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Aliases for GARNL3 Gene

Aliases for GARNL3 Gene

  • GTPase Activating Rap/RanGAP Domain Like 3 2 3 5
  • GTPase Activating RANGAP Domain-Like 3 2 3
  • GTPase-Activating Rap/Ran-GAP Domain-Like Protein 3 3
  • GTPase Activating Rap/RanGAP Domain-Like 3 2
  • BA356B19.1 3

External Ids for GARNL3 Gene

Previous GeneCards Identifiers for GARNL3 Gene

  • GC09P125403
  • GC09P127106
  • GC09P129045
  • GC09P129987
  • GC09P099642

Summaries for GARNL3 Gene

GeneCards Summary for GARNL3 Gene

GARNL3 (GTPase Activating Rap/RanGAP Domain Like 3) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SIPA1L1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GARNL3 Gene

Genomics for GARNL3 Gene

Regulatory Elements for GARNL3 Gene

Enhancers for GARNL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GARNL3 on UCSC Golden Path with GeneCards custom track

Promoters for GARNL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GARNL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GARNL3 Gene

Chromosome:
9
Start:
127,224,265 bp from pter
End:
127,393,660 bp from pter
Size:
169,396 bases
Orientation:
Plus strand

Genomic View for GARNL3 Gene

Genes around GARNL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GARNL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GARNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GARNL3 Gene

Proteins for GARNL3 Gene

  • Protein details for GARNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVW2-GARL3_HUMAN
    Recommended name:
    GTPase-activating Rap/Ran-GAP domain-like protein 3
    Protein Accession:
    Q5VVW2
    Secondary Accessions:
    • B4DEP7
    • B7Z3Q6
    • Q8IYU1
    • Q8N951
    • Q8ND89
    • Q9BQH6

    Protein attributes for GARNL3 Gene

    Size:
    1013 amino acids
    Molecular mass:
    112852 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34983.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66508.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH72927.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI41459.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GARNL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GARNL3 Gene

Post-translational modifications for GARNL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GARNL3 Gene

Domains & Families for GARNL3 Gene

Protein Domains for GARNL3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VVW2

UniProtKB/Swiss-Prot:

GARL3_HUMAN :
  • Contains 1 CNH domain.
  • Belongs to the GARNL3 family.
Domain:
  • Contains 1 CNH domain.
  • Contains 1 Rap-GAP domain.
Family:
  • Belongs to the GARNL3 family.
genes like me logo Genes that share domains with GARNL3: view

No data available for Gene Families for GARNL3 Gene

Function for GARNL3 Gene

Gene Ontology (GO) - Molecular Function for GARNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with GARNL3: view
genes like me logo Genes that share phenotypes with GARNL3: view

Animal Model Products

CRISPR Products

miRNA for GARNL3 Gene

miRTarBase miRNAs that target GARNL3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GARNL3 Gene

Localization for GARNL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GARNL3 Gene COMPARTMENTS Subcellular localization image for GARNL3 gene
Compartment Confidence
cytosol 3
mitochondrion 2
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GARNL3 Gene

Pathways & Interactions for GARNL3 Gene

SuperPathways for GARNL3 Gene

No Data Available

Interacting Proteins for GARNL3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362485%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000357907%0d%0a9606.ENSP00000370938%0d%0a
Selected Interacting proteins: ENSP00000362485 Q5VVW2-GARL3_HUMAN for GARNL3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GARNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with GARNL3: view

No data available for Pathways by source and SIGNOR curated interactions for GARNL3 Gene

Drugs & Compounds for GARNL3 Gene

No Compound Related Data Available

Transcripts for GARNL3 Gene

Unigene Clusters for GARNL3 Gene

GTPase activating Rap/RanGAP domain-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GARNL3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b
SP1: - - - - - -
SP2:
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for GARNL3 Gene

GeneLoc Exon Structure for
GARNL3
ECgene alternative splicing isoforms for
GARNL3

Expression for GARNL3 Gene

mRNA expression in normal human tissues for GARNL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GARNL3 Gene

This gene is overexpressed in Brain - Cerebellum (x4.6) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for GARNL3 Gene

This gene is overexpressed in Pancreatic juice (47.3), Peripheral blood mononuclear cells (13.4), and Fetal Brain (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GARNL3 Gene



Protein tissue co-expression partners for GARNL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GARNL3 Gene:

GARNL3

SOURCE GeneReport for Unigene cluster for GARNL3 Gene:

Hs.29304
genes like me logo Genes that share expression patterns with GARNL3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GARNL3 Gene

Orthologs for GARNL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GARNL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GARNL3 34
  • 92.05 (n)
  • 96.07 (a)
GARNL3 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GARNL3 34
  • 91.51 (n)
  • 93.98 (a)
GARNL3 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Garnl3 34
  • 88.97 (n)
  • 93.72 (a)
Garnl3 16
Garnl3 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GARNL3 34
  • 99.61 (n)
  • 99.8 (a)
GARNL3 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Garnl3 34
  • 85.18 (n)
  • 88.83 (a)
oppossum
(Monodelphis domestica)
Mammalia GARNL3 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves GARNL3 34
  • 76.8 (n)
  • 82.71 (a)
GARNL3 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GARNL3 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia garnl3 34
  • 73.09 (n)
  • 80 (a)
zebrafish
(Danio rerio)
Actinopterygii garnl3 34
  • 68.9 (n)
  • 75.3 (a)
GARNL3 35
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002573 34
  • 56.52 (n)
  • 51.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42629 35
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea sipa-1 35
  • 17 (a)
ManyToMany
Species where no ortholog for GARNL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GARNL3 Gene

ENSEMBL:
Gene Tree for GARNL3 (if available)
TreeFam:
Gene Tree for GARNL3 (if available)

Paralogs for GARNL3 Gene

genes like me logo Genes that share paralogs with GARNL3: view

Variants for GARNL3 Gene

Sequence variations from dbSNP and Humsavar for GARNL3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs11550746 - 127,313,444(+) AGTCC(A/G)TCAGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs34608132 - 127,383,530(+) ACCAG(G/T)CTCCC nc-transcript-variant, reference, missense
rs7853317 -- 127,324,491(+) GGCTC(A/T)CCTGG intron-variant
rs7854854 -- 127,277,518(+) TTATG(A/C)ATTCA intron-variant
rs7855101 -- 127,335,563(+) TGTGC(A/G)TGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GARNL3 Gene

Variant ID Type Subtype PubMed ID
esv24866 CNV loss 19812545
esv2492436 CNV deletion 19546169
esv2676607 CNV deletion 23128226
esv2739049 CNV deletion 23290073
esv3303990 CNV mobile element insertion 20981092
esv3446884 CNV insertion 20981092
esv3621777 CNV loss 21293372
esv3621778 CNV loss 21293372
esv3621780 CNV loss 21293372
nsv1042177 CNV loss 25217958
nsv516966 CNV gain+loss 19592680
nsv521594 CNV loss 19592680
nsv523364 CNV loss 19592680
nsv525053 CNV loss 19592680
nsv527127 CNV gain 19592680

Variation tolerance for GARNL3 Gene

Residual Variation Intolerance Score: 9.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GARNL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GARNL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GARNL3 Gene

Disorders for GARNL3 Gene

Relevant External Links for GARNL3

Genetic Association Database (GAD)
GARNL3
Human Genome Epidemiology (HuGE) Navigator
GARNL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GARNL3

No disorders were found for GARNL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GARNL3 Gene

Publications for GARNL3 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PMID: 18711365) Ferreira M.A. … Craddock N. (Nat. Genet. 2008) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 65

Products for GARNL3 Gene

Sources for GARNL3 Gene

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