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Aliases for GAS2 Gene

Aliases for GAS2 Gene

  • Growth Arrest Specific 2 2 3 5
  • GAS-2 3 4
  • Growth Arrest-Specific 2 3

External Ids for GAS2 Gene

Previous GeneCards Identifiers for GAS2 Gene

  • GC11P024106
  • GC11P023491
  • GC11P022728
  • GC11P022653
  • GC11P022646
  • GC11P022371

Summaries for GAS2 Gene

Entrez Gene Summary for GAS2 Gene

  • The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

GeneCards Summary for GAS2 Gene

GAS2 (Growth Arrest Specific 2) is a Protein Coding gene. Diseases associated with GAS2 include gnathodiaphyseal dysplasia. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. An important paralog of this gene is GAS2L1.

UniProtKB/Swiss-Prot for GAS2 Gene

  • May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).

Gene Wiki entry for GAS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS2 Gene

Genomics for GAS2 Gene

Regulatory Elements for GAS2 Gene

Promoters for GAS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAS2 Gene

Chromosome:
11
Start:
22,625,642 bp from pter
End:
22,813,055 bp from pter
Size:
187,414 bases
Orientation:
Plus strand

Genomic View for GAS2 Gene

Genes around GAS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS2 Gene

Proteins for GAS2 Gene

  • Protein details for GAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43903-GAS2_HUMAN
    Recommended name:
    Growth arrest-specific protein 2
    Protein Accession:
    O43903
    Secondary Accessions:
    • B2R9C8
    • D3DQZ0
    • Q6ICV8
    • Q7Z3X8

    Protein attributes for GAS2 Gene

    Size:
    313 amino acids
    Molecular mass:
    34945 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS2 Gene

Proteomics data for GAS2 Gene at MOPED

Post-translational modifications for GAS2 Gene

  • Cleaved, during apoptosis, on a specific aspartic residue by caspases.
  • Phosphorylated on serine residues during the G0-G1 transition phase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for GAS2 Gene

Domains & Families for GAS2 Gene

Protein Domains for GAS2 Gene

Suggested Antigen Peptide Sequences for GAS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43903

UniProtKB/Swiss-Prot:

GAS2_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the GAS2 family.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 GAR domain.
Family:
  • Belongs to the GAS2 family.
genes like me logo Genes that share domains with GAS2: view

No data available for Gene Families for GAS2 Gene

Function for GAS2 Gene

Molecular function for GAS2 Gene

GENATLAS Biochemistry:
growth arrest specific gene 2,expressed in liver,lung and kidney,involved in the regulation of microfilament dynamico during both cell cycle and apoptosis,homolog to GAR22,? same family
UniProtKB/Swiss-Prot Function:
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).
genes like me logo Genes that share phenotypes with GAS2: view

Animal Model Products

miRNA for GAS2 Gene

miRTarBase miRNAs that target GAS2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS2 Gene

Localization for GAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS2 Gene

Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAS2 Gene COMPARTMENTS Subcellular localization image for GAS2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5

Gene Ontology (GO) - Cellular Components for GAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with GAS2: view

Pathways & Interactions for GAS2 Gene

genes like me logo Genes that share pathways with GAS2: view

Interacting Proteins for GAS2 Gene

SIGNOR curated interactions for GAS2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
genes like me logo Genes that share ontologies with GAS2: view

Drugs & Compounds for GAS2 Gene

No Compound Related Data Available

Transcripts for GAS2 Gene

Unigene Clusters for GAS2 Gene

Growth arrest-specific 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAS2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for GAS2 Gene

GeneLoc Exon Structure for
GAS2
ECgene alternative splicing isoforms for
GAS2

Expression for GAS2 Gene

mRNA expression in normal human tissues for GAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAS2 Gene

This gene is overexpressed in Liver (x7.1) and Brain - Spinal cord (cervical c-1) (x5.2).

Protein differential expression in normal tissues from HIPED for GAS2 Gene

This gene is overexpressed in Liver (25.8), Fetal Liver (19.0), and Pancreas (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GAS2 Gene



SOURCE GeneReport for Unigene cluster for GAS2 Gene Hs.711297

mRNA Expression by UniProt/SwissProt for GAS2 Gene

O43903-GAS2_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
genes like me logo Genes that share expression patterns with GAS2: view

Protein tissue co-expression partners for GAS2 Gene

Primer Products

In Situ Assay Products

Orthologs for GAS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAS2 35
  • 99.79 (n)
  • 100 (a)
GAS2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAS2 36
  • 98 (a)
OneToOne
GAS2 35
  • 93.82 (n)
  • 98.08 (a)
dog
(Canis familiaris)
Mammalia GAS2 35
  • 95.1 (n)
  • 98.08 (a)
GAS2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gas2 16
Gas2 35
  • 89.35 (n)
  • 97.44 (a)
Gas2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAS2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAS2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gas2 35
  • 88.82 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves GAS2 35
  • 81.73 (n)
  • 91.99 (a)
GAS2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAS2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gas2 35
  • 74.68 (n)
  • 86.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5535 35
zebrafish
(Danio rerio)
Actinopterygii GAS2 36
  • 75 (a)
OneToOne
Dr.28064 35
gas2b 35
  • 63.35 (n)
  • 60.14 (a)
worm
(Caenorhabditis elegans)
Secernentea D2096.11 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4664 36
  • 50 (a)
OneToMany
Species with no ortholog for GAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GAS2 Gene

ENSEMBL:
Gene Tree for GAS2 (if available)
TreeFam:
Gene Tree for GAS2 (if available)

Paralogs for GAS2 Gene

Paralogs for GAS2 Gene

(3) SIMAP similar genes for GAS2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GAS2: view

Variants for GAS2 Gene

Sequence variations from dbSNP and Humsavar for GAS2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs91294 -- 22,689,598(-) TGAGT(G/T)TAACA intron-variant
rs91295 -- 22,689,544(-) TAACC(C/T)TCTGG intron-variant
rs411591 -- 22,719,835(+) acttt(A/G)ccatc intron-variant
rs186806 -- 22,718,590(-) gattt(C/T)ggtgc intron-variant
rs189244 -- 22,720,398(+) CAAAG(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAS2 Gene

Variant ID Type Subtype PubMed ID
nsv510246 CNV Loss 20534489
nsv523451 CNV Loss 19592680

Variation tolerance for GAS2 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAS2 Gene

HapMap Linkage Disequilibrium report
GAS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS2 Gene

Disorders for GAS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GAS2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gnathodiaphyseal dysplasia
  • levin syndrome 2
- elite association - COSMIC cancer census association via MalaCards
Search GAS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GAS2

Genetic Association Database (GAD)
GAS2
Human Genome Epidemiology (HuGE) Navigator
GAS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAS2
genes like me logo Genes that share disorders with GAS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS2 Gene

Publications for GAS2 Gene

  1. cDNA characterization and chromosome mapping of the human GAS2 gene. (PMID: 9521882) Collavin L. … Schneider C. (Genomics 1998) 2 3 4 23 67
  2. Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis. (PMID: 10564664) Sgorbissa A. … Brancolini C. (J. Cell. Sci. 1999) 3 23
  3. Gas2, a growth arrest-specific protein, is a component of the microfilament network system. (PMID: 1607387) Brancolini C. … Schneider C. (J. Cell Biol. 1992) 3 23
  4. Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth. (PMID: 24465953) Zhou H. … Zhao Y. (PLoS ONE 2014) 3
  5. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3

Products for GAS2 Gene

Sources for GAS2 Gene

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