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Aliases for GAREM2 Gene

Aliases for GAREM2 Gene

  • GRB2 Associated Regulator Of MAPK1 Subtype 2 2 3 5
  • Family With Sequence Similarity 59, Member B 2 3
  • GRB2-Associated And Regulator Of MAPK1-Like 3 4
  • GRB2 Associated, Regulator Of MAPK1-Like 2 3
  • FAM59B 3 4
  • GAREML 3 4
  • GRB2-Associated And Regulator Of MAPK Protein-Like 3
  • GRB2-Associated And Regulator Of MAPK Protein 2 3
  • GRB2 Associated Regulator Of MAPK1 2 3
  • Protein FAM59B 3
  • KIAA2038 4

External Ids for GAREM2 Gene

Previous HGNC Symbols for GAREM2 Gene

  • FAM59B
  • GAREML

Summaries for GAREM2 Gene

GeneCards Summary for GAREM2 Gene

GAREM2 (GRB2 Associated Regulator Of MAPK1 Subtype 2) is a Protein Coding gene. An important paralog of this gene is GAREM1.

UniProtKB/Swiss-Prot for GAREM2 Gene

  • Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAREM2 Gene

Genomics for GAREM2 Gene

Regulatory Elements for GAREM2 Gene

Enhancers for GAREM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F026178 0.9 Ensembl ENCODE 10 +6.4 6381 1.8 BCOR CTCF HINFP ZMYM3 SIN3A ZBTB40 ZNF335 ZNF121 ZFHX2 ZBTB48 HADHA HADHB GAREM2 CENPA GC02P026194
GH02F026242 0.4 ENCODE 9.6 +71.7 71724 5.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 HADHA CAD GAREM2 LOC105374334
GH02F026066 1.5 FANTOM5 Ensembl ENCODE 9.4 -103.7 -103723 4.9 HDGF PKNOX1 ATF1 ARNT BRCA1 FOS JUNB NCOA1 TBX21 SMARCB1 RAB10 RNU6-942P KIF3C GAREM2 HADHB GC02P026059 RPS2P15
GH02F026074 1.3 Ensembl ENCODE 9.1 -98.2 -98231 1.3 RNF2 TBL1XR1 ZEB2 DPF2 SMARCB1 NCOR1 SMARCA4 IRF1 GAREM2 GC02P026059 RPS2P15
GH02F026240 0.8 ENCODE 9 +68.1 68050 1.0 TBP ESRRA CEBPG ZNF644 TEAD3 ZNF362 TEAD1 NFYC ATF2 PPARG HADHA GAREM2 HADHB GC02P026215
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GAREM2 on UCSC Golden Path with GeneCards custom track

Promoters for GAREM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001820813 209 1801 HDAC1 ATF1 TBL1XR1 ARNT RAD21 CREM EGR2 SMARCA5 USF2 NCOA1

Genomic Location for GAREM2 Gene

Chromosome:
2
Start:
26,173,091 bp from pter
End:
26,202,529 bp from pter
Size:
29,439 bases
Orientation:
Plus strand

Genomic View for GAREM2 Gene

Genes around GAREM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAREM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAREM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREM2 Gene

Proteins for GAREM2 Gene

  • Protein details for GAREM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75VX8-GARE2_HUMAN
    Recommended name:
    GRB2-associated and regulator of MAPK protein 2
    Protein Accession:
    Q75VX8
    Secondary Accessions:
    • B5MC97
    • B7WNK9
    • Q8NF27
    • Q9UIK8

    Protein attributes for GAREM2 Gene

    Size:
    874 amino acids
    Molecular mass:
    92882 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC99057.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GAREM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAREM2 Gene

Post-translational modifications for GAREM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAREM2 Gene

No data available for DME Specific Peptides for GAREM2 Gene

Domains & Families for GAREM2 Gene

Protein Domains for GAREM2 Gene

Suggested Antigen Peptide Sequences for GAREM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75VX8

UniProtKB/Swiss-Prot:

GARE2_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the GAREM family.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREM2: view

No data available for Gene Families for GAREM2 Gene

Function for GAREM2 Gene

Molecular function for GAREM2 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.
genes like me logo Genes that share phenotypes with GAREM2: view

Animal Model Products

miRNA for GAREM2 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAREM2 Gene

Localization for GAREM2 Gene

Gene Ontology (GO) - Cellular Components for GAREM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GAREM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for GAREM2 Gene

Pathways & Interactions for GAREM2 Gene

SuperPathways for GAREM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAREM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAREM2 Gene

Transcripts for GAREM2 Gene

Unigene Clusters for GAREM2 Gene

GRB2 associated, regulator of MAPK1-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAREM2 Gene

No ASD Table

Relevant External Links for GAREM2 Gene

GeneLoc Exon Structure for
GAREM2
ECgene alternative splicing isoforms for
GAREM2

Expression for GAREM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAREM2 Gene:

GAREM2

SOURCE GeneReport for Unigene cluster for GAREM2 Gene:

Hs.187912
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GAREM2 Gene

Orthologs for GAREM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM59B 34
  • 98.5 (n)
GAREML 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAREML 34 35
  • 89.93 (n)
cow
(Bos Taurus)
Mammalia FAM59B 34
  • 87.95 (n)
GAREML 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gareml 34 16 35
  • 85.6 (n)
rat
(Rattus norvegicus)
Mammalia Gareml 34
  • 84.45 (n)
oppossum
(Monodelphis domestica)
Mammalia GAREML 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAREML 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM59B 34
  • 70.32 (n)
GAREML 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gareml 34
  • 65.06 (n)
zebrafish
(Danio rerio)
Actinopterygii gareml 34 35
  • 61.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToMany
Species where no ortholog for GAREM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAREM2 Gene

ENSEMBL:
Gene Tree for GAREM2 (if available)
TreeFam:
Gene Tree for GAREM2 (if available)

Paralogs for GAREM2 Gene

Paralogs for GAREM2 Gene

genes like me logo Genes that share paralogs with GAREM2: view

Variants for GAREM2 Gene

Sequence variations from dbSNP and Humsavar for GAREM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs137852769 Pathogenic 26,195,184(-) TGCTG(C/G)AGATT intron-variant, nc-transcript-variant, reference, missense
rs137852771 Pathogenic 26,194,581(-) TCATC(C/T)GAATC intron-variant, reference, stop-gained
rs779113356 Pathogenic 26,192,343(+) TCGCT(-/A)AAATA intron-variant, upstream-variant-2KB, reference, frameshift-variant
rs794727198 Pathogenic 26,192,392(-) TCTAT(C/T)AGGAG intron-variant, upstream-variant-2KB, reference, stop-gained
rs794727219 Pathogenic 26,191,482(-) GGGAG(A/G)TTGGT intron-variant, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for GAREM2 Gene

Variant ID Type Subtype PubMed ID
esv22083 CNV loss 19812545
esv33316 CNV loss 17666407
nsv1071583 CNV deletion 25765185
nsv1144893 CNV deletion 24896259
nsv2648 CNV deletion 18451855
nsv520638 CNV loss 19592680
nsv524918 CNV gain 19592680

Variation tolerance for GAREM2 Gene

Gene Damage Index Score: 2.03; 37.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAREM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAREM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAREM2 Gene

Disorders for GAREM2 Gene

Relevant External Links for GAREM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM2

No disorders were found for GAREM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAREM2 Gene

Publications for GAREM2 Gene

  1. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. (PMID: 24003223) Taniguchi T. … Konishi H. (J. Biol. Chem. 2013) 2 3 64
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PMID: 22558309) Wong K.A. … O'Bryan J.P. (PLoS ONE 2012) 3 64

Products for GAREM2 Gene

Sources for GAREM2 Gene

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