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Aliases for GAREM1 Gene

Aliases for GAREM1 Gene

  • GRB2 Associated Regulator Of MAPK1 Subtype 1 2 3 5
  • Family With Sequence Similarity 59, Member A 2 3
  • Grb2-Associated And Regulator Of Erk/MAPK 2 3
  • GRB2-Associated And Regulator Of MAPK1 3 4
  • GRB2 Associated, Regulator Of MAPK1 2 3
  • C18orf11 3 4
  • FAM59A 3 4
  • GAREM 3 4
  • GRB2-Associated And Regulator Of MAPK Protein 1 3
  • GRB2-Associated And Regulator Of MAPK Protein 3
  • GRB2 Associated Regulator Of MAPK1 1 3
  • Chromosome 18 Open Reading Frame 11 2
  • Protein FAM59A 3
  • Gm944 3

External Ids for GAREM1 Gene

Previous HGNC Symbols for GAREM1 Gene

  • C18orf11
  • FAM59A
  • GAREM

Summaries for GAREM1 Gene

Entrez Gene Summary for GAREM1 Gene

  • This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for GAREM1 Gene

GAREM1 (GRB2 Associated Regulator Of MAPK1 Subtype 1) is a Protein Coding gene. An important paralog of this gene is GAREM2.

UniProtKB/Swiss-Prot for GAREM1 Gene

  • Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAREM1 Gene

Genomics for GAREM1 Gene

Regulatory Elements for GAREM1 Gene

Enhancers for GAREM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F032348 1.1 Ensembl ENCODE 5.4 +119.9 119928 3.3 ELF3 PKNOX1 SAP130 JUN MAX TEAD3 FOXK2 ZNF366 PRDM10 FOS GAREM1 GC18M032358 GC18P032312
GH18F032435 1 ENCODE 5 +34.4 34395 1.1 HNF4G NFE2 MAFK NFE2L2 YY1 GAREM1 GC18M032427
GH18F032381 0.8 Ensembl ENCODE 5 +87.7 87731 3.2 ELF3 INSM2 KLF17 FEZF1 RAD21 ZNF2 ZEB1 RARA ZNF366 SCRT2 ENSG00000263924 TRAPPC8 ENSG00000263393 GAREM1 GC18M032358 ENSG00000262477
GH18F032309 0.6 ENCODE 4.3 +160.0 160042 1.6 RFX1 REST GAREM1 GC18P032312 ENSG00000264982
GH18F032346 0.8 Ensembl ENCODE 4.3 +123.7 123721 1.0 GAREM1 GC18M032358 GC18P032312
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GAREM1 on UCSC Golden Path with GeneCards custom track

Promoters for GAREM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000524203 395 3400 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS

Genomic Location for GAREM1 Gene

Chromosome:
18
Start:
32,124,877 bp from pter
End:
32,470,496 bp from pter
Size:
345,620 bases
Orientation:
Minus strand

Genomic View for GAREM1 Gene

Genes around GAREM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAREM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAREM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREM1 Gene

Proteins for GAREM1 Gene

  • Protein details for GAREM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H706-GARE1_HUMAN
    Recommended name:
    GRB2-associated and regulator of MAPK protein 1
    Protein Accession:
    Q9H706
    Secondary Accessions:
    • Q0VAG3
    • Q0VAG4
    • Q8ND03
    • Q9BSF5

    Protein attributes for GAREM1 Gene

    Size:
    876 amino acids
    Molecular mass:
    97186 Da
    Quaternary structure:
    • Isoform 1 interacts with EGFR. Isoform 1 interacts (via proline-rich domain and phosphorylated at Tyr-105 and Tyr-453) with GRB2 (via SH3 domains); the interaction occurs upon EGF stimulation. Isoform 1 interacts (phosphorylated at Tyr-453) with PTPN11; the interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation. Isoform 2 does not interact with GRB2.
    SequenceCaution:
    • Sequence=CAD39149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GAREM1 Gene

    Alternative splice isoforms for GAREM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAREM1 Gene

Post-translational modifications for GAREM1 Gene

  • On EGF stimulation, phosphorylated on Tyr-105 and Tyr-453.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAREM1 Gene

No data available for DME Specific Peptides for GAREM1 Gene

Domains & Families for GAREM1 Gene

Protein Domains for GAREM1 Gene

Suggested Antigen Peptide Sequences for GAREM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H706

UniProtKB/Swiss-Prot:

GARE1_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the GAREM family.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREM1: view

No data available for Gene Families for GAREM1 Gene

Function for GAREM1 Gene

Molecular function for GAREM1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.

Gene Ontology (GO) - Molecular Function for GAREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19509291
GO:0070064 proline-rich region binding IDA 19509291
genes like me logo Genes that share ontologies with GAREM1: view
genes like me logo Genes that share phenotypes with GAREM1: view

Animal Model Products

miRNA for GAREM1 Gene

miRTarBase miRNAs that target GAREM1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAREM1 Gene

Localization for GAREM1 Gene

Gene Ontology (GO) - Cellular Components for GAREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 19509291
genes like me logo Genes that share ontologies with GAREM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for GAREM1 Gene

Pathways & Interactions for GAREM1 Gene

SuperPathways for GAREM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway IDA 19509291
GO:0008284 positive regulation of cell proliferation IDA 19509291
GO:0051781 positive regulation of cell division IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP 19509291
GO:0071364 cellular response to epidermal growth factor stimulus IDA 19509291
genes like me logo Genes that share ontologies with GAREM1: view

No data available for Pathways by source and SIGNOR curated interactions for GAREM1 Gene

Transcripts for GAREM1 Gene

Unigene Clusters for GAREM1 Gene

GRB2 associated, regulator of MAPK1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAREM1 Gene

No ASD Table

Relevant External Links for GAREM1 Gene

GeneLoc Exon Structure for
GAREM1
ECgene alternative splicing isoforms for
GAREM1

Expression for GAREM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GAREM1 Gene:

GAREM1

SOURCE GeneReport for Unigene cluster for GAREM1 Gene:

Hs.444314

mRNA Expression by UniProt/SwissProt for GAREM1 Gene:

Q9H706-GARE1_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed.
genes like me logo Genes that share expression patterns with GAREM1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GAREM1 Gene

Orthologs for GAREM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM59A 34
  • 99.38 (n)
GAREM 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAREM 35
  • 93 (a)
OneToOne
FAM59A 34
  • 90.42 (n)
rat
(Rattus norvegicus)
Mammalia Garem 34
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Garem 34 16 35
  • 87.96 (n)
cow
(Bos Taurus)
Mammalia GAREM 34 35
  • 86.05 (n)
oppossum
(Monodelphis domestica)
Mammalia GAREM 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAREM 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAREM 35
  • 84 (a)
OneToOne
FAM59A 34
  • 78.44 (n)
lizard
(Anolis carolinensis)
Reptilia GAREM 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia garem 34
  • 73.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30446 34
zebrafish
(Danio rerio)
Actinopterygii garem 34 35
  • 64.11 (n)
zgc55634 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for GAREM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAREM1 Gene

ENSEMBL:
Gene Tree for GAREM1 (if available)
TreeFam:
Gene Tree for GAREM1 (if available)

Paralogs for GAREM1 Gene

Paralogs for GAREM1 Gene

genes like me logo Genes that share paralogs with GAREM1: view

Variants for GAREM1 Gene

Sequence variations from dbSNP and Humsavar for GAREM1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000779 -- 32,453,073(+) CACAG(C/T)TCCAC intron-variant
rs10048362 -- 32,391,971(+) CATTT(A/G)CTGTG intron-variant
rs10163678 -- 32,295,837(+) TTGCT(A/G)TTATT intron-variant
rs1035799 -- 32,467,425(-) TTCTG(A/C)CTCTG intron-variant
rs1037753 -- 32,376,511(+) AAAAT(C/T)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAREM1 Gene

Variant ID Type Subtype PubMed ID
dgv11e198 CNV loss 23635498
esv2159930 CNV deletion 18987734
esv2517711 CNV loss 19546169
esv2632529 CNV deletion 19546169
esv26402 CNV gain 19812545
esv2672557 CNV deletion 23128226
esv2716949 CNV deletion 23290073
esv3555196 CNV deletion 23714750
esv3583001 CNV loss 25503493
esv3642150 CNV loss 21293372
esv3642152 CNV loss 21293372
nsv1056007 CNV gain 25217958
nsv1118785 CNV deletion 24896259
nsv482915 CNV gain 15286789
nsv528846 CNV gain 19592680
nsv576637 CNV loss 21841781
nsv576638 CNV loss 21841781
nsv576639 CNV loss 21841781
nsv820046 CNV gain 19587683
nsv821392 CNV deletion 20802225
nsv828205 CNV loss 20364138
nsv828206 CNV gain 20364138
nsv833616 CNV gain 17160897
nsv961041 CNV duplication 23825009
nsv9623 CNV gain 18304495

Variation tolerance for GAREM1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAREM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAREM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAREM1 Gene

Disorders for GAREM1 Gene

Relevant External Links for GAREM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAREM1

No disorders were found for GAREM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAREM1 Gene

Publications for GAREM1 Gene

  1. GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. (PMID: 19509291) Tashiro K. … Konishi H. (J. Biol. Chem. 2009) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for GAREM1 Gene

Sources for GAREM1 Gene

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