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Aliases for GAS1 Gene

Aliases for GAS1 Gene

  • Growth Arrest Specific 1 2 3 5
  • Growth Arrest-Specific Gene-1 2 3
  • GAS-1 3 4
  • Growth Arrest-Specific 1 3

External Ids for GAS1 Gene

Previous GeneCards Identifiers for GAS1 Gene

  • GC09M080603
  • GC09M081412
  • GC09M083114
  • GC09M085016
  • GC09M086788
  • GC09M088749
  • GC09M089559
  • GC09M059383

Summaries for GAS1 Gene

Entrez Gene Summary for GAS1 Gene

  • Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAS1 Gene

GAS1 (Growth Arrest Specific 1) is a Protein Coding gene. Diseases associated with GAS1 include lobar holoprosencephaly and alobar holoprosencephaly. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts.

UniProtKB/Swiss-Prot for GAS1 Gene

  • Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.

Gene Wiki entry for GAS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS1 Gene

Genomics for GAS1 Gene

Regulatory Elements for GAS1 Gene

Promoters for GAS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAS1 Gene

Chromosome:
9
Start:
86,944,362 bp from pter
End:
86,947,189 bp from pter
Size:
2,828 bases
Orientation:
Minus strand

Genomic View for GAS1 Gene

Genes around GAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS1 Gene

Proteins for GAS1 Gene

  • Protein details for GAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54826-GAS1_HUMAN
    Recommended name:
    Growth arrest-specific protein 1
    Protein Accession:
    P54826
    Secondary Accessions:
    • B9EGM4
    • Q6B086

    Protein attributes for GAS1 Gene

    Size:
    345 amino acids
    Molecular mass:
    35693 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAS1 Gene

Proteomics data for GAS1 Gene at MOPED

Post-translational modifications for GAS1 Gene

Other Protein References for GAS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GAS1 Gene

Domains & Families for GAS1 Gene

Protein Domains for GAS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GAS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GAS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GAS1 Gene

Function for GAS1 Gene

Molecular function for GAS1 Gene

GENATLAS Biochemistry:
growth arrest specific gene 1,45kDa,predominantly expressed in lung and heart
UniProtKB/Swiss-Prot Function:
Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
genes like me logo Genes that share phenotypes with GAS1: view

Human Phenotype Ontology for GAS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GAS1 Gene

MGI Knock Outs for GAS1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for GAS1 Gene

Localization for GAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAS1 Gene COMPARTMENTS Subcellular localization image for GAS1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
lysosome 2
mitochondrion 2
nucleus 2
vacuole 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 8127893
genes like me logo Genes that share ontologies with GAS1: view

Pathways & Interactions for GAS1 Gene

genes like me logo Genes that share pathways with GAS1: view

Gene Ontology (GO) - Biological Process for GAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
GO:0008589 regulation of smoothened signaling pathway ISS --
GO:0035924 cellular response to vascular endothelial growth factor stimulus IEP 15070677
GO:0045165 cell fate commitment ISS --
GO:0045930 negative regulation of mitotic cell cycle IGI 11356029
genes like me logo Genes that share ontologies with GAS1: view

No data available for SIGNOR curated interactions for GAS1 Gene

Drugs & Compounds for GAS1 Gene

(1) Additional Compounds for GAS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GAS1: view

Transcripts for GAS1 Gene

mRNA/cDNA for GAS1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(104) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAS1 Gene

Growth arrest-specific 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAS1 Gene

No ASD Table

Relevant External Links for GAS1 Gene

GeneLoc Exon Structure for
GAS1
ECgene alternative splicing isoforms for
GAS1

Expression for GAS1 Gene

mRNA expression in normal human tissues for GAS1 Gene

mRNA differential expression in normal tissues according to GTEx for GAS1 Gene

This gene is overexpressed in Uterus (x6.1) and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for GAS1 Gene

This gene is overexpressed in Pancreatic juice (27.2), Gallbladder (13.2), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GAS1 Gene



SOURCE GeneReport for Unigene cluster for GAS1 Gene Hs.65029

genes like me logo Genes that share expression patterns with GAS1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GAS1 Gene

Orthologs for GAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAS1 36
  • 100 (a)
OneToOne
GAS1 35
  • 98.16 (n)
  • 98.55 (a)
cow
(Bos Taurus)
Mammalia GAS1 35
  • 91.72 (n)
  • 92.33 (a)
GAS1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAS1 36
  • 92 (a)
OneToOne
GAS1 35
  • 93.29 (n)
  • 92.97 (a)
mouse
(Mus musculus)
Mammalia Gas1 36
  • 75 (a)
OneToOne
Gas1 16
Gas1 35
  • 84.5 (n)
  • 82.07 (a)
oppossum
(Monodelphis domestica)
Mammalia GAS1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gas1 35
  • 84.35 (n)
  • 81.4 (a)
chicken
(Gallus gallus)
Aves GAS1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAS1 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16153 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gas1 35
  • 72.62 (n)
  • 68.37 (a)
Str.10719 35
zebrafish
(Danio rerio)
Actinopterygii gas1a 35
  • 63.47 (n)
  • 58.76 (a)
gas1a 36
  • 45 (a)
OneToMany
gas1b 36
  • 46 (a)
OneToMany
Species with no ortholog for GAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAS1 Gene

ENSEMBL:
Gene Tree for GAS1 (if available)
TreeFam:
Gene Tree for GAS1 (if available)

Paralogs for GAS1 Gene

No data available for Paralogs for GAS1 Gene

Variants for GAS1 Gene

Sequence variations from dbSNP and Humsavar for GAS1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7869285 -- 86,944,619(+) ACTTC(A/C)CAATG utr-variant-3-prime
rs7854863 -- 86,943,901(+) AAAAG(G/T)GTGAA downstream-variant-500B
rs11795098 -- 86,944,642(+) TGATT(C/G)CTGAT utr-variant-3-prime
rs13296389 -- 86,944,248(+) TCTTG(G/T)ACTGT downstream-variant-500B
rs73654914 -- 86,943,976(+) TGTTT(C/G)ATTGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GAS1 Gene

Variant ID Type Subtype PubMed ID
nsv893542 CNV Gain 21882294
esv29661 CNV Loss 19812545

Variation tolerance for GAS1 Gene

Gene Damage Index Score: 0.37; 8.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAS1 Gene

HapMap Linkage Disequilibrium report
GAS1
Human Gene Mutation Database (HGMD)
GAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS1 Gene

Disorders for GAS1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for GAS1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GAS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GAS1

Genetic Association Database (GAD)
GAS1
Human Genome Epidemiology (HuGE) Navigator
GAS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAS1
genes like me logo Genes that share disorders with GAS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS1 Gene

Publications for GAS1 Gene

  1. Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene. (PMID: 8127893) del Sal G. … Schneider C. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23 67
  2. Localization of the human growth arrest-specific gene (GAS1) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies. (PMID: 8307588) Evdokiou A. … Cowled P.A. (Genomics 1993) 2 3 23
  3. Gas1 inhibits cell proliferation and induces apoptosis of human primary gliomas in the absence of Shh. (PMID: 19460624) DomA-nguez-MonzA^n G. … Segovia J. (Int. J. Dev. Neurosci. 2009) 3 23
  4. Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin. (PMID: 20050020) RittiAc L. … Fisher G.J. (Aging Cell 2009) 3 23
  5. Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling. (PMID: 18394855) LA^pez-RamA-rez M.A. … Segovia J. (Int. J. Dev. Neurosci. 2008) 3 23

Products for GAS1 Gene

Sources for GAS1 Gene

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