V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

GAPDH Gene

protein-coding GIFtS: 69

GC12P006514

glyceraldehyde-3-phosphate dehydrogenase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GAPD)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.2.1.12 ^³
G3PD ^²
GAPD ^², ³, ⁵
MGC88685 ^²
OTTHUMP00000174431 ^²
OTTHUMP00000174432 ^²

Descriptions
aging-associated gene 9 protein ^²
glyceraldehyde 3-phosphate dehydrogenase ^²
glyceraldehyde-3-phosphate dehydrogenase ^²

External Ids
HGNC: 4141¹
Entrez Gene: 2597²
UniProtKB: P04406³
Ensembl: ENSG00000111640⁷

Search outside databases for aliases for GAPDH gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GAPDH:

The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism,

the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of

inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer

of identical chains. Many pseudogenes similar to this locus are present in the human genome.

[provided by RefSeq]

UniProtKB/Swiss-Prot: G3P_HUMAN, P04406

Function: Independent of its glycolytic activity it is also involved in membrane trafficking in the

early secretory pathway

Gene Wiki entry for GAPDH (Glyceraldehyde_3-phosphate_dehydrogenase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GAPDH gene

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

GAPDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P006514: (about GC identifiers)

Start:	6,513,918 bp from pter
End:	6,517,797 bp from pter
Size:	3,880 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009759.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: G3P_HUMAN, P04406 (See protein sequence)

Recommended Name: Glyceraldehyde-3-phosphate dehydrogenase

Size: 335 amino acids; 36053 Da

Subunit: Homotetramer. Binds PRKCI

Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Membrane. Note=Postnuclear and

Perinuclear regions

Sequence caution: Sequence=Ref.14; Type=Miscellaneous discrepancy; Note=Differs quite extensively;

PDB structures from and Proteopedia :

1U8F (3D)

1ZNQ (3D)

2FEH (3D)

3GPD (3D)

Secondary accessions: P00354

Post-translational modifications:

Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous

ADP-ribosylation, which inhibits the enzyme in a non-reversible manner. The latter modification is

more likely to be a pathophysiological event associated with inhibition of gluconeogenesis (By

similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002037.2

ENSEMBL proteins:

ENSP00000380065 ENSP00000380067 ENSP00000380070 ENSP00000380068 ENSP00000229239 ENSP00000384819

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for GAPDH
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GAPDH)
	Human Recombinant Proteins from Abnova (GAPDH)

OriGene Purified Recombinant Human Protein: GAPDH

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	--
GO:0016020	membrane	IEA	--

About this table

Antibodies for GAPDH:

	Invitrogen Antibodies for GAPDH
	Millipore Mono- and Polyclonal Antibodies for the study of GAPDH
	Sigma-Aldrich Antibody Arrays and Antibodies for GAPDH
	R&D Systems Antibodies for GAPDH
	Cell Signaling Technology (CST) Antibodies for GAPDH
	Antibodies from Abcam (GAPDH), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for G3P

Assays for GAPDH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04406

ProtoNet protein and cluster: P04406

1 Blocks protein family: IPB000173 Glyceraldehyde 3-phosphate dehydrogenase

UniProtKB/Swiss-Prot: G3P_HUMAN, P04406

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GAPDH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GAPDH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002046

Applied Biosystems Silencer® siRNAs for GAPDH

Sigma-Aldrich siRNA and siRNA Panels for GAPDH

Sigma-Aldrich shRNA for GAPDH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GAPDH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002046
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002046
untagged cDNA clones in CMV expression vector (see all 4): NM_002046

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002046

UniProtKB/Swiss-Prot: G3P_HUMAN, P04406

Function: Independent of its glycolytic activity it is also involved in membrane trafficking in the

early secretory pathway

Catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl

phosphate + NADH

Enzyme Number (IUBMB): EC 1.2.1.12

9 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Gapdh):

	growth/size	hematopoietic system	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	renal/urinary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	NAS	3170585 7030790
GO:0005515	protein binding	IPI	17540579
GO:0016491	oxidoreductase activity	IEA	--
GO:0051287	NAD or NADH binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for GAPDH (Your Favorite Gene powered by Ingenuity)

Glycolysis/Gluconeogenesis
Maturity Onset Diabetes of Young (MODY) Signaling

GeneDecks GAPDH for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: G3P_HUMAN, P04406

Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5

Gene Network Central^TM Interacting Genes and Proteins Network for GAPDH

5/169 Interacting proteins for GAPDH (ENSP00000229239³ P04406^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 169 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATN1	P54259²	STRING (score=.991) MINT-2859138 MINT-2859119
ACTB	P60709²	STRING (score=.889) MINT-4054731
HSPD1P4	P10809²	STRING (score=.944) MINT-4054731
YWHAZ	P63104²	STRING (score=.768) MINT-3304469
TXN	Q5T937¹	STRING (score=.88) EBI-354056, EBI-1042712

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006006	glucose metabolic process	IEA	--
GO:0006096	glycolysis	NAS	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GAPDH

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GAPDH
10/51 Novoseek chemical compound relationships for GAPDH gene (see all 51 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glyceraldehyde 3-phosphate	98.93	2471	7534983 (7), 9264469 (7), 12882642 (5), 11371431 (4) (see all 99)
actb	85.41	40	10378372 (3), 18191039 (2), 16777070 (2), 18317805 (2) (see all 24)
koningic acid	82.22	40	8439569 (4), 2226438 (4), 15788719 (4), 7902582 (3) (see all 8)
1,3-bisphosphoglycerate	77.34	10	9308888 (2), 8075252 (1), 15950210 (1), 9369240 (1) (see all 7)
nad+	73.47	71	7639707 (5), 9354374 (4), 7540026 (3), 7531693 (3) (see all 35)
cgp-3466	68.79	1	10617673 (1)
3-phosphoglycerate	67.48	24	2390992 (2), 8075252 (2), 15564524 (2), 18416820 (1) (see all 14)
pssg	62.49	1	12958160 (1)
nadh	60.76	51	10391884 (6), 8912669 (4), 16444750 (3), 12893257 (2) (see all 29)
vtcs	60.74	6	16473604 (1), 15485821 (1), 16452474 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GAPDH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GAPDH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002046

Sigma-Aldrich siRNA and siRNA Panels for GAPDH

Sigma-Aldrich shRNA for GAPDH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002046

REFSEQ mRNAs for GAPDH gene:

NM_002046.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002046

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002046
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002046
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_002046

Additional cDNA sequence:

AJ844645.1 CR594180.1 CR612987.1 CR615404.1 CR626004.1 M36164.1

24/308 DOTS entries (see all 308 ):

DT.97869929 DT.100749347 DT.95375100 DT.97869918 DT.100749258 DT.92476260 DT.102841638 DT.92475902

DT.95375081 DT.95375098 DT.100749097 DT.100865568 DT.87000287 DT.95326333 DT.100749022 DT.91832908

DT.100830267 DT.100749019 DT.100749379 DT.100749245 DT.95375056 DT.92476269 DT.100749358 DT.100749129

24/65 AceView cDNA sequences (see all 65 ):

CR616330 CR598463 CR626004 CR617884 M36164 CR611578 CR606107 CR615404

CR593979 CR609371 CR615270 CR609914 CR608307 CR591732 CR597244 CR590092

CR598400 CR594204 CR598048 CR600441 CR621806 CR601654 CR590910 CR622647

highest scoring ESTs for GAPDH:

AB062273 AF261085 AI751648 AY007133 BC001601 BC004109 BC009081 BC013310 BC013852 BC020308

Unigene Clusters for GAPDH:

Glyceraldehyde-3-phosphate dehydrogenase

Hs.544577 [show with all ESTs], Hs.592355 [show with all ESTs], Hs.598320 [show with all ESTs]

Unigene Representative Sequences: BF983396, XR_018331, BG403493

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GAPDH (see all 7 )

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	·	8c	^	9
SP1:
SP2:							-
SP3:											-		-		-
SP4:																			-		-		-
SP5:																			-

About this scheme

ECgene alternative splicing isoforms for GAPDH

6 Ensembl transcripts including schematic representations:

ENST00000396856 ENST00000396858 ENST00000396861 ENST00000396859 ENST00000229239 ENST00000406765

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GAPDH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GAPDH

¹ / ² / ³

7 probe-sets matching GAPDH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35905_s_at²^{, 3}	U95-A	7	1.00	0.69	1.00	1.00	U34995	0.80	1.00	0.91	1
217398_x_at²^{, 3}	U133-A	25	1.00	0.53	--	--	AK026525	0.60	1.00	0.82	1
212581_x_at²^{, 3}	U133-A	23	1.00	0.43	--	--	BE561479	0.40	0.67	0.55	1
213453_x_at²^{, 3}	U133-A	23	1.00	0.35	--	--	BF689355	0.40	1.00	0.76	1
217398_x_at²	U133Plus2	25	1.00	0.53	--	--	--	--	--	--	--
212581_x_at²	U133Plus2	23	1.00	0.43	--	--	--	--	--	--	--
213453_x_at²	U133Plus2	23	1.00	0.35	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.544577 Hs.592355 Hs.598320
Expression variation in blood from EXPOLDB for GAPDH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GAPDH gene from 5/28 species (see all 28 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GAPDH¹	--	glyceraldehyde-3-phosphate dehydrogenase	91.27(n) 95.18(a)	403755 NM_001003142.1 NP_001003142.1
chimpanzee (Pan troglodytes)	GAPDH¹	--	glyceraldehyde-3-phosphate dehydrogenase	99.6(n) 100(a)	451783 XM_001162057.1 XP_001162057.1
cow (Bos taurus)	GAPDH¹	--	glyceraldehyde-3-phosphate dehydrogenase	90.86(n) 94.88(a)	281181 NM_001034034.1 NP_001029206.1
rat (Rattus norvegicus)	Gapdh¹	--	glyceraldehyde-3-phosphate dehydrogenase	89.66(n) 94.28(a)	24383 NM_017008.2 NP_058704.1
mouse (Mus musculus)	Gapdh⁵ OTTMUSG00000014946¹	6 (56.00 cM)⁵	glyceraldehyde-3-phosphate dehydrogenase⁵ predicted gene, OTTMUSG00000014946¹	88.55(n)¹ 91.57(a)¹	100043349¹ XM_001479851.1¹ XP_001479901.1¹ AI835452⁵ AK002273⁵ (see all 87)

About this table Species with no ortholog for GAPDH

ENSEMBL Gene Tree for GAPDH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GAPDH gene

GAPDHS²

Pseudogenes

52 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/13 NCBI SNPs in GAPDH are shown (see all 13 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 54)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6489721^1,2	A,C,F,H	6513577(+)	`AGTCGT/CTCCCA`	1	--	ng5¹		17		EU EA WA NS	1824
	rs7971637^1,2	A,C,F,H	6513590(+)	`GTCCTC/TCTGTT`	1	--	ng5¹		19		EU EA WA NS	2066
	rs1136666^1,2	C,F,H	6514252(+)	`TCGCTC/GAGACA`	1	--	ut5¹		9		EA MN EU WA NS	2382
--	rs45459592^1,2	F	6513247(+)	`TCCCCC/GTCAAG`	1	--	ng5¹		1		NS	172
--	rs45612631^1,2	F	6513331(+)	`AGAGAT/GGCCAG`	1	--	ng5¹		1		NS	172
--	rs45509198^1,2	F	6512220(+)	`TTTGCG/AGGGAG`	1	--	ng5¹		1		NS	160
	rs3759342^1,2	--	6512143(+)	`GTGACC/TACACT`	1	--	ng5¹		0	--	--	--	--
--	rs36015908^1,2	--	6513398(+)	`CCGAG-/GCCCAT`	1	--	ng5¹		0	--	--	--	--
--	rs45564644^1,2	--	6513114(+)	`CCTGTC/TCTCCG`	1	--	ng5¹		1		NS	164
--	rs45540931^1,2	--	6512200(+)	`CCTGGG/ACACTG`	1	--	ng5¹		1		NS	154

About this table

HapMap Linkage Disequilibrium images for GAPDH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 138400

10/91 Novoseek disease relationships for GAPDH gene (see all 91 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases	41.62	20	12428732 (3), 11208907 (3), 15822178 (2), 17613523 (1) (see all 12)
tumors	35.90	82	17597534 (3), 10897012 (3), 18629778 (3), 19144146 (3) (see all 51)
huntington disease	30.05	11	11208907 (4), 9779656 (2), 12428732 (1), 15486605 (1) (see all 7)
disseminated candidiasis	29.75	1	10219595 (1)
hepatocellular carcinoma	25.21	9	19144146 (2), 8666326 (2), 9472111 (1)
sleeping sickness	23.73	6	7562915 (2), 7932587 (2), 9822549 (1)
shock	23.37	25	12517784 (2), 15498039 (1), 12669348 (1), 17521179 (1) (see all 20)
alzheimers disease	20.61	19	7891898 (2), 9779656 (2), 16186172 (2), 12503091 (2) (see all 14)
leukemia	19.92	4	9794812 (2), 15854547 (1), 8834064 (1)
cancer	19.88	31	19161537 (3), 15079082 (2), 18651557 (2), 16515701 (2) (see all 18)

About this table

Genetic Association Database: GAPDH
Human Genome Epidemiology Navigator: GAPDH (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/780 PubMed articles for GAPDH gene (see all 780 ):

Isolation and complete sequence of a functional human glyceraldehyde- 3-phosphate dehydrogenase gene. (PubMed id 3170585)^{2, 3, 4} Ercolani L.... Alexander M. (1988)
Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function. (PubMed id 12829261)^{1, 3, 4} Mazzola J.L. and Sirover M.A. (2003)
Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16239728)^{1, 3, 4} Ismail S.A. and Park H.W. (2005)
High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase. (PubMed id 16510976)^{3, 4} Jenkins J.L. and Tanner J.J. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. (PubMed id 15507493)^{3, 6} Li Y....Grupe A. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway. (PubMed id 11724794)^{3, 4} Tisdale E.J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2597	HGNC: 4141	AceView: GAPD	Ensembl:ENSG00000111640	euGenes: HUgn2597
ECgene: GAPDH	H-InvDB: GAPDH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GAPDH	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/gapd/
Wikipedia	http://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate_dehydrogenase

Licensable Technologies for GAPDH
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GAPDH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GAPDH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GAPDH		Antibodies for GAPDH
	Explore super-pooled esiRNAs		Proteins for GAPDH
	Lentivirus-delivered shRNAs for GAPDH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GAPDH)
	Search for Antibodies
	Chimera RNAi (GAPDH)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GAPDH

	Recombinant Proteins (GAPDH)
	Antibodies (GAPDH)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for GAPDH

	Drugs for GAPDH
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for G3P

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GAPDH Gene at Home site.
Version 2.41.1
server5.xennexinc.com

GAPDH Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for GAPDH

Summaries
for GAPDH

Genomic Location
for GAPDH

Proteins
for GAPDH

Protein Domains/
Families
for GAPDH

Gene Function
for GAPDH

Pathways & Interactions
for GAPDH

Drugs & Compounds
for GAPDH

Transcripts
for GAPDH

Expression
for GAPDH

Orthologs
for GAPDH

Paralogs
for GAPDH

SNPs/Variants
for GAPDH

Disorders & Mutations
for GAPDH

Medical News
for GAPDH

Publications
for GAPDH

Search for GAPDH

Genome Databases showing GAPDH

Other Databases showing GAPDH

Specialized Databases showing GAPDH

Licensable Technologies
for GAPDH

Services
for GAPDH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GAPDH Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor GAPDH

Summariesfor GAPDH

Genomic Locationfor GAPDH

Proteinsfor GAPDH

Protein Domains/Familiesfor GAPDH

Gene Functionfor GAPDH

Pathways & Interactionsfor GAPDH

Drugs & Compoundsfor GAPDH

Transcriptsfor GAPDH

Expression for GAPDH

Orthologsfor GAPDH

Paralogsfor GAPDH

SNPs/Variantsfor GAPDH

Disorders & Mutationsfor GAPDH

Medical Newsfor GAPDH

Publicationsfor GAPDH

Search for GAPDH

Genome Databases showing GAPDH

Other Databases showing GAPDH

Specialized Databases showing GAPDH

Licensable Technologiesfor GAPDH

Servicesfor GAPDH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GAPDH

Summaries
for GAPDH

Genomic Location
for GAPDH

Proteins
for GAPDH

Protein Domains/
Families
for GAPDH

Gene Function
for GAPDH

Pathways & Interactions
for GAPDH

Drugs & Compounds
for GAPDH

Transcripts
for GAPDH

Expression
for GAPDH

Orthologs
for GAPDH

Paralogs
for GAPDH

SNPs/Variants
for GAPDH

Disorders & Mutations
for GAPDH

Medical News
for GAPDH

Publications
for GAPDH

Licensable Technologies
for GAPDH

Services
for GAPDH