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Aliases for GAREM1 Gene

Aliases for GAREM1 Gene

  • GRB2 Associated Regulator Of MAPK1 Subtype 1 2 3 5
  • Family With Sequence Similarity 59, Member A 2 3
  • Grb2-Associated And Regulator Of Erk/MAPK 2 3
  • GRB2-Associated And Regulator Of MAPK1 3 4
  • GRB2 Associated, Regulator Of MAPK1 2 3
  • C18orf11 3 4
  • FAM59A 3 4
  • GAREM 3 4
  • GRB2-Associated And Regulator Of MAPK Protein 3
  • GRB2 Associated Regulator Of MAPK1 1 3
  • Chromosome 18 Open Reading Frame 11 2
  • Protein FAM59A 3
  • Gm944 3

External Ids for GAREM1 Gene

Previous HGNC Symbols for GAREM1 Gene

  • C18orf11
  • FAM59A
  • GAREM

Summaries for GAREM1 Gene

Entrez Gene Summary for GAREM1 Gene

  • This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for GAREM1 Gene

GAREM1 (GRB2 Associated Regulator Of MAPK1 Subtype 1) is a Protein Coding gene. An important paralog of this gene is GAREM2.

UniProtKB/Swiss-Prot for GAREM1 Gene

  • Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAREM1 Gene

Genomics for GAREM1 Gene

Regulatory Elements for GAREM1 Gene

Enhancers for GAREM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GAREM1 on UCSC Golden Path with GeneCards custom track

Promoters for GAREM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAREM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAREM1 Gene

Chromosome:
18
Start:
32,124,877 bp from pter
End:
32,470,496 bp from pter
Size:
345,620 bases
Orientation:
Minus strand

Genomic View for GAREM1 Gene

Genes around GAREM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAREM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAREM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREM1 Gene

Proteins for GAREM1 Gene

  • Protein details for GAREM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H706-GARE1_HUMAN
    Recommended name:
    GRB2-associated and regulator of MAPK protein 1
    Protein Accession:
    Q9H706
    Secondary Accessions:
    • Q0VAG3
    • Q0VAG4
    • Q8ND03
    • Q9BSF5

    Protein attributes for GAREM1 Gene

    Size:
    876 amino acids
    Molecular mass:
    97186 Da
    Quaternary structure:
    • Isoform 1 interacts with EGFR. Isoform 1 interacts (via proline-rich domain and phosphorylated at Tyr-105 and Tyr-453) with GRB2 (via SH3 domains); the interaction occurs upon EGF stimulation. Isoform 1 interacts (phosphorylated at Tyr-453) with PTPN11; the interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation. Isoform 2 does not interact with GRB2.
    SequenceCaution:
    • Sequence=CAD39149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GAREM1 Gene

    Alternative splice isoforms for GAREM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAREM1 Gene

Proteomics data for GAREM1 Gene at MOPED

Post-translational modifications for GAREM1 Gene

  • On EGF stimulation, phosphorylated on Tyr-105 and Tyr-453.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAREM1 Gene

No data available for DME Specific Peptides for GAREM1 Gene

Domains & Families for GAREM1 Gene

Protein Domains for GAREM1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAREM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H706

UniProtKB/Swiss-Prot:

GARE1_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the GAREM family.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREM1: view

No data available for Gene Families for GAREM1 Gene

Function for GAREM1 Gene

Molecular function for GAREM1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.
genes like me logo Genes that share phenotypes with GAREM1: view

Animal Model Products

miRNA for GAREM1 Gene

miRTarBase miRNAs that target GAREM1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAREM1 Gene

Localization for GAREM1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAREM1 Gene

Pathways & Interactions for GAREM1 Gene

SuperPathways for GAREM1 Gene

No Data Available

Interacting Proteins for GAREM1 Gene

Gene Ontology (GO) - Biological Process for GAREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway IDA 19509291
GO:0071364 cellular response to epidermal growth factor stimulus IDA 19509291
genes like me logo Genes that share ontologies with GAREM1: view

No data available for Pathways by source and SIGNOR curated interactions for GAREM1 Gene

Drugs & Compounds for GAREM1 Gene

No Compound Related Data Available

Transcripts for GAREM1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GAREM1 Gene

No ASD Table

Relevant External Links for GAREM1 Gene

GeneLoc Exon Structure for
GAREM1
ECgene alternative splicing isoforms for
GAREM1

Expression for GAREM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for GAREM1 Gene

Q9H706-GARE1_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed.
genes like me logo Genes that share expression patterns with GAREM1: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GAREM1 Gene

Orthologs for GAREM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAREM 35
  • 86.05 (n)
  • 91.06 (a)
GAREM 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM59A 35
  • 90.42 (n)
  • 93.77 (a)
GAREM 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Garem 35
  • 87.96 (n)
  • 91.66 (a)
Garem 16
Garem 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM59A 35
  • 99.38 (n)
  • 99.47 (a)
GAREM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Garem 35
  • 88.71 (n)
  • 94.7 (a)
oppossum
(Monodelphis domestica)
Mammalia GAREM 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAREM 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM59A 35
  • 78.44 (n)
  • 84.91 (a)
GAREM 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAREM 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia garem 35
  • 73.06 (n)
  • 79.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30446 35
zebrafish
(Danio rerio)
Actinopterygii garem 35
  • 64.11 (n)
  • 66.27 (a)
zgc55634 35
garem 36
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for GAREM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAREM1 Gene

ENSEMBL:
Gene Tree for GAREM1 (if available)
TreeFam:
Gene Tree for GAREM1 (if available)

Paralogs for GAREM1 Gene

Paralogs for GAREM1 Gene

genes like me logo Genes that share paralogs with GAREM1: view

Variants for GAREM1 Gene

Sequence variations from dbSNP and Humsavar for GAREM1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs671138 - 32,287,869(+) GCCTG(G/T)TTTTC reference, missense
rs3744921 - 32,287,725(-) CAACA(A/G)GATCC reference, missense
rs16962974 - 32,287,128(+) AAGTC(A/G)CACAT reference, missense
rs3891458 - 32,268,764(-) GCAGC(A/G)TCACT reference, missense, utr-variant-3-prime
rs2276374 - 32,268,343(+) ATGAC(A/G)TACTC downstream-variant-500B, reference, missense

Variation tolerance for GAREM1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GAREM1 Gene

Disorders for GAREM1 Gene

Relevant External Links for GAREM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM1

No disorders were found for GAREM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAREM1 Gene

Publications for GAREM1 Gene

  1. GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. (PMID: 19509291) Tashiro K. … Konishi H. (J. Biol. Chem. 2009) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Functional relationship between CABIT, SAM and 14-3-3 binding domains of GAREM1 that play a role in its subcellular localization. (PMID: 26164232) Nishino T. … Konishi H. (Biochem. Biophys. Res. Commun. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for GAREM1 Gene

Sources for GAREM1 Gene

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