GAPDH Gene
protein-coding GIFtS : 74 GCID: GC12 P006643
glyceraldehyde-3-phosphate dehydrogenase GAPD )
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Aliasesfor GAPDH gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Glyceraldehyde-3-Phosphate Dehydrogenase 1 2 G3PD2 GAPD1 2 3 5 Aging-Associated Gene 9 Protein2 Peptidyl-Cysteine S-Nitrosylase GAPDH2 3 EC 2.6.99.-3 EC 1.2.1.123 8 EC 1.2.18
Export aliases for GAPDH gene to outside databases Previous GC identifer: GC12P006514
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Summariesfor GAPDH gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for GAPDH : The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2012) UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 Function : Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role inglycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation Gene Wiki entry for GAPDH (Glyceraldehyde 3-phosphate dehydrogenase)
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Genomic Viewsfor GAPDH gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009759.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the GAPDH gene promoter:N-Myc TBP PPAR-gamma1 NF-1 p53 TFIID PPAR-gamma2 GATA-2 Other transcription factors Search SABiosciences Chromatin IP Primers for GAPDH Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31 GAPDH Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P006643: view genomic region
(about GC identifiers )
Start: 6,643,093 bp from pter End:
6,647,537 bp from pter
Size: 4,445 bases Orientation:
plus strand
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Proteinsfor GAPDH gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 See
protein sequence )Recommended Name: Size : 335 amino acids; 36053 DaSubunit : Homotetramer. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1;leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS. Component of the GAIT complex
Subcellular location : Cytoplasm, cytosol. Nucleus (By similarity). Cytoplasm, perinuclear region. Membrane. Cytoplasm,cytoskeleton (By similarity). Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions
4 PDB 3D structures from :1U8F (3D) 1ZNQ (3D) 2FEH (3D) 3GPD (3D) Secondary accessions : P00354 Q53X65Explore the universe of human proteins at neXtProt for GAPDH: NX_P04406 Post-translational modifications:
S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By similarity)1 ISGylated (Probable)1 Sulfhydration at Cys-152 increases catalytic activity (By similarity)1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P04406 4/40 DME Specific Peptides for GAPDH (P04406 ) (see all 40 )GAPDH Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001243728.1 NP_002037.2 ENSEMBL proteins: ENSP00000229239 ENSP00000380065 ENSP00000380070 ENSP00000380068 ENSP00000380067 Reactome Protein details: P04406 Human Recombinant Protein Products: Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing GAPDH Antibody Products: Assay Products for GAPDH:
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Protein
Domains /for GAPDH gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry P04406 ProtoNet protein and cluster: P04406
1 Blocks protein family : IPB000173 UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 Similarity : Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
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Functionfor GAPDH gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 Function : Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role inglycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation Catalytic activity : D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADHEnzyme Numbers (IUBMB): EC 1.2.1.12 1 2 EC 1.2.1 2 EC 2.6.99.- 1
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: GAPDH (NM_002046 ) Sino Biological Human cDNA Clone for GAPDH DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAPDH Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GAPDH
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding
-- -- GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NAS 3170585 GO:0005515 protein binding
IPI -- GO:0008017 microtubule binding
ISS -- GO:0035605 peptidyl-cysteine S-nitrosylase activity
ISS --
About GeneDecksing 3 GenomeRNAi human phenotypes for GAPDH :Animal Models: 7 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Gapdh) :About GeneDecksing
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Pathways & Interactionsfor GAPDH gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Glycolysis and gluconeogenesis (short map) 2 Glucose metabolism 3 Metabolism 4 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 5 Glucose / Energy Metabolism
Pathway sources See GeneCards unified pathways Show all pathways 1 1 1 4 5 3 (Kegg details for GAPDH) :UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 Pathway : Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAPDH STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/849 Interacting proteins for GAPDH (P04406 1 , 2 , 3 ENSP00000229239 4 via UniProtKB, MINT, STRING , and/or I2D (see all 849 )
About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing
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Drugs & Compoundsfor GAPDH gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for GAPDH
Browse Tocris compounds for GAPDH 6 HMDB Compounds for GAPDH About this table Compound Synonyms
CAS
# PubMed Ids D-Glyceraldehyde 3-phosphate 2-hydroxy-3-(phosphonooxy)-Propanal (see all 11 ) 142-10-9 -- NAD 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28 ) 53-84-9 -- NADH 1,4-Dihydronicotinamide adenine dinucleotide (see all 17 ) 58-68-4 -- NADP Adenine-nicotinamide dinucleotide phosphate (see all 18 ) 53-59-8 -- NADPH 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23 ) 53-57-6 -- Phosphate NFB Orthophosphate (see all 13 ) 14265-44-2 --
5 DrugBank Compounds for GAPDH About this table 10/151 Novoseek chemical compound relationships for GAPDH gene (see all 151 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
glyceraldehyde 3-phosphate
98.9
2647
7534983 (7), 9264469 (7), 12882642 (5), 11371431 (4) (see all 99 )
actb
87.4
58
10378372 (3), 18191039 (2), 18317805 (2), 20113474 (2) (see all 35 )
koningic acid
81.3
40
8439569 (4), 2226438 (4), 15788719 (4), 7902582 (3) (see all 8 )
1,3-bisphosphoglycerate
76.3
10
9308888 (2), 8075252 (1), 15950210 (1), 9369240 (1) (see all 7 )
nad+
72.4
72
7639707 (5), 9354374 (4), 7540026 (3), 7531693 (3) (see all 36 )
cgp-3466
68.1
1
10617673 (1)
3-phosphoglycerate
66.4
24
2390992 (2), 8075252 (2), 15564524 (2), 18416820 (1) (see all 14 )
pssg
61.7
1
12958160 (1)
nadh
59.7
51
10391884 (6), 8912669 (4), 16444750 (3), 12893257 (2) (see all 29 )
vtcs
59.7
6
16473604 (1), 15485821 (1), 16452474 (1)
GAPDH / G3P
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Transcriptsfor GAPDH gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for GAPDH gene (2 alternative transcripts): NM_001256799.1 NM_002046.4 Unigene Clusters for GAPDH:
Glyceraldehyde-3-phosphate dehydrogenase Hs.544577 [show with all ESTs ] , Hs.592355 [show with all ESTs ] , Hs.598320 [show with all ESTs ] Unigene Representative Sequences: BF983396 , CV357503 , BQ067557 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000229239 (uc001qop.1 ) ENST00000496049 ENST00000396856 ENST00000492719 ENST00000396861 ENST00000474249 ENST00000466588 ENST00000396859 ENST00000466525 ENST00000460556 ENST00000396858 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: GAPDH (NM_002046 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAPDH Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GAPDH
Additional cDNA sequence: AJ844645.1
307 DOTS entries (see top 24 ): DT.97869929 DT.100749347
DT.95375100 DT.100749258 DT.97869918 DT.92476260 DT.102841638 DT.92475902 DT.95375081 DT.95375098 DT.100749097 DT.100865568 DT.95326333 DT.87000287 DT.100749022 DT.91832908 DT.100830267 DT.100749019 DT.100749379 DT.100749245 DT.95375056 DT.92476269 DT.100749358 DT.100749129 DT.100749113 DT.95354546 DT.99926842 DT.92475780 DT.100749193 DT.95375078 DT.100749203 DT.100749223 DT.99926868 DT.95375084 DT.87000167 DT.91804036 DT.95085196 DT.100857850 DT.100749214 DT.75128871 DT.92045131 DT.75171615 DT.99926833 DT.100749114 DT.100749299 DT.100847895 DT.100749213 DT.95375175 DT.100749271 DT.100749376 DT.100749165 DT.121213416 DT.95109667 DT.100749116 DT.100771197 DT.102841647 DT.100749060 DT.92476266 DT.97869927 DT.121213682 DT.95375064 DT.102841651 DT.102841643 DT.100749355 DT.121213302 DT.92475787 DT.100749329 DT.95375149 DT.109596 DT.95375012 DT.121213220 DT.100749027 DT.100749038 DT.100749160 DT.100749179 DT.95378856 DT.97869919 DT.121213275 DT.121213329 DT.92475840 DT.100749074 DT.100749281 DT.121213109 DT.121213391 DT.121213479 DT.87010546 DT.92409474 DT.100749332 DT.100749367 DT.102841641 DT.121213226 DT.121213332 DT.40194172 DT.87000014 DT.92475644 DT.95352047 DT.95374953 DT.95375127 DT.95375176 DT.100749023 DT.100749260 DT.100749282 DT.101957821 DT.102841652 DT.121213112 DT.91845612 DT.98083889 DT.100042642 DT.100749279 DT.100749380 DT.100858162 DT.121213044 DT.121213154 DT.121213414 DT.121213474 DT.92475692 DT.99926873 DT.99926879 DT.100683499 DT.100749110 DT.100749166 DT.100749190 DT.100749228 DT.100749251 DT.100749298 DT.100865251 DT.102841640 DT.102841650 DT.121213280 DT.121213314 DT.121213619 DT.121213694 DT.86997291 DT.92059605 DT.95375070 DT.97869922 DT.99926886 DT.100749086 DT.100749101 DT.100749121 DT.100749146 DT.100749148 DT.100749308 DT.100838155 DT.100876375 DT.102841646 DT.121213047 DT.121213061 DT.121213075 DT.121213079 DT.121213081 DT.121213104 DT.121213189 DT.121213285 DT.121213344 DT.121213347 DT.121213360 DT.121213372 DT.121213411 DT.121213421 DT.121213445 DT.121213514 DT.121213714 DT.91847780 DT.92475834 DT.95228492 DT.95375058 DT.95375097 DT.100683496 DT.100727693 DT.100749020 DT.100749024 DT.100749063 DT.100749090 DT.100749098 DT.100749140 DT.100749188 DT.100749202 DT.100749209 DT.100749238 DT.100749250 DT.100749277 DT.100749309 DT.100749325 DT.100749348 DT.100749364 DT.100749370 DT.100759547 DT.100768468 DT.100840246 DT.100865982 DT.101957820 DT.102841639 DT.102841649 DT.121213074 DT.121213094 DT.121213124 DT.121213159 DT.121213172 DT.121213219 DT.121213259 DT.121213270 DT.121213311 DT.121213339 DT.121213361 DT.121213373 DT.121213374 DT.121213413 DT.121213436 DT.121213477 DT.121213483 DT.121213486 DT.121213546 DT.121213548 DT.121213555 DT.121213564 DT.121213577 DT.121213578 DT.121213579 DT.121213591 DT.121213610 DT.121213659 DT.121213706 DT.121288507 DT.121316457 DT.75119578 DT.85100576 DT.87008677 DT.91670289 DT.91837881 DT.91922320 DT.92000986 DT.92017143 DT.92057925 DT.92338138 DT.92364898 DT.92386091 DT.92392769 DT.92475668 DT.92475871 DT.92476142 DT.92476272 DT.95213077 DT.95223166 DT.95374915 DT.95374931 DT.95374987 DT.95375022 DT.95375074 DT.95375102 DT.95375133 DT.95375152 DT.95375178 DT.97848733 DT.97851209 DT.97867523 DT.97868077 DT.97869913 DT.97869914 DT.97869915 DT.97869928 DT.98083079 DT.98083216 DT.98083845 DT.99926855 DT.100651350 DT.100652455 DT.100728095 DT.100738576 DT.100749010 DT.100749034 DT.100749200 DT.100749229 DT.100749256 DT.100761900 DT.100800128 DT.100808261 DT.100843685 DT.100853343 DT.121021909 DT.121213107 DT.121213147 DT.121213267 DT.121213401 DT.121213497 DT.121213510 DT.121213584 DT.121213586 DT.121213593 DT.121213654 DT.121213662 DT.121321392 DT.455582 DT.87006850 DT.91780243 DT.91833662 DT.91873047 DT.92035934 DT.92325191 DT.92325208 DT.92475898 DT.95099903 DT.95232036 DT.95342479 DT.95375189 DT.97852514 DT.98083718 24/65 AceView cDNA sequences (see all 65 ):
CR606580 CR593185 CR591106 CR617884 CR626004 CR590910 CR596322 CR598463 M36164 CR602482 CR611578 CR598048 CR612181 CR621806 CR591732 CR616330 CR616023 CR594204 CR590092 CR598400 CR616276 CR597330 CR599926 CR608433 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GAPDH (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 SP1 : SP2 : - SP3 : - - - SP4 : - - - SP5 : -
ECgene alternative splicing isoforms for GAPDH
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Expression for GAPDH gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GAPDH expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACCATCAAT
About this image GAPDH expression in embryonic tissues and stem cells About this table See GAPDH Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for GAPDH SOURCE GeneReport for Unigene clusters: Hs.544577 Hs.592355 Hs.598320 SABiosciences Expression via Pathway-Focused PCR Arrays including GAPDH (see all 148 ): Antiviral Response in human mouse rat Multiple Sclerosis in human mouse rat Wound Healing in human mouse rat Prostate Cancer in human mouse rat Drug Metabolism: Phase I Enzymes in human mouse rat
Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH
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Orthologsfor GAPDH gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for GAPDH gene from 10/43 species (see all 43 ) About this table
ENSEMBL Gene Tree for GAPDH (if available)TreeFam Gene Tree for GAPDH (if available)
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Paralogsfor GAPDH gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for GAPDH gene GAPDHS 2 3 SIMAP similar genes for GAPDH using alignment to 4 protein entries: G3P_HUMAN (see all proteins ):GAPD GAPDHS YA61 About GeneDecksing 5/73 Pseudogenes.org Pseudogenes for GAPDH (see all 73 )PGOHUM00000238364 PGOHUM00000238494 PGOHUM00000242403 PGOHUM00000251011 PGOHUM00000248389
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Genomic Variantsfor GAPDH gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 12 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for GAPDH (6643093 - 6647537 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for GAPDH 2 CNVs 3872 2967 1 Indel 33243
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor GAPDH gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 138400
OMIM disorders : --20/168 (see all 168 ): About MalaCards open-angle glaucoma acth-secreting pituitary adenoma dentatorubral-pallidoluysian atrophy growth hormone secreting pituitary adenoma diffuse large b-cell lymphoma primary open angle glaucoma osteochondritis dissecans parainfluenza virus type 3 retinol binding protein maturity-onset diabetes of the young inclusion body myositis pituitary adenoma plexiform neurofibroma b-cell lymphomas pre-eclampsia functioning pituitary adenoma soft tissue sarcoma type 2 diabetes mellitus congestive heart failure primary biliary cirrhosis 1 disease from the University of Copenhagen DISEASES database for GAPDH :Cancer 10/93 Novoseek disease relationships for GAPDH gene (see all 93 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases
40.6
21
12428732 (3), 11208907 (3), 15822178 (2), 17613523 (1) (see all 13 )
tumors
36.8
88
17597534 (3), 10897012 (3), 18629778 (3), 19144146 (3) (see all 55 )
disseminated candidiasis
28
1
10219595 (1)
huntington disease
27.7
11
11208907 (4), 9779656 (2), 12428732 (1), 15486605 (1) (see all 7 )
trypanosomiasis african
25.8
8
7562915 (2), 7932587 (2), 19748525 (1), 9822549 (1)
shock
25.8
29
12517784 (2), 15498039 (1), 17194899 (1), 12669348 (1) (see all 23 )
cancer
25.1
39
19161537 (3), 20044597 (3), 15079082 (2), 18651557 (2) (see all 22 )
hepatocellular carcinoma
24.4
10
19144146 (2), 8666326 (2), 9472111 (1)
alzheimers disease
20.2
23
7891898 (2), 9779656 (2), 16186172 (2), 12503091 (2) (see all 16 )
leukemia
18.6
4
9794812 (2), 15854547 (1), 8834064 (1)
Genetic Association Database (GAD): GAPDH Human Genome Epidemiology (HuGE) Navigator: GAPDH (11 documents) Export disorders for GAPDH gene to outside databases
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Publicationsfor GAPDH gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for GAPDH gene, integrated from 9 sources (see all 1109 ):(articles sorted by number of sources associating them with GAPDH) Utopia : connect your pdf to the dynamic
Isolation and complete sequence of a functional human glyceraldehyde- 3-phosphate dehydrogenase gene. (PubMed id 3170585) 1 , 2 , 3(1988) Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function. (PubMed id 12829261) 1 , 2 , 9(2003) Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16239728) 1 , 2 , 9(2005) High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16510976) 1 , 2 (2006) The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. (PubMed id 16501887) 1 , 2 (2006) HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975) 1 , 2 (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 (2006) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 1 , 2 (2005) Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase. (PubMed id 15628863) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004)
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External Searches for GAPDH gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing GAPDH gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing GAPDH gene
(According to HUGE )
About This Section --
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Specialized Databases showing GAPDH gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for GAPDH Pharmacogenomics, SNPs, Pathways ATLAS Chromosomes in Cancer entry for GAPDHGenetics and Cytogenetics in Oncology and Haematology NIEHS-SNPs http://egp.gs.washington.edu/data/gapd/ Wikipedia http://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate_dehydrogenase
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About This Section Patent Information for GAPDH gene: GAPDH GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor GAPDH gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for GAPDH OriGene shRNA RFP for GAPDH OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for GAPDH Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for GAPDH OriGene 3'-UTR Clone for GAPDH OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for GAPDH OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for GAPDH OriGene Custom Protein Services for GAPDH OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAPDH QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for GAPDH
Search Tocris compounds for GAPDH
Recombinant Protein for GAPDH
GAPDH Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAPDH
ThermoFisher Antibody for GAPDH
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GAPDH
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and Proteopedia 
for GAPDH:
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
