GART Gene
protein-coding GIFtS: 63
GCID: GC21M034870
|
|
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide...
(Previous symbols: PRGS, PGFT)
| |
Aliases
for GART gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
|
| Aliases |
|---|
| Phosphoribosylglycinamide Formyltransferase, PhosphoribosylglycinamideSynthetase, Phosphoribosylaminoimidazole Synthetase1 2 | | GARTF2 | | PGFT1 2 3 5 | | PAIS2 | | PRGS1 2 3 5 | | Trifunctional Purine Biosynthetic Protein Adenosine-32 | | Phosphoribosylglycinamide Formyltransferase, EC 2.1.2.211 | | EC 6.3.3.18 | | AIRS2 | | EC 6.3.4.138 | | GARS2 | | |
Export aliases for GART gene to outside databasesPrevious GC identifers: GC21M031453 GC21M031536 GC21M033796 GC21M033798 GC21M020354 |
Summaries
for GART gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GART:
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase,phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novopurine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in twotranscript variants encoding different isoforms. (provided by RefSeq, Jul 2008)
Gene Wiki entry for GART (Trifunctional purine biosynthetic protein adenosine-3)
|
Genomic Views
for GART gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
|
| GC21M034870: |
GeneLoc |
Nature:405,311-319 |
Start:
|
34,870,940 bp from pter |
20,452,917 bp from centromere |
End:
|
34,915,797 bp from pter |
20,491,053 bp from centromere |
Size:
|
44,858 bases |
38,137 bases |
Orientation:
|
minus strand |
minus strand |
1 alternative location:
| Chr21-,PATCHES 34,881,017-34,888,544 |
Proteins
for GART gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PUR2_HUMAN, P22102 (See
protein sequence)Recommended Name: Trifunctional purine biosynthetic protein adenosine-3 Size: 1010 amino acids; 107767 Da
6/14 PDB 3D structures from  and Proteopedia  for GART (see all 14):1MEJ (3D)
1MEN (3D)
1MEO (3D)
1NJS (3D)
1RBM (3D)
1RBQ (3D)
Secondary accessions: A8K945 A8KA32 D3DSF3 D3DSF4 O14659 Q52M77Alternative splicing: 2 isoforms: P22102-1 P22102-2 Explore the universe of human proteins at neXtProt for GART: NX_P22102
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P22102
4/17 DME Specific Peptides for GART (P22102) (see all 17)
GART Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_000810.1 NP_001129477.1 NP_001129478.1 NP_780294.1
ENSEMBL proteins: ENSP00000416085 ENSP00000420041 ENSP00000371236 ENSP00000371253 ENSP00000371261 ENSP00000390003 ENSP00000354388 ENSP00000409771 ENSP00000413040 ENSP00000398631 ENSP00000413803 ENSP00000407783 ENSP00000443579 Reactome Protein details: P22102
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
GART for ontologies About GeneDecksing
GART Antibody Products:
Assay Products for GART: |
Protein
Domains /
Families
for GART gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GART for domains About GeneDecksing
5/17 InterPro domains/families (see all 17):Graphical View of Domain Structure for InterPro Entry P22102ProtoNet protein and cluster: P22102 3 Blocks protein families: IPB000115 Phosphoribosylglycinamide synthetase IPB000728 AIR synthase related protein IPB010918 AIR synthase related protein
UniProtKB/Swiss-Prot: PUR2_HUMAN, P22102Similarity: In the N-terminal section; belongs to the GARS familySimilarity: In the central section; belongs to the AIR synthase familySimilarity: In the C-terminal section; belongs to the GART familySimilarity: Contains 1 ATP-grasp domain |
Function
for GART gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PUR2_HUMAN, P22102Catalytic activity: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamideCatalytic activity: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate +5-amino-1-(5-phospho-D-ribosyl)imidazoleCatalytic activity: 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate +N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide Genatlas biochemistry entry for GART:glycineamide formyltransferase,catalyzing the third step of the de novo purine biosynthesis,leading toformylglycinamide ribonucleotide (FGAR)
Enzyme Numbers (IUBMB): EC 6.3.4.132 EC 6.3.3.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GART (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GART (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for GART | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GART |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GART |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004637 | phosphoribosylamine-glycine ligase activity |
IEA | -- | | GO:0004641 | phosphoribosylformylglycinamidine cyclo-ligase activity |
IEA | -- | | GO:0004644 | phosphoribosylglycinamide formyltransferase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0008168 | methyltransferase activity |
IEA | -- |
GART for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GART:
Animal Models:
1 MGI phenotypic allele  for Gart (no phenotypes)
GART for phenotypes About GeneDecksing
|
Pathways & Interactions
for GART gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | purine nucleotides de novo biosynthesis II | | | 2 | Antimetabolite Pathway - Folate Cycle, Pharmacodynamics | | | 3 | Purine metabolism | | | 4 | One Carbon Metabolism | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for GART
4 
Reactome Pathways for GART
3  PharmGKB Pathways for GART
3 
Kegg Pathways (Kegg details for GART):
UniProtKB/Swiss-Prot: PUR2_HUMAN, P22102Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole fromN(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from5-phospho-alpha-D-ribose 1-diphosphate: step 2/2Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamidefrom N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1
GART for pathways About GeneDecksing
Interactions:
 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GART
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/57 Interacting proteins for GART (P221022, 3 ENSP000003712364) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006144 | purine nucleobase metabolic process |
TAS | -- | | GO:0006189 | 'de novo' IMP biosynthetic process |
IEA | -- | | GO:0009113 | purine nucleobase biosynthetic process |
IEA | -- | | GO:0009168 | purine ribonucleoside monophosphate biosynthetic process |
TAS | -- | | GO:0010033 | response to organic substance |
-- | -- |
GART for ontologies About GeneDecksing
|
Drugs & Compounds
for GART gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GART for compounds About GeneDecksing
 Browse Tocris compounds for GART
10/16 HMDB Compounds for GART (see all 16) About this table
3 DrugBank Compounds for GART About this table
10/17 Novoseek chemical compound relationships for GART gene (see all 17) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glycinamide ribonucleotide |
97.9 |
58 |
11604543 (4), 15777723 (2), 7532005 (2), 2289000 (1) (see all 26) |
| aminoimidazole ribonucleotide |
88.8 |
10 |
17982461 (1), 9328467 (1), 9473452 (1), 8299947 (1) |
| lometrexol |
88.5 |
1 |
12234990 (1) |
| phosphoribosylamine |
88.2 |
4 |
7532005 (2), 8238909 (1) |
| 1843u89 |
86.2 |
2 |
12494465 (1) |
| 10-formyltetrahydrofolate |
82.4 |
6 |
8806778 (2), 19007868 (1), 1848231 (1) |
| purine |
77.5 |
26 |
1887337 (2), 12234990 (1), 12501179 (1), 15777723 (1) (see all 12) |
| aminopterin |
76.1 |
2 |
12494465 (1) |
| tomudex |
73.6 |
2 |
12494465 (1) |
| aicar |
70.9 |
4 |
12501179 (1), 10888335 (1), 13129585 (1), 13129586 (1) |
Search CenterWatch for drugs/clinical trials and news about GART / PUR2
|
Transcripts
for GART gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GART gene (4 alternative transcripts): NM_000819.4 NM_001136005.1 NM_001136006.1 NM_175085.2 Unigene Cluster for GART: Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Hs.473648 [show with all ESTs]Unigene Representative Sequence: BC06843818/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000414353 ENST00000492008 ENST00000381815(uc002yrx.3) ENST00000381831
ENST00000381839 ENST00000424203(uc002yrz.3 uc010gmd.3 uc002yry.3)
ENST00000482663 ENST00000487155 ENST00000460305 ENST00000467575 ENST00000361093(uc002ysa.2)
ENST00000366093 ENST00000466882 ENST00000497313 ENST00000430874 ENST00000426819
ENST00000476524 ENST00000488791
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GART (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GART (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): GART (NM_000819) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GART | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GART |
Additional cDNA sequence: AB208785.1 AF008655.1 AK292560.1 AK292897.1 AK295980.1 BC038958.1 BC068438.1 BC093641.1 BC101565.1 BC107712.1 BX648124.1 D32051.1 M32082.1 X54199.1 24/25 DOTS entries (see all 25): DT.100036758 DT.121141404 DT.100819299 DT.456326 DT.121141007 DT.121141360 DT.75102580 DT.99940405 DT.92446508 DT.121141111 DT.427150 DT.91915247 DT.121141457 DT.92049909 DT.121141349 DT.92446506 DT.121141517 DT.75116473 DT.100819302 DT.92012505 DT.95184922 DT.121141430 DT.95204743 DT.75100764 24/426 AceView cDNA sequences (see all 426): BF034217 CD513460 F12616 AI824313 BQ691119 BF056279 AW025739 BQ051498 H98518 BM478955 F07474 CR593828 BI092026 BX279962 T24695 CN479424 AA411780 AU130025 BU683069 AI033239 AA024698 BX473323 BX956194 AL705931
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for GART (see all 18) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | |
| ExUns: | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 |
|---|
|
| SP1: | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GART
|
Expression
for GART gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GART expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GART Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GART
SOURCE GeneReport for Unigene cluster: Hs.473648
SABiosciences Custom PCR Arrays for GART
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GART
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GART | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GART | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GART | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GART |
Orthologs
for GART gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GART gene from 11/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gart1 , 5 |
phosphoribosylglycinamide formyltransferase1, 5 |
83.2(n)1
85.94(a)1 |
|
16 (53.18 cM)5
144501 NM_010256.21 NP_034386.21
916211865 |
chicken
(Gallus gallus) |
Aves |
GART1 |
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide more |
73.4(n)
75.1(a) |
|
395315 NM_001001469.1 NP_001001469.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GART6 |
-- |
70(a) |
1 ↔ 1 |
3(143015801-143061665) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ619402.12 |
-- |
75.32(n) |
|
BJ619402.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
gart2 |
phosphoribosylglycinamide formyltransferase |
72.76(n) |
|
58141 AF257743.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ade31 , 3 |
'de novo' IMP biosynthesis
phosphoribosylamine-glycine more3
adenosine 31 |
47(a)3
52.4(n)1
48.46(a)1 |
|
27D43
339861 NM_078773.21 NP_523497.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
F38B6.41 , 3 |
GARS/AIRS/GART3
Protein F38B6.41 |
43(a)3
52.24(n)1
45.36(a)1 |
|
X(6710141-6715049)3
1809351 NM_076721.31 NP_509122.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ADE5,7(YGL234W)4
ADE5,71 |
Bifunctional enzyme of the 'de novo' purine nucleotide more4
Ade5,7p1 |
52.02(n)1
46.38(a)1 |
|
7(56482-58890)4
8526171, 4 NP_011280.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G098306 |
phosphoribosylamine--glycine ligase |
37(a) |
1 ↔ 1 |
1(3192681-3195025) |
rice
(Oryza sativa) |
Liliopsida |
Os.86352 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
73.09(n) |
|
AK067808.1 |
ENSEMBL Gene Tree for GART (if available)
TreeFam Gene Tree for GART (if available) |
Paralogs
for GART gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GART gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GART (34870940 - 34915797 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GART: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GART |
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Disorders
/ Diseases
for GART gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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GART for disorders About GeneDecksing
OMIM gene information: 138440
OMIM disorders: --
20  diseases for GART: About MalaCardswhite piedra cleft lip/palate patent ductus arteriosus amyotrophic lateral sclerosis
cleft lip malignant pleural mesothelioma lateral sclerosis spina bifida
dermatophytosis benign mesothelioma monilethrix down syndrome
lymphoblastic leukemia alzheimer's disease colorectal cancer leukemia
breast cancer pneumonia tuberculosis mycobacterium tuberculosis
3 diseases from the University of Copenhagen DISEASES database for GART:Benign mesothelioma Lung cancer Malignant pleural mesothelioma 6 Novoseek disease relationships for GART gene About this table
Human Genome Epidemiology (HuGE) Navigator: GART (6 documents)
Export disorders for GART gene to outside databases
|
Publications
for GART gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for GART gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with GART) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations. (PubMed id 2183217)1, 2, 9 Schild D.... Barr P.J. (1990)
- Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes. (PubMed id 2050105)1, 3, 9 Gnirke A....Olson M.V. (1991)
- Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene. (PubMed id 9224613)1, 2, 9 Kan J.L.C. and Moran R.G. (1997)
- De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli. (PubMed id 2147474)1, 2, 9 Aimi J.... Dixon J.E. (1990)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. (PubMed id 16026156)1, 2 Dahms T.E.... Smith J.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10- dideazaacyclic-5,6,7,8-tetrahydrofolic acid. (PubMed id 12755606)1, 2 Zhang Y.... Wilson I.A. (2003)
- Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR. (PubMed id 12450384)1, 2 Zhang Y....Wilson I.A. (2002)
- Mouse cDNAs encoding a trifunctional protein of de novo purine synthesis and a related single-domain glycinamide ribonucleotide synthetase. (PubMed id 8299947)1, 9 Kan J.L....Moran R.G. (1993)
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External Searches for GART gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GART gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GART gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GART gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GART | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GART gene:
Search GeneIP for patents involving GART
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GART gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GART | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GART | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GART | | | OriGene Protein Over-expression Lysate for GART | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GART | | OriGene 3'-UTR Clone for GART | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GART | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GART | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GART | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GART | | OriGene Custom Protein Services for GART | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GART | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GART | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GART | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GART | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GART | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GART |
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| | | | Search Tocris compounds for GART |
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 | | | GART Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GART |
|  |  |  | | | | Search ThermoFisher Antibodies for GART |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GART |
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