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Aliases for GAP43 Gene

Aliases for GAP43 Gene

  • Growth Associated Protein 43 2 3 5
  • Axonal Membrane Protein GAP-43 2 3 4
  • Neural Phosphoprotein B-50 2 3 4
  • Neuron Growth-Associated Protein 43 2 3
  • Nerve Growth-Related Peptide GAP43 2 3
  • Calmodulin-Binding Protein P-57 2 3
  • Neuromodulin 2 3
  • Protein F1 2 3
  • PP46 3 4
  • Growth-Associated Protein 43 4
  • B-50 3

External Ids for GAP43 Gene

Previous GeneCards Identifiers for GAP43 Gene

  • GC03P112171
  • GC03P114924
  • GC03P116623
  • GC03P116663
  • GC03P116825
  • GC03P115342
  • GC03P112715

Summaries for GAP43 Gene

Entrez Gene Summary for GAP43 Gene

  • The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAP43 Gene

GAP43 (Growth Associated Protein 43) is a Protein Coding gene. Diseases associated with GAP43 include Myositis Fibrosa and Pneumonic Plague. Among its related pathways are Developmental Biology and Spinal Cord Injury. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for GAP43 Gene

  • This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Gene Wiki entry for GAP43 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAP43 Gene

Genomics for GAP43 Gene

Regulatory Elements for GAP43 Gene

Enhancers for GAP43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G115512 1.1 Ensembl ENCODE 10.5 -110.3 -110316 1.8 PKNOX1 RAD21 ZNF366 EGR2 ZNF263 SP3 ZNF362 ZEB2 ZNF398 RAD51 GAP43 GC03M115514 GC03P115510
GH03G115692 1.1 Ensembl ENCODE 10.4 +69.7 69678 0.9 GTF2F1 ELF3 CTCF TFAP4 PKNOX1 ATF1 SAP130 MAX BRCA1 RAD21 GAP43 ENSG00000241596 GC03P115763
GH03G115657 1 ENCODE 10.5 +35.5 35526 3.1 HDGF PKNOX1 ATF1 ZNF48 GLIS2 SP3 SP5 JUNB ZNF592 SMARCA4 GAP43 ENSG00000241596 GC03P115763
GH03G115279 0.8 FANTOM5 ENCODE 9.9 -342.9 -342932 1.7 SUZ12 PCBP1 PRDM1 NFE2L2 GAP43 EIF4E2P2 GC03M115395
GH03G115660 0.7 Ensembl ENCODE 10.2 +37.7 37673 0.8 ZNF146 SMARCA4 GAP43 ENSG00000241596 GC03P115763
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GAP43 on UCSC Golden Path with GeneCards custom track

Promoters for GAP43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156898 297 800 RAD21 ZNF366 ZNF263 ZNF362 ZNF398 REST ZFP69B ZNF610 SMARCA4 KLF16

Genomic Location for GAP43 Gene

Chromosome:
3
Start:
115,623,304 bp from pter
End:
115,721,490 bp from pter
Size:
98,187 bases
Orientation:
Plus strand

Genomic View for GAP43 Gene

Genes around GAP43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAP43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAP43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAP43 Gene

Proteins for GAP43 Gene

  • Protein details for GAP43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17677-NEUM_HUMAN
    Recommended name:
    Neuromodulin
    Protein Accession:
    P17677
    Secondary Accessions:
    • A8K0Y4

    Protein attributes for GAP43 Gene

    Size:
    238 amino acids
    Molecular mass:
    24803 Da
    Quaternary structure:
    • Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.

    Alternative splice isoforms for GAP43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAP43 Gene

Post-translational modifications for GAP43 Gene

  • Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.
  • Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAP43 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GAP43 (GAP43)

No data available for DME Specific Peptides for GAP43 Gene

Domains & Families for GAP43 Gene

Suggested Antigen Peptide Sequences for GAP43 Gene

Graphical View of Domain Structure for InterPro Entry

P17677

UniProtKB/Swiss-Prot:

NEUM_HUMAN :
  • Belongs to the neuromodulin family.
Family:
  • Belongs to the neuromodulin family.
genes like me logo Genes that share domains with GAP43: view

No data available for Gene Families for GAP43 Gene

Function for GAP43 Gene

Molecular function for GAP43 Gene

GENATLAS Biochemistry:
growth associated protein 43,expressed in elongating terminals of neurites,located in granules diffusely dispersed throughout the anterior horn neuropil and at the surface of horn cells,overexpressed in amyotropic lateral sclerosis,component of neurons regenerative response
UniProtKB/Swiss-Prot Function:
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Gene Ontology (GO) - Molecular Function for GAP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IEA --
GO:0005515 protein binding IPI 9139733
GO:0005516 calmodulin binding IEA --
GO:0035727 lysophosphatidic acid binding IEA --
GO:1901981 phosphatidylinositol phosphate binding IEA --
genes like me logo Genes that share ontologies with GAP43: view
genes like me logo Genes that share phenotypes with GAP43: view

Animal Models for GAP43 Gene

MGI Knock Outs for GAP43:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GAP43

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAP43 Gene

Localization for GAP43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAP43 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAP43 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
cytoskeleton 3
extracellular 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for GAP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0014069 postsynaptic density IEA,IBA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GAP43: view

Pathways & Interactions for GAP43 Gene

genes like me logo Genes that share pathways with GAP43: view

Pathways by source for GAP43 Gene

2 Cell Signaling Technology pathways for GAP43 Gene
3 Reactome pathways for GAP43 Gene

Gene Ontology (GO) - Biological Process for GAP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 3272162
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0007411 axon guidance TAS --
GO:0009611 response to wounding TAS 3272162
genes like me logo Genes that share ontologies with GAP43: view

No data available for SIGNOR curated interactions for GAP43 Gene

Drugs & Compounds for GAP43 Gene

(41) Drugs for GAP43 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(25) Additional Compounds for GAP43 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GAP43: view

Transcripts for GAP43 Gene

mRNA/cDNA for GAP43 Gene

Unigene Clusters for GAP43 Gene

Growth associated protein 43:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GAP43

Alternative Splicing Database (ASD) splice patterns (SP) for GAP43 Gene

No ASD Table

Relevant External Links for GAP43 Gene

GeneLoc Exon Structure for
GAP43
ECgene alternative splicing isoforms for
GAP43

Expression for GAP43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAP43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAP43 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Frontal Cortex (BA9) (x7.5), Brain - Cortex (x7.1), Brain - Amygdala (x5.1), and Brain - Hypothalamus (x5.1).

Protein differential expression in normal tissues from HIPED for GAP43 Gene

This gene is overexpressed in Brain (24.8), Fetal Brain (19.8), and Frontal cortex (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GAP43 Gene



Protein tissue co-expression partners for GAP43 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GAP43 Gene:

GAP43

SOURCE GeneReport for Unigene cluster for GAP43 Gene:

Hs.134974

Evidence on tissue expression from TISSUES for GAP43 Gene

  • Nervous system(5)
  • Intestine(2.9)
  • Eye(2.4)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with GAP43: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAP43 Gene

Orthologs for GAP43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAP43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAP43 34 35
  • 96.36 (n)
cow
(Bos Taurus)
Mammalia GAP43 34 35
  • 88.38 (n)
dog
(Canis familiaris)
Mammalia GAP43 34 35
  • 87.82 (n)
mouse
(Mus musculus)
Mammalia Gap43 34 16 35
  • 81.86 (n)
rat
(Rattus norvegicus)
Mammalia Gap43 34
  • 81.19 (n)
oppossum
(Monodelphis domestica)
Mammalia GAP43 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAP43 34 35
  • 77.49 (n)
lizard
(Anolis carolinensis)
Reptilia GAP43 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gap43 34
  • 61.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia gap43-prov 34
zebrafish
(Danio rerio)
Actinopterygii gap43 34 35
  • 39 (a)
Species where no ortholog for GAP43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAP43 Gene

ENSEMBL:
Gene Tree for GAP43 (if available)
TreeFam:
Gene Tree for GAP43 (if available)

Paralogs for GAP43 Gene

(1) SIMAP similar genes for GAP43 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GAP43: view

No data available for Paralogs for GAP43 Gene

Variants for GAP43 Gene

Sequence variations from dbSNP and Humsavar for GAP43 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000027277 -- 115,714,040(+) TTACA(A/G)TAATT intron-variant
rs1000043573 -- 115,661,845(+) TTTTT(A/T)ACCTG intron-variant, upstream-variant-2KB
rs1000044539 -- 115,629,078(+) TATTT(A/C)AACTC intron-variant
rs1000076106 -- 115,662,103(+) AGAGA(A/G)CTTCT intron-variant, utr-variant-5-prime
rs1000097371 -- 115,706,966(+) AGGTA(A/G)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAP43 Gene

Variant ID Type Subtype PubMed ID
esv1060470 CNV insertion 17803354
esv2672570 CNV deletion 23128226
esv3321631 CNV insertion 20981092
esv3354785 CNV insertion 20981092
esv3442342 CNV insertion 20981092
esv3597478 CNV loss 21293372

Variation tolerance for GAP43 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAP43 Gene

Human Gene Mutation Database (HGMD)
GAP43
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAP43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAP43 Gene

Disorders for GAP43 Gene

MalaCards: The human disease database

(6) MalaCards diseases for GAP43 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myositis fibrosa
  • interstitial myositis
pneumonic plague
  • primary pneumonic plague
status epilepticus
  • gcse
pheochromocytoma
  • pheochromocytoma, modifier of
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search GAP43 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GAP43

Genetic Association Database (GAD)
GAP43
Human Genome Epidemiology (HuGE) Navigator
GAP43
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAP43
genes like me logo Genes that share disorders with GAP43: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAP43 Gene

Publications for GAP43 Gene

  1. Structure of the human gene for the neural phosphoprotein B-50 (GAP- 43). (PMID: 8231732) Nielander H.B. … Schotman P. (Brain Res. Mol. Brain Res. 1993) 2 3 4 22 64
  2. Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. (PMID: 3272162) Kosik K.S. … Neve R. (Neuron 1988) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. (PMID: 21152083) Tomatis V.M. … Daniotti J.L. (PLoS ONE 2010) 3 4 64
  5. Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia. (PMID: 15694236) Chambers J.S. … Perrone-Bizzozero N.I. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2005) 3 22 64

Products for GAP43 Gene

  • Addgene plasmids for GAP43

Sources for GAP43 Gene

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