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GANC Gene

protein-coding   GIFtS: 50

GC15P040354
glucosidase, alpha; neutral C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 3.2.1.20 3
MGC138256 2
Descriptions
glucosidase, alpha; neutral C 2
neutral alpha-glucosidase C 2
External Ids
HGNC: 41391
Entrez Gene: 25952
UniProtKB: Q8TET43
Ensembl: ENSG000002140137
Search outside databases for aliases for GANC gene

Previous GC identifers: GC15U990022 GC15P040282

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GANC:
Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or
between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl
hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose
residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene
localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes.
[provided by RefSeq]

UniProtKB/Swiss-Prot: GANC_HUMAN, Q8TET4
Function: Has alpha-glucosidase activity

Gene Wiki entry for GANC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the GANC gene  

Entrez Gene cytogenetic band: 15q15.2   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.2

GANC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P040354:     (about GC identifiers)

Start:
40,353,658 bp from pter
End:
40,433,156 bp from pter
Size:
79,499 bases
Orientation:
plus strand
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GANC_HUMAN, Q8TET4 (See protein sequence)
Recommended Name: Neutral alpha-glucosidase C  
Size: 914 amino acids; 104348 Da
Secondary accessions: Q52LQ4 Q8IWZ0 Q8IZM4 Q8IZM5

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_937784.2  

    ENSEMBL proteins: 
    ENSP00000326227 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (GANC)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for GANC: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GANC
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (GANC)
    Novus Biologicals Antibody for GANC

    Assays for GANC: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR000322 Glyco_hydro_31


       GeneDecks  GANC for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8TET4

    ProtoNet protein and cluster: Q8TET4

    1 Blocks protein family: IPB000322 Glycoside hydrolase

    UniProtKB/Swiss-Prot: GANC_HUMAN, Q8TET4
    Similarity: Belongs to the glycosyl hydrolase 31 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (GANC)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_198141

                  Applied Biosystems Silencer® siRNAs for GANC

                  Sigma-Aldrich siRNA and siRNA Panels for GANC  
                         Sigma-Aldrich shRNA for GANC  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_198141
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_198141
                                     untagged cDNA clones in CMV expression vector (see all 2): AK074037 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_198141

    UniProtKB/Swiss-Prot: GANC_HUMAN, Q8TET4
    Function: Has alpha-glucosidase activity
    Catalytic activity: Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues
    with release of alpha-D-glucose
    Enzyme Number (IUBMB): EC 3.2.1.20 

    Genatlas biochemistry entry for GANC:
    glucosidase,alpha-,neutral C

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA--
    GO:0004558 alpha-glucosidase activity NAS12370436
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  GANC  (Your Favorite Gene powered by Ingenuity) 
     Starch and Sucrose Metabolism
     Galactose Metabolism

       GeneDecks  GANC for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for GANC):
     hsa00052 Galactose metabolism
     hsa00500 Starch and sucrose metabolism

       GeneDecks  GANC for the pathways selected above  
    About GeneDecksing

    5/40 Interacting proteins for GANC (ENSP000003262273) via UniProtKB, MINT, and/or STRING (see all 40 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TTNENSP000003405543STRING (score=.996)
    DYSFENSP000002581043STRING (score=.983)
    SGCGENSP000002188673STRING (score=.965)
    AGLENSP000003090203STRING (score=.963)
    SERPINB8ENSP000002952113STRING (score=.963)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975 carbohydrate metabolic process IEA--
    GO:0008152 metabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for GANC
    Browse Small Molecules at Sigma-Aldrich

    Compounds for GANC available from Tocris Bioscience
    CompoundAction CAS number
    1-DeoxynojirimycinGlucosidase I and II inhibitor[19130-96-2]
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (GANC)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_198141

                  Sigma-Aldrich siRNA and siRNA Panels for GANC  
                         Sigma-Aldrich shRNA for GANC  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_198141  

    REFSEQ mRNAs for GANC gene: 

    NM_198141.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_198141  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_198141
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_198141
                                     untagged cDNA clones in CMV expression vector (see all 2): AK074037 

    24/72 AceView cDNA sequences (see all 72 ):

    BG034181 BC003169 BU194969 BC003521 BF059173 AL044086 BU160598 BQ878602 
    BQ425112 BE220887 NM_212464 AF127764 BQ427836 NM_000070 BG393547 BQ223604 
    NM_212465 F24048 CF552300 BU161124 AJ574026 AA278997 X85030 BG574232 

    highest scoring ESTs for GANC:

    BM999150 AI610343 AW104781 AW572233 AW627922 AA195092 AI671238 AA278326 AA278997 AA459075 


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000318010  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    GANC expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for GANC

    1 / 2 / 3

    8 probe-sets matching GANC gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    81801_at2, 3 U95-E 1 1.00 1.00 0.93 1.24 AI671238 0.60 0.75 0.68 1

    50939_at2, 3 U95-B 1 1.00 1.00 0.71 0.77 AA195092 0.60 0.75 0.68 1

    236077_at2, 3 U133-B 1 1.00 1.00 -- -- AI671238 0.60 0.75 0.68 1

    235340_at2, 3 U133-B 1 1.00 1.00 -- -- BE220887 0.60 0.62 0.61 1

    235714_at2 U133-B 1 0.55 1.00 -- -- -- -- -- -- --

    236077_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    235340_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    235714_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    GeneDecks  GANC for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for GANC gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GANC1   -- glucosidase, alpha; neutral C 89.05(n)
    87.73(a)
    487517  XM_544641.2  XP_544641.2 
    chimpanzee
    (Pan troglodytes)
    GANC1   -- glucosidase, alpha; neutral C 99.34(n)
    99.23(a)
    453361  XM_001152286.1  XP_001152286.1 
    cow
    (Bos taurus)
    GANC1   -- glucosidase, alpha; neutral C 88.17(n)
    86.86(a)
    530330  XM_608799.3  XP_608799.2 
    mouse
    (Mus musculus)
    Ganc1, 5 25
    glucosidase, alpha; neutral C1, 5 85.53(n)1
    84.43(a)1
    760511  NM_172672.21  NP_766260.21 
     AK0179945  AK0763335  (see all 14)
    chicken
    (Gallus gallus)
    GANC1   -- glucosidase, alpha; neutral C 70.65(n)
    66.48(a)
    423232  XM_421156.2  XP_421156.2 
    About this table        Species with no ortholog for GANC

    ENSEMBL Gene Tree for GANC
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for GANC gene
    GAA2  GANAB2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/448 NCBI SNPs in GANC are shown (see all 448 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 214)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs80247321,2
    A,C,F,H40358010(+) CTATCG/AGGCAT 1 R/Q mis116Minor allele frequency- A:0.25EA NA EU WA 1418
    rs80435151,2
    C,F,H40355839(+) TTAGTG/CTTGAA 1 V/L mis18Minor allele frequency- C:0.06EU EA WA 840
    rs25786521,2
    C,F,H40405823(-) TCAGGA/TTCAAT 1 D/E mis18Minor allele frequency- T:0.04EU EA WA 826
    rs169730151,2
    C,F,H40372391(+) TACAGA/GTTCTT 1 I/V mis112Minor allele frequency- G:0.01NA EU EA WA 1026
    rs80376271,2
    A,C,F,H40367240(+) ATTAAC/TGAAGA 1 N/N syn112Minor allele frequency- T:0.13NA EU EA WA 1020
    rs169730081,2
    C,F,H40367276(+) GTTCCG/AGATGT 1 P/P syn115Minor allele frequency- A:0.11NA EU EA WA 1400
    rs360231271,2
    F40419220(+) CAGGCT/CGGAGC 1 A/A syn11Minor allele frequency- C:0.10NA 42
    rs350391861,2
    F40419268(+) ACCAAG/ACGACG 1 K/K syn11Minor allele frequency- A:0.10NA 42
    rs24126941,2
    A,C,F,H,O40390375(+) TGTTAT/CATATC 1 -- int112Minor allele frequency- C:0.11NS EU EA WA NA 668
    rs16592191,2
    A,C,F,H,O40402784(-) TACCAC/TAGCAT 1 -- int17Minor allele frequency- T:0.22EU EA WA NA 562
    About this table

    HapMap Linkage Disequilibrium images for GANC (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 104180

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/44 PubMed articles for GANC gene (see all 44 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2595 HGNC: 4139 AceView: CAPN3 Ensembl:ENSG00000214013 euGenes: HUgn2595
    ECgene: GANC H-InvDB: GANC
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GANC:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GANC-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for GANC Antibodies for GANC
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GANC Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Rabbit Pab from Full-length Protein
      
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     Search for Antibodies
     Search OriGene for GANC
     Tocris compounds for GANC




     Drugs for GANC
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for GANC

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