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Aliases for GAREM Gene

Aliases for GAREM Gene

  • GRB2 Associated, Regulator Of MAPK1 2 3
  • Family With Sequence Similarity 59, Member A 2 3
  • Grb2-Associated And Regulator Of Erk/MAPK 2 3
  • GRB2-Associated And Regulator Of MAPK1 3 4
  • C18orf11 3 4
  • FAM59A 3 4
  • GRB2-Associated And Regulator Of MAPK Protein 3
  • Chromosome 18 Open Reading Frame 11 2
  • Protein FAM59A 3
  • Gm944 3

External Ids for GAREM Gene

Previous HGNC Symbols for GAREM Gene

  • C18orf11
  • FAM59A

Previous GeneCards Identifiers for GAREM Gene

  • GC18M029704

Summaries for GAREM Gene

Entrez Gene Summary for GAREM Gene

  • This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for GAREM Gene

GAREM (GRB2 Associated, Regulator Of MAPK1) is a Protein Coding gene. GO annotations related to this gene include proline-rich region binding. An important paralog of this gene is GAREML.

UniProtKB/Swiss-Prot for GAREM Gene

  • Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAREM Gene

Genomics for GAREM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GAREM Gene

Start:
32,124,877 bp from pter
End:
32,470,484 bp from pter
Size:
345,608 bases
Orientation:
Minus strand

Genomic View for GAREM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAREM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAREM Gene

No data available for Regulatory Elements for GAREM Gene

Proteins for GAREM Gene

  • Protein details for GAREM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H706-GAREM_HUMAN
    Recommended name:
    GRB2-associated and regulator of MAPK protein
    Protein Accession:
    Q9H706
    Secondary Accessions:
    • Q0VAG3
    • Q0VAG4
    • Q8ND03
    • Q9BSF5

    Protein attributes for GAREM Gene

    Size:
    876 amino acids
    Molecular mass:
    97186 Da
    Quaternary structure:
    • Isoform 1 interacts with EGFR. Isoform 1 interacts (via proline-rich domain and phosphorylated at Tyr-105 and Tyr-453) with GRB2 (via SH3 domains); the interaction occurs upon EGF stimulation. Isoform 1 interacts (phosphorylated at Tyr-453) with PTPN11; the interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation. Isoform 2 does not interact with GRB2.
    SequenceCaution:
    • Sequence=CAD39149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GAREM Gene

    Alternative splice isoforms for GAREM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAREM Gene

Proteomics data for GAREM Gene at MOPED

Post-translational modifications for GAREM Gene

  • On EGF stimulation, phosphorylated on Tyr-105 and Tyr-453.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAREM Gene

No data available for DME Specific Peptides for GAREM Gene

Domains for GAREM Gene

Protein Domains for GAREM Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H706

UniProtKB/Swiss-Prot:

GAREM_HUMAN :
  • Q9H706
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the GAREM family.
genes like me logo Genes that share domains with GAREM: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GAREM Gene

Function for GAREM Gene

Molecular function for GAREM Gene

UniProtKB/Swiss-Prot Function: Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.

Gene Ontology (GO) - Molecular Function for GAREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19509291
GO:0070064 proline-rich region binding IDA 19509291
genes like me logo Genes that share ontologies with GAREM: view

Phenotypes for GAREM Gene

GenomeRNAi human phenotypes for GAREM:
genes like me logo Genes that share phenotypes with GAREM: view

Animal Model Products

CRISPR Products

miRNA for GAREM Gene

miRTarBase miRNAs that target GAREM

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GAREM Gene

Localization for GAREM Gene

Gene Ontology (GO) - Cellular Components for GAREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 19509291
genes like me logo Genes that share ontologies with GAREM: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for GAREM Gene

Pathways for GAREM Gene

SuperPathways for GAREM Gene

No Data Available

Interacting Proteins for GAREM Gene

Gene Ontology (GO) - Biological Process for GAREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway IDA 19509291
GO:0008284 positive regulation of cell proliferation IDA 19509291
GO:0051781 positive regulation of cell division IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP 19509291
GO:0071364 cellular response to epidermal growth factor stimulus IDA 19509291
genes like me logo Genes that share ontologies with GAREM: view

No data available for Pathways by source for GAREM Gene

Transcripts for GAREM Gene

Unigene Clusters for GAREM Gene

GRB2 associated, regulator of MAPK1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAREM

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GAREM
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAREM Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2:

Relevant External Links for GAREM Gene

GeneLoc Exon Structure for
GAREM
ECgene alternative splicing isoforms for
GAREM

Expression for GAREM Gene

mRNA expression in normal human tissues for GAREM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GAREM Gene

SOURCE GeneReport for Unigene cluster for GAREM Gene Hs.444314

mRNA Expression by UniProt/SwissProt for GAREM Gene

Q9H706-GAREM_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed.
genes like me logo Genes that share expressions with GAREM: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GAREM Gene

Orthologs for GAREM Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAREM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM59A 35
  • 99.38 (n)
  • 99.47 (a)
GAREM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAREM 35
  • 86.05 (n)
  • 91.06 (a)
GAREM 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM59A 35
  • 90.42 (n)
  • 93.77 (a)
GAREM 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Garem 35
  • 87.96 (n)
  • 91.66 (a)
Garem 16
Garem 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAREM 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAREM 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Garem 35
  • 88.71 (n)
  • 94.7 (a)
chicken
(Gallus gallus)
Aves FAM59A 35
  • 78.44 (n)
  • 84.91 (a)
GAREM 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAREM 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30446 35
tropical clawed frog
(Silurana tropicalis)
Amphibia garem 35
  • 73.06 (n)
  • 79.54 (a)
zebrafish
(Danio rerio)
Actinopterygii garem 35
  • 64.11 (n)
  • 66.27 (a)
garem 36
  • 63 (a)
OneToOne
zgc55634 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for GAREM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAREM Gene

ENSEMBL:
Gene Tree for GAREM (if available)
TreeFam:
Gene Tree for GAREM (if available)

Paralogs for GAREM Gene

Paralogs for GAREM Gene

Selected SIMAP similar genes for GAREM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GAREM: view

Variants for GAREM Gene

Sequence variations from dbSNP and Humsavar for GAREM Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs9510 -- 32,263,808(-) AAAAT(A/G)TTTAA utr-variant-3-prime
rs186706 -- 32,466,822(-) GAGGT(C/T)TAAGC intron-variant
rs186707 -- 32,465,341(-) CATCA(A/G)AGGTC intron-variant
rs189129 -- 32,470,847(-) TCTCA(A/G)ACCCG upstream-variant-2KB
rs191364 -- 32,468,987(-) TTGAA(C/G)CGGTG intron-variant

Relevant External Links for GAREM Gene

HapMap Linkage Disequilibrium report
GAREM
Human Gene Mutation Database (HGMD)
GAREM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GAREM Gene

Disorders for GAREM Gene

No disorders were found for GAREM Gene.

No data available for UniProtKB/Swiss-Prot for GAREM Gene

Publications for GAREM Gene

  1. GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. (PMID: 19509291) Tashiro K. … Konishi H. (J. Biol. Chem. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3
  5. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PMID: 15951569) Zhang Y. … White F.M. (Mol. Cell. Proteomics 2005) 3

Products for GAREM Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GAREM
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GAREM
    • Block miRNA regulation of GAREM using miScript Target Protectors

    Sources for GAREM Gene

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