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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAS2 Gene

protein-coding   GIFtS: 58
GCID: GC11P022688

Growth Arrest-Specific 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Arrest-Specific 21 2
GAS-22 3
Growth Arrest-Specific Protein 22

External Ids:    HGNC: 41671   Entrez Gene: 26202   Ensembl: ENSG000001489357   OMIM: 6028355   UniProtKB: O439033   

Export aliases for GAS2 gene to outside databases

Previous GC identifers: GC11P024106 GC11P023491 GC11P022728 GC11P022653 GC11P022646 GC11P022371


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GAS2 Gene:
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell
shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting
calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.
(provided by RefSeq, Jan 2009)

GeneCards Summary for GAS2 Gene: 
GAS2 (growth arrest-specific 2) is a protein-coding gene. Diseases associated with GAS2 include gnathodiaphyseal dysplasia, and narcolepsy, and among its related super-pathways are Rac1 Pathway and Ras Pathway. An important paralog of this gene is GAS2L2.

UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903
Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during
apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in
the shape of the affected cells. May be involved in the membrane ruffling process (By similarity)

Gene Wiki entry for GAS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAS2 gene promoter:
         Max1   HNF-3beta   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GAS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GAS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3   Ensembl cytogenetic band:  11p14.3   HGNC cytogenetic band: 11p14.3

GAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAS2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P022688:  view genomic region     (about GC identifiers)

Start:
22,647,188 bp from pter      End:
22,834,601 bp from pter
Size:
187,414 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903 (See protein sequence)
Recommended Name: Growth arrest-specific protein 2  
Size: 313 amino acids; 34945 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Membrane; Peripheral membrane protein (By
similarity). Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and
along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated,
accumulates at membrane ruffles (By similarity)
Developmental stage: Specifically expressed at growth arrest
Secondary accessions: B2R9C8 D3DQZ0 Q6ICV8

Explore the universe of human proteins at neXtProt for GAS2: NX_O43903

Explore proteomics data for GAS2 at MOPED 

Post-translational modifications:

  • UniProtKB: Cleaved, during apoptosis, on a specific aspartic residue by caspases
  • UniProtKB: Phosphorylated on serine residues during the G0-G1 transition phase (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43903

  • GAS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GAS2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001137302.1  NP_005247.1  NP_808221.1  

    ENSEMBL proteins: 
     ENSP00000432584   ENSP00000401145   ENSP00000434478   ENSP00000278187   ENSP00000432026  
     ENSP00000433182   ENSP00000435946   ENSP00000396708  
    Reactome Protein details: O43903
    Human Recombinant Protein Products for GAS2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GAS2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005884actin filament TAS1607387
    GO:0016020membrane IEA--

    GAS2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003108 GAS2_dom
     IPR001715 CH-domain

    Graphical View of Domain Structure for InterPro Entry O43903

    ProtoNet protein and cluster: O43903

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB003108 Growth-arrest-specific protein 2


    UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903
    Similarity: Belongs to the GAS2 family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 GAR domain


    GAS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GAS2_HUMAN, O43903
    Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during
    apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in
    the shape of the affected cells. May be involved in the membrane ruffling process (By similarity)

         Genatlas biochemistry entry for GAS2:
    growth arrest specific gene 2,expressed in liver,lung and kidney,involved in the regulation of microfilament
    dynamico during both cell cycle and apoptosis,homolog to GAR22,? same family

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    GAS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GAS2:
     Decreased Hepatitis C virus re 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidGAS2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GAS2 About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GAS2 (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for GAS2
        Caspase cascade in apoptosis

    4        Reactome Pathways for GAS2
        Apoptotic execution phase
    Apoptotic cleavage of cellular proteins
    Caspase-mediated cleavage of cytoskeletal proteins
    Apoptosis



    GAS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for GAS2 (O439033 ENSP000002781874) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN1P073843, ENSP000002792474I2D: score=1 STRING: ENSP00000279247
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    CAPN2P176553, ENSP000002950064I2D: score=1 STRING: ENSP00000295006
    CASP3ENSP000003110324STRING: ENSP00000311032
    ACTC1ENSP000002903784STRING: ENSP00000290378
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007050cell cycle arrest IEA--
    GO:0008360regulation of cell shape IEA--

    GAS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAS2

    Search CenterWatch for drugs/clinical trials and news about GAS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GAS2 gene (3 alternative transcripts): 
    NM_001143830.1  NM_005256.3  NM_177553.2  

    Unigene Cluster for GAS2:

    Growth arrest-specific 2
    Hs.711297  [show with all ESTs]
    Unigene Representative Sequence: NM_001143830
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528582 ENST00000533092 ENST00000454584(uc009yie.3) ENST00000533363
    ENST00000278187 ENST00000524701(uc001mqm.3 uc001mqn.3) ENST00000534801
    ENST00000532398 ENST00000526665 ENST00000433790(uc001mqo.3)
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    hsa-miR-520f hsa-miR-300 hsa-miR-539 hsa-miR-381 hsa-miR-1267 hsa-miR-133b hsa-miR-512-3p hsa-miR-3159
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    Additional mRNA sequence: 

    AK313734.1 BC005077.1 BC040470.1 CR450285.1 U95032.1 

    9 DOTS entries:

    DT.452228  DT.100747066  DT.408917  DT.95261084  DT.92051414  DT.87046930  DT.95075596  DT.95164585 
    DT.95261085 

    24/47 AceView cDNA sequences (see all 47):

    NM_177553 BM718174 AU099094 NM_005256 AU119167 AA347777 BE047747 BV174364 
    BM126952 BF109696 BE550832 BG493040 AA329777 BU741801 AI565342 BP360415 
    BX500361 AI038844 BC013326 BV179615 AI866528 AI697811 BC040470 BX118863 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GAS2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -                 -                                   -                     
    SP2:              -                 -                 -                 -                     
    SP3:                                -                 -                 -                     
    SP4:        -     -                 -                                                         
    SP5:                                                                                          


    ECgene alternative splicing isoforms for GAS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAS2 expression in normal human tissues (normalized intensities)      GAS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GAS2 Expression
    About this image


    GAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Epiphyseal End
     
     Kidney (Urinary System)
             Renal Vesicle
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    See GAS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAS2

    SOURCE GeneReport for Unigene cluster: Hs.711297

    UniProtKB/Swiss-Prot: GAS2_HUMAN, O43903
    Tissue specificity: Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GAS2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gas21 , 5 growth arrest specific 21, 5 89.35(n)1
    97.44(a)1
      7 (32.87 cM)5
    144531  NM_008087.21  NP_032113.11 
     518620155 
    chicken
    (Gallus gallus)
    Aves GAS21 growth arrest-specific 2 82.16(n)
    92.31(a)
      422970  NM_001199470.1  NP_001186399.1 
    lizard
    (Anolis carolinensis)
    Reptilia GAS26
    GAS2L26
    Uncharacterized protein
    92(a)
    11(a)
    1 ↔ 1
    possible ortholog
    1(58867801-58989611)
    GL344864.1(1336-10114)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.280642 Transcribed sequence with weak similarity to protein more 72.24(n)    AL916292.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pigs6
    pickled eggs
    10(a)
    1 → many
    X(6494098-6546131)


    ENSEMBL Gene Tree for GAS2 (if available)
    TreeFam Gene Tree for GAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAS2 gene
    GAS2L22  GAS2L32  GAS2L12  
    3 SIMAP similar genes for GAS2 using alignment to 6 protein entries:     GAS2_HUMAN (see all proteins):
    GAS2L3    GAS2L2    GAS2L1

    GAS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3284 SNPs in GAS2 are shown (see all 3284)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399463001,2
    Cuntested122721997(+) AAGACA/G/TGAAGA 3 -- int10--------
    rs629954631,2
    C--22621663(+) TCATA-/A/CTATAG 3 -- int11NA 2
    rs1853691341,2
    --22686237(+) AAAATA/TCTTAG 1 -- us2k10--------
    rs1428729151,2
    --22686305(+) TATTGA/GTTTTG 1 -- us2k10--------
    rs1462283831,2
    --22686381(+) TATCCA/GTGTCT 1 -- us2k10--------
    rs2014266701,2
    --22686424(+) TCACC-/AAAAAA 1 -- us2k10--------
    rs1393115731,2
    --22686484(+) TATTTA/CTTCTC 1 -- us2k10--------
    rs671061311,2
    C--22686551(+) AAGAC-/AAAAAA 1 -- us2k12Minor allele frequency- A:0.00NA CSA 4
    rs1878912601,2
    C--22686751(+) CTGGGC/GAGAAA 1 -- us2k10--------
    rs1499574431,2
    --22686930(+) TTGTTA/GGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GAS2 (22647188 - 22834601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GAS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510246CNV Loss20534489
    nsv523451CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602835    OMIM disorders: --

    5 diseases for GAS2:    About MalaCards
    gnathodiaphyseal dysplasia    narcolepsy    adenocarcinoma    pancreatitis
    breast cancer


    GAS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GAS2
    Human Genome Epidemiology (HuGE) Navigator: GAS2 (1 document)

    Export disorders for GAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAS2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with GAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA characterization and chromosome mapping of the human GAS2 gene. (PubMed id 9521882)1, 2, 3, 9 Collavin L.... Schneider C. (1998)
    2. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1, 4 Murea M....Freedman B.I. (2011)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis. (PubMed id 10564664)1, 9 Sgorbissa A....Brancolini C. (1999)
    6. Gas2, a growth arrest-specific protein, is a componen t of the microfilament network system. (PubMed id 1607387)1, 9 Brancolini C....Schneider C. (1992)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcript ion. (PubMed id 20679491)1 Huang W....Eklund E.A. (2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2620 HGNC: 4167 AceView: GAS2 Ensembl:ENSG00000148935 euGenes: HUgn2620
    ECgene: GAS2 H-InvDB: GAS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GAS2 gene:
    Search GeneIP for patents involving GAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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