2 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GAS2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4