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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAPDHS Gene

protein-coding   GIFtS: 60
GCID: GC19P036024

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic


(Previous symbol: GAPDS)
 Explore 9 diseases affiliated with
GAPDHS via our new
 Human Malady Compendium 
Biological research products
for GAPDHS
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic1 2     EC 1.2.1.123 8
GAPD21 2 3 5     HSD-352
GAPDH-21 2 3     Glyceraldehyde-3-Phosphate Dehydrogenase, Testis-Specific2
GAPDS1 2 3     GAPDH23
Spermatogenic Cell-Specific Glyceraldehyde 3-Phosphate Dehydrogenase 22 3     EC 1.2.18
Spermatogenic Glyceraldehyde-3-Phosphate Dehydrogenase2 3     

External Ids:    HGNC: 248641   Entrez Gene: 263302   Ensembl: ENSG000001056797   OMIM: 6091695   UniProtKB: O145563   

Export aliases for GAPDHS gene to outside databases

Previous GC identifers: GC19P040717 GC19P032529


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GAPDHS:
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an
important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in
a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde
3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in
regulating the switch between different energy-producing pathways, and it is required for sperm motility and male
fertility. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
Function: May play an important role in regulating the switch between different pathways for energy production during
spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)

Gene Wiki entry for GAPDHS


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAPDHS gene promoter:
         AP-1   AML1a   E47   MZF-1   POU2F1   POU2F1a   FOXO1a   ATF   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGAPDHS promoter sequence
   Search SABiosciences Chromatin IP Primers for GAPDHS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAPDHS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

GAPDHS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAPDHS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036024:  view genomic region     (about GC identifiers)

Start:
36,024,314 bp from pter      End:
36,036,221 bp from pter
Size:
11,908 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556 (See protein sequence)
Recommended Name: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific  
Size: 408 amino acids; 44501 Da
Subunit: Homotetramer. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation
Subcellular location: Cytoplasm (By similarity)
2 PDB 3D structures from and Proteopedia for GAPDHS:
3H9E (3D)        3PFW (3D)    
Secondary accessions: B2RC82 O60823 Q6JTT9 Q9HCU6

Explore the universe of human proteins at neXtProt for GAPDHS: NX_O14556

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14556

  • 4/29 DME Specific Peptides for GAPDHS (O14556) (see all 29)
     GLMTTVH  FDAKAGI  VAVNDPF  TTVHSYT 

    GAPDHS Protein expression data from MOPED and PaxDb:    About this image 
    GAPDHS Protein Expression
    REFSEQ proteins: NP_055179.1  
    ENSEMBL proteins: 
     ENSP00000222286   ENSP00000466432   ENSP00000467255  
    Reactome Protein details: O14556
    Human Recombinant Protein Products for GAPDHS: 
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    Uscn Proteins for GAPDHS

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0019861flagellum ----

    GAPDHS for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GAPDHS for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR020831 GlycerAld/Erythrose_P_DH
     IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
     IPR006424 Glyceraldehyde-3-P_DH_1
     IPR020830 GlycerAld_3-P_DH_AS
     IPR020829 GlycerAld_3-P_DH_cat

    Graphical View of Domain Structure for InterPro Entry O14556

    ProtoNet protein and cluster: O14556

    1 Blocks protein family: IPB000173 Glyceraldehyde 3-phosphate dehydrogenase

    UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
    Domain: The testis-specific N-terminal extension mediates tight association with the cytoskeletal fibrous sheath of the
    spermatozoa flagellum, possibly via interchain disulfide-bonding of Cys-21 with sheath components (PubMed:18298375)
    Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: G3PT_HUMAN, O14556
    Function: May play an important role in regulating the switch between different pathways for energy production during
    spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)
    Catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

         Enzyme Numbers (IUBMB): EC 1.2.1.121 2 EC 1.2.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity TAS10714828
    GO:0005515protein binding IPI16820410
    GO:0050661NADP binding IEA--
    GO:0051287NAD binding IEA--
         
    GAPDHS for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gapdhs):
     reproductive system 

    GAPDHS for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Gapdhstm1Dao for GAPDHS
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GAPDHS 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and gluconeogenesis (short map)1.00
    Glycolysis and Gluconeogenesis0.60
    Glycolysis and gluconeogenesis (short map)0.97
    Glycolysis / Gluconeogenesis0.41
    2Glucose metabolism
    Glucose metabolism1.00
    Glycolysis0.44
    Gluconeogenesis0.50
    3Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    4gluconeogenesis I
    gluconeogenesis I1.00
    glycolysis I0.58
    5MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GAPDHS
        Glycolysis and gluconeogenesis (short map)


    1 GeneGo (Thomson Reuters) Pathway for GAPDHS
        Glycolysis and gluconeogenesis (short map)

    3 BioSystems Pathways for GAPDHS 
        Glycolysis and Gluconeogenesis
    glycolysis I
    gluconeogenesis I

    5        Reactome Pathways for GAPDHS
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Glycolysis


    2         Kegg Pathways  (Kegg details for GAPDHS):
        Glycolysis / Gluconeogenesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
    Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5


    GAPDHS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAPDHS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for GAPDHS (O145563 ENSP000002222864) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTHL1P785493, ENSP000002190664I2D: score=2 STRING: ENSP00000219066
    SH3BP4Q9P0V33, ENSP000003402374I2D: score=1 STRING: ENSP00000340237
    E2F4Q162543I2D: score=1 
    FANCGO152873I2D: score=1 
    KAT2AQ928303I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006096glycolysis TAS--
    GO:0007286spermatid development IEA--

    GAPDHS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GAPDHS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GAPDHS

    7 HMDB Compounds for GAPDHS    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    Glyceric acid 1,3-biphosphate1,3-Biphosphoglycerate (see all 25)1981-49-3--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    5 DrugBank Compounds for GAPDHS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--12492483 17139284 15488735 16239728 17016423
    N-1,2,3,4-Tetrahydronaphth-1-Yl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine-- --target--17139284 17016423 10592235
    N-Naphthalen-1-Ylmethyl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine-- --target--17139284 17016423 10592235
    6-(1,1-Dimethylallyl)-2-(1-Hydroxy-1-Methylethyl)-2,3-Dihydro-7h-Furo[3,2-G]Chromen-7-One-- --target--10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--10592235

    1 Novoseek chemical compound relationship for GAPDHS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 78.5 6 7736666 (2), 17680766 (1), 16700075 (1), 10714828 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about GAPDHS / G3PT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GAPDHS gene: 
    NM_014364.4  

    Unigene Cluster for GAPDHS:

    Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
    Hs.248017  [show with all ESTs]
    Unigene Representative Sequence: NM_014364
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222286(uc002oaf.1) ENST00000586334 ENST00000585510

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    Additional cDNA sequence: 

    AJ005371.1 AK225727.1 AK314980.1 AY306129.1 BC036373.2 

    3 DOTS entries:

    DT.432666  DT.75133827  DT.121504578 

    24/48 AceView cDNA sequences (see all 48):

    BG769351 BI520157 BM564052 BX280438 AJ005371 BM563402 BU726467 BI826019 
    BI520497 BI520542 R88358 BP370184 BG764341 BG718767 BI827996 BI828765 
    BP369039 BP371243 NM_014364 BG761940 BI828646 BG764531 BG765069 BF689842 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GAPDHS    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                                                               
    SP2:                                                                              
    SP3:              -     -                                                         


    ECgene alternative splicing isoforms for GAPDHS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAPDHS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGAAATAAA
    GAPDHS Expression
    About this image
    See GAPDHS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAPDHS

    SOURCE GeneReport for Unigene cluster: Hs.248017

    UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
    Tissue specificity: Testis specific

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDHS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for GAPDHS gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gapdhs1 , 5 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic1, 5 79.41(n)1
    82.6(a)1
      7 (19.23 cM)5
    144471  NM_008085.11  NP_032111.11 
     307298875 
    lizard
    (Anolis carolinensis)
    Reptilia GAPDHS6
    --
    68(a)
    1 ↔ 1
    GL343281.1(84810-93909)
    zebrafish
    (Danio rerio)
    Actinopterygii gapdhs1 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 72.27(n)
    78.08(a)
      406367  NM_213094.2  NP_998259.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    --
    53(a)
    38(a)
    1 ↔ 1
    possible ortholog
    Group10.8(237008-238830)
    GroupUn.7179(80-976)
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0F20988g1 hypothetical protein 60.8(n)
    65.43(a)
      2894950  XM_456022.1  XP_456022.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GAPC11 glyceraldehyde-3-phosphate dehydrogenase, cytosolic 63.02(n)
    64.74(a)
      819567  NM_111283.3  NP_187062.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06013001 hypothetical protein 64.85(n)
    65.76(a)
      4329892  NM_001053883.1  NP_001047348.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria gapA6
    epd6
    D-erythrose 4-phosphate dehydrogenase
    63(a)
    35(a)
    many → 1
    possible ortholog
    Chromosome(1860795-1861790)
    Chromosome(3070694-3071713)


    ENSEMBL Gene Tree for GAPDHS (if available)
    TreeFam Gene Tree for GAPDHS (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAPDHS gene
    GAPDH2  
    1 SIMAP similar gene for GAPDHS using alignment to 3 protein entries:     G3PT_HUMAN (see all proteins):
    GAPDH

    GAPDHS for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for GAPDHS
    PGOHUM00000262850 PGOHUM00000239823 PGOHUM00000250531


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/210 NCBI SNPs in GAPDHS are shown (see all 210    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81128531,2
    C,F,A,H--36022352(+) TGCAGG/CTGATG 1 -- us2k117Minor allele frequency- C:0.22NS EA NA WA 934
    rs1446483751,2
    --36022407(+) GGGGCC/TGCAGG 1 -- us2k10--------
    rs739282221,2
    C--36022498(+) CAGTCG/ATGAAC 1 -- us2k12Minor allele frequency- A:0.12WA 120
    rs1895854401,2
    --36022547(+) CCCAAC/GGGGGA 1 -- us2k10--------
    rs126087941,2
    C,F,H--36022638(+) AGATAT/CAACGT 1 -- us2k1 tfbs310Minor allele frequency- C:0.10EA NS NA WA 666
    rs48061711,2
    C,F,A,H--36022641(+) TATAAC/TGTGAA 1 -- us2k1 tfbs314Minor allele frequency- N:0.00EA NA NS CSA 882
    rs1478831301,2
    --36022779(+) GAAACC/TCCGTC 1 -- us2k10--------
    rs1807856891,2
    --36022813(+) AAAAAA/TATTAG 1 -- us2k10--------
    rs1133406341,2
    C,F--36022968(+) TCAAAA/GAAAAG 1 -- us2k14Minor allele frequency- G:0.26NA CSA 125
    rs1855861021,2
    --36023034(+) ATTCAA/GGTATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GAPDHS (36024314 - 36036221 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GAPDHS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAPDHS
    DNA2.0 Custom Variant and Variant Library Synthesis for GAPDHS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GAPDHS for disorders           About GeneDecksing

    OMIM gene information: 609169    OMIM disorders: --

    9 diseases for GAPDHS:    About MalaCards
    male infertility    infertility    alzheimer's disease    pneumonia
    tuberculosis    malaria    mycobacterium tuberculosis    pancreatic cancer
    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: GAPDHS (4 documents)

    Export disorders for GAPDHS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAPDHS gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with GAPDHS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells. (PubMed id 10714828)1, 2, 3, 9 Welch J.E.... Eddy E.M. (2000)
    2. Investigation of glyceraldehyde-3-phosphate dehydrogenase from human sperms. (PubMed id 18298375)1, 2, 9 Shchutskaya Y.Y....Schmalhausen E.V. (2008)
    3. Structure and kinetic characterization of human sperm -specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS. (PubMed id 21269272)1, 2 Chaikuad A....Yue W.W. (2011)
    4. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    7. Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis. (PubMed id 16700075)1, 9 Welch J.E....O'Brien D.A. (2006)
    8. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Recombinant human sperm-specific glyceraldehyde-3-pho sphate dehydrogenase (GAPDHS) is expressed at high yield as an active homotetra mer in baculovirus-infected insect cells. (PubMed id 20828617)1 Lamson D.R....Williams K.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26330 HGNC: 24864 AceView: GAPDS Ensembl:ENSG00000105679 euGenes: HUgn26330
    ECgene: GAPDHS Kegg: 26330 H-InvDB: GAPDHS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAPDHS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GAPDHS gene:
    Search GeneIP for patents involving GAPDHS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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