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Aliases for GAREM2 Gene

Aliases for GAREM2 Gene

  • GRB2 Associated Regulator Of MAPK1 Subtype 2 2 3 5
  • Family With Sequence Similarity 59, Member B 2 3
  • GRB2-Associated And Regulator Of MAPK1-Like 3 4
  • GRB2 Associated, Regulator Of MAPK1-Like 2 3
  • FAM59B 3 4
  • GAREML 3 4
  • GRB2-Associated And Regulator Of MAPK Protein-Like 3
  • GRB2 Associated Regulator Of MAPK1 2 3
  • Protein FAM59B 3
  • KIAA2038 4

External Ids for GAREM2 Gene

Previous HGNC Symbols for GAREM2 Gene

  • FAM59B
  • GAREML

Summaries for GAREM2 Gene

GeneCards Summary for GAREM2 Gene

GAREM2 (GRB2 Associated Regulator Of MAPK1 Subtype 2) is a Protein Coding gene. An important paralog of this gene is GAREM1.

UniProtKB/Swiss-Prot for GAREM2 Gene

  • Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAREM2 Gene

Genomics for GAREM2 Gene

Regulatory Elements for GAREM2 Gene

Promoters for GAREM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAREM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAREM2 Gene

Chromosome:
2
Start:
26,173,091 bp from pter
End:
26,202,529 bp from pter
Size:
29,439 bases
Orientation:
Plus strand

Genomic View for GAREM2 Gene

Genes around GAREM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAREM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAREM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREM2 Gene

Proteins for GAREM2 Gene

  • Protein details for GAREM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75VX8-GARE2_HUMAN
    Recommended name:
    GRB2-associated and regulator of MAPK protein 2
    Protein Accession:
    Q75VX8
    Secondary Accessions:
    • B5MC97
    • B7WNK9
    • Q8NF27
    • Q9UIK8

    Protein attributes for GAREM2 Gene

    Size:
    874 amino acids
    Molecular mass:
    92882 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC99057.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GAREM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAREM2 Gene

Proteomics data for GAREM2 Gene at MOPED

Post-translational modifications for GAREM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAREM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAREM2 Gene

Domains & Families for GAREM2 Gene

Protein Domains for GAREM2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAREM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75VX8

UniProtKB/Swiss-Prot:

GARE2_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the GAREM family.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREM2: view

No data available for Gene Families for GAREM2 Gene

Function for GAREM2 Gene

Molecular function for GAREM2 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.
genes like me logo Genes that share phenotypes with GAREM2: view

Animal Model Products

miRNA for GAREM2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAREM2 Gene

Localization for GAREM2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAREM2 Gene

Pathways & Interactions for GAREM2 Gene

SuperPathways for GAREM2 Gene

No Data Available

Interacting Proteins for GAREM2 Gene

Gene Ontology (GO) - Biological Process for GAREM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAREM2 Gene

Drugs & Compounds for GAREM2 Gene

No Compound Related Data Available

Transcripts for GAREM2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GAREM2 Gene

No ASD Table

Relevant External Links for GAREM2 Gene

GeneLoc Exon Structure for
GAREM2
ECgene alternative splicing isoforms for
GAREM2

Expression for GAREM2 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GAREM2 Gene

Orthologs for GAREM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM59B 35
  • 87.95 (n)
  • 90.38 (a)
GAREML 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAREML 35
  • 89.93 (n)
  • 90.9 (a)
GAREML 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gareml 35
  • 85.6 (n)
  • 87.3 (a)
Gareml 16
Gareml 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM59B 35
  • 98.5 (n)
  • 97.99 (a)
GAREML 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gareml 35
  • 84.45 (n)
  • 87.88 (a)
oppossum
(Monodelphis domestica)
Mammalia GAREML 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAREML 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM59B 35
  • 70.32 (n)
  • 68.58 (a)
GAREML 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gareml 35
  • 65.06 (n)
  • 65.27 (a)
zebrafish
(Danio rerio)
Actinopterygii gareml 35
  • 61.36 (n)
  • 61.5 (a)
gareml 36
  • 52 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for GAREM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAREM2 Gene

ENSEMBL:
Gene Tree for GAREM2 (if available)
TreeFam:
Gene Tree for GAREM2 (if available)

Paralogs for GAREM2 Gene

Paralogs for GAREM2 Gene

genes like me logo Genes that share paralogs with GAREM2: view

Variants for GAREM2 Gene

Sequence variations from dbSNP and Humsavar for GAREM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs892447 -- 26,187,081(-) ATGGC(C/T)GTGTT intron-variant
rs1019972 -- 26,187,345(-) GGACC(A/C/G)GGGGC intron-variant, reference, synonymous-codon
rs930263 -- 26,179,725(-) GGGAG(C/G)CCTCC intron-variant, upstream-variant-2KB
rs1465720 -- 26,189,769(-) CACAC(A/C)CACAT intron-variant, downstream-variant-500B
rs1560866 -- 26,178,661(-) CTAAA(A/G)TCACG intron-variant

Variation tolerance for GAREM2 Gene

Gene Damage Index Score: 2.03; 37.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAREM2 Gene

HapMap Linkage Disequilibrium report
GAREM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GAREM2 Gene

Disorders for GAREM2 Gene

Relevant External Links for GAREM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM2

No disorders were found for GAREM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAREM2 Gene

Publications for GAREM2 Gene

  1. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. (PMID: 24003223) Taniguchi T. … Konishi H. (J. Biol. Chem. 2013) 2 3 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PMID: 22558309) Wong K.A. … O'Bryan J.P. (PLoS ONE 2012) 3
  5. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3

Products for GAREM2 Gene

Sources for GAREM2 Gene

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