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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GAS2 Gene

protein-coding GIFtS: 56
GCID: GC11P022688

growth arrest-specific 2

Explore 4 diseases affiliated with
GAS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Growth Arrest-Specific 2¹ ²
GAS-2² ³
Growth Arrest-Specific Protein 2²

External Ids:	HGNC: 4167¹	Entrez Gene: 2620²	Ensembl: ENSG00000148935⁷	OMIM: 602835⁵	UniProtKB: O43903³

Export aliases for GAS2 gene to outside databases

Previous GC identifers: GC11P024106 GC11P023491 GC11P022728 GC11P022653 GC11P022646 GC11P022371

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GAS2:

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape

changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain

activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided by

RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903

Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis

and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the

affected cells. May be involved in the membrane ruffling process (By similarity)

Gene Wiki entry for GAS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GAS2 gene promoter:
Max1 HNF-3beta c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GAS2 promoter sequence

Search SABiosciences Chromatin IP Primers for GAS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3 Ensembl cytogenetic band: 11p14.3 HGNC cytogenetic band: 11p14.3

GAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAS2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P022688: view genomic region (about GC identifiers)

Start:	22,647,188 bp from pter	End:	22,834,601 bp from pter
Size:	187,414 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903 (See protein sequence)

Recommended Name: Growth arrest-specific protein 2

Size: 313 amino acids; 34945 Da

Subcellular location: Cytoplasm, cytoskeleton (By similarity). Membrane; Peripheral membrane protein (By similarity).

Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress

fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane

ruffles (By similarity)

Developmental stage: Specifically expressed at growth arrest

Secondary accessions: B2R9C8 D3DQZ0 Q6ICV8

Explore the universe of human proteins at neXtProt for GAS2: NX_O43903

Post-translational modifications:

Cleaved, during apoptosis, on a specific aspartic residue by caspases¹

Phosphorylated on serine residues during the G0-G1 transition phase (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43903

GAS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001137302.1 NP_005247.1 NP_808221.1

ENSEMBL proteins:

ENSP00000432584 ENSP00000401145 ENSP00000434478 ENSP00000278187 ENSP00000432026

ENSP00000433182 ENSP00000435946 ENSP00000396708

Reactome Protein details: O43903
Human Recombinant Protein Products for GAS2:

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	Uscn Proteins for GAS2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005884	actin filament	TAS	1607387
GO:0016020	membrane	IEA	--

GAS2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GAS2 for domains About GeneDecksing

2 InterPro domains/families:

IPR003108 GAS2_dom

IPR001715 CH-domain

Graphical View of Domain Structure for InterPro Entry O43903

ProtoNet protein and cluster: O43903

2 Blocks protein families:

IPB001715 Calponin-like actin-binding

IPB003108 Growth-arrest-specific protein 2

UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903

Similarity: Belongs to the GAS2 family

Similarity: Contains 1 CH (calponin-homology) domain

Similarity: Contains 1 GAR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GAS2_HUMAN, O43903

Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis

and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the

affected cells. May be involved in the membrane ruffling process (By similarity)

Genatlas biochemistry entry for GAS2:

growth arrest specific gene 2,expressed in liver,lung and kidney,involved in the regulation of microfilament dynamico

during both cell cycle and apoptosis,homolog to GAR22,? same family

Phenotypes:
1 GenomeRNAi human phenotype for GAS2:

Decreased Hepatitis C virus re

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GAS2

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		hsa-miR-520f hsa-miR-300 hsa-miR-539 hsa-miR-381 hsa-miR-1267 hsa-miR-133b hsa-miR-512-3p hsa-miR-3159

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAS2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GAS2 (see all 55)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 BioSystems Pathway for GAS2

Caspase cascade in apoptosis

4 Reactome Pathways for GAS2

	Apoptotic execution phase
	Apoptotic cleavage of cellular proteins
	Caspase-mediated cleavage of cytoskeletal proteins
	Apoptosis

GAS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GAS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for GAS2 (O43903³ ENSP00000278187⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAPN1	P07384³, ENSP00000279247⁴	I2D: score=1 STRING: ENSP00000279247
ACTA1	P68133³, ENSP00000355645⁴	I2D: score=1 STRING: ENSP00000355645
CAPN2	P17655³, ENSP00000295006⁴	I2D: score=1 STRING: ENSP00000295006
CASP3	ENSP00000311032⁴	STRING: ENSP00000311032
ACTC1	ENSP00000290378⁴	STRING: ENSP00000290378

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	TAS	--
GO:0007050	cell cycle arrest	IEA	--
GO:0008360	regulation of cell shape	IEA	--

GAS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GAS2
Search CenterWatch for drugs/clinical trials and news about GAS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GAS2 gene (3 alternative transcripts):

NM_001143830.1 NM_005256.3 NM_177553.2

Unigene Cluster for GAS2:

Growth arrest-specific 2

Hs.741320 [show with all ESTs]

Unigene Representative Sequence: NM_001143830

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000528582 ENST00000533092 ENST00000454584(uc009yie.3) ENST00000533363

ENST00000278187 ENST00000524701(uc001mqm.3 uc001mqn.3) ENST00000534801

ENST00000532398 ENST00000526665 ENST00000433790(uc001mqo.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAS2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate GAS2 (see all 11):
		hsa-miR-520f hsa-miR-300 hsa-miR-539 hsa-miR-381 hsa-miR-1267 hsa-miR-133b hsa-miR-512-3p hsa-miR-3159

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Additional cDNA sequence:

AK313734.1 BC005077.1 BC040470.1 CR450285.1 U95032.1

8 DOTS entries:

DT.452228 DT.408917 DT.100747066 DT.95261084 DT.92051414 DT.87046930 DT.95075596 DT.95164585

24/47 AceView cDNA sequences (see all 47):

BE047747 AU099094 AU119167 BF109696 BV174364 AA347777 BM718174 BM126952

NM_177553 NM_005256 AI697811 BX500361 AA329777 BV179615 BC040470 BE550832

AI758363 BX118863 BG427391 BP360415 AI565342 BI793201 CR450285 AW614159

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GAS2 (see all 6) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b
SP1:					-						-												-
SP2:					-						-						-						-
SP3:											-						-						-
SP4:			-		-						-
SP5:

ECgene alternative splicing isoforms for GAS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GAS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

GAS2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Liver

Liver Lobule

Periportal Hepatocytes

Liver

Bone

Zeugopod Epiphyseal End

Bone

Cartilage

Lumbar Intervertebral Disc

Cartilage

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GAS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAS2

SOURCE GeneReport for Unigene cluster: Hs.741320

UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903

Tissue specificity: Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen

SABiosciences Custom PCR Arrays for GAS2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GAS2 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GAS2¹	growth arrest-specific 2	82.16(n) 92.31(a)		422970 NM_001199470.1 NP_001186399.1
lizard (Anolis carolinensis)	Reptilia	GAS2⁶	--	92(a)	1 ↔ 1	1(58989393-58989611)
zebrafish (Danio rerio)	Actinopterygii	Dr.28064²	Transcribed sequence with weak similarity to protein more	72.24(n)		AL916292.1
honey bee (Apis mellifera)	Insecta	--	--	25(a)	1 → many	Group6.25(617609-633785)

ENSEMBL Gene Tree for GAS2 (if available)
TreeFam Gene Tree for GAS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GAS2 gene

GAS2L2² GAS2L3² GAS2L1²

3 SIMAP similar genes for GAS2 using alignment to 6 protein entries: GAS2_HUMAN (see all proteins):

GAS2L3 GAS2L2 GAS2L1

GAS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139946300^1,2	C	unknown	22721997(+)	`AAGACA/G/TGAAGA`	3	--	int¹		0	--	--	--	--
rs11292924^1,2	C,F	--	22484671(+)	`AAAAC-/AAAAAA`	1	--	int¹ trp³		3		NA CSA	6
rs185369134^1,2		--	22686237(+)	`AAAATA/TCTTAG`	1	--	us2k¹		0	--	--	--	--
rs142872915^1,2		--	22686305(+)	`TATTGA/GTTTTG`	1	--	us2k¹		0	--	--	--	--
rs146228383^1,2		--	22686381(+)	`TATCCA/GTGTCT`	1	--	us2k¹		0	--	--	--	--
rs201426670^1,2		--	22686424(+)	`TCACC-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs139311573^1,2		--	22686484(+)	`TATTTA/CTTCTC`	1	--	us2k¹		0	--	--	--	--
rs67106131^1,2	C	--	22686551(+)	`AAGAC-/AAAAAA`	1	--	us2k¹		2		NA CSA	4
rs187891260^1,2		--	22686751(+)	`CTGGGC/GAGAAA`	1	--	us2k¹		0	--	--	--	--
rs149957443^1,2		--	22686930(+)	`TTGTTA/GGGGCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GAS2 (22647188 - 22834601 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GAS2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GAS2 for disorders           About GeneDecksing

OMIM gene information: 602835    OMIM disorders: --

4 diseases for GAS2:    About MalaCards

gnathodiaphyseal dysplasia breast cancer adenocarcinoma pancreatitis

Human Genome Epidemiology (HuGE) Navigator: GAS2 (1 document)

Export disorders for GAS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GAS2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with GAS2)

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cDNA characterization and chromosome mapping of the human GAS2 gene. (PubMed id 9521882)^{1, 2, 3, 9} Collavin L.... Schneider C. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis. (PubMed id 10564664)^{1, 9} Sgorbissa A....Brancolini C. (1999)
Gas2, a growth arrest-specific protein, is a componen t of the microfilament network system. (PubMed id 1607387)^{1, 9} Brancolini C....Schneider C. (1992)
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)¹ Murea M....Freedman B.I. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcript ion. (PubMed id 20679491)¹ Huang W....Eklund E.A. (2010)
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)¹ Shimada M....Tokunaga K. (2010)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2620	HGNC: 4167	AceView: GAS2	Ensembl:ENSG00000148935	euGenes: HUgn2620
ECgene: GAS2	H-InvDB: GAS2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GAS2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GAS2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GAS2 gene
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Patent Information for GAS2 gene:
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