GAPDH Gene
protein-coding GIFtS : 74 GCID: GC12 P006643
glyceraldehyde-3-phosphate dehydrogenase GAPD )
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Aliasesfor GAPDH gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Glyceraldehyde-3-Phosphate Dehydrogenase 1 2 G3PD2 GAPD1 2 3 5 Aging-Associated Gene 9 Protein2 Peptidyl-Cysteine S-Nitrosylase GAPDH2 3 EC 2.6.99.-3 EC 1.2.1.123 8 EC 1.2.18
Export aliases for GAPDH gene to outside databases Previous GC identifer: GC12P006514
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Summariesfor GAPDH gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for GAPDH : The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2012) UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 Function : Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role inglycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation Gene Wiki entry for GAPDH (Glyceraldehyde 3-phosphate dehydrogenase)
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Genomic Viewsfor GAPDH gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009759.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the GAPDH gene promoter:N-Myc TBP PPAR-gamma1 NF-1 p53 TFIID PPAR-gamma2 GATA-2 Other transcription factors Search SABiosciences Chromatin IP Primers for GAPDH Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31 GAPDH Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P006643: view genomic region
(about GC identifiers )
Start: 6,643,093 bp from pter End:
6,647,537 bp from pter
Size: 4,445 bases Orientation:
plus strand
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Proteinsfor GAPDH gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 See
protein sequence )Recommended Name: Size : 335 amino acids; 36053 DaSubunit : Homotetramer. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1;leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS. Component of the GAIT complex
Subcellular location : Cytoplasm, cytosol. Nucleus (By similarity). Cytoplasm, perinuclear region. Membrane. Cytoplasm,cytoskeleton (By similarity). Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions
4 PDB 3D structures from :1U8F (3D) 1ZNQ (3D) 2FEH (3D) 3GPD (3D) Secondary accessions : P00354 Q53X65Explore the universe of human proteins at neXtProt for GAPDH: NX_P04406 Post-translational modifications:
S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By similarity)1 ISGylated (Probable)1 Sulfhydration at Cys-152 increases catalytic activity (By similarity)1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P04406 4/40 DME Specific Peptides for GAPDH (P04406 ) (see all 40 )GAPDH Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001243728.1 NP_002037.2 ENSEMBL proteins: ENSP00000229239 ENSP00000380065 ENSP00000380070 ENSP00000380068 ENSP00000380067 Reactome Protein details: P04406 Human Recombinant Protein Products for GAPDH: Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing GAPDH Antibody Products: Assay Products for GAPDH:
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Protein
Domains /for GAPDH gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry P04406 ProtoNet protein and cluster: P04406
1 Blocks protein family : IPB000173 UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 Similarity : Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
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Functionfor GAPDH gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: G3P_HUMAN, P04406 Function : Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role inglycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation Catalytic activity : D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH Enzyme Numbers (IUBMB): EC 1.2.1.12 1 2 EC 1.2.1 2 EC 2.6.99.- 1
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding
-- -- GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NAS 3170585 GO:0005515 protein binding
IPI -- GO:0008017 microtubule binding
ISS -- GO:0035605 peptidyl-cysteine S-nitrosylase activity
ISS --
About GeneDecksing Phenotypes: 3 GenomeRNAi human phenotypes for GAPDH :7 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Gapdh) :About GeneDecksing Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: GAPDH (NM_002046 ) Sino Biological Human cDNA Clone for GAPDH DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAPDH Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GAPDH
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH
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Pathways & Interactionsfor GAPDH gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Glycolysis and gluconeogenesis (short map) 2 Glucose metabolism 3 Metabolism 4 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 5 Glucose / Energy Metabolism
Pathway sources See GeneCards unified pathways Show all pathways 1 1 1 4 5 3 (Kegg details for GAPDH) :UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 Pathway : Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAPDH STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/849 Interacting proteins for GAPDH (P04406 1 , 2 , 3 ENSP00000229239 4 via UniProtKB, MINT, STRING , and/or I2D (see all 849 )
About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing
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Drugs & Compoundsfor GAPDH gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for GAPDH
Browse Tocris compounds for GAPDH 6 HMDB Compounds for GAPDH About this table Compound Synonyms
CAS
# PubMed Ids D-Glyceraldehyde 3-phosphate 2-hydroxy-3-(phosphonooxy)-Propanal 3-Phosphoglyceraldehyde D-Glyceraldehyde 3-phosphate D-Glyceraldehyde 3-phosphic acid D-glyceraldehyde-3-P DL-Glyceraldehyde 3-phosphate GAP Glyceraldehyde-3-phosphate glyceraldehyde-3-P glyceraldehyde-P glyceraldehyde-phosphate see top 1 )142-10-9 -- NAD 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt Adenine-nicotinamide dinucleotide CO-I Codehydrase I Codehydrogenase I Coenzyme I Cozymase Cozymase I Diphosphopyridine nucleotide Endopride NAD trihydrate NAD-oxidized Nicotinamide adenine dinucleotide Nicotinamide dinucleotide Nicotineamide adenine dinucleotide Oxidized diphosphopyridine nucleotide Pyridine nucleotide diphosphate [(3S,2R,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3S,2R,4R,5R)-5-(3-carbamoylpyridyl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxyphosphoryl) hydrogen phosphate [adenylate-32-P]-NAD beta-Diphosphopyridine nucleotide beta-NAD beta-Nicotinamide adenine dinucleotide beta-Nicotinamide adenine dinucleotide trihydrate diphosphopyridine nucleotide oxidized nicotinamide adenine dinucleotide oxidized 3-Carbamoyl-1-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate 3-Carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt see top 1 )53-84-9 -- NADH 1,4-Dihydronicotinamide adenine dinucleotide DPNH Dihydrocodehydrogenase I Dihydrocozymase Dihydronicotinamide adenine dinucleotide Dihydronicotinamide mononucleotide ENADA NADH NADH2 Reduced codehydrogenase I Reduced diphosphopyridine nucleotide Reduced nicotinamide adenine diphosphate Reduced nicotinamide-adenine dinucleotide b-DPNH b-NADH beta-DPNH beta-NADH see top 1 )58-68-4 -- NADP Adenine-nicotinamide dinucleotide phosphate Codehydrase II Codehydrogenase II Coenzyme II Cozymase II NAD phosphate NADP NADP+ Nicotinamide adenine dinucleotide phosphate Nicotinamide-adenine dinucleotide phosphate TPN Triphosphopyridine nucleotide b-NADP b-Nicotinamide adenine dinucleotide phosphate b-TPN beta-NADP beta-Nicotinamide adenine dinucleotide phosphate beta-TPN see top 1 )53-59-8 -- NADPH 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide Dihydrocodehydrogenase II NADP-reduced NADPH Nicotinamide-adenine-dinucleotide-phosphorate Nicotinamide-adenine-dinucleotide-phosphoric acid Reduced triphosphopyridine nucleotide Triphosphopyridine nucleotide reduced b-NADPH b-Nicotinamide-adenine-dinucleotide-phosphorate b-Nicotinamide-adenine-dinucleotide-phosphoric acid dihydronicotinamide adenine dinucleotide phosphate dihydronicotinamide adenine dinucleotide-P dihydrotriphosphopyridine nucleotide reduced reduced Codehydrase II reduced Coenzyme II reduced Cozymase II beta-NADPH beta-Nicotinamide-adenine-dinucleotide-phosphorate beta-Nicotinamide-adenine-dinucleotide-phosphoric acid 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide see top 1 )53-57-6 -- Phosphate NFB Orthophosphate O-phosphoric acid Ortho-phosphate Orthophosphate (PO43-) Orthophosphate(3-) Phosphate Phosphate (PO43-) Phosphate anion(3-) Phosphate ion (PO43-) Phosphate ion(3-) Phosphate trianion Phosphate(3-) Phosphoric acid ion(3-);Pi see top 1 )14265-44-2 --
5 DrugBank Compounds for GAPDH About this table 10/151 Novoseek chemical compound relationships for GAPDH gene (see all 151 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
glyceraldehyde 3-phosphate
98.9
2647
7534983 (7), 9264469 (7), 12882642 (5), 11371431 (4) (see all 99 )
actb
87.4
58
10378372 (3), 18191039 (2), 18317805 (2), 20113474 (2) (see all 35 )
koningic acid
81.3
40
8439569 (4), 2226438 (4), 15788719 (4), 7902582 (3) (see all 8 )
1,3-bisphosphoglycerate
76.3
10
9308888 (2), 8075252 (1), 15950210 (1), 9369240 (1) (see all 7 )
nad+
72.4
72
7639707 (5), 9354374 (4), 7540026 (3), 7531693 (3) (see all 36 )
cgp-3466
68.1
1
10617673 (1)
3-phosphoglycerate
66.4
24
2390992 (2), 8075252 (2), 15564524 (2), 18416820 (1) (see all 14 )
pssg
61.7
1
12958160 (1)
nadh
59.7
51
10391884 (6), 8912669 (4), 16444750 (3), 12893257 (2) (see all 29 )
vtcs
59.7
6
16473604 (1), 15485821 (1), 16452474 (1)
GAPDH / G3P
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Transcriptsfor GAPDH gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for GAPDH gene (2 alternative transcripts): NM_001256799.1 NM_002046.4 Unigene Clusters for GAPDH:
Glyceraldehyde-3-phosphate dehydrogenase Hs.544577 [show with all ESTs ] , Hs.592355 [show with all ESTs ] , Hs.598320 [show with all ESTs ] Unigene Representative Sequences: BF983396 , CV357503 , BQ067557 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000229239 (uc001qop.1 ) ENST00000496049 ENST00000396856 ENST00000492719 ENST00000396861 ENST00000474249 ENST00000466588 ENST00000396859 ENST00000466525 ENST00000460556 ENST00000396858 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: GAPDH (NM_002046 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAPDH Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GAPDH
Additional cDNA sequence: AJ844645.1
24/307 DOTS entries (see all 307 ): DT.97869929 DT.100749347
DT.95375100 DT.100749258 DT.97869918 DT.92476260 DT.102841638 DT.92475902 DT.95375081 DT.95375098 DT.100749097 DT.100865568 DT.95326333 DT.87000287 DT.100749022 DT.91832908 DT.100830267 DT.100749019 DT.100749379 DT.100749245 DT.95375056 DT.92476269 DT.100749358 DT.100749129 24/65 AceView cDNA sequences (see all 65 ):
CR606580 CR593185 CR591106 CR617884 CR626004 CR590910 CR596322 CR598463 M36164 CR602482 CR611578 CR598048 CR612181 CR621806 CR591732 CR616330 CR616023 CR594204 CR590092 CR598400 CR616276 CR597330 CR599926 CR608433 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GAPDH (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 SP1 : SP2 : - SP3 : - - - SP4 : - - - SP5 : -
ECgene alternative splicing isoforms for GAPDH
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Expression for GAPDH gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GAPDH expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACCATCAATAbout this image GAPDH expression in embryonic tissues and stem cells About this table
See GAPDH Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for GAPDH SOURCE GeneReport for Unigene clusters: Hs.544577 Hs.592355 Hs.598320 SABiosciences Expression via Pathway-Focused PCR Arrays including GAPDH (see all 148 ): Antiviral Response in human mouse rat Multiple Sclerosis in human mouse rat Wound Healing in human mouse rat Prostate Cancer in human mouse rat Drug Metabolism: Phase I Enzymes in human mouse rat
Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH
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Orthologsfor GAPDH gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for GAPDH gene from 10/43 species (see all 43 ) About this table
ENSEMBL Gene Tree for GAPDH (if available)TreeFam Gene Tree for GAPDH (if available)
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Paralogsfor GAPDH gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for GAPDH gene GAPDHS 2 3 SIMAP similar genes for GAPDH using alignment to 4 protein entries: G3P_HUMAN (see all proteins ):GAPD GAPDHS YA61 About GeneDecksing 5/73 Pseudogenes.org Pseudogenes for GAPDH (see all 73 )PGOHUM00000238364 PGOHUM00000238494 PGOHUM00000242403 PGOHUM00000251011 PGOHUM00000248389
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Genomic Variantsfor GAPDH gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 12 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for GAPDH (6643093 - 6647537 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for GAPDH 2 CNVs 3872 2967 1 Indel 33243
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor GAPDH gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 138400
OMIM disorders : --20/168 (see all 168 ): About MalaCards open-angle glaucoma acth-secreting pituitary adenoma dentatorubral-pallidoluysian atrophy growth hormone secreting pituitary adenoma diffuse large b-cell lymphoma primary open angle glaucoma osteochondritis dissecans parainfluenza virus type 3 retinol binding protein maturity-onset diabetes of the young inclusion body myositis pituitary adenoma plexiform neurofibroma b-cell lymphomas pre-eclampsia functioning pituitary adenoma soft tissue sarcoma type 2 diabetes mellitus congestive heart failure primary biliary cirrhosis 1 disease from the University of Copenhagen DISEASES database for GAPDH :Cancer 10/93 Novoseek disease relationships for GAPDH gene (see all 93 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases
40.6
21
12428732 (3), 11208907 (3), 15822178 (2), 17613523 (1) (see all 13 )
tumors
36.8
88
17597534 (3), 10897012 (3), 18629778 (3), 19144146 (3) (see all 55 )
disseminated candidiasis
28
1
10219595 (1)
huntington disease
27.7
11
11208907 (4), 9779656 (2), 12428732 (1), 15486605 (1) (see all 7 )
trypanosomiasis african
25.8
8
7562915 (2), 7932587 (2), 19748525 (1), 9822549 (1)
shock
25.8
29
12517784 (2), 15498039 (1), 17194899 (1), 12669348 (1) (see all 23 )
cancer
25.1
39
19161537 (3), 20044597 (3), 15079082 (2), 18651557 (2) (see all 22 )
hepatocellular carcinoma
24.4
10
19144146 (2), 8666326 (2), 9472111 (1)
alzheimers disease
20.2
23
7891898 (2), 9779656 (2), 16186172 (2), 12503091 (2) (see all 16 )
leukemia
18.6
4
9794812 (2), 15854547 (1), 8834064 (1)
Genetic Association Database (GAD): GAPDH Human Genome Epidemiology (HuGE) Navigator: GAPDH (11 documents) Export disorders for GAPDH gene to outside databases
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Publicationsfor GAPDH gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for GAPDH gene, integrated from 9 sources (see all 1109 ):(articles sorted by number of sources associating them with GAPDH) Utopia : connect your pdf to the dynamic
Isolation and complete sequence of a functional human glyceraldehyde- 3-phosphate dehydrogenase gene. (PubMed id 3170585) 1 , 2 , 3(1988) Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function. (PubMed id 12829261) 1 , 2 , 9(2003) Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16239728) 1 , 2 , 9(2005) High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16510976) 1 , 2 (2006) The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. (PubMed id 16501887) 1 , 2 (2006) HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975) 1 , 2 (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 (2006) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 1 , 2 (2005) Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase. (PubMed id 15628863) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004)
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External Searches for GAPDH gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing GAPDH gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing GAPDH gene
(According to HUGE )
About This Section --
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Specialized Databases showing GAPDH gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for GAPDH Pharmacogenomics, SNPs, Pathways ATLAS Chromosomes in Cancer entry for GAPDHGenetics and Cytogenetics in Oncology and Haematology NIEHS-SNPs http://egp.gs.washington.edu/data/gapd/ Wikipedia http://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate_dehydrogenase
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About This Section Patent Information for GAPDH gene: GAPDH GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor GAPDH gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for GAPDH OriGene shRNA RFP for GAPDH OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for GAPDH Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for GAPDH OriGene 3'-UTR Clone for GAPDH OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for GAPDH OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for GAPDH OriGene Custom Protein Services for GAPDH OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAPDH QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for GAPDH
Search Tocris compounds for GAPDH
Recombinant Protein for GAPDH
GAPDH Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH
ThermoFisher Antibody for GAPDH
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GAPDH
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and Proteopedia 
for GAPDH:
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
