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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAP43 Gene

protein-coding   GIFtS: 64
GCID: GC03P115342

Growth Associated Protein 43

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Associated Protein 431 2     Neuron Growth-Associated Protein 431 2
Axonal Membrane Protein GAP-431 2 3     Protein F11 2
Neural Phosphoprotein B-501 2 3     Growth-Associated Protein 432 3
Calmodulin-Binding Protein P-571 2     B-502
Nerve Growth-Related Peptide GAP431 2     PP462
neuromodulin1 2     pp463

External Ids:    HGNC: 41401   Entrez Gene: 25962   Ensembl: ENSG000001720207   OMIM: 1620605   UniProtKB: P176773   

Export aliases for GAP43 gene to outside databases

Previous GC identifers: GC03P112171 GC03P114924 GC03P116623 GC03P116663 GC03P116825 GC03P112715


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GAP43 Gene:
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at
high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a
crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript
variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GAP43 Gene: 
GAP43 (growth associated protein 43) is a protein-coding gene. Diseases associated with GAP43 include acute cervicitis, and myositis fibrosa. GO annotations related to this gene include protein binding and calmodulin binding.

UniProtKB/Swiss-Prot: NEUM_HUMAN, P17677
Function: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that
form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction

Gene Wiki entry for GAP43 (Gap-43 protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAP43 gene promoter:
         AML1a   MAZR   MyoD   CUTL1   LCR-F1   C/EBPalpha   CREB   SRY   deltaCREB   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGAP43 promoter sequence
   Search SABiosciences Chromatin IP Primers for GAP43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAP43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.31   Ensembl cytogenetic band:  3q13.31   HGNC cytogenetic band: 3q13.31

GAP43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAP43 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P115342:  view genomic region     (about GC identifiers)

Start:
115,342,151 bp from pter      End:
115,440,337 bp from pter
Size:
98,187 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEUM_HUMAN, P17677 (See protein sequence)
Recommended Name: Neuromodulin  
Size: 238 amino acids; 24803 Da
Subunit: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By
similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By
similarity)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone
membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium
membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes
Secondary accessions: A8K0Y4
Alternative splicing: 2 isoforms:  P17677-1   P17677-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GAP43: NX_P17677

Explore proteomics data for GAP43 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated
    with certain forms of synaptic plasticity
  • UniProtKB: Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction.
    Deacylated by LYPLA2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17677

  • GAP43 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GAP43 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001123536.1  NP_002036.1  

    ENSEMBL proteins: 
     ENSP00000305010   ENSP00000377372  

    Human Recombinant Protein Products for GAP43: 
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    ProSpec Recombinant Protein for GAP43
    Cloud-Clone Corp. Proteins for GAP43 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0030054cell junction IEA--
    GO:0030424axon IEA--
    GO:0031527filopodium membrane IDA14978216
    GO:0032584growth cone membrane IEA--

    GAP43 for ontologies           About GeneDecksing



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    Assay Products for GAP43: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR017454 Neuromodulin_C
     IPR001422 Neuromodulin
     IPR000048 IQ_motif_EF-hand-BS
     IPR018947 Neuromodulin_gap-junction_N
     IPR018243 Neuromodulin_palmitoyl/P_site

    Graphical View of Domain Structure for InterPro Entry P17677

    ProtoNet protein and cluster: P17677

    2 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB001422 Neuromodulin (GAP-43)


    UniProtKB/Swiss-Prot: NEUM_HUMAN, P17677
    Similarity: Belongs to the neuromodulin family
    Similarity: Contains 1 IQ domain


    GAP43 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUM_HUMAN, P17677
    Function: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that
    form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction

         Genatlas biochemistry entry for GAP43:
    growth associated protein 43,expressed in elongating terminals of neurites,located in granules diffusely dispersed
    throughout the anterior horn neuropil and at the surface of horn cells,overexpressed in amyotropic lateral
    sclerosis,component of neurons regenerative response

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI9139733
    GO:0005516calmodulin binding IEA--
         
    GAP43 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GAP43:
     Decreased telomerase activity 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gap43):
     cellular  growth/size  immune system  mortality/aging  nervous system 
     vision/eye 

    GAP43 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GAP43: Gap43tm1Mcf Gap43tm1Kmr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GAP43 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GAP43

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GAP43 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GAP43 

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    SwitchGear 3'UTR luciferase reporter plasmidGAP43 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GAP43 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2Spinal Cord Injury
    Spinal Cord Injury
    3Neuroscience
    Neuroscience
    4N-cadherin signaling events
    N-cadherin signaling events
    5Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GAP43
        Transcription factors in neurogenesis


    2 Cell Signaling Technology (CST) Pathways for GAP43
        Neuroscience
    Cytoskeletal Signaling

    3 BioSystems Pathways for GAP43
        Spinal Cord Injury
    Glial Cell Differentiation
    N-cadherin signaling events




    GAP43 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAP43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/19 Interacting proteins for GAP43 (P176771, 3 ENSP000003773724) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056551, 3, ENSP000003316024EBI-1267511,EBI-704279 I2D: score=1 STRING: ENSP00000331602
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway TAS3272162
    GO:0007399nervous system development ----
    GO:0007411axon guidance ----
    GO:0009611response to wounding TAS3272162
    GO:0010001glial cell differentiation IEA--

    GAP43 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GAP43 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAP43 (NEUM)

    10/66 Novoseek inferred chemical compound relationships for GAP43 gene (see all 66)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dbc-amp 39.6 12 1646299 (2), 1319472 (2), 8393086 (1), 11972796 (1) (see all 6)
    palmitate 38.3 3 17110192 (1), 18654638 (1)
    tyrosine 31.9 25 8741767 (1), 7743648 (1), 17212696 (1), 1348695 (1) (see all 20)
    retinoic acid 31.2 8 11120388 (1), 10640639 (1), 9298234 (1), 12820386 (1) (see all 7)
    calcium 29.6 44 11274743 (3), 7896819 (3), 7514037 (2), 9139733 (2) (see all 20)
    12-o-tetradecanoylphorbol 13-acetate 28.7 13 10209306 (4), 8393086 (1), 1348695 (1), 1319472 (1) (see all 6)
    acth 1-24 25.8 11 8445991 (4), 2178253 (2)
    bryostatin 1 24.4 1 8482723 (1)
    adenylate 19.6 5 12034726 (4), 7509864 (1)
    iodoacetamide 15.7 1 10446390 (1)

    Search CenterWatch for drugs/clinical trials and news about GAP43 / NEUM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GAP43 gene (2 alternative transcripts): 
    NM_001130064.1  NM_002045.3  

    Unigene Cluster for GAP43:

    Growth associated protein 43
    Hs.134974  [show with all ESTs]
    Unigene Representative Sequence: AK091466
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305124(uc003ebq.2) ENST00000393780(uc003ebr.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate GAP43 (see all 36):
    hsa-miR-21* hsa-miR-25 hsa-miR-301a hsa-miR-890 hsa-miR-4330 hsa-miR-23a hsa-miR-92b hsa-miR-130b
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    Additional mRNA sequence: 

    AF279774.1 AK091466.1 AK123311.1 AK289699.1 AK290100.1 AK313658.1 BC007936.2 BT019771.1 
    BT019810.1 BX648458.1 M25667.1 

    10 DOTS entries:

    DT.416583  DT.92039380  DT.101981587  DT.100762749  DT.99937146  DT.100788962  DT.120844192  DT.91751612 
    DT.92067603  DT.100806792 

    24/225 AceView cDNA sequences (see all 225):

    BF439700 AA323511 AI929651 BF432407 BC007936 BI963060 AV729219 F02494 
    CK903641 BQ898873 BM663887 AA339346 CK005415 AA171547 AW160592 AI419299 
    BG207119 M25667 CD671800 BM705081 CR623492 BG202954 BP348536 CD247455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAP43 expression in normal human tissues (normalized intensities)      GAP43 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGTAATCA
    GAP43 Expression
    About this image


    GAP43 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 58 entries
             Epithalamus
             Fetal Neuronal Stem Cells (NSC)   
             Globus Pallidus   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 11 entries
             Schwann Precursor Cells Peripheral Nerve Domain
             colon ; peripheral nerve/ganglion   
             spinal/nerve plexus   
     
     Spinal Cord (Nervous System)    fully expand to see all 5 entries
             Ventral Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer

    See GAP43 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAP43

    SOURCE GeneReport for Unigene cluster: Hs.134974
        SABiosciences Expression via Pathway-Focused PCR Array including GAP43: 
              Alzheimer's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAP43

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GAP43 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gap431 , 5 growth associated protein 431, 5 89.09(n)1
    85.84(a)1
      16 (28.37 cM)5
    144321  NM_008083.21  NP_032109.11 
     422484425 
    chicken
    (Gallus gallus)
    Aves GAP431 growth associated protein 43 80.17(n)
    72.15(a)
      427955  XM_425527.3  XP_425527.3 
    lizard
    (Anolis carolinensis)
    Reptilia GAP436
    growth associated protein 43
    60(a)
    1 ↔ 1
    3(177523061-177605920)
    African clawed frog
    (Xenopus laevis)
    Amphibia gap43-prov2 growth associated protein 43 78.53(n)    BC042240.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gap432 growth associated protein 43 77.49(n)   30608  L27645.1 


    ENSEMBL Gene Tree for GAP43 (if available)
    TreeFam Gene Tree for GAP43 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAP43 gene
    1 SIMAP similar gene for GAP43 using alignment to 2 protein entries:     NEUM_HUMAN (see all proteins):
    NRGN

    GAP43 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2127 SNPs in GAP43 are shown (see all 2127)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441136411,2
    --115340163(+) TCACAC/TATTTA 2 -- us2k10--------
    rs1464900191,2
    --115340169(+) ATTTAC/GTCACA 2 -- us2k10--------
    rs22180541,2
    C,F,O,H--115340177(+) ACAAAG/TTTCAT 2 -- us2k134Minor allele frequency- T:0.29EA NA NS WA CSA 3410
    rs1836370571,2
    --115340247(+) CCAAGA/GTTCCT 2 -- us2k10--------
    rs14383581,2
    C,F,O,H--115340373(+) TCAATG/TGAGTT 2 -- us2k123Minor allele frequency- N:0.00MN NS EA NA 2618
    rs1895246481,2
    --115340570(+) TCACGG/TAAGGC 2 -- us2k10--------
    rs23995261,2
    C,F,H--115340577(+) AGGCTG/CTTCTG 2 -- us2k19Minor allele frequency- C:0.47NS EA NA WA 782
    rs1115753461,2
    C--115340590(+) GCGGCTGGGCTTT
    CAAAAT
    /-
    CTGGG
    2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs61480261,2
    C--115340596(+) GGGCT-/TTCAAA
    ATTGGGCT
    CCTTG
    2 -- us2k10--------
    rs1422216221,2
    --115340665(+) AAACTA/GGGAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GAP43 (115342151 - 115440337 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for GAP43:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672570CNV Deletion23128226
    esv274109CNV Insertion20981092
    esv1060470CNV Insertion17803354
    esv270312CNV Insertion20981092
    dgv5234n71CNV Gain21882294
    nsv877356CNV Gain21882294


    Human Gene Mutation Database (HGMD): GAP43
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GAP43
    DNA2.0 Custom Variant and Variant Library Synthesis for GAP43

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 162060    OMIM disorders: --

    20/47 diseases for GAP43 (see all 47):    About MalaCards
    acute cervicitis    myositis fibrosa    appendicitis    status epilepticus
    retinal detachment    frontotemporal dementia    allergic contact dermatitis    contact dermatitis
    cystitis    tetanus    cutaneous malignant melanoma    toxic encephalopathy
    dementia    brain ischemia    spinal cord injury    cholera
    neuroma    pheochromocytoma    temporal lobe epilepsy    bipolar disorder


    GAP43 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/40 Novoseek inferred disease relationships for GAP43 gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    senile plaques 44.8 6 9011750 (1), 8402154 (1), 10837922 (1), 1283445 (1) (see all 5)
    alzheimers disease 42.3 13 9011750 (3), 11215757 (2), 11351137 (1), 7573369 (1) (see all 7)
    neurodegeneration 36.9 2 9973230 (1), 10666665 (1)
    neurofibrillary tangles 32.2 8 1283445 (4), 9011750 (1)
    amyotrophic lateral sclerosis 29.1 2 9973230 (1), 1387517 (1)
    pheochromocytoma 24.3 5 8928618 (1), 1839071 (1), 9774477 (1), 2139463 (1) (see all 5)
    carcinoma embryonal 23.9 2 10640639 (2)
    atrophy 20.5 12 9391013 (3), 17495772 (2), 15296835 (2), 11569536 (1) (see all 7)
    astrocytosis 19.6 1 11569536 (1)
    schizophrenia 17.9 30 15694236 (7), 11208668 (4), 8943081 (4), 17095155 (3) (see all 11)

    Genetic Association Database (GAD): GAP43
    Human Genome Epidemiology (HuGE) Navigator: GAP43 (1 document)

    Export disorders for GAP43 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAP43 gene, integrated from 9 sources (see all 410):
    (articles sorted by number of sources associating them with GAP43)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human gene for the neural phosphoprotein B-50 (GAP- 43). (PubMed id 8231732)1, 2, 3, 9 Nielander H.B....Schotman P. (1993)
    2. Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. (PubMed id 3272162)1, 2, 3 Kosik K.S.... Neve R. (1988)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. (PubMed id 21152083)1, 2 Tomatis V.M....Daniotti J.L. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. (PubMed id 14978216)1, 2 Gauthier-Campbell C....El-Husseini A.e.l.-.D. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)1, 2 Cargill M....Lander E.S. (1999)
    9. Cloning of human GAP-43: growth association and ischemic resurgence. (PubMed id 3272163)1, 2 Ng S.-C.... Fishman M.C. (1988)
    10. Immunocytochemical detection of the growth-associated protein B-50 by newly characterized monoclonal antibodies in human brain and muscle. (PubMed id 1385623)1, 9 Mercken M....Oestreicher A.B. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2596 HGNC: 4140 AceView: GAP43 Ensembl:ENSG00000172020 euGenes: HUgn2596
    ECgene: GAP43 H-InvDB: GAP43

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAP43 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gap43/
    Wikipedia http://en.wikipedia.org/wiki/Gap-43_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GAP43 gene:
    Search GeneIP for patents involving GAP43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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