Aliases for GAPVD1 Gene
External Ids for GAPVD1 Gene
Previous GeneCards Identifiers for GAPVD1 Gene
GeneCards Summary for GAPVD1 Gene
GAPVD1 (GTPase Activating Protein And VPS9 Domains 1) is a Protein Coding gene. Among its related pathways are Clathrin-mediated endocytosis and RAB GEFs exchange GTP for GDP on RABs. GO annotations related to this gene include GTPase activator activity and GTPase activating protein binding. An important paralog of this gene is RABGEF1.
UniProtKB/Swiss-Prot for GAPVD1 Gene
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.