Aliases for GARS Gene
External Ids for GARS Gene
Previous HGNC Symbols for GARS Gene
Previous GeneCards Identifiers for GARS Gene
This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
GeneCards Summary for GARS Gene
GARS (Glycyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with GARS include Charcot-Marie-Tooth Disease, Type 2D and Neuropathy, Distal Hereditary Motor, Type Va. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include nucleotide binding and aminoacyl-tRNA ligase activity.
UniProtKB/Swiss-Prot for GARS Gene
Catalyzes the ligation of glycine to the 3-end of its cognate tRNA. Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.