Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAP43 Gene

protein-coding   GIFtS: 62
GCID: GC03P115342

growth associated protein 43
 Explore 51 diseases affiliated with
GAP43 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GAP43    

Aliases
for GAP43 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Growth Associated Protein 431 2     Calmodulin-Binding Protein P-572
B-501 2     Nerve Growth-Related Peptide GAP432
PP461 2     Neuromodulin1
Axonal Membrane Protein GAP-432 3     Neuron Growth-Associated Protein 432
Growth-Associated Protein 432 3     Protein F12
Neural Phosphoprotein B-502 3     Pp461

External Ids:    HGNC: 41401   Entrez Gene: 25962   Ensembl: ENSG000001720207   OMIM: 1620605   UniProtKB: P176773   

Export aliases for GAP43 gene to outside databases

Previous GC identifers: GC03P112171 GC03P114924 GC03P116623 GC03P116663 GC03P116825 GC03P112715


Summaries
for GAP43 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GAP43:
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high
levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial
component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NEUM_HUMAN, P17677
Function: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form
the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction

Gene Wiki entry for GAP43 (Gap-43 protein)


Genomic Views
for GAP43 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAP43 gene promoter:
         AML1a   MAZR   MyoD   CUTL1   LCR-F1   C/EBPalpha   CREB   SRY   deltaCREB   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GAP43 promoter sequence
   Search SABiosciences Chromatin IP Primers for GAP43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAP43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.1-q13.2   Ensembl cytogenetic band:  3q13.31   HGNC cytogenetic band: 3q21-qter

GAP43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAP43 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P115342:  view genomic region     (about GC identifiers)

Start:
 115,342,151 bp from pter      End:
 115,440,337 bp from pter
Size:
 98,187 bases      Orientation:
 plus strand

Proteins
for GAP43 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NEUM_HUMAN, P17677 (See protein sequence)
Recommended Name: Neuromodulin  
Size: 238 amino acids; 24803 Da
Subunit: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity).
Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone
membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane;
Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes
Secondary accessions: A8K0Y4
Alternative splicing: 2 isoforms:  P17677-1   P17677-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GAP43: NX_P17677

Post-translational modifications:

  • Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with
    • certain forms of synaptic plasticity1
  • Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction.
    • Deacylated by LYPLA21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17677

    • GAP43 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123536.1  NP_002036.1  

    ENSEMBL proteins: 
     ENSP00000305010   ENSP00000377372  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: GAP43
    OriGene Protein Over-expression Lysate: GAP43
    OriGene Custom Protein Services for GAP43 
    GenScript Custom Purified and Recombinant Proteins Services for GAP43
    Novus Biologicals GAP43 Protein
    Novus Biologicals GAP43 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for GAP43
    Uscn Proteins for GAP43

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0030054cell junction IEA--
    GO:0030424axon IEA--
    GO:0031527filopodium membrane IDA14978216
    GO:0032584growth cone membrane IEA--


    GAP43 for ontologies           About GeneDecksing



    GAP43 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GAP43
    R&D Systems Antibodies for GAP43 (GAP-43)
    Cell Signaling Technology (CST) Antibodies for GAP43 
    OriGene Antibodies (see all 3): GAP43
    OriGene Custom Antibody Services for GAP43 
    GenScript Superior Antibodies for GAP43
    Novus Biologicals GAP43 Antibodies
    Abcam antibodies for GAP43 
    Uscn Antibodies for GAP43
    ThermoFisher Antibodies for GAP43

    Assay Products for GAP43: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GAP43
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GAP43

    Protein Domains /
    Families
    for GAP43 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GAP43 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017454 Neuromodulin_C
     IPR001422 Neuromodulin
     IPR000048 IQ_motif_EF-hand-BS
     IPR018947 Neuromodulin_gap-junction_N
     IPR018243 Neuromodulin_palmitoyl/P_site

    Graphical View of Domain Structure for InterPro Entry P17677

    ProtoNet protein and cluster: P17677

    2 Blocks protein families:
    IPB000048 IQ calmodulin-binding region
    IPB001422 Neuromodulin (GAP-43)


    UniProtKB/Swiss-Prot: NEUM_HUMAN, P17677
    Similarity: Belongs to the neuromodulin family
    Similarity: Contains 1 IQ domain


    Function
    for GAP43 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NEUM_HUMAN, P17677
    Function: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form
    the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction

         Genatlas biochemistry entry for GAP43:
    growth associated protein 43,expressed in elongating terminals of neurites,located in granules diffusely dispersed
    throughout the anterior horn neuropil and at the surface of horn cells,overexpressed in amyotropic lateral
    sclerosis,component of neurons regenerative response

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): GAP43
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAP43
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate GAP43 (see all 36):
    hsa-miR-21* hsa-miR-25 hsa-miR-301a hsa-miR-890 hsa-miR-4330 hsa-miR-23a hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: GAP43 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAP43 (see all 7)
    OriGene shRNA RFP: GAP43
    OriGene siRNA: GAP43
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAP43

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GAP43

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAP43 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAP43 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): GAP43 (NM_002045)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAP43
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAP43 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for GAP43
    Search LifeMap BioReagents cell lines for GAP43

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAP43

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI9139733
    GO:0005516calmodulin binding IEA--


    GAP43 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GAP43:
     Decreased telomerase activity 

    Animal Models:
         Mouse knock-outs for GAP43: Gap43tm1Mcf Gap43tm1Kmr
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gap43):
     cellular  growth/size  immune system  mortality/aging  nervous system 
     vision/eye 

    GAP43 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GAP43 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00
    2Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    3Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00
    4N-cadherin signaling events
    		N-cadherin signaling events1.00
    5Glial Cell Differentiation
    		Glial Cell Differentiation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GAP43
        Transcription factors in neurogenesis


    2 Cell Signaling Technology (CST) Pathways for GAP43
        Neuroscience
    Cytoskeletal Signaling

    2 BioSystems Pathways for GAP43 
        Glial Cell Differentiation
    N-cadherin signaling events



    GAP43 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAP43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/19 Interacting proteins for GAP43 (P176771, 3 ENSP000003773724) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056551, 3, ENSP000003316024EBI-1267511,EBI-704279 I2D: score=1 STRING: ENSP00000331602
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway TAS3272162
    GO:0007399nervous system development ----
    GO:0007411axon guidance ----
    GO:0009611response to wounding TAS3272162
    GO:0010001glial cell differentiation IEA--


    GAP43 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GAP43 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GAP43 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAP43
    10/66 Novoseek chemical compound relationships for GAP43 gene (see all 66)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dbc-amp 39.6 12 1646299 (2), 1319472 (2), 8393086 (1), 11972796 (1) (see all 6)
    palmitate 38.3 3 17110192 (1), 18654638 (1)
    tyrosine 31.9 25 8741767 (1), 7743648 (1), 17212696 (1), 1348695 (1) (see all 20)
    retinoic acid 31.2 8 11120388 (1), 10640639 (1), 9298234 (1), 12820386 (1) (see all 7)
    calcium 29.6 44 11274743 (3), 7896819 (3), 7514037 (2), 9139733 (2) (see all 20)
    12-o-tetradecanoylphorbol 13-acetate 28.7 13 10209306 (4), 8393086 (1), 1348695 (1), 1319472 (1) (see all 6)
    acth 1-24 25.8 11 8445991 (4), 2178253 (2)
    bryostatin 1 24.4 1 8482723 (1)
    adenylate 19.6 5 12034726 (4), 7509864 (1)
    iodoacetamide 15.7 1 10446390 (1)

    Search CenterWatch for drugs/clinical trials and news about GAP43 / NEUM 

    Transcripts
    for GAP43 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GAP43 gene (2 alternative transcripts): 
    NM_001130064.1  NM_002045.3  

    Unigene Cluster for GAP43:

    Growth associated protein 43
    Hs.134974  [show with all ESTs]
    Unigene Representative Sequence: AK091466
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305124(uc003ebq.2) ENST00000393780(uc003ebr.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): GAP43
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAP43
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate GAP43 (see all 36):
    hsa-miR-21* hsa-miR-25 hsa-miR-301a hsa-miR-890 hsa-miR-4330 hsa-miR-23a hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: GAP43 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAP43 (see all 7)
    OriGene shRNA RFP: GAP43
    OriGene siRNA: GAP43
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAP43
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAP43 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAP43 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): GAP43 (NM_002045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAP43
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAP43 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAP43
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GAP43
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAP43
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAP43

    Additional cDNA sequence: 

    AF279774.1 AK091466.1 AK123311.1 AK289699.1 AK290100.1 AK313658.1 BC007936.2 BT019771.1 
    BT019810.1 BX648458.1 M25667.1 

    10 DOTS entries:

    DT.416583  DT.92039380  DT.101981587  DT.100762749  DT.99937146  DT.100788962  DT.120844192  DT.91751612 
    DT.92067603  DT.100806792 

    24/225 AceView cDNA sequences (see all 225):

    AI359319 CK005415 BF439700 BM548002 BQ068112 BF432407 AI815479 AA322300 
    BM683029 AA339583 AA338509 BQ024440 CR612258 NM_002045 BM729091 M25667 
    CD671800 BM705081 F02494 AA171547 AW160592 CR614045 BI963060 CR623492 

    GeneLoc Exon Structure


    Expression
    for GAP43 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAP43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAGTAATCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GAP43 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    OvaryAntral FollicleCumulus CellsOvary
    HeartOutflow TractHeart
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See GAP43 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAP43

    SOURCE GeneReport for Unigene cluster: Hs.134974
        SABiosciences Expression via Pathway-Focused PCR Array including GAP43: 
              Alzheimer's Disease in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAP43
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GAP43
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAP43
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAP43
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAP43

    Orthologs
    for GAP43 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for GAP43 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GAP431 growth associated protein 43 80.17(n)
    72.15(a)    		   427955  XM_425527.3  XP_425527.3 
    lizard
    (Anolis carolinensis)    		 Reptilia GAP436
    		 --
    		 60(a)
    		 1 ↔ 1
    		 3(177564137-177564934)
    African clawed frog
    (Xenopus laevis)    		 Amphibia gap43-prov2 growth associated protein 43 78.53(n)    BC042240.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gap432 growth associated protein 43 77.49(n)   30608  L27645.1 


    ENSEMBL Gene Tree for GAP43 (if available)
    TreeFam Gene Tree for GAP43 (if available) 

    Paralogs
    for GAP43 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAP43 gene
    BASP12  
    1 SIMAP similar gene for GAP43 using alignment to 2 protein entries:     NEUM_HUMAN (see all proteins):
    NRGN

    GAP43 for paralogs           About GeneDecksing



    Genomic Variants
    for GAP43 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1817 NCBI SNPs in GAP43 are shown (see all 1817)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs58519661,2
    		C,F,--112716427(+) TTTGC-/AAAAAA 1 -- int13Minor allele frequency- A:0.33NA CSA 6
    rs1441136411,2
    		--115340163(+) TCACAC/TATTTA 2 -- us2k10--------
    rs1464900191,2
    		--115340169(+) ATTTAC/GTCACA 2 -- us2k10--------
    rs22180541,2
    		C,F,O,H,--115340177(+) ACAAAG/TTTCAT 2 -- us2k134Minor allele frequency- T:0.29EA NA NS WA CSA 3410
    rs1836370571,2
    		--115340247(+) CCAAGA/GTTCCT 2 -- us2k10--------
    rs14383581,2
    		C,F,O,H,--115340373(+) TCAATG/TGAGTT 2 -- us2k123Minor allele frequency- N:0.00MN NS EA NA 2618
    rs1895246481,2
    		--115340570(+) TCACGG/TAAGGC 2 -- us2k10--------
    rs23995261,2
    		C,F,H,--115340577(+) AGGCTG/CTTCTG 2 -- us2k19Minor allele frequency- C:0.47NS EA NA WA 782
    rs1115753461,2
    		C,--115340590(+) GCGGCTGGGCTTT
    CAAAAT    /-    TGGGC     		2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1422216221,2
    		--115340665(+) AAACTA/GGGAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GAP43 (115342151 - 115440337 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GAP43
         1 CNV: 91483
    Human Gene Mutation Database (HGMD): GAP43

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAP43
    DNA2.0 Custom Variant and Variant Library Synthesis for GAP43

    Disorders / Diseases
    for GAP43 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GAP43 for disorders           About GeneDecksing

    OMIM gene information: 162060    OMIM disorders: --

    20/51 diseases for GAP43 (see all 51):    About MalaCards
    spinal cord injury    neuronitis    status epilepticus    amyotrophic lateral sclerosis
    temporal lobe epilepsy    myositis fibrosa    allergic contact dermatitis    contact dermatitis
    frontotemporal dementia    retinal detachment    lateral sclerosis    toxic encephalopathy
    cutaneous malignant melanoma    appendicitis    bipolar disorder    cystitis
    inflammatory bowel disease    down syndrome    tetanus    neurodegenerative disease

    10/40 Novoseek disease relationships for GAP43 gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    senile plaques 44.8 6 9011750 (1), 8402154 (1), 10837922 (1), 1283445 (1) (see all 5)
    alzheimers disease 42.3 13 9011750 (3), 11215757 (2), 11351137 (1), 7573369 (1) (see all 7)
    neurodegeneration 36.9 2 9973230 (1), 10666665 (1)
    neurofibrillary tangles 32.2 8 1283445 (4), 9011750 (1)
    amyotrophic lateral sclerosis 29.1 2 9973230 (1), 1387517 (1)
    pheochromocytoma 24.3 5 8928618 (1), 1839071 (1), 9774477 (1), 2139463 (1) (see all 5)
    carcinoma embryonal 23.9 2 10640639 (2)
    atrophy 20.5 12 9391013 (3), 17495772 (2), 15296835 (2), 11569536 (1) (see all 7)
    astrocytosis 19.6 1 11569536 (1)
    schizophrenia 17.9 30 15694236 (7), 11208668 (4), 8943081 (4), 17095155 (3) (see all 11)

    Human Genome Epidemiology (HuGE) Navigator: GAP43 (1 document)

    Export disorders for GAP43 gene to outside databases

    Publications
    for GAP43 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAP43 gene, integrated from 9 sources (see all 407):
    (articles sorted by number of sources associating them with GAP43)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human gene for the neural phosphoprotein B-50 (GAP- 43). (PubMed id 8231732)1, 2, 3, 9 Nielander H.B....Schotman P. (1993)
    2. Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. (PubMed id 3272162)1, 2, 3 Kosik K.S.... Neve R. (1988)
    3. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. (PubMed id 21152083)1, 2 Tomatis V.M....Daniotti J.L. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. (PubMed id 14978216)1, 2 Gauthier-Campbell C....El-Husseini A.e.l.-.D. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)1, 2 Cargill M....Lander E.S. (1999)
    8. Cloning of human GAP-43: growth association and ischemic resurgence. (PubMed id 3272163)1, 2 Ng S.-C.... Fishman M.C. (1988)
    9. Immunocytochemical detection of the growth-associated protein B-50 by newly characterized monoclonal antibodies in human brain and muscle. (PubMed id 1385623)1, 9 Mercken M....Oestreicher A.B. (1992)
    10. Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia. (PubMed id 15694236)1, 9 Chambers J.S....Perrone-Bizzozero N.I. (2005)

    External Searches for GAP43 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GAP43 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2596 HGNC: 4140 AceView: GAP43 Ensembl:ENSG00000172020 euGenes: HUgn2596
    ECgene: GAP43 H-InvDB: GAP43

    Other Databases showing GAP43 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GAP43 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAP43 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gap43/
    Wikipedia http://en.wikipedia.org/wiki/Gap-43_protein

    Intellectual Property
    for GAP43 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GAP43 gene:
    Search GeneIP for patents involving GAP43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for GAP43 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GAP43
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for GAP43 (GAP-43)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for GAP43   OriGene shRNA RFP for GAP43  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAP43   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAP43  
     OriGene Protein Over-expression Lysate for GAP43   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for GAP43   OriGene 3'-UTR Clone for GAP43  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAP43   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAP43  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for GAP43   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GAP43   OriGene Custom Protein Services for GAP43  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAP43
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAP43
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAP43
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAP43
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAP43
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAP43
     GenScript Custom Purified and Recombinant Proteins Services for GAP43 GenScript cDNA clones with any tag delivered in your preferred vector for GAP43
     GenScript Custom Assay Services for GAP43 GenScript Superior Antibodies for GAP43
     GenScript Custom overexpressing Cell Line Services for GAP43 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for GAP43 

     Regulatory tfbs in GAP43 promoter
     Search Chromatin IP Primers for GAP43
     RT2 qPCR Primer Assay in human, mouse, rat GAP43
     GNC Network for GAP43
     SABiosciences PCR Arrays including human, mouse, rat GAP43
     Search Tocris compounds for GAP43
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GAP43 antibodies
     GAP43 proteins
     GAP43 lysates
     Antibodies for GAP43
     See all of Abcam's Antibodies, Kits and Proteins for GAP43
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GAP43




     GAP43 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for GAP43
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAP43
     SwitchGear 3'UTR luciferase reporter plasmids for GAP43
     SwitchGear Promoter luciferase reporter plasmids for GAP43
     ThermoFisher Antibodies for GAP43
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAP43
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      GAP43 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4