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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAPDH Gene

protein-coding   GIFtS: 74
GCID: GC12P006643

glyceraldehyde-3-phosphate dehydrogenase


(Previous symbol: GAPD)
 Explore 168 diseases affiliated with
GAPDH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GAPDH    

Aliases
for GAPDH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glyceraldehyde-3-Phosphate Dehydrogenase1 2     G3PD2
GAPD1 2 3 5     Aging-Associated Gene 9 Protein2
Peptidyl-Cysteine S-Nitrosylase GAPDH2 3     EC 2.6.99.-3
EC 1.2.1.123 8     EC 1.2.18

External Ids:    HGNC: 41411   Entrez Gene: 25972   Ensembl: ENSG000001116407   OMIM: 1384005   UniProtKB: P044063   

Export aliases for GAPDH gene to outside databases

Previous GC identifer: GC12P006514


Summaries
for GAPDH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GAPDH:
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible
oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide
adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this
locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: G3P_HUMAN, P04406
Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in
glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport,
DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine
S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of
the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to
stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key
enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P)
into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation)
complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.
Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in
the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation

Gene Wiki entry for GAPDH (Glyceraldehyde 3-phosphate dehydrogenase)


Genomic Views
for GAPDH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAPDH gene promoter:
         N-Myc   TBP   PPAR-gamma1   NF-1   p53   TFIID   PPAR-gamma2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GAPDH promoter sequence
   Search SABiosciences Chromatin IP Primers for GAPDH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAPDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

GAPDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAPDH gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006643:  view genomic region     (about GC identifiers)

Start:
 6,643,093 bp from pter      End:
 6,647,537 bp from pter
Size:
 4,445 bases      Orientation:
 plus strand

Proteins
for GAPDH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 (See protein sequence)
Recommended Name: Glyceraldehyde-3-phosphate dehydrogenase  
Size: 335 amino acids; 36053 Da
Subunit: Homotetramer. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1;
leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and
SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with
microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS. Component of
the GAIT complex
Subcellular location: Cytoplasm, cytosol. Nucleus (By similarity). Cytoplasm, perinuclear region. Membrane. Cytoplasm,
cytoskeleton (By similarity). Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1,
which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions
4 PDB 3D structures from and Proteopedia for GAPDH:
1U8F (3D)        1ZNQ (3D)        2FEH (3D)        3GPD (3D)    
Secondary accessions: P00354 Q53X65

Explore the universe of human proteins at neXtProt for GAPDH: NX_P04406

Post-translational modifications:

  • S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By similarity)1
  • ISGylated (Probable)1
  • Sulfhydration at Cys-152 increases catalytic activity (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04406

    • 4/40 DME Specific Peptides for GAPDH (P04406) (see all 40)
     GVNHEKY  GKLVING  LAKVIHD  PELNGKL 

    GAPDH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243728.1  NP_002037.2  

    ENSEMBL proteins: 
     ENSP00000229239   ENSP00000380065   ENSP00000380070   ENSP00000380068   ENSP00000380067  
    Reactome Protein details: P04406
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: GAPDH
    OriGene Protein Over-expression Lysate: GAPDH
    OriGene Custom Protein Services for GAPDH 
    GenScript Custom Purified and Recombinant Proteins Services for GAPDH
    Novus Biologicals GAPDH Proteins
    Novus Biologicals GAPDH Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for GAPDH
    Uscn Proteins for GAPDH

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm NAS--
    GO:0005811lipid particle IDA14741744
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--


    GAPDH for ontologies           About GeneDecksing



    GAPDH Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GAPDH
    R&D Systems Antibodies for GAPDH (GAPDH/G3PDH)
    Cell Signaling Technology (CST) Antibodies for GAPDH 
    OriGene Antibodies (see all 4): GAPDH
    OriGene Custom Antibody Services for GAPDH 
    GenScript Superior Antibodies for GAPDH
    Novus Biologicals GAPDH Antibodies
    Abcam antibodies for GAPDH 
    Uscn Antibodies for GAPDH
    ThermoFisher Antibody for GAPDH

    Assay Products for GAPDH: 
    EMD Millipore Kits and Assays for the Analysis of GAPDH
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for GAPDH (GAPDH/G3PDH)
    GenScript Custom Assay Services for GAPDH
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GAPDH

    Protein Domains /
    Families
    for GAPDH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GAPDH for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR020831 GlycerAld/Erythrose_P_DH
     IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
     IPR006424 Glyceraldehyde-3-P_DH_1
     IPR020830 GlycerAld_3-P_DH_AS
     IPR020829 GlycerAld_3-P_DH_cat

    Graphical View of Domain Structure for InterPro Entry P04406

    ProtoNet protein and cluster: P04406

    1 Blocks protein family: IPB000173 Glyceraldehyde 3-phosphate dehydrogenase

    UniProtKB/Swiss-Prot: G3P_HUMAN, P04406
    Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family


    Function
    for GAPDH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: G3P_HUMAN, P04406
    Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in
    glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport,
    DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine
    S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of
    the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to
    stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key
    enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P)
    into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation)
    complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.
    Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in
    the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation
    Catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

    Enzyme Numbers (IUBMB): EC 1.2.1.121 2 EC 1.2.12 EC 2.6.99.-1

    miRNA
    Products:            		miRTarBase miRNAs that target GAPDH:
    hsa-mir-29c (MIRT001929)

    OriGene 3'-UTR Clone: GAPDH
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAPDH
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GAPDH:
    hsa-miR-185* hsa-miR-4302 hsa-miR-323-5p
    SwitchGear 3'UTR luciferase reporter plasmid: GAPDH 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAPDH (see all 7)
    OriGene shRNA RFP: GAPDH
    OriGene siRNA: GAPDH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAPDH

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GAPDH

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAPDH (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAPDH
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GAPDH (NM_002046)
    Sino Biological Human cDNA Clone for GAPDH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAPDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAPDH 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for GAPDH
    Search LifeMap BioReagents cell lines for GAPDH

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity NAS3170585
    GO:0005515protein binding IPI--
    GO:0008017microtubule binding ISS--
    GO:0035605peptidyl-cysteine S-nitrosylase activity ISS--


    GAPDH for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for GAPDH:
     Increased S DNA content  Increased number of mitotic ce  Synthetic lethal with imatinib 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Gapdh):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  liver/biliary system 
     mortality/aging  renal/urinary system 

    GAPDH for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GAPDH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycolysis and gluconeogenesis (short map)
    		Glycolysis and gluconeogenesis (short map)1.00
    		Glycolysis and Gluconeogenesis0.60
    		Glycolysis and gluconeogenesis (short map)0.97
    		Glycolysis / Gluconeogenesis0.41
    2Glucose metabolism
    		Glucose metabolism1.00
    		Glycolysis0.44
    		Gluconeogenesis0.50
    3Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Alzheimer's disease0.43
    		Alzheimers Disease0.00
    5Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GAPDH
        Glycolysis and gluconeogenesis (short map)


    1 Cell Signaling Technology (CST) Pathway for GAPDH
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for GAPDH
        Glycolysis and gluconeogenesis (short map)

    4 BioSystems Pathways for GAPDH 
        SIDS Susceptibility Pathways
    Glycolysis and Gluconeogenesis
    Alzheimers Disease
    Validated targets of C-MYC transcriptional activation

    5        Reactome Pathways for GAPDH
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Glycolysis


    3         Kegg Pathways  (Kegg details for GAPDH):
        Glycolysis / Gluconeogenesis
    Metabolic pathways
    Alzheimer's disease

    UniProtKB/Swiss-Prot: G3P_HUMAN, P04406
    Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5


    GAPDH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAPDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    807/849 Interacting proteins for GAPDH (P044061, 2, 3 ENSP000002292394) via UniProtKB, MINT, STRING, and/or I2D (see all 849) (see top 5)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622582, 3, ENSP000002643354MINT-8256415 MINT-7947479 I2D: score=4 STRING: ENSP00000264335
    ACTBP607092, 3, ENSP000003499604MINT-7947479 MINT-4054731 I2D: score=3 STRING: ENSP00000349960
    HSP90AB1P082382, 3, ENSP000003258754MINT-72648 MINT-7947479 I2D: score=3 STRING: ENSP00000325875
    BIDP559572, 3, ENSP000003188224MINT-8249531 MINT-7947479 I2D: score=2 STRING: ENSP00000318822
    PCNAP120042, 3MINT-7995141 MINT-7995351 MINT-7995132 I2D: score=2 
    SMN1Q166372, 3MINT-7947479 MINT-8271168 I2D: score=2 
    SMN2Q166372, 3MINT-7947479 MINT-8271168 I2D: score=2 
    TBK1Q9UHD22, 3, ENSP000003299674MINT-49284 MINT-5208380 I2D: score=2 STRING: ENSP00000329967
    PRDX1Q068302, 3, ENSP000002627464MINT-64057 I2D: score=5 STRING: ENSP00000262746
    GAS7O608612, 3, ENSP000003226084MINT-72922 I2D: score=3 STRING: ENSP00000322608
    ACTC1P680322, 3, ENSP000002903784MINT-8256327 I2D: score=2 STRING: ENSP00000290378
    GOT2P005052, 3, ENSP000002452064MINT-8256338 I2D: score=2 STRING: ENSP00000245206
    KARSQ150462, 3, ENSP000003254484MINT-8256360 I2D: score=2 STRING: ENSP00000325448
    NFYCQ139522, 3, ENSP000003966204MINT-8256371 I2D: score=2 STRING: ENSP00000396620
    OSMRQ996502, 3, ENSP000002742764MINT-8256382 I2D: score=2 STRING: ENSP00000274276
    OSTF1Q928822, 3, ENSP000003408364MINT-8256393 I2D: score=2 STRING: ENSP00000340836
    TNFRSF1BP203332, 3, ENSP000003654354MINT-49454 I2D: score=2 STRING: ENSP00000365435
    TRAF1Q130772, 3, ENSP000003629944MINT-49528 I2D: score=2 STRING: ENSP00000362994
    GSSP486372, 3, ENSP000002169514MINT-6540721 I2D: score=1 STRING: ENSP00000216951
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    ARL15Q9NXU52, 3MINT-64612 I2D: score=5 
    BTBD2Q9BX702, 3MINT-65378 I2D: score=5 
    LAMTOR5O435042, 3MINT-63149 I2D: score=5 
    PAFAH1B3Q151022, 3MINT-64201 I2D: score=5 
    PCDHA4Q9UN742, 3MINT-65769 I2D: score=4 
    RPA2P159271, 3EBI-354056,EBI-621404 I2D: score=4 
    HSP90AA1P079002, 3MINT-7947479 I2D: score=3 
    ANAPC2Q9UJX62, 3MINT-7947479 I2D: score=2 
    ANXA1P040832, 3MINT-8247797 I2D: score=2 
    ANXA7P200732, 3MINT-8248384 I2D: score=2 
    CCT6AP402272, 3MINT-7947479 I2D: score=2 
    GADD45AP245222, 3MINT-8255816 I2D: score=2 
    GSK3BP498412, 3MINT-8257262 I2D: score=2 
    KCNE3Q9Y6H62, 3MINT-8259073 I2D: score=2 
    MAP3K14Q995582, 3MINT-48862 I2D: score=2 
    CCT2P783712, 3MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7947479 I2D: score=1 
    CCT4P509912, 3MINT-7947479 I2D: score=1 
    CCT5P486432, 3MINT-7947479 I2D: score=1 
    CCT8P509902, 3MINT-7947479 I2D: score=1 
    DNAJA1P316892, 3MINT-7947479 I2D: score=1 
    HSPA8P111422, 3MINT-7947479 I2D: score=1 
    KPNB1Q149742, 3MINT-7947479 I2D: score=1 
    NSFP464592, 3MINT-7947479 I2D: score=1 
    PSMC3P179802, 3MINT-7947479 I2D: score=1 
    PSMD2Q132002, 3MINT-7947479 I2D: score=1 
    SEH1LQ96EE32, 3MINT-7947479 I2D: score=1 
    TLN1Q9Y4902, 3MINT-7947479 I2D: score=1 
    TUBA4AP683662, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    PGK1P005582, 3, ENSP000003624134MINT-7386573 MINT-7386555 I2D: score=4 STRING: ENSP00000362413
    ATN1P542592, 3, ENSP000003490764MINT-2859138 MINT-2859119 I2D: score=2 STRING: ENSP00000349076
    TK1P041832, 3, ENSP000003016344MINT-63364 MINT-8273466 I2D: score=5 STRING: ENSP00000301634
    PSMD11O002312, 3, ENSP000002617124MINT-63022 MINT-7947479 I2D: score=5 STRING: ENSP00000261712
    CCNB1P146352, 3, ENSP000002564424MINT-7947479 I2D: score=1 STRING: ENSP00000256442
    SUMO1P631652, 3, ENSP000003760764MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    CDKN2AQ8N7263, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    EGFRP005331, 3, ENSP000002754934EBI-354056,EBI-297353 I2D: score=4 STRING: ENSP00000275493
    KAT5Q929932, 3, ENSP000003403304MINT-3980540 I2D: score=4 STRING: ENSP00000340330
    RBM5P527562, 3, ENSP000003430544MINT-8256404 I2D: score=2 STRING: ENSP00000343054
    YWHAZP631042, 3, ENSP000003095034MINT-3304469 I2D: score=1 STRING: ENSP00000309503
    RIPK2O433532, 3, ENSP000002207514MINT-49074 I2D: score=2 STRING: ENSP00000220751
    MAP3K3Q997592, 3, ENSP000003549274MINT-48508 I2D: score=2 STRING: ENSP00000354927
    HES1Q144692, 3, ENSP000002324244MINT-8256349 I2D: score=2 STRING: ENSP00000232424
    SERPINB9P504532, 3, ENSP000003700744MINT-63813 I2D: score=5 STRING: ENSP00000370074
    SNCAP378402, 3, ENSP000003383454MINT-8271839 I2D: score=2 STRING: ENSP00000338345
    HSPD1P108092, ENSP000003400194MINT-7947479 MINT-4054731 STRING: ENSP00000340019
    HTTP428583, ENSP000003471844I2D: score=3 STRING: ENSP00000347184
    PLD2O149393, ENSP000002630884I2D: score=3 STRING: ENSP00000263088
    PRKCIP417433, ENSP000002957974I2D: score=3 STRING: ENSP00000295797
    SIAH1Q8IUQ43, ENSP000003491564I2D: score=3 STRING: ENSP00000349156
    APPP050673, ENSP000002849814I2D: score=2 STRING: ENSP00000284981
    CAMK4Q165663, ENSP000002823564I2D: score=2 STRING: ENSP00000282356
    CDKN1AP389363, ENSP000002447414I2D: score=2 STRING: ENSP00000244741
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    PDIA2Q130873, ENSP000002194064I2D: score=2 STRING: ENSP00000219406
    QRICH2Q9H0J43, ENSP000002627654I2D: score=2 STRING: ENSP00000262765
    SLC2A1P111663, ENSP000004162934I2D: score=2 STRING: ENSP00000416293
    DHRS2Q132683, ENSP000003446744I2D: score=1 STRING: ENSP00000344674
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    POU2F1P148593, ENSP000002714114I2D: score=1 STRING: ENSP00000271411
    PPM1EQ8WY543, ENSP000003124114I2D: score=1 STRING: ENSP00000312411
    PPP2R2AP631513, ENSP000003701134I2D: score=1 STRING: ENSP00000370113
    PSMA3P257883, ENSP000002164554I2D: score=1 STRING: ENSP00000216455
    RAD52P433513, ENSP000003512844I2D: score=1 STRING: ENSP00000351284
    RELQ048643, ENSP000002950254I2D: score=1 STRING: ENSP00000295025
    S100A6P067033, ENSP000003577084I2D: score=1 STRING: ENSP00000357708
    SUMO4Q6EEV63, ENSP000003186354I2D: score=1 STRING: ENSP00000318635
    TPPPO948113, ENSP000003537854I2D: score=1 STRING: ENSP00000353785
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    UBCP0CG483, ENSP000003448184I2D: score=3 STRING: ENSP00000344818
    TXNP105993, ENSP000003636414I2D: score=3 STRING: ENSP00000363641
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    ATXN1P542533, ENSP000002447694I2D: score=3 STRING: ENSP00000244769
    BPGMP077383, ENSP000003420324I2D: score=2 STRING: ENSP00000342032
    CAMK1Q140123, ENSP000002564604I2D: score=2 STRING: ENSP00000256460
    CAMK2BQ135543, ENSP000002586824I2D: score=2 STRING: ENSP00000258682
    FKBP6O753443, ENSP000002520374I2D: score=1 STRING: ENSP00000252037
    GRM1Q132553, ENSP000002827534I2D: score=2 STRING: ENSP00000282753
    MCL1Q078202, ENSP000003580224MINT-7255781 STRING: ENSP00000358022
    PRKG1Q139763, ENSP000003630924I2D: score=1 STRING: ENSP00000363092
    RAB2AP610193, ENSP000002626464I2D: score=3 STRING: ENSP00000262646
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    CBLP226813, ENSP000002640334I2D: score=1 STRING: ENSP00000264033
    NPATQ142073, ENSP000002786124I2D: score=1 STRING: ENSP00000278612
    SETQ011053, ENSP000003617774I2D: score=2 STRING: ENSP00000361777
    STIP1P319483, ENSP000003059584I2D: score=2 STRING: ENSP00000305958
    USP25Q9UHP33, ENSP000002856794I2D: score=1 STRING: ENSP00000285679
    POU2F2P090863, ENSP000003739924I2D: score=1 STRING: ENSP00000373992
    PTK2Q053973, ENSP000003411894I2D: score=1 STRING: ENSP00000341189
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    SGK1O001413, ENSP000003568324I2D: score=1 STRING: ENSP00000356832
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    SIRT3Q9NTG73, ENSP000003721914I2D: score=1 STRING: ENSP00000372191
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    SLC2A4P146723, ENSP000003209354I2D: score=3 STRING: ENSP00000320935
    MAPK13O152643, ENSP000002112874I2D: score=1 STRING: ENSP00000211287
    PSEN1P497683, ENSP000003263664I2D: score=1 STRING: ENSP00000326366
    CASKO149363, ENSP000003674084I2D: score=4 STRING: ENSP00000367408
    RAD50Q928782, ENSP000002653354MINT-7947479 STRING: ENSP00000265335
    SLC27A2O149753, ENSP000002678424I2D: score=1 STRING: ENSP00000267842
    NFS1Q9Y6973, ENSP000003632054I2D: score=1 STRING: ENSP00000363205
    PSMD4P550363, ENSP000003578794I2D: score=1 STRING: ENSP00000357879
    HSPA5P110212MINT-7947479 MINT-4054731
    IRF3Q146532, ENSP000003101274MINT-5208380 STRING: ENSP00000310127
    RPLP0P053882, ENSP000003390274MINT-7947479 STRING: ENSP00000339027
    DTNBO609413I2D: score=4 
    KPNA6O606843I2D: score=4 
    LAMA4Q163633I2D: score=4 
    MYO1EQ129653I2D: score=4 
    MYO1FO001603I2D: score=4 
    DYNLL1P631673I2D: score=3 
    HNF4GQ145413I2D: score=3 
    NR1H4Q96RI13I2D: score=3 
    OSBPP220593I2D: score=3 
    GABARAPO951663I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=2 
    KCNMA1Q127913I2D: score=2 
    MAP1LC3AQ9H4923I2D: score=2 
    MAP2K2P365073I2D: score=2 
    PAK2Q131773I2D: score=2 
    PDCD6IPQ8WUM43I2D: score=2 
    PRPF40AO754003I2D: score=2 
    SYNCRIPO605063I2D: score=2 
    UBE2AP494593I2D: score=2 
    ABCB7O750273I2D: score=1 
    ACAT1P247523I2D: score=1 
    ACSS1Q9NUB13I2D: score=1 
    ADAP008133I2D: score=1 
    AHSA1O954333I2D: score=1 
    AKT1P317493I2D: score=1 
    AMBRA1Q9C0C73I2D: score=1 
    ARRB2P321213I2D: score=1 
    ATAD2Q6PL183I2D: score=1 
    ATG10Q9H0Y03I2D: score=1 
    ATG12O948173I2D: score=1 
    ATG13O751433I2D: score=1 
    ATG14Q6ZNE53I2D: score=1 
    ATG16L1Q676U53I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    ATG3Q9NT623I2D: score=1 
    ATG4CQ96DT63I2D: score=1 
    ATG5Q9H1Y03I2D: score=1 
    ATG7O953523I2D: score=1 
    BECN1Q144573I2D: score=1 
    C12orf44Q9BSB43I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    CAMPP499133I2D: score=1 
    CDC40O605083I2D: score=1 
    CDK1P064933I2D: score=1 
    CLN3Q132863I2D: score=1 
    CLPXO760313I2D: score=1 
    CNBPP626333I2D: score=1 
    COG3Q96JB23I2D: score=1 
    CSF1P096033I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    DDIT3P356383I2D: score=1 
    DLG4P783523I2D: score=1 
    EIF1BO607393I2D: score=1 
    ENO3P139293I2D: score=1 
    FA2HQ7L5A83I2D: score=1 
    FAHD1Q6P5873I2D: score=1 
    FAM63AQ8N5J23I2D: score=1 
    FOXO3O435243I2D: score=1 
    FYCO1Q9BQS83I2D: score=1 
    GABARAPL2P605203I2D: score=1 
    GBASO753233I2D: score=1 
    GLRX3O760033I2D: score=1 
    GOSR1O952493I2D: score=1 
    GPD1P216953I2D: score=1 
    GRID2O434243I2D: score=1 
    GRIN2BQ132243I2D: score=1 
    HIF1AQ166653I2D: score=1 
    HPCAL1P372353I2D: score=1 
    IL7RP168713I2D: score=1 
    IPO4Q8TEX93I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=1 
    KDELR3O437313I2D: score=1 
    KIAA0368Q5VYK33I2D: score=1 
    KLHDC10Q6PID83I2D: score=1 
    LSM14AQ8ND563I2D: score=1 
    MAP1LC3CQ9BXW43I2D: score=1 
    MAPK3P273613I2D: score=1 
    MDM2Q009873I2D: score=1 
    ME1P481633I2D: score=1 
    MLST8Q9BVC43I2D: score=1 
    NCALDP616013I2D: score=1 
    NEK9Q8TD193I2D: score=1 
    NMD3Q96D463I2D: score=1 
    NPEPPSP557863I2D: score=1 
    NRBF2Q96F243I2D: score=1 
    NSMAFQ926363I2D: score=1 
    NUDT2P505833I2D: score=1 
    PCDHA13Q9Y5I03I2D: score=1 
    PDPK1O155303I2D: score=1 
    PGAM2P152593I2D: score=1 
    PIK3C2AO004433I2D: score=1 
    PIK3C3Q8NEB93I2D: score=1 
    PIK3CGP487363I2D: score=1 
    POLR2BP308763I2D: score=1 
    POU5F1Q018603I2D: score=1 
    PPIDQ087523I2D: score=1 
    PPP1CCP368733I2D: score=1 
    PPP5CP530413I2D: score=1 
    PRIM2P496433I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    PRKAA2P546463I2D: score=1 
    PRKAB1Q9Y4783I2D: score=1 
    PRKAB2O437413I2D: score=1 
    PRKAG1P546193I2D: score=1 
    PRKAG2Q9UGJ03I2D: score=1 
    PRKCEQ021563I2D: score=1 
    PSMD10O758323I2D: score=1 
    PSMD14O004873I2D: score=1 
    PXNP490233I2D: score=1 
    RAB24Q969Q53I2D: score=1 
    RABGAP1Q9Y3P93I2D: score=1 
    RB1CC1Q8TDY23I2D: score=1 
    RPF2Q9H7B23I2D: score=1 
    RPL37P619273I2D: score=1 
    SH3GLB1Q9Y3713I2D: score=1 
    SH3GLB2Q9NR463I2D: score=1 
    SLC35C2Q9NQQ73I2D: score=1 
    SLC35F5Q8WV833I2D: score=1 
    SQSTM1Q135013I2D: score=1 
    STK11Q158313I2D: score=1 
    STK4Q130433I2D: score=1 
    TIMM44O436153I2D: score=1 
    TRAF2Q129333I2D: score=1 
    ULK1O753853I2D: score=1 
    ULK2Q8IYT83I2D: score=1 
    UVRAGQ9P2Y53I2D: score=1 
    VCLP182063I2D: score=1 
    WDR45Q9Y4843I2D: score=1 
    WIPI1Q5MNZ93I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    XPO1O149803I2D: score=1 
    YME1L1Q96TA23I2D: score=1 
    YWHABP319463I2D: score=1 
    A2MP010232MINT-4054731
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTL6AO960192MINT-7947479
    ACTR1AP611632MINT-7947479
    ACTR2P611602MINT-7947479
    ADNPQ9H2P02MINT-7947479
    AHNAKQ096662MINT-7947479
    AKAP8O438232MINT-7947479
    ALPPP051872MINT-4054731
    ANAPC1Q9H1A42MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANLNQ9NQW62MINT-7947479
    ANXA11P509952MINT-7947479
    AP1B1Q105672MINT-7947479
    APODP050902MINT-4054731
    ARCN1P484442MINT-7947479
    ARGLU1Q9NWB62MINT-7947479
    ARHGEF1Q928882MINT-7947479
    ARHGEF2Q929742MINT-7947479
    ARID1AO144972MINT-7947479
    ARL8BQ9NVJ22MINT-4054731
    ASAH1Q135102MINT-4054731
    ATP5A1P257052MINT-4054731
    ATP5BP065762MINT-4054731
    ATP6V0D1P614212MINT-4054731
    ATP6V1AP386062MINT-4054731
    AURKBQ96GD42MINT-7947479
    AZU1P201602MINT-4054731
    BAZ1AQ9NRL22MINT-7947479
    BCAS2O759342MINT-7947479
    BCLAF1Q9NYF82MINT-7947479
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRD8Q9H0E92MINT-7947479
    BTAF1O149812MINT-7947479
    BUB1O436832MINT-7947479
    BUB1BO605662MINT-7947479
    BUB3O436842MINT-7947479
    BZW1Q7L1Q62MINT-7947479
    C22orf28Q9Y3I02MINT-7947479
    C7orf13Q8NI282MINT-7947479
    CAPGP401212MINT-7947479
    CAPN6Q9Y6Q12MINT-4054731
    CAPZA1P529072MINT-7947479
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCT7Q998322MINT-7947479
    CDC16Q130422MINT-7947479
    CDC20Q128342MINT-7947479
    CDC23Q9UJX22MINT-7947479
    CDC27P302602MINT-7947479
    CDC73Q6P1J92MINT-7947479
    CDK9P507502MINT-7947479
    CDKN2AIPQ9NXV62MINT-7947479
    CHD1LQ86WJ12MINT-7947479
    CHD8Q9HCK82MINT-7947479
    CHEK1O147572MINT-7947479
    CKAP5Q140082MINT-7947479
    CKMT1AP125322MINT-4054731
    CKMT1BP125322MINT-4054731
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPAP536212MINT-7947479
    COPB1P536182MINT-7947479
    COPB2P356062MINT-7947479
    COPG1Q9Y6782MINT-7947479
    COPG2Q9UBF22MINT-7947479
    COPS5Q929052MINT-7947479
    CPSF2Q9P2I02MINT-7947479
    CPSF3Q9UKF62MINT-7947479
    CPSF7Q8N6842MINT-7947479
    CSE1LP550602MINT-7947479
    CSTF3Q129962MINT-7947479
    CTNND1O607162MINT-7947479
    CTSGP083112MINT-4054731
    CUL1Q136162MINT-7947479
    CWC15Q9P0132MINT-7947479
    CYP11A1P051082MINT-4054731
    CYP19A1P115112MINT-4054731
    DCTN2Q135612MINT-7947479
    DDB1Q165312MINT-7947479
    DDOSTP396562MINT-4054731
    DDX17Q928412MINT-7947479
    DDX19AQ9NUU72MINT-7947479
    DDX19BQ9UMR22MINT-7947479
    DDX39AO001482MINT-7947479
    DDX39BQ138382MINT-7947479
    DDX3XO005712MINT-7947479
    DDX41Q9UJV92MINT-7947479
    DDX42Q86XP32MINT-7947479
    DDX47Q9H0S42MINT-7947479
    DDX5P178442MINT-7947479
    DDX6P261962MINT-7947479
    DEPDC7Q96QD52MINT-7947479
    DFNA5O604432MINT-7947479
    DIAPH1O606102MINT-7947479
    DIDO1Q9BTC02MINT-7947479
    DLSTP369572MINT-4054731
    DMAP1Q9NPF52MINT-7947479
    DNM1LO004292MINT-7947479
    DNM2P505702MINT-7947479
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DRG1Q9Y2952MINT-7947479
    DSPP159242MINT-7947479
    DTYMKP239192MINT-7947479
    DYNC1H1Q142042MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    DYNC1LI2O432372MINT-7947479
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEF1A1P681042MINT-7947479
    EFTUD2Q150292MINT-7947479
    EHD1Q9H4M92MINT-7947479
    EHD4Q9H2232MINT-7947479
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S3P410912MINT-7947479
    EIF3BP558842MINT-7947479
    EIF3GO758212MINT-7947479
    EIF3IQ133472MINT-7947479
    EIF4A1P608422MINT-7947479
    EIF4A2Q142402MINT-7947479
    EIF4A3P389192MINT-7947479
    EIF4G2P783442MINT-7947479
    EIF5BO608412MINT-7947479
    ELAVL1Q157172MINT-7947479
    ELF2Q157232MINT-7947479
    ENAHQ8N8S72MINT-7947479
    ENSG00000266714Q96JP22MINT-7947479
    EPB41L3Q9Y2J22MINT-7947479
    EPPK1P581072MINT-7947479
    EPS8L2Q9H6S32MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    ETF1P624952MINT-7947479
    ETV6P412122MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC2Q96KP12MINT-7947479
    EXOC4Q96A652MINT-7947479
    EXOC5O004712MINT-7947479
    EXOC7Q9UPT52MINT-7947479
    EXOSC10Q017802MINT-7947479
    FAF1Q9UNN52MINT-7947479
    FAM129BQ96TA12MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FANCIQ9NVI12MINT-7947479
    FASNP493272MINT-7947479
    FEN1P397482MINT-7947479
    FERMT1Q9BQL62MINT-7947479
    FHOD1Q9Y6132MINT-7947479
    FUSP356372MINT-7947479
    GAPDHP044062MINT-7386590
    GATAD2AQ86YP42MINT-7947479
    GBAP040622MINT-4054731
    GCN1L1Q926162MINT-7947479
    GEMIN4P576782MINT-7947479
    GEMIN6Q8WXD52MINT-7947479
    GLB1P162782MINT-4054731
    GMPSP499152MINT-7947479
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GTF2IP783472MINT-7947479
    GTF3C2Q8WUA42MINT-7947479
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GULP1Q9UBP92MINT-7947479
    GUSBP082362MINT-4054731
    HAUS7Q998712MINT-7947479
    HBS1LQ9Y4502MINT-7947479
    HDAC1Q135472MINT-7947479
    HDAC2Q927692MINT-7947479
    HDLBPQ003412MINT-7947479
    HELLSQ9NRZ92MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIP1RO751462MINT-7947479
    HIRAP541982MINT-7947479
    HLTFQ145272MINT-7947479
    HNRNPA2B1P226262MINT-7947479
    HNRNPCP079102MINT-7947479
    HNRNPFP525972MINT-7947479
    HNRNPH1P319432MINT-7947479
    HNRNPKP619782MINT-7947479
    HNRNPMP522722MINT-7947479
    HNRNPUQ008392MINT-7947479
    HSP90B1P146252MINT-7947479
    HSPA12AO433012MINT-7947479
    HSPA6P170662MINT-7947479
    HSPB1P047922MINT-7947479
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF2Q129052MINT-7947479
    INTS1Q8N2012MINT-7947479
    INTS3Q68E012MINT-7947479
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO5O004102MINT-7947479
    IPO7O953732MINT-7947479
    IPO9Q96P702MINT-7947479
    IQGAP1P469402MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KDM1AO603412MINT-7947479
    KHDRBS1Q076662MINT-7947479
    KIF11P527322MINT-7947479
    KIF21AQ7Z4S62MINT-7947479
    KIF2CQ996612MINT-7947479
    KIF4AO952392MINT-7947479
    KPNA2P522922MINT-7947479
    LAS1LQ9Y4W22MINT-7947479
    LENG9Q96B702MINT-7947479
    LIMS1P480592MINT-7947479
    LMNAP025452MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC40Q9H9A62MINT-7947479
    LRWD1Q9UFC02MINT-7947479
    MAD1L1Q9Y6D92MINT-7947479
    MAGEE2Q8TD902MINT-7947479
    MAOAP213972MINT-4054731
    MAP2K4P459852MINT-7947479
    MAP2K7O147332MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MATR3P432432MINT-7947479
    MDN1Q9NU222MINT-7947479
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MED4Q9NPJ62MINT-7947479
    MELKQ146802MINT-7947479
    MPOP051642MINT-4054731
    MPP2Q141682MINT-7947479
    MRE11AP499592MINT-7947479
    MSH2P432462MINT-7947479
    MSH6P527012MINT-7947479
    MTA2O947762MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MVPQ147642MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH9P355792MINT-7947479
    MYO15BQ96JP22MINT-7947479
    NACC1Q96RE72MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NBNO609342MINT-7947479
    NCAPD2Q150212MINT-7947479
    NCAPHQ150032MINT-7947479
    NCOR1O753762MINT-7947479
    NDC80O147772MINT-7947479
    NELFBQ8WX922MINT-7947479
    NF1P213592MINT-7947479
    NIPBLQ6KC792MINT-7947479
    NONOQ152332MINT-7947479
    NPM1P067482MINT-7947479
    NRG1Q022972MINT-7947479
    NSUN5Q96P112MINT-7947479
    NUDCQ9Y2662MINT-7947479
    NUDT21O438092MINT-7947479
    NUF2Q9BZD42MINT-7947479
    NUP107P577402MINT-7947479
    NUP155O756942MINT-7947479
    NUP93Q8N1F72MINT-7947479
    ORC2Q134162MINT-7947479
    ORC3Q9UBD52MINT-7947479
    OXSR1O957472MINT-7947479
    PAK4O960132MINT-7947479
    PARVAQ9NVD72MINT-7947479
    PARVBQ9HBI12MINT-7947479
    PCBP1Q153652MINT-7947479
    PCBP2Q153662MINT-7947479
    PCNTO956132MINT-7947479
    PDLIM7Q9NR122MINT-7947479
    PELOQ9BRX22MINT-7947479
    PFKMP082372MINT-7947479
    PFKPQ018132MINT-7947479
    PHGDHO431752MINT-7947479
    PICALMQ134922MINT-7947479
    PKN2Q165132MINT-7947479
    PLECQ151492MINT-7947479
    PLK1P533502MINT-7947479
    PLRG1O436602MINT-7947479
    PNNQ9H3072MINT-7947479
    POLD1P283402MINT-7947479
    POLR1CO151602MINT-7947479
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP1CAP621362MINT-7947479
    PPP2R1AP301532MINT-7947479
    PRCCQ927332MINT-7947479
    PRKDCP785272MINT-7947479
    PRPF19Q9UMS42MINT-7947479
    PRPF3O433952MINT-7947479
    PRPF4BQ135232MINT-7947479
    PRPF6O949062MINT-7947479
    PRPF8Q6P2Q92MINT-7947479
    PRTN3P241582MINT-4054731
    PSMC1P621912MINT-7947479
    PSMC2P359982MINT-7947479
    PSMC4P436862MINT-7947479
    PSMC5P621952MINT-7947479
    PSMC6P623332MINT-7947479
    PSMD1Q994602MINT-7947479
    PSMD12O002322MINT-7947479
    PSMD13Q9UNM62MINT-7947479
    PSMD3O432422MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP1P265992MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUM1Q146712MINT-7947479
    RACGAP1Q9H0H52MINT-7947479
    RAD18Q9NS912MINT-7947479
    RALYQ9UKM92MINT-7947479
    RANBP2P497922MINT-7947479
    RANGAP1P460602MINT-7947479
    RAVER1Q8IY672MINT-7947479
    RBBP4Q090282MINT-7947479
    RBBP5Q152912MINT-7947479
    RBBP7Q165762MINT-7947479
    RBM17Q96I252MINT-7947479
    RBM39Q144982MINT-7947479
    RBM4Q9BWF32MINT-7947479
    RBM45Q8IUH32MINT-7947479
    RBM7Q9Y5802MINT-7947479
    RBMXP381592MINT-7947479
    RCOR1Q9UKL02MINT-7947479
    RFC2P352502MINT-7947479
    RFC3P409382MINT-7947479
    RFC4P352492MINT-7947479
    RFC5P409372MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RIF1Q5UIP02MINT-7947479
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    ROCK2O751162MINT-7947479
    RPL13P263732MINT-7947479
    RPL22P352682MINT-7947479
    RPL24P837312MINT-7947479
    RPL31P628992MINT-7947479
    RPS13P622772MINT-7947479
    RPS6KA4O756762MINT-7947479
    RPS6KB2Q9UBS02MINT-7947479
    RUVBL1Q9Y2652MINT-7947479
    RUVBL2Q9Y2302MINT-7947479
    RXRBP287022MINT-7947479
    SART1O432902MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCARB2Q141082MINT-4054731
    SCRIBQ141602MINT-7947479
    SCYL2Q6P3W72MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC24CP539922MINT-7947479
    SENP3Q9H4L42MINT-7947479
    SEPT9Q9UHD82MINT-7947479
    SETXQ7Z3332MINT-7947479
    SF3A1Q154592MINT-7947479
    SF3A2Q154282MINT-7947479
    SF3A3Q128742MINT-7947479
    SF3B1O755332MINT-7947479
    SF3B14Q9Y3B42MINT-7947479
    SF3B2Q134352MINT-7947479
    SF3B3Q153932MINT-7947479
    SFPQP232462MINT-7947479
    SHC1P293532MINT-7947479
    SHROOM3Q8TF722MINT-7947479
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SLC25A5P051412MINT-4054731
    SLC25A6P122362MINT-4054731
    SMARCA5O602642MINT-7947479
    SMARCAD1Q9H4L72MINT-7947479
    SMARCB1Q128242MINT-7947479
    SMARCC1Q929222MINT-7947479
    SMARCC2Q8TAQ22MINT-7947479
    SMARCD1Q96GM52MINT-7947479
    SMARCE1Q969G32MINT-7947479
    SMC1AQ146832MINT-7947479
    SMC2O953472MINT-7947479
    SMC3Q9UQE72MINT-7947479
    SMC4Q9NTJ32MINT-7947479
    SMCHD1A6NHR92MINT-7947479
    SNAPC4Q5SXM22MINT-7947479
    SNRNP200O756432MINT-7947479
    SNRNP40Q96DI72MINT-7947479
    SNRNP70P086212MINT-7947479
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPD1P623142MINT-7947479
    SNRPD3P623182MINT-7947479
    SNRPEP623042MINT-7947479
    SNW1Q135732MINT-7947479
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SOGA2Q9Y4B52MINT-7947479
    SPATA5Q8NB902MINT-7947479
    SPENQ96T582MINT-7947479
    SPTAN1Q138132MINT-7947479
    SPTBN1Q010822MINT-7947479
    SREK1Q8WXA92MINT-7947479
    SRP54P610112MINT-7947479
    SRP68Q9UHB92MINT-7947479
    SRP72O760942MINT-7947479
    SRRM1Q8IYB32MINT-7947479
    SRSF1Q079552MINT-7947479
    SRSF4Q081702MINT-7947479
    SRSF7Q166292MINT-7947479
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    STSP088422MINT-4054731
    SUGT1Q9Y2Z02MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SYMPKQ927972MINT-7947479
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TANC2Q9HCD62MINT-7947479
    TARDBPQ131482MINT-7947479
    TBL1XR1Q9BZK72MINT-7947479
    TCP1P179872MINT-7947479
    THAP1Q9NVV92MINT-7947479
    THRAP3Q9Y2W12MINT-7947479
    TIAL1Q010852MINT-7947479
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TMPOP421662MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TNPO1Q929732MINT-7947479
    TPP1O147732MINT-4054731
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRAP1Q129312MINT-7947479
    TRIM21P194742MINT-7947479
    TRIM28Q132632MINT-7947479
    TRIP13Q156452MINT-7947479
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TRUB1Q8WWH52MINT-7947479
    TSG101Q998162MINT-7947479
    TUBA1CQ9BQE32MINT-7947479
    TUBBP074372MINT-7947479
    TUBB4BP683712MINT-7947479
    TUBG1P232582MINT-7947479
    TUBGCP2Q9BSJ22MINT-7947479
    TUBGCP3Q96CW52MINT-7947479
    TUBGCP4Q9UGJ12MINT-7947479
    TWF1Q127922MINT-7947479
    U2AF1Q010812MINT-7947479
    U2AF2P263682MINT-7947479
    U2SURPO150422MINT-7947479
    UBE2MP610812MINT-7947479
    UBE2NP610882MINT-7947479
    UBE2SQ167632MINT-7947479
    UBL4AP114412MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UCHL5Q9Y5K52MINT-7947479
    UMPSP111722MINT-7947479
    UNC45AQ9H3U12MINT-7947479
    UPF1Q929002MINT-7947479
    UPF2Q9HAU52MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP39Q53GS92MINT-7947479
    VDAC1P217962MINT-4054731
    VIMP086702MINT-7947479
    VPS33AQ96AX12MINT-7947479
    VPS33BQ9H2672MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    WDR18Q9BV382MINT-7947479
    WDR33Q9C0J82MINT-7947479
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    XRN2Q9H0D62MINT-7947479
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF638Q149662MINT-7947479
    ALDOAENSP000003369274STRING: ENSP00000336927
    ALDOBENSP000003639884STRING: ENSP00000363988
    ALDOCENSP000002262534STRING: ENSP00000226253
    MAXENSP000003514904STRING: ENSP00000351490
    MYCENSP000003672074STRING: ENSP00000367207
    TPI1ENSP000003799334STRING: ENSP00000379933
    APOA1BPENSP000003572184STRING: ENSP00000357218
    CARKDENSP000003119844STRING: ENSP00000311984
    DERAENSP000004165834STRING: ENSP00000416583
    GPIENSP000003488774STRING: ENSP00000348877
    TALDO1ENSP000003212594STRING: ENSP00000321259
    TKTENSP000004054554STRING: ENSP00000405455
    TKTL1ENSP000003589314STRING: ENSP00000358931
    TKTL2ENSP000002806054STRING: ENSP00000280605
    EP300ENSP000002632534STRING: ENSP00000263253
    PARK2ENSP000003558654STRING: ENSP00000355865
    TP53ENSP000002693054STRING: ENSP00000269305
    SMG1ENSP000004025154STRING: ENSP00000402515
    S100A4ENSP000003462944STRING: ENSP00000346294
    IQCB1ENSP000003115054STRING: ENSP00000311505
    ATF2ENSP000002641104STRING: ENSP00000264110
    POLR2GENSP000003017884STRING: ENSP00000301788
    KNCNENSP000003796074STRING: ENSP00000379607
    ACDENSP000003774964STRING: ENSP00000377496
    POT1ENSP000003502494STRING: ENSP00000350249
    TERF1ENSP000002766034STRING: ENSP00000276603
    TINF2ENSP000002674154STRING: ENSP00000267415
    GAPDHSENSP000002222864STRING: ENSP00000222286
    SIRT2ENSP000002493964STRING: ENSP00000249396
    UBBENSP000003046974STRING: ENSP00000304697
    ABCE1ENSP000002965774STRING: ENSP00000296577
    CLPBENSP000002940534STRING: ENSP00000294053
    PKMENSP000003201714STRING: ENSP00000320171
    PGK2ENSP000003059954STRING: ENSP00000305995
    TXN2ENSP000002161854STRING: ENSP00000216185
    EIF2S1ENSP000002563834STRING: ENSP00000256383
    POLEENSP000003225704STRING: ENSP00000322570
    PKLRENSP000003399334STRING: ENSP00000339933
    RAE1ENSP000003602864STRING: ENSP00000360286
    CNR1ENSP000003585114STRING: ENSP00000358511
    POLA1ENSP000003683494STRING: ENSP00000368349
    SUMO2ENSP000004059654STRING: ENSP00000405965
    SUMO3ENSP000003303434STRING: ENSP00000330343
    SOD1ENSP000002701424STRING: ENSP00000270142
    SLC27A1ENSP000002525954STRING: ENSP00000252595
    MGMTENSP000003021114STRING: ENSP00000302111
    MAD2L1ENSP000002965094STRING: ENSP00000296509
    SRFENSP000002653544STRING: ENSP00000265354
    --Q6LET93, 2MINT-64630 I2D: score=1 
    --Q6LET93, 2MINT-64630 I2D: score=1 
    --C9JW422MINT-7947479
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ISS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006096glycolysis TAS--


    GAPDH for ontologies           About GeneDecksing



    Drugs & Compounds
    for GAPDH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GAPDH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for GAPDH

    Browse Tocris compounds for GAPDH

    6 HMDB Compounds for GAPDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    5 DrugBank Compounds for GAPDH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17508915 16898590 17194030 17031544
    Adenosine-5-Diphosphoribose-- --target--17139284 17016423 10592235
    Thionicotinamide-Adenine-Dinucleotide-- --target--17139284 17016423 10592235
    4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE-- --target--10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--10592235

    10/151 Novoseek chemical compound relationships for GAPDH gene (see all 151)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 98.9 2647 7534983 (7), 9264469 (7), 12882642 (5), 11371431 (4) (see all 99)
    actb 87.4 58 10378372 (3), 18191039 (2), 18317805 (2), 20113474 (2) (see all 35)
    koningic acid 81.3 40 8439569 (4), 2226438 (4), 15788719 (4), 7902582 (3) (see all 8)
    1,3-bisphosphoglycerate 76.3 10 9308888 (2), 8075252 (1), 15950210 (1), 9369240 (1) (see all 7)
    nad+ 72.4 72 7639707 (5), 9354374 (4), 7540026 (3), 7531693 (3) (see all 36)
    cgp-3466 68.1 1 10617673 (1)
    3-phosphoglycerate 66.4 24 2390992 (2), 8075252 (2), 15564524 (2), 18416820 (1) (see all 14)
    pssg 61.7 1 12958160 (1)
    nadh 59.7 51 10391884 (6), 8912669 (4), 16444750 (3), 12893257 (2) (see all 29)
    vtcs 59.7 6 16473604 (1), 15485821 (1), 16452474 (1)

    Search CenterWatch for drugs/clinical trials and news about GAPDH / G3P 

    Transcripts
    for GAPDH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GAPDH gene (2 alternative transcripts): 
    NM_001256799.1  NM_002046.4  

    Unigene Clusters for GAPDH:

    Glyceraldehyde-3-phosphate dehydrogenase
    Hs.544577  [show with all ESTs], Hs.592355  [show with all ESTs], Hs.598320  [show with all ESTs]
    Unigene Representative Sequences: BF983396, CV357503, BQ067557
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229239(uc001qop.1) ENST00000496049 ENST00000396856 ENST00000492719
    ENST00000396861 ENST00000474249 ENST00000466588 ENST00000396859 ENST00000466525
    ENST00000460556 ENST00000396858

    miRNA
    Products:             		 OriGene 3'-UTR Clone: GAPDH
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAPDH
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GAPDH:
    hsa-miR-185* hsa-miR-4302 hsa-miR-323-5p
    SwitchGear 3'UTR luciferase reporter plasmid: GAPDH 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAPDH (see all 7)
    OriGene shRNA RFP: GAPDH
    OriGene siRNA: GAPDH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAPDH
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAPDH (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAPDH
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GAPDH (NM_002046)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAPDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAPDH 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAPDH
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GAPDH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAPDH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAPDH

    Additional cDNA sequence: AJ844645.1 

    24/307 DOTS entries (see all 307):

    DT.97869929  DT.100749347  DT.95375100  DT.100749258  DT.97869918  DT.92476260  DT.102841638  DT.92475902 
    DT.95375081  DT.95375098  DT.100749097  DT.100865568  DT.95326333  DT.87000287  DT.100749022  DT.91832908 
    DT.100830267  DT.100749019  DT.100749379  DT.100749245  DT.95375056  DT.92476269  DT.100749358  DT.100749129 

    24/65 AceView cDNA sequences (see all 65):

    CR606580 CR593185 CR591106 CR617884 CR626004 CR590910 CR596322 CR598463 
    M36164 CR602482 CR611578 CR598048 CR612181 CR621806 CR591732 CR616330 
    CR616023 CR594204 CR590092 CR598400 CR616276 CR597330 CR599926 CR608433 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GAPDH (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9
    SP1:                                                                                                            
    SP2:                    -                                                                                       
    SP3:                                -     -     -                                                               
    SP4:                                                        -     -     -                                       
    SP5:                                                        -                                                   


    ECgene alternative splicing isoforms for GAPDH

    Expression
    for GAPDH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAPDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACCATCAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GAPDH expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive ErythrocytesBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GAPDH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAPDH

    SOURCE GeneReport for Unigene clusters: Hs.544577 Hs.592355 Hs.598320
        SABiosciences Expression via Pathway-Focused PCR Arrays including GAPDH (see all 148): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
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    Orthologs
    for GAPDH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for GAPDH gene from 10/43 species (see all 43)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GAPDH1 glyceraldehyde-3-phosphate dehydrogenase 83.73(n)
    92.17(a)    		   374193  NM_204305.1  NP_989636.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GAPDH6
    		 --
    		 89(a)
    		 1 ↔ 1
    		 GL343381.1(640486-654220)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC043972.12   -- 81.89(n)    BC043972.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BI896468.12   -- 80.47(n)   326976  BI896468.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gapdh11 Glyceraldehyde 3 phosphate dehydrogenase 1 72.42(n)
    76.67(a)    		   35728  NM_080369.2  NP_525108.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea gpd-21 Protein GPD-2 70.86(n)
    76.35(a)    		   3565504  NM_076134.4  NP_508535.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TDH1(YJL052W)4
    TDH31    		 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, more4
    Tdh3p1    		 62.11(n)1
    65.05(a)1    		   10(338271-339269)4
    8531061  NP_011708.31  8533954 
     NP_012483.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GAPC6
    GAPC-26
    (see all 7)    		 glyceraldehyde 3-phosphate dehydrogenase
    (see all 7)    		 67(a)
    66(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 3(1080950-1083530)
    1(4608196-4610647)
    rice
    (Oryza sativa)    		 Liliopsida Os.227812 Oryza sativa (japonica cultivar-group) cultivar cpslo17 more 76.79(n)    AK062215.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria gapA6
    epd6
    		 D-erythrose 4-phosphate dehydrogenase
    		 66(a)
    35(a)
    		 1 ↔ many
    possible ortholog
    		 Chromosome(1860795-1861790)
    Chromosome(3070694-3071713)


    ENSEMBL Gene Tree for GAPDH (if available)
    TreeFam Gene Tree for GAPDH (if available) 

    Paralogs
    for GAPDH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAPDH gene
    GAPDHS2  
    3 SIMAP similar genes for GAPDH using alignment to 4 protein entries:     G3P_HUMAN (see all proteins):
    GAPD    GAPDHS    YA61

    GAPDH for paralogs           About GeneDecksing


    5/73 Pseudogenes.org Pseudogenes for GAPDH (see all 73)
    PGOHUM00000238364 PGOHUM00000238494 PGOHUM00000242403 PGOHUM00000251011 PGOHUM00000248389


    Genomic Variants
    for GAPDH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/180 NCBI SNPs in GAPDH are shown (see all 180)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs793136141,2
    		F,--6496028(+) GCAGGC/GGGGCT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs37593421,2
    		C,--6496126(+) GTGACC/TACACT 1 -- us2k10--------
    rs792644551,2
    		F,--6496169(+) CGTCAG/CTAGTG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs455409311,2
    		C,--6496183(+) CCTGGG/ACACTG 1 -- us2k11Minor allele frequency- A:0.01NS 154
    rs455091981,2
    		C,F,--6496203(+) TTTGCG/AGGGAG 1 -- us2k12Minor allele frequency- A:0.01NS WA 278
    rs455788411,2
    		C,F,--6496299(+) TCTCAA/GTGAGA 1 -- us2k12Minor allele frequency- G:0.02NS WA 282
    rs454595921,2
    		C,F,--6497230(+) TCCCCC/GTCAAG 2 -- us2k12Minor allele frequency- G:0.02NS WA 290
    rs456126311,2
    		C,F,--6497314(+) AGAGAT/GGCCAG 2 -- us2k12Minor allele frequency- G:0.06NS WA 290
    rs454619951,2
    		F--6497797(+) TTTTAC/TGGGCG 2 -- us2k11Minor allele frequency- T:0.01NS 176
    rs73072291,2
    		C,F,--6497847(+) TGAGCC/GTGGCG 2 -- us2k1 ut51 tfbs34Minor allele frequency- G:0.11NS WA 302

    HapMap Linkage Disequilibrium report for GAPDH (6643093 - 6647537 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for GAPDH
         2 CNVs: 3872 2967
         1 Indel: 33243

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    Disorders / Diseases
    for GAPDH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GAPDH for disorders           About GeneDecksing

    OMIM gene information: 138400    OMIM disorders: --

    20/168 diseases for GAPDH (see all 168):    About MalaCards
    open-angle glaucoma    acth-secreting pituitary adenoma    dentatorubral-pallidoluysian atrophy    growth hormone secreting pituitary adenoma
    diffuse large b-cell lymphoma    primary open angle glaucoma    osteochondritis dissecans    parainfluenza virus type 3
    retinol binding protein    maturity-onset diabetes of the young    inclusion body myositis    pituitary adenoma
    plexiform neurofibroma    b-cell lymphomas    pre-eclampsia    functioning pituitary adenoma
    soft tissue sarcoma    type 2 diabetes mellitus    congestive heart failure    primary biliary cirrhosis

    1 disease from the University of Copenhagen DISEASES database for GAPDH:
    Cancer

    10/93 Novoseek disease relationships for GAPDH gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 40.6 21 12428732 (3), 11208907 (3), 15822178 (2), 17613523 (1) (see all 13)
    tumors 36.8 88 17597534 (3), 10897012 (3), 18629778 (3), 19144146 (3) (see all 55)
    disseminated candidiasis 28 1 10219595 (1)
    huntington disease 27.7 11 11208907 (4), 9779656 (2), 12428732 (1), 15486605 (1) (see all 7)
    trypanosomiasis african 25.8 8 7562915 (2), 7932587 (2), 19748525 (1), 9822549 (1)
    shock 25.8 29 12517784 (2), 15498039 (1), 17194899 (1), 12669348 (1) (see all 23)
    cancer 25.1 39 19161537 (3), 20044597 (3), 15079082 (2), 18651557 (2) (see all 22)
    hepatocellular carcinoma 24.4 10 19144146 (2), 8666326 (2), 9472111 (1)
    alzheimers disease 20.2 23 7891898 (2), 9779656 (2), 16186172 (2), 12503091 (2) (see all 16)
    leukemia 18.6 4 9794812 (2), 15854547 (1), 8834064 (1)

    Genetic Association Database (GAD): GAPDH
    Human Genome Epidemiology (HuGE) Navigator: GAPDH (11 documents)

    Export disorders for GAPDH gene to outside databases

    Publications
    for GAPDH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAPDH gene, integrated from 9 sources (see all 1109):
    (articles sorted by number of sources associating them with GAPDH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and complete sequence of a functional human glyceraldehyde- 3-phosphate dehydrogenase gene. (PubMed id 3170585)1, 2, 3 Ercolani L.... Alexander M. (1988)
    2. Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function. (PubMed id 12829261)1, 2, 9 Mazzola J.L. and Sirover M.A. (2003)
    3. Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16239728)1, 2, 9 Ismail S.A. and Park H.W. (2005)
    4. High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16510976)1, 2 Jenkins J.L. and Tanner J.J. (2006)
    5. The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. (PubMed id 16501887)1, 2 Bosch-Comas A....Marfany G. (2006)
    6. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975)1, 2 Wong J.J....Chin K.C. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    9. Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase. (PubMed id 15628863)1, 2 Wakasugi K....Morishima I. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for GAPDH gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GAPDH gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2597 HGNC: 4141 AceView: GAPD Ensembl:ENSG00000111640 euGenes: HUgn2597
    ECgene: GAPDH Kegg: 2597 H-InvDB: GAPDH

    Other Databases showing GAPDH gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GAPDH gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAPDH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAPDH Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gapd/
    Wikipedia http://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate_dehydrogenase

    Intellectual Property
    for GAPDH gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GAPDH gene:
    Search GeneIP for patents involving GAPDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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