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GAPDH Gene

protein-coding   GIFtS: 74
GCID: GC12P006643

Glyceraldehyde-3-Phosphate Dehydrogenase


(Previous symbol: GAPD)
  See GAPDH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glyceraldehyde-3-Phosphate Dehydrogenase1 2     HEL-S-162eP2
GAPD1 2 3 5     Aging-Associated Gene 9 Protein2
Peptidyl-Cysteine S-Nitrosylase GAPDH2 3     Epididymis Secretory Sperm Binding Protein Li 162eP2
EC 1.2.1.123 8     EC 2.6.99.-3
G3PD2     EC 1.2.18

External Ids:    HGNC: 41411   Entrez Gene: 25972   Ensembl: ENSG000001116407   OMIM: 1384005   UniProtKB: P044063   

Export aliases for GAPDH gene to outside databases

Previous GC identifer: GC12P006514


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GAPDH Gene:
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has
been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The
product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible
oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide
adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase
activity in the nucleus. Studies of a similar protein in mouse have assigned a variety of additional functions
including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin
receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human
genome. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for GAPDH Gene:
GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is a protein-coding gene. Diseases associated with GAPDH include plexiform neurofibroma, and turcot syndrome. GO annotations related to this gene include NADP binding and identical protein binding. An important paralog of this gene is GAPDHS.

UniProtKB/Swiss-Prot: G3P_HUMAN, P04406
Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in
glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA
transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that
mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the
organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane
associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity).
Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the
pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the
GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced
transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles
into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory
mRNAs (such as ceruplasmin) and suppresses their translation

Gene Wiki entry for GAPDH (Glyceraldehyde 3-phosphate dehydrogenase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GAPDH gene promoter:
         N-Myc   TBP   PPAR-gamma1   NF-1   p53   TFIID   PPAR-gamma2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GAPDH promoter sequence
   Search Chromatin IP Primers for GAPDH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAPDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

GAPDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAPDH gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006643:  view genomic region     (about GC identifiers)

Start:
6,643,093 bp from pter      End:
6,647,537 bp from pter
Size:
4,445 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 (See protein sequence)
Recommended Name: Glyceraldehyde-3-phosphate dehydrogenase  
Size: 335 amino acids; 36053 Da
Subunit: Homotetramer. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1;
leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH
and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1
with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS.
Component of the GAIT complex
4 PDB 3D structures from and Proteopedia for GAPDH:
1U8F (3D)        1ZNQ (3D)        2FEH (3D)        3GPD (3D)    
Secondary accessions: E7EUT4 P00354 Q53X65
Alternative splicing: 2 isoforms:  P04406-1   P04406-2   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for GAPDH: NX_P04406

Explore proteomics data for GAPDH at MOPED

Post-translational modifications: 

  • S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By
    similarity)1
  • ISGylated (Probable)1
  • Sulfhydration at Cys-152 increases catalytic activity (By similarity)1
  • Ubiquitination2 at Lys5, Lys61, Lys66, Lys84, Lys86, Lys107, Lys139, Lys145, Lys162, Lys186,
                                 Lys194, Lys215, Lys219, Lys227, Lys263, Lys334
  • Glycosylation2 at Asn149
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GAPDH (P04406) (see all 40)
     GVNHEKY  GKLVING  LAKVIHD  PELNGKL 


    See GAPDH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001243728.1  NP_001276674.1  NP_001276675.1  NP_002037.2  

    ENSEMBL proteins: 
     ENSP00000229239   ENSP00000380065   ENSP00000380070   ENSP00000380068   ENSP00000380067  
    Reactome Protein details: P04406

    GAPDH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GAPDH
    OriGene Protein Over-expression Lysate for GAPDH
    OriGene MassSpec for GAPDH
    OriGene Custom Protein Services for GAPDH
    GenScript Custom Purified and Recombinant Proteins Services for GAPDH
    Novus Biologicals GAPDH Proteins
    Novus Biologicals GAPDH Lysates
    Sino Biological Recombinant Protein for GAPDH
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GAPDH
    Cloud-Clone Corp. Proteins for GAPDH

     
    Search eBioscience for Proteins for GAPDH 

     
    antibodies-online proteins for GAPDH (42 products) 

     
    antibodies-online peptides for GAPDH

    GAPDH Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GAPDH
    R&D Systems Antibodies for GAPDH (GAPDH/G3PDH)
    Cell Signaling Technology (CST) Antibodies for GAPDH 
    OriGene Antibodies for GAPDH
    OriGene Custom Antibody Services for GAPDH
    Novus Biologicals GAPDH Antibodies
    Abcam antibodies for GAPDH
    Cloud-Clone Corp. Antibodies for GAPDH
    ThermoFisher Antibodies for GAPDH
    antibodies-online antibodies for GAPDH (539 products) 

    GAPDH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GAPDH
    R&D Systems ELISAs for GAPDH (GAPDH/G3PDH)
    GenScript Custom Assay Services for GAPDH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GAPDH
    Cloud-Clone Corp. CLIAs for GAPDH
    Search eBioscience for ELISAs for GAPDH 
    antibodies-online kits for GAPDH (41 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR020831 GlycerAld/Erythrose_P_DH
     IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
     IPR006424 Glyceraldehyde-3-P_DH_1
     IPR020830 GlycerAld_3-P_DH_AS
     IPR020829 GlycerAld_3-P_DH_cat

    Graphical View of Domain Structure for InterPro Entry P04406

    ProtoNet protein and cluster: P04406

    1 Blocks protein domain: IPB000173 Glyceraldehyde 3-phosphate dehydrogenase

    UniProtKB/Swiss-Prot: G3P_HUMAN, P04406
    Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family


    Find genes that share domains with GAPDH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: G3P_HUMAN, P04406
    Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in
    glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA
    transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that
    mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the
    organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane
    associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity).
    Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the
    pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the
    GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced
    transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles
    into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory
    mRNAs (such as ceruplasmin) and suppresses their translation
    Catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

         Enzyme Numbers (IUBMB): EC 1.2.1.121 2 EC 1.2.12 EC 2.6.99.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity NAS3170585
    GO:0005515protein binding IPI11724794
    GO:0008017microtubule binding ISS--
    GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ----
    GO:0035605peptidyl-cysteine S-nitrosylase activity ISS--
         
    Find genes that share ontologies with GAPDH           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for GAPDH:
     Increased S DNA content  Increased number of mitotic ce  Synthetic lethal with imatinib 

         7 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Gapdh):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  liver/biliary system 
     mortality/aging  renal/urinary system 

    Find genes that share phenotypes with GAPDH           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GAPDH

    miRNA
    Products:
        
    miRTarBase miRNAs that target GAPDH:
    hsa-mir-296-3p (MIRT038345), hsa-mir-17-3p (MIRT050751), hsa-mir-769-3p (MIRT039090), hsa-mir-1229-3p (MIRT036280), hsa-mir-29b-2-5p (MIRT038710), hsa-mir-501-5p (MIRT041139), hsa-mir-342-5p (MIRT038226), hsa-mir-92a-3p (MIRT049457), hsa-mir-766-3p (MIRT039028), hsa-mir-17-5p (MIRT050952), hsa-mir-96-5p (MIRT048718), hsa-let-7b-5p (MIRT052138), hsa-mir-484 (MIRT041819), hsa-mir-644a (MIRT007162), hsa-mir-106b-3p (MIRT038579), hsa-mir-615-3p (MIRT039782), hsa-mir-29c-3p (MIRT001929), hsa-mir-877-3p (MIRT036904), hsa-mir-423-5p (MIRT038105), hsa-mir-331-3p (MIRT043451), hsa-mir-324-3p (MIRT042878), hsa-mir-149-5p (MIRT045446), hsa-mir-25-3p (MIRT050206), hsa-mir-23b-3p (MIRT046276), hsa-mir-320a (MIRT044658), hsa-mir-93-5p (MIRT048761)

    Block miRNA regulation of human, mouse, rat GAPDH using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GAPDH:
    hsa-miR-185* hsa-miR-4302 hsa-miR-323-5p
    SwitchGear 3'UTR luciferase reporter plasmidGAPDH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GAPDH
    Predesigned siRNA for gene silencing in human, mouse, rat GAPDH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GAPDH

    Clone
    Products:
         
    OriGene clones in human, mouse for GAPDH (see all 9)
    OriGene ORF clones in mouse, rat for GAPDH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GAPDH (NM_002046)
    Sino Biological Human cDNA Clone for GAPDH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAPDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAPDH

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GAPDH
    Browse ESI BIO Cell Lines and PureStem Progenitors for GAPDH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    G3P_HUMAN, P04406: Cytoplasm, cytosol. Nucleus (By similarity). Cytoplasm, perinuclear region. Membrane.
    Cytoplasm, cytoskeleton (By similarity). Note=Translocates to the nucleus following S-nitrosylation and
    interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear
    regions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    cytoskeleton4
    nucleus4
    plasma membrane4
    chloroplast3
    endoplasmic reticulum2
    mitochondrion2
    peroxisome2
    golgi apparatus1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005811lipid particle IDA14741744
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with GAPDH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GAPDH About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and gluconeogenesis short map 0.60
    Glycolysis / Gluconeogenesis0.46
    Glycolysis and Gluconeogenesis0.60
    Glycolysis0.40
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Glucose metabolism
    Glucose metabolism0.44
    Gluconeogenesis0.44
    5Carbon metabolism
    Carbon metabolism0.38
    Biosynthesis of amino acids0.38


    Find genes that share SuperPaths with GAPDH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GAPDH
        Huntington's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for GAPDH
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for GAPDH
        Glycolysis and gluconeogenesis (short map)

    4 BioSystems Pathways for GAPDH
        SIDS Susceptibility Pathways
    Glycolysis and Gluconeogenesis
    Alzheimers Disease
    Validated targets of C-MYC transcriptional activation


    2 Reactome Pathways for GAPDH
        Gluconeogenesis
    Glycolysis


    Selected Kegg Pathways  (Kegg details for GAPDH) (see all 6):
        Glycolysis / Gluconeogenesis
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids
    HIF-1 signaling pathway

    UniProtKB/Swiss-Prot: G3P_HUMAN, P04406
    Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GAPDH (see all 148): 

              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GAPDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GAPDH (P044061, 2, 3 ENSP000002292394) via UniProtKB, MINT, STRING, and/or I2D (see all 988) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120041, 2, 3EBI-354056,EBI-358311 MINT-7995141 MINT-7995351 MINT-7995132 I2D: score=2 
    YWHAEP622582, 3, ENSP000002643354MINT-8256415 MINT-7947479 I2D: score=4 STRING: ENSP00000264335
    ACTBP607092, 3, ENSP000003499604MINT-7947479 MINT-4054731 I2D: score=3 STRING: ENSP00000349960
    HSP90AB1P082382, 3, ENSP000003258754MINT-72648 MINT-7947479 I2D: score=3 STRING: ENSP00000325875
    BIDP559572, 3, ENSP000003188224MINT-8249531 MINT-7947479 I2D: score=2 STRING: ENSP00000318822
    SMN1Q166372, 3MINT-7947479 MINT-8271168 I2D: score=2 
    SMN2Q166372, 3MINT-7947479 MINT-8271168 I2D: score=2 
    TBK1Q9UHD22, 3, ENSP000003299674MINT-49284 MINT-5208380 I2D: score=2 STRING: ENSP00000329967
    PRDX1Q068302, 3, ENSP000002627464MINT-64057 I2D: score=5 STRING: ENSP00000262746
    GAS7O608612, 3, ENSP000003226084MINT-72922 I2D: score=3 STRING: ENSP00000322608
    ACTC1P680322, 3, ENSP000002903784MINT-8256327 I2D: score=2 STRING: ENSP00000290378
    GOT2P005052, 3, ENSP000002452064MINT-8256338 I2D: score=2 STRING: ENSP00000245206
    KARSQ150462, 3, ENSP000003254484MINT-8256360 I2D: score=2 STRING: ENSP00000325448
    NFYCQ139522, 3, ENSP000003966204MINT-8256371 I2D: score=2 STRING: ENSP00000396620
    OSMRQ996502, 3, ENSP000002742764MINT-8256382 I2D: score=2 STRING: ENSP00000274276
    OSTF1Q928822, 3, ENSP000003408364MINT-8256393 I2D: score=2 STRING: ENSP00000340836
    TNFRSF1BP203332, 3, ENSP000003654354MINT-49454 I2D: score=2 STRING: ENSP00000365435
    TRAF1Q130772, 3, ENSP000003629944MINT-49528 I2D: score=2 STRING: ENSP00000362994
    GSSP486372, 3, ENSP000002169514MINT-6540721 I2D: score=1 STRING: ENSP00000216951
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    ARL15Q9NXU52, 3MINT-64612 I2D: score=5 
    BTBD2Q9BX702, 3MINT-65378 I2D: score=5 
    LAMTOR5O435042, 3MINT-63149 I2D: score=5 
    PAFAH1B3Q151022, 3MINT-64201 I2D: score=5 
    PCDHA4Q9UN742, 3MINT-65769 I2D: score=4 
    RPA2P159271, 3EBI-354056,EBI-621404 I2D: score=4 
    ANAPC2Q9UJX62, 3MINT-7947479 I2D: score=2 
    ANXA1P040832, 3MINT-8247797 I2D: score=2 
    ANXA7P200732, 3MINT-8248384 I2D: score=2 
    GADD45AP245222, 3MINT-8255816 I2D: score=2 
    GSK3BP498412, 3MINT-8257262 I2D: score=2 
    KCNE3Q9Y6H62, 3MINT-8259073 I2D: score=2 
    MAP3K14Q995582, 3MINT-48862 I2D: score=2 
    CCT2P783712, 3MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7947479 I2D: score=1 
    CCT4P509912, 3MINT-7947479 I2D: score=1 
    CCT5P486432, 3MINT-7947479 I2D: score=1 
    CCT8P509902, 3MINT-7947479 I2D: score=1 
    DNAJA1P316892, 3MINT-7947479 I2D: score=1 
    KPNB1Q149742, 3MINT-7947479 I2D: score=1 
    NSFP464592, 3MINT-7947479 I2D: score=1 
    PSMC3P179802, 3MINT-7947479 I2D: score=1 
    PSMD2Q132002, 3MINT-7947479 I2D: score=1 
    SEH1LQ96EE32, 3MINT-7947479 I2D: score=1 
    TLN1Q9Y4902, 3MINT-7947479 I2D: score=1 
    TUBA4AP683662, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    GAPDHP044061, 2EBI-354056,EBI-354056 MINT-7386590
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    ENSG00000237582Q018603I2D: score=1 
    POU5F1Q018603I2D: score=1 
    PGK1P005581, 2, 3, ENSP000003624134EBI-354056,EBI-709599 MINT-7386573 MINT-7386555 I2D: score=4 STRING: ENSP00000362413
    ATN1P542592, 3, ENSP000003490764MINT-2859138 MINT-2859119 I2D: score=2 STRING: ENSP00000349076
    TK1P041832, 3, ENSP000003016344MINT-63364 MINT-8273466 I2D: score=5 STRING: ENSP00000301634
    PSMD11O002312, 3, ENSP000002617124MINT-63022 MINT-7947479 I2D: score=5 STRING: ENSP00000261712
    CCNB1P146352, 3, ENSP000002564424MINT-7947479 I2D: score=1 STRING: ENSP00000256442
    SUMO1P631652, 3, ENSP000003760764MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    CDKN2AQ8N7263, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    EGFRP005331, 3, ENSP000002754934EBI-354056,EBI-297353 I2D: score=4 STRING: ENSP00000275493
    KAT5Q929932, 3, ENSP000003403304MINT-3980540 I2D: score=4 STRING: ENSP00000340330
    YWHAZP631042, 3, ENSP000003095034MINT-3304469 I2D: score=1 STRING: ENSP00000309503
    RBM5P527562, 3, ENSP000003430544MINT-8256404 I2D: score=2 STRING: ENSP00000343054
    RIPK2O433532, 3, ENSP000002207514MINT-49074 I2D: score=2 STRING: ENSP00000220751
    MAP3K3Q997592, 3, ENSP000003549274MINT-48508 I2D: score=2 STRING: ENSP00000354927
    HES1Q144692, 3, ENSP000002324244MINT-8256349 I2D: score=2 STRING: ENSP00000232424
    SERPINB9P504532, 3, ENSP000003700744MINT-63813 I2D: score=5 STRING: ENSP00000370074
    SNCAP378402, 3, ENSP000003383454MINT-8271839 I2D: score=2 STRING: ENSP00000338345
    HSPA8P111422, 3, ENSP000002273784MINT-7947479 I2D: score=1 STRING: ENSP00000227378
    CCT6AP402272, 3, ENSP000002756034MINT-7947479 I2D: score=2 STRING: ENSP00000275603
    HSP90AA1P079002, 3, ENSP000003351534MINT-7947479 I2D: score=3 STRING: ENSP00000335153
    HSPA5P110212, ENSP000003241734MINT-7947479 MINT-4054731 STRING: ENSP00000324173
    HTTP428583, ENSP000003471844I2D: score=3 STRING: ENSP00000347184
    PLD2O149393, ENSP000002630884I2D: score=3 STRING: ENSP00000263088
    PRKCIP417433, ENSP000002957974I2D: score=3 STRING: ENSP00000295797
    SIAH1Q8IUQ43, ENSP000003491564I2D: score=3 STRING: ENSP00000349156
    APPP050673, ENSP000002849814I2D: score=2 STRING: ENSP00000284981
    CAMK4Q165663, ENSP000002823564I2D: score=2 STRING: ENSP00000282356
    CDKN1AP389363, ENSP000002447414I2D: score=2 STRING: ENSP00000244741
    CHP1Q996533, ENSP000003356324I2D: score=2 STRING: ENSP00000335632
    KCNMA1Q127913, ENSP000002866274I2D: score=2 STRING: ENSP00000286627
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    PDIA2Q130873, ENSP000002194064I2D: score=2 STRING: ENSP00000219406
    QRICH2Q9H0J43, ENSP000002627654I2D: score=2 STRING: ENSP00000262765
    SLC2A1P111663, ENSP000004162934I2D: score=2 STRING: ENSP00000416293
    UBE2AP494593, ENSP000003606134I2D: score=2 STRING: ENSP00000360613
    DHRS2Q132683, ENSP000003446744I2D: score=1 STRING: ENSP00000344674
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    KIAA0368Q5VYK33, ENSP000002593354I2D: score=1 STRING: ENSP00000259335
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    NPEPPSP557863, ENSP000003203244I2D: score=1 STRING: ENSP00000320324
    PGAM2P152593, ENSP000002972834I2D: score=1 STRING: ENSP00000297283
    POU2F1P148593, ENSP000002714114I2D: score=1 STRING: ENSP00000271411
    PPIDQ087523, ENSP000003037544I2D: score=1 STRING: ENSP00000303754
    PPM1EQ8WY543, ENSP000003124114I2D: score=1 STRING: ENSP00000312411
    PPP2R2AP631513, ENSP000003701134I2D: score=1 STRING: ENSP00000370113
    PSMA3P257883, ENSP000002164554I2D: score=1 STRING: ENSP00000216455
    PSMD10O758323, ENSP000002179584I2D: score=1 STRING: ENSP00000217958
    RAD52P433513, ENSP000003512844I2D: score=1 STRING: ENSP00000351284
    RELQ048643, ENSP000002950254I2D: score=1 STRING: ENSP00000295025
    S100A6P067033, ENSP000003577084I2D: score=1 STRING: ENSP00000357708
    SUMO4Q6EEV63, ENSP000003186354I2D: score=1 STRING: ENSP00000318635
    TPPPO948113, ENSP000003537854I2D: score=1 STRING: ENSP00000353785
    YWHABP319463, ENSP000003001614I2D: score=1 STRING: ENSP00000300161
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    UBCP0CG483, ENSP000003448184I2D: score=3 STRING: ENSP00000344818
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    ATXN1P542533, ENSP000002447694I2D: score=3 STRING: ENSP00000244769
    BPGMP077383, ENSP000003420324I2D: score=2 STRING: ENSP00000342032
    CAMK1Q140123, ENSP000002564604I2D: score=2 STRING: ENSP00000256460
    CAMK2BQ135543, ENSP000002586824I2D: score=2 STRING: ENSP00000258682
    FKBP6O753443, ENSP000002520374I2D: score=1 STRING: ENSP00000252037
    GRM1Q132553, ENSP000002827534I2D: score=2 STRING: ENSP00000282753
    MCL1Q078202, ENSP000003580224MINT-7255781 STRING: ENSP00000358022
    PRKG1Q139763, ENSP000003630924I2D: score=1 STRING: ENSP00000363092
    RAB2AP610193, ENSP000002626464I2D: score=3 STRING: ENSP00000262646
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    CBLP226813, ENSP000002640334I2D: score=1 STRING: ENSP00000264033
    NPATQ142073, ENSP000002786124I2D: score=1 STRING: ENSP00000278612
    SETQ011053, ENSP000003617774I2D: score=2 STRING: ENSP00000361777
    STIP1P319483, ENSP000003059584I2D: score=2 STRING: ENSP00000305958
    USP25Q9UHP33, ENSP000002856794I2D: score=1 STRING: ENSP00000285679
    POU2F2P090863, ENSP000003739924I2D: score=1 STRING: ENSP00000373992
    PTK2Q053973, ENSP000003411894I2D: score=1 STRING: ENSP00000341189
    TXNP105993, ENSP000003636414I2D: score=3 STRING: ENSP00000363641
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    GPD1P216953, ENSP000003011494I2D: score=1 STRING: ENSP00000301149
    CASKO149363, ENSP000003674084I2D: score=4 STRING: ENSP00000367408
    SGK1O001413, ENSP000003568324I2D: score=1 STRING: ENSP00000356832
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    ENO3P139293, ENSP000003241054I2D: score=1 STRING: ENSP00000324105
    POLR1CO151602, ENSP000003614654MINT-7947479 STRING: ENSP00000361465
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    AKT1P317493, ENSP000002702024I2D: score=1 STRING: ENSP00000270202
    NUP93Q8N1F72, ENSP000003106684MINT-7947479 STRING: ENSP00000310668
    RAD50Q928782, ENSP000002653354MINT-7947479 STRING: ENSP00000265335
    SLC2A4P146723, ENSP000003209354I2D: score=3 STRING: ENSP00000320935
    MAPK13O152643, ENSP000002112874I2D: score=1 STRING: ENSP00000211287
    ACAT1P247523, ENSP000002658384I2D: score=1 STRING: ENSP00000265838
    PSEN1P497683, ENSP000003263664I2D: score=1 STRING: ENSP00000326366
    SIRT3Q9NTG73, ENSP000003721914I2D: score=1 STRING: ENSP00000372191
    POLR2BP308763, ENSP000003127354I2D: score=1 STRING: ENSP00000312735
    CSF1P096033, ENSP000003275134I2D: score=1 STRING: ENSP00000327513
    SLC27A2O149753, ENSP000002678424I2D: score=1 STRING: ENSP00000267842
    AHSA1O954333, ENSP000002164794I2D: score=1 STRING: ENSP00000216479
    ATG7O953523, ENSP000003464374I2D: score=1 STRING: ENSP00000346437
    HSP90B1P146252, ENSP000002997674MINT-7947479 STRING: ENSP00000299767
    SMARCA5O602642, ENSP000002831314MINT-7947479 STRING: ENSP00000283131
    CKMT1BP125322, ENSP000003002834MINT-4054731 STRING: ENSP00000300283
    EEF1A1P681042, ENSP000003300544MINT-7947479 STRING: ENSP00000330054
    HSPD1P108092MINT-7947479 MINT-4054731
    IRF3Q146532, ENSP000003101274MINT-5208380 STRING: ENSP00000310127
    MAP2K4P459852, ENSP000002624454MINT-7947479 STRING: ENSP00000262445
    PPP2R1AP301532, ENSP000003248044MINT-7947479 STRING: ENSP00000324804
    RPLP0P053882, ENSP000003390274MINT-7947479 STRING: ENSP00000339027
    DTNBO609413I2D: score=4 
    KPNA6O606843I2D: score=4 
    LAMA4Q163633I2D: score=4 
    MYO1EQ129653I2D: score=4 
    MYO1FO001603I2D: score=4 
    DYNLL1P631673I2D: score=3 
    HNF4GQ145413I2D: score=3 
    NR1H4Q96RI13I2D: score=3 
    OSBPP220593I2D: score=3 
    GABARAPO951663I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=2 
    MAP1LC3AQ9H4923I2D: score=2 
    MAP2K2P365073I2D: score=2 
    PAK2Q131773I2D: score=2 
    PDCD6IPQ8WUM43I2D: score=2 
    PRPF40AO754003I2D: score=2 
    SYNCRIPO605063I2D: score=2 
    ABCB7O750273I2D: score=1 
    ACSS1Q9NUB13I2D: score=1 
    ADAP008133I2D: score=1 
    AMBRA1Q9C0C73I2D: score=1 
    ARRB2P321213I2D: score=1 
    ATAD2Q6PL183I2D: score=1 
    ATG10Q9H0Y03I2D: score=1 
    ATG101Q9BSB43I2D: score=1 
    ATG12O948173I2D: score=1 
    ATG13O751433I2D: score=1 
    ATG14Q6ZNE53I2D: score=1 
    ATG16L1Q676U53I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    ATG3Q9NT623I2D: score=1 
    ATG4CQ96DT63I2D: score=1 
    ATG5Q9H1Y03I2D: score=1 
    BECN1Q144573I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    CAMPP499133I2D: score=1 
    CDC40O605083I2D: score=1 
    CDK1P064933I2D: score=1 
    CLN3Q132863I2D: score=1 
    CLPXO760313I2D: score=1 
    CNBPP626333I2D: score=1 
    COG3Q96JB23I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    DDIT3P356383I2D: score=1 
    DLG4P783523I2D: score=1 
    EIF1BO607393I2D: score=1 
    FA2HQ7L5A83I2D: score=1 
    FAHD1Q6P5873I2D: score=1 
    FAM63AQ8N5J23I2D: score=1 
    FOXO3O435243I2D: score=1 
    FYCO1Q9BQS83I2D: score=1 
    GABARAPL2P605203I2D: score=1 
    GBASO753233I2D: score=1 
    GLRX3O760033I2D: score=1 
    GOSR1O952493I2D: score=1 
    GRID2O434243I2D: score=1 
    GRIN2BQ132243I2D: score=1 
    HIF1AQ166653I2D: score=1 
    HPCAL1P372353I2D: score=1 
    IL7RP168713I2D: score=1 
    IPO4Q8TEX93I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=1 
    KDELR3O437313I2D: score=1 
    KLHDC10Q6PID83I2D: score=1 
    LSM14AQ8ND563I2D: score=1 
    MAP1LC3CQ9BXW43I2D: score=1 
    MDM2Q009873I2D: score=1 
    ME1P481633I2D: score=1 
    MLST8Q9BVC43I2D: score=1 
    NCALDP616013I2D: score=1 
    NEK9Q8TD193I2D: score=1 
    NFS1Q9Y6973I2D: score=1 
    NMD3Q96D463I2D: score=1 
    NRBF2Q96F243I2D: score=1 
    NSMAFQ926363I2D: score=1 
    NUDT2P505833I2D: score=1 
    PCDHA13Q9Y5I03I2D: score=1 
    PDPK1O155303I2D: score=1 
    PIK3C2AO004433I2D: score=1 
    PIK3C3Q8NEB93I2D: score=1 
    PIK3CGP487363I2D: score=1 
    PPP1CCP368733I2D: score=1 
    PPP5CP530413I2D: score=1 
    PRIM2P496433I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    PRKAA2P546463I2D: score=1 
    PRKAB1Q9Y4783I2D: score=1 
    PRKAB2O437413I2D: score=1 
    PRKAG1P546193I2D: score=1 
    PRKAG2Q9UGJ03I2D: score=1 
    PRKCEQ021563I2D: score=1 
    PSMD14O004873I2D: score=1 
    PSMD4P550363I2D: score=1 
    PXNP490233I2D: score=1 
    RAB24Q969Q53I2D: score=1 
    RABGAP1Q9Y3P93I2D: score=1 
    RB1CC1Q8TDY23I2D: score=1 
    RPF2Q9H7B23I2D: score=1 
    RPL37P619273I2D: score=1 
    SH3GLB1Q9Y3713I2D: score=1 
    SH3GLB2Q9NR463I2D: score=1 
    SLC35C2Q9NQQ73I2D: score=1 
    SLC35F5Q8WV833I2D: score=1 
    SQSTM1Q135013I2D: score=1 
    STK11Q158313I2D: score=1 
    STK4Q130433I2D: score=1 
    TIMM44O436153I2D: score=1 
    TRAF2Q129333I2D: score=1 
    ULK1O753853I2D: score=1 
    ULK2Q8IYT83I2D: score=1 
    UVRAGQ9P2Y53I2D: score=1 
    VCLP182063I2D: score=1 
    WDR45Q9Y4843I2D: score=1 
    WIPI1Q5MNZ93I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    XPO1O149803I2D: score=1 
    YME1L1Q96TA23I2D: score=1 
    A2MP010232MINT-4054731
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTL6AO960192MINT-7947479
    ACTR1AP611632MINT-7947479
    ACTR2P611602MINT-7947479
    ADNPQ9H2P02MINT-7947479
    AHNAKQ096662MINT-7947479
    AKAP8O438232MINT-7947479
    ALPPP051872MINT-4054731
    ANAPC1Q9H1A42MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANLNQ9NQW62MINT-7947479
    ANXA11P509952MINT-7947479
    AP1B1Q105672MINT-7947479
    APODP050902MINT-4054731
    ARCN1P484442MINT-7947479
    ARGLU1Q9NWB62MINT-7947479
    ARHGEF1Q928882MINT-7947479
    ARHGEF2Q929742MINT-7947479
    ARID1AO144972MINT-7947479
    ARL8BQ9NVJ22MINT-4054731
    ASAH1Q135102MINT-4054731
    ATP5A1P257052MINT-4054731
    ATP5BP065762MINT-4054731
    ATP6V0D1P614212MINT-4054731
    ATP6V1AP386062MINT-4054731
    AURKBQ96GD42MINT-7947479
    AZU1P201602MINT-4054731
    BAZ1AQ9NRL22MINT-7947479
    BCAS2O759342MINT-7947479
    BCLAF1Q9NYF82MINT-7947479
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRD8Q9H0E92MINT-7947479
    BTAF1O149812MINT-7947479
    BUB1O436832MINT-7947479
    BUB1BO605662MINT-7947479
    BUB3O436842MINT-7947479
    BZW1Q7L1Q62MINT-7947479
    C7orf13Q8NI282MINT-7947479
    CAPGP401212MINT-7947479
    CAPN6Q9Y6Q12MINT-4054731
    CAPZA1P529072MINT-7947479
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCT7Q998322MINT-7947479
    CDC16Q130422MINT-7947479
    CDC20Q128342MINT-7947479
    CDC23Q9UJX22MINT-7947479
    CDC27P302602MINT-7947479
    CDC73Q6P1J92MINT-7947479
    CDK9P507502MINT-7947479
    CDKN2AIPQ9NXV62MINT-7947479
    CHD1LQ86WJ12MINT-7947479
    CHD8Q9HCK82MINT-7947479
    CHEK1O147572MINT-7947479
    CKAP5Q140082MINT-7947479
    CKMT1AP125322MINT-4054731
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPAP536212MINT-7947479
    COPB1P536182MINT-7947479
    COPB2P356062MINT-7947479
    COPG1Q9Y6782MINT-7947479
    COPG2Q9UBF22MINT-7947479
    COPS5Q929052MINT-7947479
    CPSF2Q9P2I02MINT-7947479
    CPSF3Q9UKF62MINT-7947479
    CPSF7Q8N6842MINT-7947479
    CSE1LP550602MINT-7947479
    CSTF3Q129962MINT-7947479
    CTNND1O607162MINT-7947479
    CTSGP083112MINT-4054731
    CUL1Q136162MINT-7947479
    CWC15Q9P0132MINT-7947479
    CYP11A1P051082MINT-4054731
    CYP19A1P115112MINT-4054731
    DCTN2Q135612MINT-7947479
    DDB1Q165312MINT-7947479
    DDOSTP396562MINT-4054731
    DDX17Q928412MINT-7947479
    DDX19AQ9NUU72MINT-7947479
    DDX19BQ9UMR22MINT-7947479
    DDX39AO001482MINT-7947479
    DDX39BQ138382MINT-7947479
    DDX3XO005712MINT-7947479
    DDX41Q9UJV92MINT-7947479
    DDX42Q86XP32MINT-7947479
    DDX47Q9H0S42MINT-7947479
    DDX5P178442MINT-7947479
    DDX6P261962MINT-7947479
    DEPDC7Q96QD52MINT-7947479
    DFNA5O604432MINT-7947479
    DIAPH1O606102MINT-7947479
    DIDO1Q9BTC02MINT-7947479
    DLSTP369572MINT-4054731
    DMAP1Q9NPF52MINT-7947479
    DNM1LO004292MINT-7947479
    DNM2P505702MINT-7947479
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DRG1Q9Y2952MINT-7947479
    DSPP159242MINT-7947479
    DTYMKP239192MINT-7947479
    DYNC1H1Q142042MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    DYNC1LI2O432372MINT-7947479
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EFTUD2Q150292MINT-7947479
    EHD1Q9H4M92MINT-7947479
    EHD4Q9H2232MINT-7947479
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S3P410912MINT-7947479
    EIF3BP558842MINT-7947479
    EIF3GO758212MINT-7947479
    EIF3IQ133472MINT-7947479
    EIF4A1P608422MINT-7947479
    EIF4A2Q142402MINT-7947479
    EIF4A3P389192MINT-7947479
    EIF4G2P783442MINT-7947479
    EIF5BO608412MINT-7947479
    ELAVL1Q157172MINT-7947479
    ELF2Q157232MINT-7947479
    ENAHQ8N8S72MINT-7947479
    ENSG00000183311P074372MINT-7947479
    ENSG00000206289P287022MINT-7947479
    ENSG00000206490Q8NE712MINT-7947479
    ENSG00000215077P254402MINT-7947479
    ENSG00000215425Q138382MINT-7947479
    ENSG00000224156P074372MINT-7947479
    ENSG00000225073Q138382MINT-7947479
    ENSG00000225859Q138382MINT-7947479
    ENSG00000225989Q8NE712MINT-7947479
    ENSG00000227322P287022MINT-7947479
    ENSG00000227739P074372MINT-7947479
    ENSG00000228333P287022MINT-7947479
    ENSG00000229496Q138382MINT-7947479
    ENSG00000229684P074372MINT-7947479
    ENSG00000230624Q138382MINT-7947479
    ENSG00000231129Q8NE712MINT-7947479
    ENSG00000231321P287022MINT-7947479
    ENSG00000232169Q8NE712MINT-7947479
    ENSG00000232421P074372MINT-7947479
    ENSG00000232575P074372MINT-7947479
    ENSG00000234507P254402MINT-7947479
    ENSG00000234704P254402MINT-7947479
    ENSG00000235067P074372MINT-7947479
    ENSG00000235307P254402MINT-7947479
    ENSG00000235439Q138382MINT-7947479
    ENSG00000235712P287022MINT-7947479
    ENSG00000236149Q8NE712MINT-7947479
    ENSG00000236342Q8NE712MINT-7947479
    EPB41L3Q9Y2J22MINT-7947479
    EPPK1P581072MINT-7947479
    EPS8L2Q9H6S32MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    ETF1P624952MINT-7947479
    ETV6P412122MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC2Q96KP12MINT-7947479
    EXOC4Q96A652MINT-7947479
    EXOC5O004712MINT-7947479
    EXOC7Q9UPT52MINT-7947479
    EXOSC10Q017802MINT-7947479
    FAF1Q9UNN52MINT-7947479
    FAM129BQ96TA12MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FANCIQ9NVI12MINT-7947479
    FASNP493272MINT-7947479
    FEN1P397482MINT-7947479
    FERMT1Q9BQL62MINT-7947479
    FHOD1Q9Y6132MINT-7947479
    FUSP356372MINT-7947479
    GATAD2AQ86YP42MINT-7947479
    GBAP040622MINT-4054731
    GCN1L1Q926162MINT-7947479
    GEMIN4P576782MINT-7947479
    GEMIN6Q8WXD52MINT-7947479
    GLB1P162782MINT-4054731
    GMPSP499152MINT-7947479
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GTF2IP783472MINT-7947479
    GTF3C2Q8WUA42MINT-7947479
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GULP1Q9UBP92MINT-7947479
    GUSBP082362MINT-4054731
    HAUS7Q998712MINT-7947479
    HBS1LQ9Y4502MINT-7947479
    HDAC1Q135472MINT-7947479
    HDAC2Q927692MINT-7947479
    HDLBPQ003412MINT-7947479
    HELLSQ9NRZ92MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIP1RO751462MINT-7947479
    HIRAP541982MINT-7947479
    HLTFQ145272MINT-7947479
    HNRNPA2B1P226262MINT-7947479
    HNRNPCP079102MINT-7947479
    HNRNPFP525972MINT-7947479
    HNRNPH1P319432MINT-7947479
    HNRNPKP619782MINT-7947479
    HNRNPMP522722MINT-7947479
    HNRNPUQ008392MINT-7947479
    HSPA12AO433012MINT-7947479
    HSPA6P170662MINT-7947479
    HSPB1P047922MINT-7947479
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF2Q129052MINT-7947479
    INTS1Q8N2012MINT-7947479
    INTS3Q68E012MINT-7947479
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO5O004102MINT-7947479
    IPO7O953732MINT-7947479
    IPO9Q96P702MINT-7947479
    IQGAP1P469402MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KDM1AO603412MINT-7947479
    KHDRBS1Q076662MINT-7947479
    KIF11P527322MINT-7947479
    KIF21AQ7Z4S62MINT-7947479
    KIF2CQ996612MINT-7947479
    KIF4AO952392MINT-7947479
    KPNA2P522922MINT-7947479
    LAS1LQ9Y4W22MINT-7947479
    LENG9Q96B702MINT-7947479
    LIMS1P480592MINT-7947479
    LMNAP025452MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC40Q9H9A62MINT-7947479
    LRWD1Q9UFC02MINT-7947479
    MAD1L1Q9Y6D92MINT-7947479
    MAGEE2Q8TD902MINT-7947479
    MAOAP213972MINT-4054731
    MAP2K7O147332MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MATR3P432432MINT-7947479
    MDN1Q9NU222MINT-7947479
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MED4Q9NPJ62MINT-7947479
    MELKQ146802MINT-7947479
    MPOP051642MINT-4054731
    MPP2Q141682MINT-7947479
    MRE11AP499592MINT-7947479
    MSH2P432462MINT-7947479
    MSH6P527012MINT-7947479
    MTA2O947762MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MTCL1Q9Y4B52MINT-7947479
    MVPQ147642MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH9P355792MINT-7947479
    MYO15BQ96JP22MINT-7947479
    NACC1Q96RE72MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NBNO609342MINT-7947479
    NCAPD2Q150212MINT-7947479
    NCAPHQ150032MINT-7947479
    NCOR1O753762MINT-7947479
    NDC80O147772MINT-7947479
    NELFBQ8WX922MINT-7947479
    NF1P213592MINT-7947479
    NIPBLQ6KC792MINT-7947479
    NONOQ152332MINT-7947479
    NPM1P067482MINT-7947479
    NRG1Q022972MINT-7947479
    NSUN5Q96P112MINT-7947479
    NUDCQ9Y2662MINT-7947479
    NUDT21O438092MINT-7947479
    NUF2Q9BZD42MINT-7947479
    NUP107P577402MINT-7947479
    NUP155O756942MINT-7947479
    ORC2Q134162MINT-7947479
    ORC3Q9UBD52MINT-7947479
    OXSR1O957472MINT-7947479
    PAK4O960132MINT-7947479
    PARVAQ9NVD72MINT-7947479
    PARVBQ9HBI12MINT-7947479
    PCBP1Q153652MINT-7947479
    PCBP2Q153662MINT-7947479
    PCNTO956132MINT-7947479
    PDLIM7Q9NR122MINT-7947479
    PELOQ9BRX22MINT-7947479
    PFKMP082372MINT-7947479
    PFKPQ018132MINT-7947479
    PHGDHO431752MINT-7947479
    PICALMQ134922MINT-7947479
    PKN2Q165132MINT-7947479
    PLECQ151492MINT-7947479
    PLK1P533502MINT-7947479
    PLRG1O436602MINT-7947479
    PNNQ9H3072MINT-7947479
    POLD1P283402MINT-7947479
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP1CAP621362MINT-7947479
    PRCCQ927332MINT-7947479
    PRKDCP785272MINT-7947479
    PRPF19Q9UMS42MINT-7947479
    PRPF3O433952MINT-7947479
    PRPF4BQ135232MINT-7947479
    PRPF6O949062MINT-7947479
    PRPF8Q6P2Q92MINT-7947479
    PRTN3P241582MINT-4054731
    PSMC1P621912MINT-7947479
    PSMC2P359982MINT-7947479
    PSMC4P436862MINT-7947479
    PSMC5P621952MINT-7947479
    PSMC6P623332MINT-7947479
    PSMD1Q994602MINT-7947479
    PSMD12O002322MINT-7947479
    PSMD13Q9UNM62MINT-7947479
    PSMD3O432422MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP1P265992MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUM1Q146712MINT-7947479
    RACGAP1Q9H0H52MINT-7947479
    RAD18Q9NS912MINT-7947479
    RALYQ9UKM92MINT-7947479
    RANBP2P497922MINT-7947479
    RANGAP1P460602MINT-7947479
    RAVER1Q8IY672MINT-7947479
    RBBP4Q090282MINT-7947479
    RBBP5Q152912MINT-7947479
    RBBP7Q165762MINT-7947479
    RBM17Q96I252MINT-7947479
    RBM39Q144982MINT-7947479
    RBM4Q9BWF32MINT-7947479
    RBM45Q8IUH32MINT-7947479
    RBM7Q9Y5802MINT-7947479
    RBMXP381592MINT-7947479
    RCOR1Q9UKL02MINT-7947479
    RFC2P352502MINT-7947479
    RFC3P409382MINT-7947479
    RFC4P352492MINT-7947479
    RFC5P409372MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RIF1Q5UIP02MINT-7947479
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    ROCK2O751162MINT-7947479
    RPL13P263732MINT-7947479
    RPL22P352682MINT-7947479
    RPL24P837312MINT-7947479
    RPL31P628992MINT-7947479
    RPS13P622772MINT-7947479
    RPS6KA4O756762MINT-7947479
    RPS6KB2Q9UBS02MINT-7947479
    RTCBQ9Y3I02MINT-7947479
    RUVBL1Q9Y2652MINT-7947479
    RUVBL2Q9Y2302MINT-7947479
    RXRBP287022MINT-7947479
    SART1O432902MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCARB2Q141082MINT-4054731
    SCRIBQ141602MINT-7947479
    SCYL2Q6P3W72MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC24CP539922MINT-7947479
    SENP3Q9H4L42MINT-7947479
    SEPT9Q9UHD82MINT-7947479
    SETXQ7Z3332MINT-7947479
    SF3A1Q154592MINT-7947479
    SF3A2Q154282MINT-7947479
    SF3A3Q128742MINT-7947479
    SF3B1O755332MINT-7947479
    SF3B2Q134352MINT-7947479
    SF3B3Q153932MINT-7947479
    SF3B6Q9Y3B42MINT-7947479
    SFPQP232462MINT-7947479
    SHC1P293532MINT-7947479
    SHROOM3Q8TF722MINT-7947479
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SLC25A5P051412MINT-4054731
    SLC25A6P122362MINT-4054731
    SMARCAD1Q9H4L72MINT-7947479
    SMARCB1Q128242MINT-7947479
    SMARCC1Q929222MINT-7947479
    SMARCC2Q8TAQ22MINT-7947479
    SMARCD1Q96GM52MINT-7947479
    SMARCE1Q969G32MINT-7947479
    SMC1AQ146832MINT-7947479
    SMC2O953472MINT-7947479
    SMC3Q9UQE72MINT-7947479
    SMC4Q9NTJ32MINT-7947479
    SMCHD1A6NHR92MINT-7947479
    SNAPC4Q5SXM22MINT-7947479
    SNRNP200O756432MINT-7947479
    SNRNP40Q96DI72MINT-7947479
    SNRNP70P086212MINT-7947479
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPD1P623142MINT-7947479
    SNRPD3P623182MINT-7947479
    SNRPEP623042MINT-7947479
    SNW1Q135732MINT-7947479
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SPATA5Q8NB902MINT-7947479
    SPENQ96T582MINT-7947479
    SPTAN1Q138132MINT-7947479
    SPTBN1Q010822MINT-7947479
    SREK1Q8WXA92MINT-7947479
    SRP54P610112MINT-7947479
    SRP68Q9UHB92MINT-7947479
    SRP72O760942MINT-7947479
    SRRM1Q8IYB32MINT-7947479
    SRSF1Q079552MINT-7947479
    SRSF4Q081702MINT-7947479
    SRSF7Q166292MINT-7947479
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    STSP088422MINT-4054731
    SUGT1Q9Y2Z02MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SYMPKQ927972MINT-7947479
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TANC2Q9HCD62MINT-7947479
    TARDBPQ131482MINT-7947479
    TBL1XR1Q9BZK72MINT-7947479
    TCP1P179872MINT-7947479
    THAP1Q9NVV92MINT-7947479
    THRAP3Q9Y2W12MINT-7947479
    TIAL1Q010852MINT-7947479
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TMPOP421662MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TNPO1Q929732MINT-7947479
    TPP1O147732MINT-4054731
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRAP1Q129312MINT-7947479
    TRIM21P194742MINT-7947479
    TRIM28Q132632MINT-7947479
    TRIP13Q156452MINT-7947479
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TRUB1Q8WWH52MINT-7947479
    TSG101Q998162MINT-7947479
    TUBA1CQ9BQE32MINT-7947479
    TUBBP074372MINT-7947479
    TUBB4BP683712MINT-7947479
    TUBG1P232582MINT-7947479
    TUBGCP2Q9BSJ22MINT-7947479
    TUBGCP3Q96CW52MINT-7947479
    TUBGCP4Q9UGJ12MINT-7947479
    TWF1Q127922MINT-7947479
    U2AF1Q010812MINT-7947479
    U2AF2P263682MINT-7947479
    U2SURPO150422MINT-7947479
    UBE2MP610812MINT-7947479
    UBE2NP610882MINT-7947479
    UBE2SQ167632MINT-7947479
    UBL4AP114412MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UCHL5Q9Y5K52MINT-7947479
    UMPSP111722MINT-7947479
    UNC45AQ9H3U12MINT-7947479
    UPF1Q929002MINT-7947479
    UPF2Q9HAU52MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP39Q53GS92MINT-7947479
    VDAC1P217962MINT-4054731
    VIMP086702MINT-7947479
    VPS33AQ96AX12MINT-7947479
    VPS33BQ9H2672MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    WDR18Q9BV382MINT-7947479
    WDR33Q9C0J82MINT-7947479
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    XRN2Q9H0D62MINT-7947479
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF638Q149662MINT-7947479
    MAXENSP000003514904STRING: ENSP00000351490
    MYCENSP000003672074STRING: ENSP00000367207
    PGK2ENSP000003059954STRING: ENSP00000305995
    TPI1ENSP000003799334STRING: ENSP00000379933
    APOA1BPENSP000003572184STRING: ENSP00000357218
    CARKDENSP000003119844STRING: ENSP00000311984
    DERAENSP000004165834STRING: ENSP00000416583
    GPIENSP000003488774STRING: ENSP00000348877
    TALDO1ENSP000003212594STRING: ENSP00000321259
    TKTENSP000004054554STRING: ENSP00000405455
    TKTL1ENSP000003589314STRING: ENSP00000358931
    TKTL2ENSP000002806054STRING: ENSP00000280605
    EP300ENSP000002632534STRING: ENSP00000263253
    PARK2ENSP000003558654STRING: ENSP00000355865
    TP53ENSP000002693054STRING: ENSP00000269305
    SMG1ENSP000004025154STRING: ENSP00000402515
    S100A4ENSP000003462944STRING: ENSP00000346294
    IQCB1ENSP000003115054STRING: ENSP00000311505
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ISS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006096glycolytic process TAS--

    Find genes that share ontologies with GAPDH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GAPDH
      Browse compounds at ApexBio 

    Browse Tocris compounds for GAPDH (G3P)

    6 HMDB Compounds for GAPDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    5 DrugBank Compounds for GAPDH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17508915 16898590 17194030 17031544
    Adenosine-5-Diphosphoribose-- --target--17139284 17016423 10592235
    Thionicotinamide-Adenine-Dinucleotide-- --target--17139284 17016423 10592235
    4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE-- --target--10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--10592235

    Selected Novoseek inferred chemical compound relationships for GAPDH gene (see all 151)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 98.9 2647 7534983 (7), 9264469 (7), 12882642 (5), 11371431 (4) (see all 99)
    actb 87.4 58 10378372 (3), 18191039 (2), 18317805 (2), 20113474 (2) (see all 35)
    koningic acid 81.3 40 8439569 (4), 2226438 (4), 15788719 (4), 7902582 (3) (see all 8)
    1,3-bisphosphoglycerate 76.3 10 9308888 (2), 8075252 (1), 15950210 (1), 9369240 (1) (see all 7)
    nad+ 72.4 72 7639707 (5), 9354374 (4), 7540026 (3), 7531693 (3) (see all 36)
    cgp-3466 68.1 1 10617673 (1)
    3-phosphoglycerate 66.4 24 2390992 (2), 8075252 (2), 15564524 (2), 18416820 (1) (see all 14)
    pssg 61.7 1 12958160 (1)
    nadh 59.7 51 10391884 (6), 8912669 (4), 16444750 (3), 12893257 (2) (see all 29)
    vtcs 59.7 6 16473604 (1), 15485821 (1), 16452474 (1)



    Find genes that share compounds with GAPDH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GAPDH gene (4 alternative transcripts): 
    NM_001256799.2  NM_001289745.1  NM_001289746.1  NM_002046.5  

    Unigene Clusters for GAPDH:

    Glyceraldehyde-3-phosphate dehydrogenase
    Hs.544577  [show with all ESTs], Hs.592355  [show with all ESTs], Hs.598320  [show with all ESTs]
    Unigene Representative Sequences: BF983396, CV357503, BQ067557
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229239(uc001qop.1) ENST00000496049 ENST00000396856 ENST00000492719
    ENST00000396861 ENST00000474249 ENST00000466588 ENST00000396859 ENST00000466525
    ENST00000396858
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GAPDH using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GAPDH:
    hsa-miR-185* hsa-miR-4302 hsa-miR-323-5p
    SwitchGear 3'UTR luciferase reporter plasmidGAPDH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GAPDH
    Predesigned siRNA for gene silencing in human, mouse, rat GAPDH
    Clone
    Products:
         
    OriGene clones in human, mouse for GAPDH (see all 9)
    OriGene ORF clones in mouse, rat for GAPDH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GAPDH (NM_002046)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAPDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAPDH
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GAPDH
    OriGene qSTAR qPCR primer pairs in human, mouse for GAPDH
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GAPDH
      QuantiTect SYBR Green Assays in human, mouse, rat GAPDH
      QuantiFast Probe-based Assays in human, mouse, rat GAPDH

    Additional mRNA sequence: AJ844645.1 

    Selected DOTS entries (see all 307):

    DT.97869929  DT.100749347  DT.95375100  DT.100749258  DT.97869918  DT.92476260  DT.102841638  DT.92475902 
    DT.95375081  DT.95375098  DT.100749097  DT.100865568  DT.95326333  DT.87000287  DT.100749022  DT.91832908 
    DT.100830267  DT.100749019  DT.100749379  DT.100749245  DT.95375056  DT.92476269  DT.100749358  DT.100749129 

    Selected AceView cDNA sequences (see all 65):

    CR593979 CR601654 CR609914 CR602408 CR598336 CR616276 CR600683 CR614775 
    CR608954 CR619302 CR597106 CR602720 CR608433 CR600131 CR597330 CR599926 
    CR623498 CR593185 CR600937 CR622647 CR610903 CR594180 CR598463 CR594204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GAPDH (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9
    SP1:                                                                                                            
    SP2:                    -                                                                                       
    SP3:                                -     -     -                                                               
    SP4:                                                        -     -     -                                       
    SP5:                                                        -                                                   


    ECgene alternative splicing isoforms for GAPDH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GAPDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCATCAAT
    GAPDH Expression
    About this image


    GAPDH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    GAPDH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GAPDH Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.544577 Hs.592355 Hs.598320
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GAPDH (see all 148): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GAPDH gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gapdh1 , 5 glyceraldehyde-3-phosphate dehydrogenase1, 5 89.56(n)1
    94.28(a)1
      6 (59.32 cM)5
    144331  NM_008084.21  NP_032110.11 
     1251618535 
    chicken
    (Gallus gallus)
    Aves GAPDH1 glyceraldehyde-3-phosphate dehydrogenase 83.73(n)
    92.17(a)
      374193  NM_204305.1  NP_989636.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043972.12   -- 81.89(n)    BC043972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI896468.12   -- 80.47(n)   326976  BI896468.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gapdh11 Glyceraldehyde 3 phosphate dehydrogenase 1 72.42(n)
    76.67(a)
      35728  NM_080369.2  NP_525108.2 
    worm
    (Caenorhabditis elegans)
    Secernentea gpd-31 gpd-3 70.86(n)
    76.35(a)
      180601  NM_076133.5  NP_508534.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TDH1(YJL052W)4
    TDH31
    Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, more4
    TDH31
    62.11(n)1
    65.05(a)1
      10(338271-339269)4
    8531061  NP_011708.31  8533954 
     NP_012483.14 
    soybean
    (Glycine max)
    eudicotyledons Gma.55052 Transcribed sequence with strong similarity to protein more 73.78(n)    BI942637.1 
    rice
    (Oryza sativa)
    Liliopsida Os.227812 Oryza sativa (japonica cultivar-group) cultivar cpslo17 more 76.79(n)    AK062215.1 


    ENSEMBL Gene Tree for GAPDH (if available)
    TreeFam Gene Tree for GAPDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GAPDH gene
    GAPDHS2  
    3 SIMAP similar genes for GAPDH using alignment to 3 protein entries:     G3P_HUMAN (see all proteins):
    GAPD    GAPDHS    YA61

    Find genes that share paralogs with GAPDH           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for GAPDH (see all 73)
    PGOHUM00000238364 PGOHUM00000238494 PGOHUM00000242403 PGOHUM00000251011 PGOHUM00000248389


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GAPDH (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151241131,2
    C,F--6573065(+) CCCTCC/TAGCTC 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs793136141,2
    C,F--6573146(+) GCAGGC/GGGGCT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1830691691,2
    --6573227(+) GCTGTA/GAGCTG 1 -- us2k10--------
    rs37593421,2
    C--6573244(+) GTGACC/TACACT 1 -- us2k10--------
    rs792644551,2
    F--6573287(+) CGTCAG/CTAGTG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs455409311,2
    C,F--6573301(+) CCTGGG/ACACTG 1 -- us2k11Minor allele frequency- A:0.01NS 154
    rs1873675321,2
    --6573305(+) GGCACC/TGAGCT 1 -- us2k10--------
    rs455091981,2
    C,F--6573321(+) TTTGCG/AGGGAG 1 -- us2k12Minor allele frequency- A:0.01NS WA 278
    rs455788411,2
    C,F--6573417(+) TCTCAA/GTGAGA 1 -- us2k12Minor allele frequency- G:0.02NS WA 282
    rs1399033171,2
    --6573449(+) CAGGAA/GTAGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GAPDH (6643093 - 6647537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GAPDH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745477CNV Deletion23290073
    nsv8896CNV Gain18304495
    nsv826208CNV Gain20364138
    dgv453e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GAPDH
    DNA2.0 Custom Variant and Variant Library Synthesis for GAPDH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138400    OMIM disorders: --

    9 diseases for GAPDH:    
    About MalaCards
    plexiform neurofibroma    turcot syndrome    osteochondritis dissecans    diffuse large b-cell lymphoma
    pituitary adenoma    parainfluenza virus type 3    sleeping sickness    acth-secreting pituitary adenoma
    obesity

    3 diseases from the University of Copenhagen DISEASES database for GAPDH:
    Cancer     Vascular disease     Neurodegenerative disease

    Find genes that share disorders with GAPDH           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GAPDH gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 40.6 21 12428732 (3), 11208907 (3), 15822178 (2), 17613523 (1) (see all 13)
    tumors 36.8 88 17597534 (3), 10897012 (3), 18629778 (3), 19144146 (3) (see all 55)
    disseminated candidiasis 28 1 10219595 (1)
    huntington disease 27.7 11 11208907 (4), 9779656 (2), 12428732 (1), 15486605 (1) (see all 7)
    trypanosomiasis african 25.8 8 7562915 (2), 7932587 (2), 19748525 (1), 9822549 (1)
    shock 25.8 29 12517784 (2), 15498039 (1), 17194899 (1), 12669348 (1) (see all 23)
    cancer 25.1 39 19161537 (3), 20044597 (3), 15079082 (2), 18651557 (2) (see all 22)
    hepatocellular carcinoma 24.4 10 19144146 (2), 8666326 (2), 9472111 (1)
    alzheimers disease 20.2 23 7891898 (2), 9779656 (2), 16186172 (2), 12503091 (2) (see all 16)
    leukemia 18.6 4 9794812 (2), 15854547 (1), 8834064 (1)

    Genetic Association Database (GAD): GAPDH
    Human Genome Epidemiology (HuGE) Navigator: GAPDH (11 documents)

    Export disorders for GAPDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GAPDH gene, integrated from 10 sources (see all 1144):
    (articles sorted by number of sources associating them with GAPDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and complete sequence of a functional human glyceraldehyde- 3-phosphate dehydrogenase gene. (PubMed id 3170585)1, 2, 3 Ercolani L.... Alexander M. (J. Biol. Chem. 1988)
    2. Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function. (PubMed id 12829261)1, 2, 9 Mazzola J.L. and Sirover M.A. (Biochim. Biophys. Acta 2003)
    3. Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16239728)1, 2, 9 Ismail S.A. and Park H.W. (Acta Crystallogr. D 2005)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. (PubMed id 18340469)1, 4 Lee J.H....Mayeux R. (Neurogenetics 2008)
    6. High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16510976)1, 2 Jenkins J.L. and Tanner J.J. (Acta Crystallogr. D 2006)
    7. The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. (PubMed id 16501887)1, 2 Bosch-Comas A....Marfany G. (Cell. Mol. Life Sci. 2006)
    8. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975)1, 2 Wong J.J.... Chin K.C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2597 HGNC: 4141 AceView: GAPD Ensembl:ENSG00000111640 euGenes: HUgn2597
    ECgene: GAPDH Kegg: 2597 H-InvDB: GAPDH

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GAPDH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAPDH Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gapd/
    Wikipedia http://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate_dehydrogenase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GAPDH gene:
    Search GeneIP for patents involving GAPDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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