Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GAPDHS Gene

Aliases for GAPDHS Gene

  • Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic 2 3 5
  • Spermatogenic Cell-Specific Glyceraldehyde 3-Phosphate Dehydrogenase 2 3 4
  • Spermatogenic Glyceraldehyde-3-Phosphate Dehydrogenase 3 4
  • EC 1.2.1.12 4 63
  • GAPDH-2 3 4
  • GAPDS 3 4
  • GAPD2 3 4
  • Epididymis Secretory Protein Li 278 3
  • HEL-S-278 3
  • EC 1.2.1 63
  • HSD-35 3
  • GAPDH2 4

External Ids for GAPDHS Gene

Previous HGNC Symbols for GAPDHS Gene

  • GAPDS

Previous GeneCards Identifiers for GAPDHS Gene

  • GC19P040717
  • GC19P036024
  • GC19P032529

Summaries for GAPDHS Gene

Entrez Gene Summary for GAPDHS Gene

  • This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAPDHS Gene

GAPDHS (Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include NAD binding and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. An important paralog of this gene is GAPDH.

UniProtKB/Swiss-Prot for GAPDHS Gene

  • May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).

Gene Wiki entry for GAPDHS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAPDHS Gene

Genomics for GAPDHS Gene

Regulatory Elements for GAPDHS Gene

Genomic Location for GAPDHS Gene

Chromosome:
19
Start:
35,533,412 bp from pter
End:
35,545,319 bp from pter
Size:
11,908 bases
Orientation:
Plus strand

Genomic View for GAPDHS Gene

Genes around GAPDHS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAPDHS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAPDHS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAPDHS Gene

Proteins for GAPDHS Gene

  • Protein details for GAPDHS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14556-G3PT_HUMAN
    Recommended name:
    Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
    Protein Accession:
    O14556
    Secondary Accessions:
    • B2RC82
    • O60823
    • Q6JTT9
    • Q9HCU6

    Protein attributes for GAPDHS Gene

    Size:
    408 amino acids
    Molecular mass:
    44501 Da
    Quaternary structure:
    • Homotetramer. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.

    Three dimensional structures from OCA and Proteopedia for GAPDHS Gene

neXtProt entry for GAPDHS Gene

Proteomics data for GAPDHS Gene at MOPED

Post-translational modifications for GAPDHS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAPDHS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for GAPDHS Gene

Suggested Antigen Peptide Sequences for GAPDHS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14556

UniProtKB/Swiss-Prot:

G3PT_HUMAN :
  • The testis-specific N-terminal extension mediates tight association with the cytoskeletal fibrous sheath of the spermatozoa flagellum, possibly via interchain disulfide-bonding of Cys-21 with sheath components.
  • Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Domain:
  • The testis-specific N-terminal extension mediates tight association with the cytoskeletal fibrous sheath of the spermatozoa flagellum, possibly via interchain disulfide-bonding of Cys-21 with sheath components.
Family:
  • Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
genes like me logo Genes that share domains with GAPDHS: view

No data available for Gene Families for GAPDHS Gene

Function for GAPDHS Gene

Molecular function for GAPDHS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
UniProtKB/Swiss-Prot Function:
May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).

Enzyme Numbers (IUBMB) for GAPDHS Gene

Gene Ontology (GO) - Molecular Function for GAPDHS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with GAPDHS: view
genes like me logo Genes that share phenotypes with GAPDHS: view

Animal Models for GAPDHS Gene

MGI Knock Outs for GAPDHS:

Animal Model Products

miRNA for GAPDHS Gene

miRTarBase miRNAs that target GAPDHS

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAPDHS Gene

Localization for GAPDHS Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAPDHS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAPDHS Gene COMPARTMENTS Subcellular localization image for GAPDHS gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3
chloroplast 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GAPDHS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with GAPDHS: view

Pathways & Interactions for GAPDHS Gene

genes like me logo Genes that share pathways with GAPDHS: view

UniProtKB/Swiss-Prot O14556-G3PT_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

Gene Ontology (GO) - Biological Process for GAPDHS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process IEA --
GO:0006094 gluconeogenesis TAS --
GO:0007286 spermatid development IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with GAPDHS: view

No data available for SIGNOR curated interactions for GAPDHS Gene

Drugs & Compounds for GAPDHS Gene

(6) Drugs for GAPDHS Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
6-(1,1-Dimethylallyl)-2-(1-Hydroxy-1-Methylethyl)-2,3-Dihydro-7h-Furo[3,2-G]Chromen-7-One Experimental Pharma Target 0
N-1,2,3,4-Tetrahydronaphth-1-Yl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine Experimental Pharma Target 0
N-Naphthalen-1-Ylmethyl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine Experimental Pharma Target 0
Glyceraldehyde-3-Phosphate Experimental Pharma 0
NADH Nutra Target 0

(7) Additional Compounds for GAPDHS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glyceric acid 1,3-biphosphate
  • 1,3-Biphosphoglycerate
  • 1,3-Biphosphoglyceric acid
  • 1,3-Bis-phosphoglycerate
  • 1,3-Bisphosphoglycerate
  • 1,3-Diphosphateglycerate
1981-49-3
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with GAPDHS: view

Transcripts for GAPDHS Gene

mRNA/cDNA for GAPDHS Gene

Unigene Clusters for GAPDHS Gene

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAPDHS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: - -

Relevant External Links for GAPDHS Gene

GeneLoc Exon Structure for
GAPDHS
ECgene alternative splicing isoforms for
GAPDHS

Expression for GAPDHS Gene

mRNA expression in normal human tissues for GAPDHS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAPDHS Gene

This gene is overexpressed in Testis (x42.0).

Protein differential expression in normal tissues from HIPED for GAPDHS Gene

This gene is overexpressed in Testis (22.6), Heart (18.8), and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GAPDHS Gene



SOURCE GeneReport for Unigene cluster for GAPDHS Gene Hs.248017

mRNA Expression by UniProt/SwissProt for GAPDHS Gene

O14556-G3PT_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with GAPDHS: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for GAPDHS Gene

Orthologs for GAPDHS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GAPDHS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAPDHS 35
  • 84.56 (n)
  • 85.32 (a)
GAPDHS 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAPDHS 35
  • 83.42 (n)
  • 83.91 (a)
GAPDHS 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gapdhs 35
  • 78.27 (n)
  • 81.62 (a)
Gapdhs 16
Gapdhs 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GAPDHS 35
  • 99.18 (n)
  • 98.77 (a)
GAPDHS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gapdhs 35
  • 78.35 (n)
  • 82.11 (a)
oppossum
(Monodelphis domestica)
Mammalia GAPDHS 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAPDHS 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAPDH 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAPDHS 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gapdhs 35
  • 72.27 (n)
  • 78.08 (a)
gapdhs 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9010 36
  • 58 (a)
OneToMany
Gapdh1 36
  • 69 (a)
OneToMany
Gapdh2 36
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gpd-1 36
  • 68 (a)
OneToMany
gpd-2 36
  • 67 (a)
OneToMany
gpd-3 36
  • 67 (a)
OneToMany
gpd-4 36
  • 67 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER031C 35
  • 63.48 (n)
  • 65.74 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11858g 35
  • 60.39 (n)
  • 63.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDH1 36
  • 65 (a)
OneToMany
TDH2 36
  • 64 (a)
OneToMany
TDH3 36
  • 64 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GAPC2 35
  • 62.8 (n)
  • 65.24 (a)
rice
(Oryza sativa)
Liliopsida Os02g0601300 35
  • 64.86 (n)
  • 65.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
CSA.4611 36
  • 70 (a)
OneToMany
Species with no ortholog for GAPDHS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GAPDHS Gene

ENSEMBL:
Gene Tree for GAPDHS (if available)
TreeFam:
Gene Tree for GAPDHS (if available)

Paralogs for GAPDHS Gene

Paralogs for GAPDHS Gene

(1) SIMAP similar genes for GAPDHS Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GAPDHS Gene

genes like me logo Genes that share paralogs with GAPDHS: view

Variants for GAPDHS Gene

Sequence variations from dbSNP and Humsavar for GAPDHS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2285514 - 35,538,389(+) TCATT(A/G)ACCCG reference, missense
rs2239942 -- 35,539,546(+) ACACA(C/T)ACACA intron-variant
rs2239943 -- 35,539,605(+) CTGTC(C/T)GGGCC intron-variant
rs2871992 -- 35,534,883(-) TCAAA(G/T)GCACC intron-variant
rs3216892 -- 35,534,193(+) AGTGC(-/GC)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAPDHS Gene

Variant ID Type Subtype PubMed ID
nsv833811 CNV Gain 17160897
nsv911628 CNV Loss 21882294

Variation tolerance for GAPDHS Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAPDHS Gene

HapMap Linkage Disequilibrium report
GAPDHS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAPDHS Gene

Disorders for GAPDHS Gene

Relevant External Links for GAPDHS

Genetic Association Database (GAD)
GAPDHS
Human Genome Epidemiology (HuGE) Navigator
GAPDHS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAPDHS

No disorders were found for GAPDHS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAPDHS Gene

Publications for GAPDHS Gene

  1. Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells. (PMID: 10714828) Welch J.E. … Eddy E.M. (J. Androl. 2000) 2 3 4 23 67
  2. Investigation of glyceraldehyde-3-phosphate dehydrogenase from human sperms. (PMID: 18298375) Shchutskaya Y.Y. … Schmalhausen E.V. (Biokhimiia 2008) 3 23
  3. Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis. (PMID: 16700075) Welch J.E. … O'Brien D.A. (Mol. Reprod. Dev. 2006) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Location and characterization of GAPDS in male reproduction. (PMID: 23306140) Liu J. … Li J.Y. (Urol. Int. 2013) 3

Products for GAPDHS Gene

Sources for GAPDHS Gene

Back to Top

Content