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Aliases for GANC Gene

Aliases for GANC Gene

  • Glucosidase, Alpha; Neutral C 2 3
  • EC 4
  • EC 3.2.1 63

External Ids for GANC Gene

Previous GeneCards Identifiers for GANC Gene

  • GC15U990022
  • GC15P040282
  • GC15P040354
  • GC15P042566
  • GC15P019414

Summaries for GANC Gene

Entrez Gene Summary for GANC Gene

  • Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014]

GeneCards Summary for GANC Gene

GANC (Glucosidase, Alpha; Neutral C) is a Protein Coding gene. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include carbohydrate binding and alpha-1,4-glucosidase activity. An important paralog of this gene is MGAM.

UniProtKB/Swiss-Prot for GANC Gene

  • Has alpha-glucosidase activity.

Tocris Summary for GANC Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

Gene Wiki entry for GANC Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GANC Gene

Genomics for GANC Gene

Genomic Location for GANC Gene

42,273,233 bp from pter
42,356,935 bp from pter
83,703 bases
Plus strand

Genomic View for GANC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GANC Gene

Proteins for GANC Gene

  • Protein details for GANC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neutral alpha-glucosidase C
    Protein Accession:
    Secondary Accessions:
    • Q52LQ4
    • Q8IWZ0
    • Q8IZM4
    • Q8IZM5

    Protein attributes for GANC Gene

    914 amino acids
    Molecular mass:
    104334 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB84863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GANC Gene

Proteomics data for GANC Gene at MOPED

Selected DME Specific Peptides for GANC Gene

Post-translational modifications for GANC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GANC Gene

Suggested Antigen Peptide Sequences for GANC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 31 family.
  • Belongs to the glycosyl hydrolase 31 family.
genes like me logo Genes that share domains with GANC: view

No data available for Gene Families for GANC Gene

Function for GANC Gene

Molecular function for GANC Gene

GENATLAS Biochemistry:
glucosidase,alpha-,neutral C
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose
UniProtKB/Swiss-Prot Function:
Has alpha-glucosidase activity.

Enzyme Numbers (IUBMB) for GANC Gene

Gene Ontology (GO) - Molecular Function for GANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004558 alpha-1,4-glucosidase activity NAS 12370436
GO:0030246 carbohydrate binding IEA --
GO:0032450 maltose alpha-glucosidase activity IEA --
genes like me logo Genes that share ontologies with GANC: view
genes like me logo Genes that share phenotypes with GANC: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GANC Gene

Localization for GANC Gene

Subcellular locations from

Jensen Localization Image for GANC Gene COMPARTMENTS Subcellular localization image for GANC gene
Compartment Confidence
cytoskeleton 2
nucleus 2
chloroplast 1
golgi apparatus 1
lysosome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GANC Gene

Pathways & Interactions for GANC Gene

genes like me logo Genes that share pathways with GANC: view

Pathways by source for GANC Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GANC Gene

Gene Ontology (GO) - Biological Process for GANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000023 maltose metabolic process IEA --
GO:0005975 carbohydrate metabolic process --
genes like me logo Genes that share ontologies with GANC: view

No data available for SIGNOR curated interactions for GANC Gene

Drugs & Compounds for GANC Gene

(4) Drugs for GANC Gene - From: HMDB, Tocris, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miglitol Approved Pharma Target, antagonist 12
maltose Experimental Pharma 0
Sucrose Experimental Pharma 0
1-Deoxynojirimycin Experimental Pharma Glucosidase I and II inhibitor 0

(10) Additional Compounds for GANC Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
  • beta-D-Arabino-hexulose
  • beta-D-Fructofuranose
  • beta-D-Fructose
  • beta-delta-Arabino-hexulose
  • beta-delta-Fructofuranose
  • (+)-Galactose
  • 5abp
  • 8abp
  • alpha D-Galactose
  • alpha-D-Galactopyranose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
  • 6-(a-D-Galactosido)-D-glucose
  • 6-(a-delta-Galactosido)-delta-glucose
  • 6-(D-Galactosido)-D-glucose
  • 6-(D-Galactosido)-delta-glucose
  • 6-O-a-D-Galactopyranosyl-D-Glucose
genes like me logo Genes that share compounds with GANC: view

Transcripts for GANC Gene

Unigene Clusters for GANC Gene

Glucosidase, alpha; neutral C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GANC Gene

No ASD Table

Relevant External Links for GANC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GANC Gene

mRNA expression in normal human tissues for GANC Gene

Protein differential expression in normal tissues from HIPED for GANC Gene

This gene is overexpressed in Cerebrospinal fluid (24.2), Bone marrow mesenchymal stem cell (12.2), Lymph node (10.1), and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GANC Gene

SOURCE GeneReport for Unigene cluster for GANC Gene Hs.730806

genes like me logo Genes that share expression patterns with GANC: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GANC Gene

Orthologs for GANC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GANC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GANC 35
  • 88.17 (n)
  • 86.86 (a)
  • 86 (a)
(Canis familiaris)
Mammalia GANC 35
  • 89.05 (n)
  • 87.73 (a)
  • 88 (a)
(Mus musculus)
Mammalia Ganc 35
  • 85.53 (n)
  • 84.43 (a)
Ganc 16
Ganc 36
  • 84 (a)
(Pan troglodytes)
Mammalia GANC 35
  • 99.34 (n)
  • 99.23 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ganc 35
  • 85.12 (n)
  • 83.44 (a)
(Monodelphis domestica)
Mammalia GANC 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia GANC 36
  • 59 (a)
(Gallus gallus)
Aves GANC 35
  • 70.65 (n)
  • 66.48 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia GANC 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ganc 35
  • 62.84 (n)
  • 60.47 (a)
(Danio rerio)
Actinopterygii LOC100536353 35
  • 56.5 (n)
  • 53.45 (a)
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14476 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea aagr-3 36
  • 40 (a)
aagr-4 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROT2 36
  • 32 (a)
(Glycine max)
eudicotyledons Gma.6669 35
(Triticum aestivum)
Liliopsida Ta.1604 35
(Zea mays)
Liliopsida Zm.13759 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for GANC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GANC Gene

Gene Tree for GANC (if available)
Gene Tree for GANC (if available)

Paralogs for GANC Gene

Paralogs for GANC Gene

(1) SIMAP similar genes for GANC Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GANC: view

Variants for GANC Gene

Sequence variations from dbSNP and Humsavar for GANC Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs12939 -- 42,284,378(+) TATTT(A/T)CGCCT intron-variant, utr-variant-3-prime
rs765830 -- 42,313,808(+) cacgc(C/G)tgtaa intron-variant
rs936603 -- 42,291,690(-) GACAA(C/T)TAAAT intron-variant
rs1659212 -- 42,333,754(-) AGCCA(A/G)GTGTT intron-variant
rs1659213 -- 42,332,501(-) GTAGT(A/G)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GANC Gene

Variant ID Type Subtype PubMed ID
nsv904133 CNV Gain 21882294
esv2671493 CNV Deletion 23128226
nsv832986 CNV Loss 17160897
esv2660428 CNV Deletion 23128226
nsv832987 CNV Gain 17160897
esv2661604 CNV Deletion 23128226

Variation tolerance for GANC Gene

Residual Variation Intolerance Score: 90.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.75; 96.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GANC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GANC Gene

Disorders for GANC Gene

Relevant External Links for GANC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GANC: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GANC Gene

Publications for GANC Gene

  1. Computer assisted cloning of human neutral alpha glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31. (PMID: 12370436) Hirschhorn R. … Kasper J.S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 23 67
  2. The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. (PMID: 19818342) Fukaya N. … Goda T. (Eur. J. Pharmacol. 2009) 25 26
  3. Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. (PMID: 19085811) Hirata A. … Tominaga M. (Horm. Metab. Res. 2009) 25 26
  4. Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene. (PMID: 14675785) Kawabata Y. … Sorimachi H. (FEBS Lett. 2003) 23 67
  5. Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15. (PMID: 6995030) Martiniuk F. … Smith M. (Cytogenet. Cell Genet. 1980) 2 67

Products for GANC Gene

Sources for GANC Gene

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