External Ids for GAS2 Gene
Previous GeneCards Identifiers for GAS2 Gene
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
GeneCards Summary for GAS2 Gene
GAS2 (Growth Arrest-Specific 2) is a Protein Coding gene. Diseases associated with GAS2 include gnathodiaphyseal dysplasia. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is GAS2L3.
UniProtKB/Swiss-Prot for GAS2 Gene
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).