Aliases for GAPDHS Gene
External Ids for GAPDHS Gene
Previous HGNC Symbols for GAPDHS Gene
Previous GeneCards Identifiers for GAPDHS Gene
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]
GeneCards Summary for GAPDHS Gene
GAPDHS (Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic) is a Protein Coding gene. Among its related pathways are Citrate cycle (TCA cycle) and Chaperonin-mediated protein folding. GO annotations related to this gene include NAD binding and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. An important paralog of this gene is GAPDH.
UniProtKB/Swiss-Prot for GAPDHS Gene
May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).