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GAN Gene

protein-coding   GIFtS: 55
GCID: GC16P081348

Gigaxonin

(Previous name: giant axonal neuropathy (gigaxonin))
  See GAN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
gigaxonin1 2
GAN12 3 5
Kelch-Like Family Member 161 2
Kelch-Like Protein 162 3
KLHL162 3
Giant Axonal Neuropathy (Gigaxonin)1

External Ids:    HGNC: 41371   Entrez Gene: 81392   Ensembl: ENSG000002616097   OMIM: 6053795   UniProtKB: Q9H2C03   

Export aliases for GAN gene to outside databases

Previous GC identifers: GC16P072189 GC16P082309 GC16P081087 GC16P081128 GC16P079906 GC16P067103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GAN Gene:
This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family.
The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination
and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). (provided by
RefSeq, Oct 2008)

GeneCards Summary for GAN Gene:
GAN (gigaxonin) is a protein-coding gene. Diseases associated with GAN include endometriosis of uterus, and giant axonal neuropathy. An important paralog of this gene is KLHDC8B.

UniProtKB/Swiss-Prot: GAN_HUMAN, Q9H2C0
Function: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament
architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates
the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB.
Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival

Gene Wiki entry for GAN (Gigaxonin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GAN gene promoter:
         Bach1   SRF   SRF (504 AA)   LCR-F1   Cdc5   GATA-2   CREB   AREB6   SRY   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGAN promoter sequence
   Search Chromatin IP Primers for GAN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q23.2   HGNC cytogenetic band: 16q24.1

GAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P081348:  view genomic region     (about GC identifiers)

Start:
81,348,557 bp from pter      End:
81,424,489 bp from pter
Size:
75,933 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GAN_HUMAN, Q9H2C0 (See protein sequence)
Recommended Name: Gigaxonin  
Size: 597 amino acids; 67638 Da
Subunit: Interacts with TBCB. Interacts with CUL3. Part of a complex that contains CUL3, RBX1 and GAN. Interacts
(via BTB domain) with UBA1. Interacts (via Kelch domains) with MAP1B (via C-terminus) and MAP1S (via C-terminus)
2 PDB 3D structures from and Proteopedia for GAN:
2PPI (3D)        3HVE (3D)    

Explore the universe of human proteins at neXtProt for GAN: NX_Q9H2C0

Explore proteomics data for GAN at MOPED

Post-translational modifications: 

  • Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for
    proteasome-independent degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GAN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071324.1  
    ENSEMBL proteins: 
     ENSP00000476795  
    Reactome Protein details: Q9H2C0

    GAN Human Recombinant Protein Products:

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    Novus Biologicals GAN Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GAN

     
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    antibodies-online proteins for GAN (4 products) 

     
    antibodies-online peptides for GAN

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    antibodies-online antibodies for GAN (26 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR017096 Kelch-like_gigaxonin-typ
     IPR000210 BTB/POZ-like
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9H2C0

    ProtoNet protein and cluster: Q9H2C0

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: GAN_HUMAN, Q9H2C0
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Find genes that share domains with GAN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GAN_HUMAN, Q9H2C0
    Function: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament
    architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates
    the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB.
    Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI12147674
         
    Find genes that share ontologies with GAN           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gan):
     behavior/neurological  cellular  growth/size/body  mortality/aging  muscle 
     nervous system 

    Find genes that share phenotypes with GAN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GAN: Gantm1Yany Gantm1Jpj

       genOway: Develop your customized and physiologically relevant rodent model for GAN

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GAN (see all 61):
    hsa-miR-429 hsa-let-7d hsa-miR-15a hsa-miR-199a-3p hsa-miR-503 hsa-miR-25 hsa-miR-30d hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidGAN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GAN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GAN (NM_198141)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GAN_HUMAN, Q9H2C0: Cytoplasm. Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19424503
    GO:0005856cytoskeleton IEA--
    GO:0005883neurofilament ----
    GO:0031463Cul3-RING ubiquitin ligase complex IDA15983046

    Find genes that share ontologies with GAN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GAN About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with GAN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for GAN
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: GAN_HUMAN, Q9H2C0
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including GAN: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GAN

    Selected Interacting proteins for GAN (Q9H2C01, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1BP468211, 3EBI-764342,EBI-764611 I2D: score=4 
    SFNP319472, 3MINT-3974974 I2D: score=2 
    TBCBQ994261, 3EBI-764342,EBI-764356 I2D: score=2 
    UBA1P223141, 3EBI-764342,EBI-709688 I2D: score=2 
    ATG16L1Q676U53I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008219cell death IEA--
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with GAN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GAN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GAN gene: 
    NM_022041.3  

    Unigene Cluster for GAN:

    Gigaxonin
    Hs.112569  [show with all ESTs]
    Unigene Representative Sequence: AF291673
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568107 ENST00000567335
    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate GAN (see all 61):
    hsa-miR-429 hsa-let-7d hsa-miR-15a hsa-miR-199a-3p hsa-miR-503 hsa-miR-25 hsa-miR-30d hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidGAN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GAN
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GAN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GAN
      QuantiTect SYBR Green Assays in human, mouse, rat GAN
      QuantiFast Probe-based Assays in human, mouse, rat GAN

    Additional mRNA sequence: 

    AF291673.1 AK095378.1 BC016717.1 BC044840.1 

    2 DOTS entries:

    DT.306282  DT.99970538 

    24 AceView cDNA sequences:

    CD677584 AA306952 NM_022041 BC044840 AF291673 AW673751 BX508770 BC016717 
    CA433046 AA084323 AK095378 AW078676 AA932250 AL706883 CB243238 CD671937 
    AW673114 AA081576 BF803108 BF083692 AA604690 AI821712 BQ311505 BQ356248 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GAN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GAN Expression
    About this image

    GAN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GAN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112569

    UniProtKB/Swiss-Prot: GAN_HUMAN, Q9H2C0
    Tissue specificity: Expressed in brain, heart and muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including GAN: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GAN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gan1 , 5 giant axonal neuropathy1, 5 87.44(n)1
    98.32(a)1
      8 (63.71 cM)5
    2092391  NM_001081151.11  NP_001074620.11 
     1171581375 
    chicken
    (Gallus gallus)
    Aves GAN1 gigaxonin 81.69(n)
    91.62(a)
      430553  XM_428110.4  XP_428110.3 
    lizard
    (Anolis carolinensis)
    Reptilia GAN6
    gigaxonin
    90(a)
    1 ↔ 1
    LGc(5843841-5869432)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.160552 Transcribed sequence with moderate similarity to protein more 75.2(n)    142032520 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005374351 gigaxonin-like 66.3(n)
    69.23(a)
      100537435  XM_003200434.2  XP_003200482.2 
    worm
    (Caenorhabditis elegans)
    Secernentea kel-106
    F47D12.76
    (see all 3)
    Protein F47D12.7 (F47D12.7) mRNA, complete cds
    (see all 3)
    18(a)
    18(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    III(10098473-10101584) WBGene00002186
    III(6293247-6295849) WBGene00018563


    ENSEMBL Gene Tree for GAN (if available)
    TreeFam Gene Tree for GAN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GAN gene
    KLHDC8B2  KLHL72  IPP2  IVNS1ABP2  KLHDC8A2  
    1 SIMAP similar gene for GAN using alignment to 1 protein entry:     GAN_HUMAN:
    KBTBD3

    Find genes that share paralogs with GAN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GAN (see all 2192)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444862411,2,,4
    C,FGiant axonal neuropathy (GAN)4 --82398018(+) CATGCC/G/TGAGAA 3 P R L mis11NA 4550
    VAR_0541134
    Giant axonal neuropathy (GAN)4--see VAR_0541132 A P mis40--------
    VAR_0156814
    Giant axonal neuropathy (GAN)4--see VAR_0156812 G R mis40--------
    VAR_0107664
    Giant axonal neuropathy (GAN)4--see VAR_0107662 R C mis40--------
    VAR_0107634
    Giant axonal neuropathy (GAN)4--see VAR_0107632 R H mis40--------
    VAR_0107594
    Giant axonal neuropathy (GAN)4--see VAR_0107592 R S mis40--------
    VAR_0155604
    Giant axonal neuropathy (GAN)4--see VAR_0155602 I T mis40--------
    VAR_0107574
    Giant axonal neuropathy (GAN)4--see VAR_0107572 E K mis40--------
    VAR_0541174
    Giant axonal neuropathy (GAN)4--see VAR_0541172 G R mis40--------
    VAR_0107614
    Giant axonal neuropathy (GAN)4--see VAR_0107612 S L mis40--------

    HapMap Linkage Disequilibrium report for GAN (81348557 - 81424489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GAN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524477CNV Gain19592680
    nsv524464CNV Gain19592680

    Human Gene Mutation Database (HGMD): GAN
    Locus Specific Mutation Databases (LSDB): GAN

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GAN
    DNA2.0 Custom Variant and Variant Library Synthesis for GAN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605379   
    OMIM disorders: 256850  
    UniProtKB/Swiss-Prot: GAN_HUMAN, Q9H2C0
  • Giant axonal neuropathy (GAN) [MIM:256850]: Severe autosomal recessive sensorimotor neuropathy affecting
    both the peripheral nerves and the central nervous system. It is characterized by neurofilament accumulation,
    leading to segmental distention of axons. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 5 diseases for GAN:    
    About MalaCards
    endometriosis of uterus    giant axonal neuropathy    axonal neuropathy    neuropathy
    neuroaxonal dystrophy

    5 diseases from the University of Copenhagen DISEASES database for GAN:
    Neuropathy     Neuroaxonal dystrophy     Borderline personality disorder     Polyneuropathy
    Endometriosis of uterus

    Find genes that share disorders with GAN           About GenesLikeMe

    2 Novoseek inferred disease relationships for GAN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuropathy, giant axonal 99 19 17587580 (3), 18595793 (2), 11062483 (2), 19295179 (2) (see all 13)
    neurodegenerative diseases 63.2 5 12655563 (1), 19168853 (1), 11062483 (1), 16227972 (1) (see all 5)

    GeneTests: GAN
    GeneReviews: GAN
    Genetic Association Database (GAD): GAN
    Human Genome Epidemiology (HuGE) Navigator: GAN (83 documents)

    Export disorders for GAN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GAN gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with GAN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. (PubMed id 11062483)1, 2, 3, 9 Bomont P.... Koenig M. (Nat. Genet. 2000)
    2. Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin. (PubMed id 12147674)1, 2, 9 Ding J....Yang Y. (J. Cell Biol. 2002)
    3. Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. (PubMed id 16227972)1, 2, 9 Allen E.... Yang Y. (Nature 2005)
    4. Identification of seven novel mutations in the GAN gene. (PubMed id 12655563)1, 2, 9 Bomont P.... Koenig M. (Hum. Mutat. 2003)
    5. Genotype-phenotype analysis in patients with giant axonal neuropathy (GAN). (PubMed id 17587580)1, 2, 9 Koop O.... Kuhlenbaeumer G. (Neuromuscul. Disord. 2007)
    6. Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway. (PubMed id 16303566)1, 2, 9 Wang W.... Yang Y. (Curr. Biol. 2005)
    7. New mutations, genotype phenotype studies and manifesting carriers in giant axonal neuropathy. (PubMed id 17578852)1, 2, 9 Houlden H.... Reilly M.M. (J. Neurol. Neurosurg. Psych. 2007)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    10. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. (PubMed id 19424503)1, 2 Wang X.J. and Zhang D.D. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8139 HGNC: 4137 AceView: GAN Ensembl:ENSG00000261609 euGenes: HUgn8139
    ECgene: GAN H-InvDB: GAN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GAN Pharmacogenomics, SNPs, Pathways
    Inherited peripheral neuropathies mutation dbhttp://www.molgen.ua.ac.be/CMTMutations/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=GAN[genesymbol]

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GAN gene:
    Search GeneIP for patents involving GAN

    GeneCards and IP:
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