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Aliases for GAREML Gene

Aliases for GAREML Gene

  • GRB2 Associated, Regulator Of MAPK1-Like 2 3
  • Family With Sequence Similarity 59, Member B 2 3
  • GRB2-Associated And Regulator Of MAPK1-Like 3 4
  • FAM59B 3 4
  • GRB2-Associated And Regulator Of MAPK Protein-Like 3
  • Protein FAM59B 3
  • KIAA2038 4

External Ids for GAREML Gene

Previous HGNC Symbols for GAREML Gene

  • FAM59B

Previous GeneCards Identifiers for GAREML Gene

  • GC02P026396

Summaries for GAREML Gene

GeneCards Summary for GAREML Gene

GAREML (GRB2 Associated, Regulator Of MAPK1-Like) is a Protein Coding gene. An important paralog of this gene is GAREM.

UniProtKB/Swiss-Prot for GAREML Gene

  • Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAREML Gene

Genomics for GAREML Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GAREML Gene

Start:
26,173,091 bp from pter
End:
26,189,663 bp from pter
Size:
16,573 bases
Orientation:
Plus strand

Genomic View for GAREML Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAREML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREML Gene

No data available for Regulatory Elements for GAREML Gene

Proteins for GAREML Gene

  • Protein details for GAREML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75VX8-GAREL_HUMAN
    Recommended name:
    GRB2-associated and regulator of MAPK protein-like
    Protein Accession:
    Q75VX8
    Secondary Accessions:
    • B5MC97
    • B7WNK9
    • Q8NF27
    • Q9UIK8

    Protein attributes for GAREML Gene

    Size:
    874 amino acids
    Molecular mass:
    92882 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC99057.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GAREML Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAREML Gene

Proteomics data for GAREML Gene at MOPED

Post-translational modifications for GAREML Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAREML Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAREML Gene

Domains for GAREML Gene

Protein Domains for GAREML Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q75VX8

UniProtKB/Swiss-Prot:

GAREL_HUMAN :
  • Q75VX8
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREML: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GAREML Gene

Function for GAREML Gene

Molecular function for GAREML Gene

UniProtKB/Swiss-Prot Function: Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

Phenotypes for GAREML Gene

GenomeRNAi human phenotypes for GAREML:
genes like me logo Genes that share phenotypes with GAREML: view

Animal Model Products

CRISPR Products

miRNA for GAREML Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for GAREML Gene

Localization for GAREML Gene

Gene Ontology (GO) - Cellular Components for GAREML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GAREML: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for GAREML Gene

Pathways for GAREML Gene

SuperPathways for GAREML Gene

No Data Available

Interacting Proteins for GAREML Gene

Gene Ontology (GO) - Biological Process for GAREML Gene

None

No data available for Pathways by source for GAREML Gene

Transcripts for GAREML Gene

Unigene Clusters for GAREML Gene

GRB2 associated, regulator of MAPK1-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAREML

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAREML Gene

No ASD Table

Relevant External Links for GAREML Gene

GeneLoc Exon Structure for
GAREML
ECgene alternative splicing isoforms for
GAREML

Expression for GAREML Gene

mRNA expression in normal human tissues for GAREML Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GAREML Gene

SOURCE GeneReport for Unigene cluster for GAREML Gene Hs.187912

genes like me logo Genes that share expressions with GAREML: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GAREML Gene

Orthologs for GAREML Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREML Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM59B 35
  • 98.5 (n)
  • 97.99 (a)
GAREML 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM59B 35
  • 87.95 (n)
  • 90.38 (a)
GAREML 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAREML 35
  • 89.93 (n)
  • 90.9 (a)
GAREML 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gareml 35
  • 85.6 (n)
  • 87.3 (a)
Gareml 16
Gareml 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAREML 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAREML 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gareml 35
  • 84.45 (n)
  • 87.88 (a)
chicken
(Gallus gallus)
Aves FAM59B 35
  • 70.32 (n)
  • 68.58 (a)
GAREML 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gareml 35
  • 65.06 (n)
  • 65.27 (a)
zebrafish
(Danio rerio)
Actinopterygii gareml 35
  • 61.36 (n)
  • 61.5 (a)
gareml 36
  • 52 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for GAREML:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAREML Gene

ENSEMBL:
Gene Tree for GAREML (if available)
TreeFam:
Gene Tree for GAREML (if available)

Paralogs for GAREML Gene

Paralogs for GAREML Gene

Selected SIMAP similar genes for GAREML Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAREML: view

Variants for GAREML Gene

Sequence variations from dbSNP and Humsavar for GAREML Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs892447 -- 26,187,081(-) ATGGC(C/T)GTGTT intron-variant
rs930263 -- 26,179,725(-) GGGAG(C/G)CCTCC intron-variant, upstream-variant-2KB
rs1019972 -- 26,187,345(-) GGACC(A/G)GGGGC reference, synonymous-codon, intron-variant
rs1465720 -- 26,189,769(-) CACAC(A/C)CACAT downstream-variant-500B
rs1560866 -- 26,178,661(-) CTAAA(A/G)TCACG intron-variant

Relevant External Links for GAREML Gene

HapMap Linkage Disequilibrium report
GAREML

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GAREML Gene

Disorders for GAREML Gene

No disorders were found for GAREML Gene.

No data available for UniProtKB/Swiss-Prot for GAREML Gene

Publications for GAREML Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2010) 3
  3. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3
  4. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PMID: 22558309) Wong K.A. … O'Bryan J.P. (PLoS ONE 2012) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for GAREML Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GAREML
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GAREML
    • Block miRNA regulation of GAREML using miScript Target Protectors
    • antibodies-online peptides for GAREML
    • antibodies-online antibodies for GAREML
    • antibodies-online kits for GAREML

    Sources for GAREML Gene

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