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Aliases for GANC Gene

Aliases for GANC Gene

  • Glucosidase Alpha, Neutral C 2 3 5
  • Glucosidase, Alpha; Neutral C 2
  • EC 3.2.1.20 4
  • EC 3.2.1 61

External Ids for GANC Gene

Previous GeneCards Identifiers for GANC Gene

  • GC15U990022
  • GC15P040282
  • GC15P040354
  • GC15P042566
  • GC15P019414

Summaries for GANC Gene

Entrez Gene Summary for GANC Gene

  • Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014]

GeneCards Summary for GANC Gene

GANC (Glucosidase Alpha, Neutral C) is a Protein Coding gene. Among its related pathways are Galactose metabolism and Metabolism. GO annotations related to this gene include carbohydrate binding and alpha-1,4-glucosidase activity. An important paralog of this gene is GANAB.

UniProtKB/Swiss-Prot for GANC Gene

  • Has alpha-glucosidase activity.

Tocris Summary for GANC Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

Gene Wiki entry for GANC Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GANC Gene

Genomics for GANC Gene

Regulatory Elements for GANC Gene

Enhancers for GANC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F041401 0.2 ENCODE 24.2 -870.7 -870734 1.6 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5 ZNF143 NDUFAF1 DNAJC17 GANC CHST14 LOC105370795 RAD51-AS1 ENSG00000259211 BAHD1 RPAP1 EHD4-AS1
GH15F041330 0.5 ENCODE 24.2 -940.2 -940239 4.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NDUFAF1 DNAJC17 GANC ENSG00000259211 RPAP1 LOC105370795 RAD51-AS1 BAHD1 ENSG00000260814 MAPKBP1
GH15F042471 0.5 ENCODE 23.9 +198.5 198545 0.2 HDGF CTCF ARID4B ZNF384 CEBPG ZSCAN9 RAD21 RFX5 ZNF316 SMC3 GANC TMEM87A UBR1 ZNF106 GC15P042438
GH15F042270 0.5 ENCODE 22.1 +0.5 520 5.8 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GANC RPS3AP47 RPAP1 LRRC57 LOC105370795 CDAN1 TMEM87A
GH15F042497 0.2 ENCODE 21.6 +226.4 226375 4.3 HDGF HDAC1 PKNOX1 ARNT CREB3L1 FEZF1 ZBTB40 GTF3C2 POLR3A ZNF366 LRRC57 TUBGCP4 GANC LCMT2 CDAN1 HAUS2 ENSG00000260814 LOC105370795 RPAP1 RPS3AP47
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GANC on UCSC Golden Path with GeneCards custom track

Promoters for GANC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001451725 567 5201 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for GANC Gene

Chromosome:
15
Start:
42,273,233 bp from pter
End:
42,356,935 bp from pter
Size:
83,703 bases
Orientation:
Plus strand

Genomic View for GANC Gene

Genes around GANC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GANC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GANC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GANC Gene

Proteins for GANC Gene

  • Protein details for GANC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TET4-GANC_HUMAN
    Recommended name:
    Neutral alpha-glucosidase C
    Protein Accession:
    Q8TET4
    Secondary Accessions:
    • Q52LQ4
    • Q8IWZ0
    • Q8IZM4
    • Q8IZM5

    Protein attributes for GANC Gene

    Size:
    914 amino acids
    Molecular mass:
    104334 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GANC Gene

Selected DME Specific Peptides for GANC Gene

Q8TET4:
  • LKISIPM
  • WNDMNEPS
  • WMSESGIIDVFL
  • SSYLDFTNP
  • GAYQPFFR
  • YRLYNLDV
  • LHNIYGFY
  • FSLGYHQ

Post-translational modifications for GANC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GANC Gene

Suggested Antigen Peptide Sequences for GANC Gene

Graphical View of Domain Structure for InterPro Entry

Q8TET4

UniProtKB/Swiss-Prot:

GANC_HUMAN :
  • Belongs to the glycosyl hydrolase 31 family.
Family:
  • Belongs to the glycosyl hydrolase 31 family.
genes like me logo Genes that share domains with GANC: view

No data available for Gene Families for GANC Gene

Function for GANC Gene

Molecular function for GANC Gene

GENATLAS Biochemistry:
glucosidase,alpha-,neutral C
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
UniProtKB/Swiss-Prot Function:
Has alpha-glucosidase activity.

Enzyme Numbers (IUBMB) for GANC Gene

Gene Ontology (GO) - Molecular Function for GANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA --
GO:0004558 alpha-1,4-glucosidase activity NAS 12370436
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with GANC: view
genes like me logo Genes that share phenotypes with GANC: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GANC Gene

Localization for GANC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GANC Gene COMPARTMENTS Subcellular localization image for GANC gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 2
chloroplast 1
golgi apparatus 1
lysosome 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GANC Gene

Pathways & Interactions for GANC Gene

genes like me logo Genes that share pathways with GANC: view

Pathways by source for GANC Gene

Gene Ontology (GO) - Biological Process for GANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000023 maltose metabolic process IEA --
GO:0005975 carbohydrate metabolic process IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GANC: view

No data available for SIGNOR curated interactions for GANC Gene

Drugs & Compounds for GANC Gene

(8) Drugs for GANC Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miglitol Approved Pharma Target, antagonist 12
Water Approved Pharma 0
Acarbose Approved, Investigational Pharma Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) 85
maltose Experimental Pharma 0
Sucrose Experimental Pharma 0

(6) Additional Compounds for GANC Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Alpha-D-Glucose
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
492-62-6
D-Fructose
  • beta-D-Arabino-hexulose
  • beta-D-Fructofuranose
  • beta-D-Fructose
  • beta-delta-Arabino-hexulose
  • beta-delta-Fructofuranose
53188-23-1
D-Galactose
  • (+)-Galactose
  • 5abp
  • 8abp
  • alpha D-Galactose
  • alpha-D-Galactopyranose
59-23-4
D-Glucose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
50-99-7
melibiose
  • 6-(a-D-Galactosido)-D-glucose
  • 6-(a-delta-Galactosido)-delta-glucose
  • 6-(D-Galactosido)-D-glucose
  • 6-(D-Galactosido)-delta-glucose
  • 6-O-a-D-Galactopyranosyl-D-Glucose
585-99-9

(5) Tocris Compounds for GANC Gene

Compound Action Cas Number
1-Deoxynojirimycin Glucosidase I and II inhibitor 19130-96-2
Acarbose Glucosidase alpha inhibitor (intestinal) 56180-94-0
Kifunensine Inhibitor of class I alpha-mannosidases 109944-15-2
Miglustat hydrochloride alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases 210110-90-0
Swainsonine Inhibitor of alpha-mannosidase II 72741-87-8
genes like me logo Genes that share compounds with GANC: view

Transcripts for GANC Gene

Unigene Clusters for GANC Gene

Glucosidase, alpha; neutral C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GANC Gene

No ASD Table

Relevant External Links for GANC Gene

GeneLoc Exon Structure for
GANC
ECgene alternative splicing isoforms for
GANC

Expression for GANC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GANC Gene

Protein differential expression in normal tissues from HIPED for GANC Gene

This gene is overexpressed in Cerebrospinal fluid (24.2), Bone marrow mesenchymal stem cell (12.2), Lymph node (10.1), and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GANC Gene



NURSA nuclear receptor signaling pathways regulating expression of GANC Gene:

GANC

SOURCE GeneReport for Unigene cluster for GANC Gene:

Hs.730806
genes like me logo Genes that share expression patterns with GANC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GANC Gene

Orthologs for GANC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GANC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GANC 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia GANC 34 35
  • 89.05 (n)
cow
(Bos Taurus)
Mammalia GANC 34 35
  • 88.17 (n)
mouse
(Mus musculus)
Mammalia Ganc 34 16 35
  • 85.53 (n)
rat
(Rattus norvegicus)
Mammalia Ganc 34
  • 85.12 (n)
oppossum
(Monodelphis domestica)
Mammalia GANC 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GANC 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves GANC 34 35
  • 70.65 (n)
lizard
(Anolis carolinensis)
Reptilia GANC 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ganc 34
  • 62.84 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536353 34
  • 56.5 (n)
GANC 35
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14476 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aagr-4 35
  • 41 (a)
ManyToMany
aagr-3 35
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROT2 35
  • 32 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6669 34
wheat
(Triticum aestivum)
Liliopsida Ta.1604 34
corn
(Zea mays)
Liliopsida Zm.13759 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for GANC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GANC Gene

ENSEMBL:
Gene Tree for GANC (if available)
TreeFam:
Gene Tree for GANC (if available)

Paralogs for GANC Gene

Paralogs for GANC Gene

(1) SIMAP similar genes for GANC Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GANC: view

Variants for GANC Gene

Sequence variations from dbSNP and Humsavar for GANC Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10438262 -- 42,346,745(+) GTAAT(C/T)CTGGG intron-variant
rs10438301 -- 42,346,509(+) gtatg(A/G)tatat intron-variant
rs10518763 -- 42,347,797(+) CACTT(A/G)TAGGA intron-variant
rs10718485 -- 42,281,437(+) CCAGC(-/A)CTTTG intron-variant
rs10775126 -- 42,307,572(+) TGATG(G/T)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GANC Gene

Variant ID Type Subtype PubMed ID
esv2660428 CNV deletion 23128226
esv2661604 CNV deletion 23128226
esv2671493 CNV deletion 23128226
esv3581651 CNV loss 25503493
esv3636263 CNV loss 21293372
esv3636264 CNV loss 21293372
esv3636265 CNV loss 21293372
nsv827310 CNV loss 20364138
nsv832986 CNV loss 17160897
nsv832987 CNV gain 17160897

Variation tolerance for GANC Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.75; 96.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GANC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GANC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GANC Gene

Disorders for GANC Gene

Relevant External Links for GANC

Genetic Association Database (GAD)
GANC
Human Genome Epidemiology (HuGE) Navigator
GANC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GANC

No disorders were found for GANC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GANC Gene

Publications for GANC Gene

  1. Computer assisted cloning of human neutral alpha glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31. (PMID: 12370436) Hirschhorn R. … Kasper J.S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 22 64
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene. (PMID: 14675785) Kawabata Y. … Sorimachi H. (FEBS Lett. 2003) 3 22 64
  5. Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15. (PMID: 6995030) Martiniuk F. … Smith M. (Cytogenet. Cell Genet. 1980) 2 3 64

Products for GANC Gene

Sources for GANC Gene

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