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Aliases for GAREM2 Gene

Aliases for GAREM2 Gene

  • GRB2 Associated Regulator Of MAPK1 Subtype 2 2 3 5
  • Family With Sequence Similarity 59, Member B 2 3
  • GRB2-Associated And Regulator Of MAPK1-Like 3 4
  • GRB2 Associated, Regulator Of MAPK1-Like 2 3
  • FAM59B 3 4
  • GAREML 3 4
  • GRB2-Associated And Regulator Of MAPK Protein-Like 3
  • GRB2-Associated And Regulator Of MAPK Protein 2 3
  • GRB2 Associated Regulator Of MAPK1 2 3
  • Protein FAM59B 3
  • KIAA2038 4

External Ids for GAREM2 Gene

Previous HGNC Symbols for GAREM2 Gene

  • FAM59B
  • GAREML

Summaries for GAREM2 Gene

GeneCards Summary for GAREM2 Gene

GAREM2 (GRB2 Associated Regulator Of MAPK1 Subtype 2) is a Protein Coding gene. An important paralog of this gene is GAREM1.

UniProtKB/Swiss-Prot for GAREM2 Gene

  • Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

Additional gene information for GAREM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAREM2 Gene

Genomics for GAREM2 Gene

Regulatory Elements for GAREM2 Gene

Enhancers for GAREM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H026342 1.4 ENCODE dbSUPER 12.2 +172.7 172679 6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CAD GTF3C2-AS1 ASXL2 ENSG00000272148 AGBL5 KIF3C GAREM2 ADGRF3 AGBL5-IT1 ENSG00000272056
GH02H026066 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -104.3 -104276 3 HDGF PKNOX1 ATF1 ARNT BRCA1 TCF12 ZNF766 FOS ATF7 RUNX3 RAB10 RNU6-942P KIF3C GAREM2 HADHB GC02P026059 RPS2P15
GH02H026032 1.8 FANTOM5 ENCODE dbSUPER 8.4 -138.6 -138604 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 RAB10 SLC35F6 GAREM2 GC02P026043
GH02H027049 1.2 ENCODE 12.1 +878.0 877978 3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF512 CAD EIF2B4 NRBP1 IFT172 SUPT7L GPN1 KHK LOC105374363 ATRAID
GH02H026017 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.5 -154.7 -154699 2 PKNOX1 SIN3A YY1 GLIS2 FOS ATF7 REST ZNF592 SREBF1 MAFF RNU6-942P KIF3C RAB10 GAREM2 TRMT112P6 GC02P025994
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GAREM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAREM2 Gene

Chromosome:
2
Start:
26,173,091 bp from pter
End:
26,202,529 bp from pter
Size:
29,439 bases
Orientation:
Plus strand

Genomic View for GAREM2 Gene

Genes around GAREM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAREM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAREM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREM2 Gene

Proteins for GAREM2 Gene

  • Protein details for GAREM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75VX8-GARE2_HUMAN
    Recommended name:
    GRB2-associated and regulator of MAPK protein 2
    Protein Accession:
    Q75VX8
    Secondary Accessions:
    • B5MC97
    • B7WNK9
    • Q8NF27
    • Q9UIK8

    Protein attributes for GAREM2 Gene

    Size:
    874 amino acids
    Molecular mass:
    92882 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC99057.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GAREM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAREM2 Gene

Post-translational modifications for GAREM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAREM2 Gene

No data available for DME Specific Peptides for GAREM2 Gene

Domains & Families for GAREM2 Gene

Gene Families for GAREM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAREM2 Gene

Suggested Antigen Peptide Sequences for GAREM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75VX8

UniProtKB/Swiss-Prot:

GARE2_HUMAN :
  • Belongs to the GAREM family.
Family:
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREM2: view

Function for GAREM2 Gene

Molecular function for GAREM2 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.
genes like me logo Genes that share phenotypes with GAREM2: view

Animal Model Products

CRISPR Products

miRNA for GAREM2 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GAREM2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAREM2 Gene

Localization for GAREM2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAREM2 gene
Compartment Confidence
extracellular 5
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GAREM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GAREM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GAREM2 Gene

Pathways & Interactions for GAREM2 Gene

SuperPathways for GAREM2 Gene

No Data Available

Interacting Proteins for GAREM2 Gene

Gene Ontology (GO) - Biological Process for GAREM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAREM2 Gene

Drugs & Compounds for GAREM2 Gene

No Compound Related Data Available

Transcripts for GAREM2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GAREM2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GAREM2 Gene

No ASD Table

Relevant External Links for GAREM2 Gene

GeneLoc Exon Structure for
GAREM2
ECgene alternative splicing isoforms for
GAREM2

Expression for GAREM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAREM2 Gene:

GAREM2

Evidence on tissue expression from TISSUES for GAREM2 Gene

  • Nervous system(4.3)
  • Spleen(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAREM2 Gene

Orthologs for GAREM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM59B 33
  • 98.5 (n)
GAREML 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAREML 33 34
  • 89.93 (n)
cow
(Bos Taurus)
Mammalia FAM59B 33
  • 87.95 (n)
GAREML 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gareml 33 34
  • 85.6 (n)
Garem2 16
rat
(Rattus norvegicus)
Mammalia Gareml 33
  • 84.45 (n)
oppossum
(Monodelphis domestica)
Mammalia GAREML 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAREML 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM59B 33
  • 70.32 (n)
GAREML 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gareml 33
  • 65.06 (n)
zebrafish
(Danio rerio)
Actinopterygii gareml 33 34
  • 61.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for GAREM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAREM2 Gene

ENSEMBL:
Gene Tree for GAREM2 (if available)
TreeFam:
Gene Tree for GAREM2 (if available)

Paralogs for GAREM2 Gene

Paralogs for GAREM2 Gene

genes like me logo Genes that share paralogs with GAREM2: view

Variants for GAREM2 Gene

Sequence variations from dbSNP and Humsavar for GAREM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs137852769 Pathogenic 26,195,184(-) TGCTG(C/G)AGATT intron-variant, nc-transcript-variant, reference, missense
rs137852771 Pathogenic 26,194,581(-) TCATC(C/T)GAATC intron-variant, reference, stop-gained
rs747985669 Pathogenic 26,193,651(+) CTTTG(-/C)CCAGA intron-variant, upstream-variant-2KB, reference, frameshift-variant
rs779113356 Pathogenic 26,192,343(+) TCGCT(-/A)AAATA intron-variant, upstream-variant-2KB, reference, frameshift-variant
rs794727198 Pathogenic 26,192,392(-) TCTAT(C/T)AGGAG intron-variant, upstream-variant-2KB, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for GAREM2 Gene

Variant ID Type Subtype PubMed ID
esv22083 CNV loss 19812545
esv33316 CNV loss 17666407
nsv1071583 CNV deletion 25765185
nsv1144893 CNV deletion 24896259
nsv2648 CNV deletion 18451855
nsv520638 CNV loss 19592680
nsv524918 CNV gain 19592680

Variation tolerance for GAREM2 Gene

Gene Damage Index Score: 2.03; 37.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAREM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAREM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAREM2 Gene

Disorders for GAREM2 Gene

Relevant External Links for GAREM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM2

No disorders were found for GAREM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAREM2 Gene

Publications for GAREM2 Gene

  1. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. (PMID: 24003223) Taniguchi T … Konishi H (The Journal of biological chemistry 2013) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 60
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 60

Products for GAREM2 Gene

Sources for GAREM2 Gene

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