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Aliases & Descriptions for GANC
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.2.1.20 3 | | MGC138256 2 |
| | | Descriptions |
|---|
| glucosidase, alpha; neutral C 2 | | neutral alpha-glucosidase C 2 |
|
| | Search outside databases for aliases for GANC genePrevious GC identifers: GC15U990022 GC15P040282 |
Summaries for GANC(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GANC: Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. [provided by RefSeq] UniProtKB/Swiss-Prot: GANC_HUMAN, Q8TET4Function: Has alpha-glucosidase activityGene Wiki entry for GANC |
Genomic Location for GANC
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GANC gene 
Entrez Gene cytogenetic band: 15q15.2 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15.2GANC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P040354:
(about GC identifiers)
Start:
|
40,353,658 bp from pter |
End:
|
40,433,156 bp from pter |
Size:
|
79,499 bases |
Orientation:
|
plus strand |
| Proteins for GANC
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GANC_HUMAN, Q8TET4 (See
protein sequence)Recommended Name: Neutral alpha-glucosidase C Size: 914 amino acids; 104348 Da
Secondary accessions: Q52LQ4 Q8IWZ0 Q8IZM4 Q8IZM5Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_937784.2
ENSEMBL proteins: ENSP00000326227
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for GANC: Assays for GANC: | Protein
Domains/ Families for GANC(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8TET4
ProtoNet protein and cluster: Q8TET4 1 Blocks protein family: IPB000322 Glycoside hydrolase
UniProtKB/Swiss-Prot: GANC_HUMAN, Q8TET4Similarity: Belongs to the glycosyl hydrolase 31 family | Gene Function for GANC
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_198141
Applied Biosystems Silencer® siRNAs for GANC
Sigma-Aldrich siRNA and siRNA Panels for GANC  Sigma-Aldrich shRNA for GANC  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_198141                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_198141                                  untagged cDNA clones in CMV expression vector (see all 2): AK074037 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_198141
UniProtKB/Swiss-Prot: GANC_HUMAN, Q8TET4Function: Has alpha-glucosidase activityCatalytic activity: Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucoseEnzyme Number (IUBMB): EC 3.2.1.20 Genatlas biochemistry entry for GANC:glucosidase,alpha-,neutral C2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
IEA | -- | | GO:0004558 | alpha-glucosidase activity |
NAS | 12370436 | About this table | Pathways & Interactions for GANC
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for GANC (Your Favorite Gene powered by Ingenuity) 
5/40 Interacting proteins for GANC (ENSP000003262273) via UniProtKB, MINT, and/or STRING (see all 40
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
IEA | -- | | GO:0008152 | metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for GANC(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for GANC |
Compounds for GANC available from Tocris Bioscience About this table
|
Transcripts for GANC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_198141
Sigma-Aldrich siRNA and siRNA Panels for GANC  Sigma-Aldrich shRNA for GANC  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_198141 REFSEQ mRNAs for GANC gene: NM_198141.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_198141               OriGene GFP tagged cDNA clone in CMV expression vector: NM_198141                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_198141                                  untagged cDNA clones in CMV expression vector (see all 2): AK074037  24/72 AceView cDNA sequences (see all 72
):BG034181 BC003169 BU194969 BC003521 BF059173 AL044086 BU160598 BQ878602 BQ425112 BE220887 NM_212464 AF127764 BQ427836 NM_000070 BG393547 BQ223604 NM_212465 F24048 CF552300 BU161124 AJ574026 AA278997 X85030 BG574232
highest scoring ESTs for GANC:BM999150 AI610343 AW104781 AW572233 AW627922 AA195092 AI671238 AA278326 AA278997 AA459075
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000318010
|
Expression for GANC
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GANC expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GANC
1 / 2 / 3 8 probe-sets matching GANC gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
|
Orthologs for GANC
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GANC gene from 5/8 species (see all 8
)
About this table Species with no ortholog for GANC
ENSEMBL Gene Tree for GANC | Paralogs for GANC(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GANC gene
- GAA2 GANAB2
|
SNPs/Variants for GANC(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GANC (up to first 250kb)
|
Disorders & Mutations for GANC
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 104180
|
Medical News for GANC(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GANC (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/44 PubMed articles for GANC gene (see all 44
): |
Search for GANC
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GANC
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GANC
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GANC(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GANC(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GANC:

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| | | | Tocris compounds for GANC |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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